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Publications 2024

  1. Abedi Kichi Z, Dini N, Rojhannezhad M, Shirvani Farsani Z. Noncoding RNAs in B cell non-Hodgkins lymphoma. Gene 2024
  2. Adam S, Maas SL, Huchzermeier R, Rakateli L, Abschlag K, Hohl M, Liao L, Bartneck M, Teunissen M, Wouters K, Santovito D, Jankowski J, Biessen EAL, van der Vorst EPC. The calcium-sensing-receptor (CaSR) in adipocytes contributes to sex-differences in the susceptibility to high fat diet induced obesity and atherosclerosis. EBioMedicine 2024 

  3. Assal RA, Abd El-Bary RBE, Youness RA, Abdelrahman MM, Zahran H, Hosny KA, Esmat G, Breuhahn K, El-Ekiaby N, Fawzy IO, Abdelaziz AI. OncomiR-181a promotes carcinogenesis by repressing the extracellular matrix proteoglycan decorin in hepatocellular carcinoma. BMC Gastroenterol 2024

  4. Barkas F, Sener YZ, Golforoush PA, Kheirkhah A, Rodriguez-Sanchez E, Novak J, Apellaniz-Ruiz M, Akyea RK, Bianconi V, Ceasovschih A, Chee YJ, Cherska M, Chora JR, D'Oria M, Demikhova N, Kocyigit Burunkaya D, Rimbert A, Macchi C, Rathod K, Roth L, Sukhorukov V, Stoica S, Scicali R, Storozhenko T, Uzokov J, Lupo MG, van der Vorst EPC, Porsch F. Advancements in risk stratification and management strategies in primary cardiovascular prevention. Atherosclerosis 2024

  5. Berndt C, ..., Bartelt A, Conrad M. Ferroptosis in health and disease. Redox Biol 2024

  6. Bherer C, Eveleigh R, Trajanoska K, St-Cyr J, Paccard A, Nadukkalam Ravindran P, Caron E, Bader Asbah N, McClelland P, Wei C, Baumgartner I, Schindewolf M, Doring Y, Perley D, Lefebvre F, Lepage P, Bourgey M, Bourque G, Ragoussis J, Mooser V, Taliun D. A cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genome. NPJ Genom Med 2024
  7. Bochenek ML, Saar K, Nazari-Jahantigh M, Gogiraju R, Wiedenroth CB, Munzel T, Mayer E, Fink L, Schober A, Hubner N, Guth S, Konstantinides S, Schafer K. Endothelial Overexpression of TGF-beta-Induced Protein Impairs Venous Thrombus Resolution: Possible Role in CTEPH. JACC Basic Transl Sci 2024

  8. Brunetta HS, Jung AS, Valdivieso-Rivera F, de Campos Zani SC, Guerra J, Furino VO, Francisco A, Bercot M, Moraes-Vieira PM, Keipert S, Jastroch M, Martinez LO, Sponton CH, Castilho RF, Mori MA, Bartelt A. IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat. EMBO J 2024

  9.  Caca J, Bartelt A, Egea V. Hypoxia Regulates Brown Adipocyte Differentiation and Stimulates miR-210 by HIF-1alpha. Int J Mol Sci 2024

  10. Chen B, Prabhu A, Li G, Kaltenbach A, Wang Y, Shakir G, Natarelli L, Megens R, Jansen Y, Ramanathan S, Geiger M, Faussner A, Hristov M, Richter D, Di X, van der Stelt M, Li Z, Sachs N, Paloschi V, Maegdefessel L, Hofmann SM, Weber C, Herzig S, Prats RG, Steffens S. Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress. bioRxiv 2024

  11. Chen W, Jin B, Cheng C, Peng H, Zhang X, Tan W, Tang R, Lian X, Diao H, Luo N, Li X, Fan J, Shi J, Yin C, Wang J, Peng S, Yu L, Li J, Wu RQ, Kuang DM, Shi GP, Zhou Y, Wang F, Jiang X. Single-cell profiling reveals kidney CD163(+) dendritic cell participation in human lupus nephritis. Ann Rheum Dis 2024
  12. Christ A, Maas SL, Jin H, Lu C, Legein B, Wijnands E, Temmerman L, Otten J, Isaacs A, Zenke M, Stoll M, Biessen EAL, van der Vorst EPC. In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naive T cells. Free Radic Biol Med 2024
  13. Dai Y, Junho CVC, Schieren L, Wollenhaupt J, Sluimer JC, van der Vorst EPC, Noels H. Cellular metabolism changes in atherosclerosis and the impact of comorbidities. Front Cell Dev Biol 2024
  14. Dong Y, Kang Z, Zhang Z, Zhang Y, Zhou H, Liu Y, Shuai X, Li J, Yin L, Wang X, Ma Y, Fan H, Jiang F, Lin Z, Ding C, Yun Jin K, Sarapultsev A, Li F, Zhang G, Xie T, Yin C, Cheng X, Luo S, Liu Y, Hu D. Single-cell profile reveals the landscape of cardiac immunity and identifies a cardio-protective Ym-1(hi) neutrophil in myocardial ischemia-reperfusion injury. Sci Bull (Beijing) 2024
  15. Döring Y, Bender A, Soehnlein O. Lack of Formyl-peptide Receptor 1 Mitigates Atherosclerosis in Hyperlipidemic Mice. Thromb Haemost 2024
  16. Döring Y, van der Vorst EPC, Weber C. Targeting immune cell recruitment in atherosclerosis. Nat Rev Cardiol 2024
  17. Döring Y, van der Vorst EPC, Yan Y, Neideck C, Blanchet X, Jansen Y, Kemmerich M, Bayasgalan S, Peters LJF, Hristov M, Bidzhekov K, Yin C, Zhang X, Leberzammer J, Li Y, Park I, Kral M, Nitz K, Parma L, Gencer S, Habenicht AJR, Faussner A, Teupser D, Monaco C, Holdt L, Megens RTA, Atzler D, Santovito D, von Hundelshausen P, Weber C. Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis. Nat Cardiov Res 2024
  18. Egea V. Caught in action: how MSCs modulate atherosclerotic plaque. Front Cell Dev Biol 2024
  19. Egea V, Lutterberg K, Steinritz D, Rothmiller S, Steinestel K, Caca J, Nerlich A, Blum H, Reschke S, Khani S, Bartelt A, Worek F, Thiermann H, Weber C, Ries C. Targeting miR-497-5p rescues human keratinocyte dysfunction upon skin exposure to sulfur mustard. Cell Death Dis 2024
  20. Frenz-Wiessner S, Fairley SD, Buser M, Goek I, Salewskij K, Jonsson G, Illig D, Zu Putlitz B, Petersheim D, Li Y, Chen PH, Kalauz M, Conca R, Sterr M, Geuder J, Mizoguchi Y, Megens RTA, Linder MI, Kotlarz D, Rudelius M, Penninger JM, Marr C, Klein C. Generation of complex bone marrow organoids from human induced pluripotent stem cells. Nat Methods 2024
  21. Guerra J, Matta L, Bartelt A. Cardiac proteostasis in obesity and cardiovascular disease. Herz 2024 
  22. Gultom M, Lin L, Brandt CB, Milusev A, Despont A, Shaw J, Doring Y, Luo Y, Rieben R. Sustained Vascular Inflammatory Effects of SARS-CoV-2 Spike Protein on Human Endothelial Cells. Inflammation 2024
  23. Henderson, J.M., Farina, F.M., Santovito, D. MicroRNAs and Cardiovascular Diseases. In: Vaschetto, L.M. (eds) miRNAs, Human Health and Diseases. Epigenetics and Human Health, Springer 2024
  24. Jia Y, Cheng L, Yang J, Mao J, Xie Y, Yang X, Zhang X, Wang D, Zhao Z, Schober A, Wei Y. miR-223-3p Prevents Necroptotic Macrophage Death by Targeting Ripk3 in a Negative Feedback Loop and Consequently Ameliorates Advanced Atherosclerosis. Arterioscler Thromb Vasc Biol 2024
  25. Kapp FG, Bazgir F, Mahammadzade N, Mehrabipour M, Vassella E, Bernhard SM, Doring Y, Holm A, Karow A, Seebauer C, Platz Batista da Silva N, Wohlgemuth WA, Oppenheimer A, Kroning P, Niemeyer CM, Schanze D, Zenker M, Eng W, Ahmadian MR, Baumgartner I, Rossler J. Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition. Angiogenesis 2024
  26. Karami S, Shamsipur M, Barati A, Mohammadi S, Abedi Kichi Z. Reductive carbon dots for reduction, ratiometric fluorescence determination, and intracellular imaging of Au(3). Spectrochim Acta A Mol Biomol Spectrosc 2024
  27. Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Guller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Bartelt A, Jastroch M, Wachten D, Kornfeld JW. Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function. Nat Metab 2024. 
  28. Kosinski J, Sechi A, Hain J, Villwock S, Ha SA, Hauschulz M, Rose M, Steib F, Ortiz-Bruchle N, Heij L, Maas SL, van der Vorst EPC, Knoesel T, Altendorf-Hofmann A, Simon R, Sauter G, Bednarsch J, Jonigk D, Dahl E. ITIH5 as a multifaceted player in pancreatic cancer suppression, impairing tyrosine kinase signaling, cell adhesion and migration. Mol Oncol 2024
  29. Kral, M., Döring, Y. & Weber, C. Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control. Sig Transduct Target Ther 2024
  30. Kral M, Van Der Vorst E, Weber ,Döring Y. (Multi-) Omics studies of ILC2s in inflammation and metabolic diseases. Frontiers in Cell and Developmental Biology 2024

  31. Lin C, Jans A, Wolters JC, Mohamed MR, Van der Vorst EPC, Trautwein C, Bartneck M. Targeting Ligand Independent Tropism of siRNA-LNP by Small Molecules for Directed Therapy of Liver or Myeloid Immune Cells. Adv Healthc Mater 2024

  32. Lip GYH, Rigby A, Weber C. A Happy New Year 2024 from Thrombosis and Haemostasis! Thromb Haemost 2024
  33. Malyaran H, Craveiro RB, Mert S, Niederau C, Maas SL, van der Vorst EPC, Holzle F, Jahnen-Dechent W, Wolf M, Neuss S. Identifying Differences in Molecular Characteristics Relevant for Remodeling of Periodontal Ligament Stem Cells from the Upper and Lower Jaw. Int J Mol Sci 2024
  34. Meiners S, Reynaert NL, Matthaiou AM, Rajesh R, Ahmed E, Guillamat-Prats R, Heijink IH, Cuevas-Ocana S. The importance of translational science within the respiratory field. Breathe (Sheff) 2024
  35. Mohanta SK, Santovito D, Weber C. Cortico-limbic restructuring and atherosclerosis: a stressful liaison. Eur Heart J 2024
  36. Mouzakis FL, Hima F, Kashefi A, Greven J, Rink L, van der Vorst EPC, Jankowski J, Mottaghy K, Spillner J. Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study. Biomedicines 2024
  37. Mueller TT, Pilartz M, Thakur M, LangHeinrich T, Luo J, Block R, Hoeflinger JKL, Meister S, Karaj F, Perez LG, Ollinger R, Engleitner T, Thoss J, Voelkl M, Tersteeg C, Koedel U, Kohlmaier AZ, Teupser D, Wygrecka M, Ye H, Preissner KT, Radbruch H, Elezkurtaj S, Mack M, Von Hundelshausen P, Weber C, Massberg S, Schulz C, Rad R, Huber S, Ishikawa-Ankerhold H, Engelmann B. Mutual regulation of CD4+ T cells and intravascular fibrin in infections. Haematologica 2024
  38. Parma L, Duchene J, Weber C. Breaking Point: How Intraplaque Hemorrhage Propels Plaque Rupture. Circ Res 2024
  39. Ramezani Rad P, Nageswaran V, Peters L, Reinshagen L, Roessler J, Simmons S, Asmus E, Wittig C, Brack MC, Nouailles G, van der Vorst EPC, Maas SL, Sonnenschein K, Verhaar B, Szulcek R, Witzenrath M, Landmesser U, Kuebler WM, Haghikia A. Pneumonia Induced Rise in Glucagon Promotes Endothelial Damage and Thrombogenicity. Circ Res 2024
  40. Rau M, Kurt B, Hartmann O, Lobo de Sa FD, Schwarz M, Thiele K, Hartmann NK, Spiesshoefer J, Mollmann J, Hohl M, Selejan SR, van der Vorst EPC, Dahl E, Marx N, Kahles F, Lehrke M. Proenkephalin A 119-159 (penKid) and mortality in stable patients at high cardiovascular risk. Clin Kidney J 2024
  41. Samus M, Rot A. Atypical chemokine receptors in cancer. Cytokine 2024
  42. Santovito D, Henderson JM, Bidzhekov K, Triantafyllidou V, Jansen Y, Chen Z, Farina FM, Diagel A, Aslani M, Blanchet X, Schunkert H, Megens RTA, Döring Y, Sattler M, Weber C. Mex3a Protects Against Atherosclerosis: Evidence From Mice and Humans. Circulation 2024 

  43. Schulze-Spate U, Wurschi L, van der Vorst EPC, Holzle F, Craveiro RB, Wolf M, Noels H. Crosstalk between periodontitis and cardiovascular risk. Front Immunol 2024

  44. Steffens S, Schroder K, Kruger M, Maack C, Streckfuss-Bomeke K, Backs J, Backofen R, Baessler B, Devaux Y, Gilsbach R, Heijman J, Knaus J, Kramann R, Linz D, Lister AL, Maatz H, Maegdefessel L, Mayr M, Meder B, Nussbeck SY, Rog-Zielinska EA, Schulz MH, Sickmann A, Yigit G, Kohl P. The challenges of research data management in cardiovascular science: a DGK and DZHK position paper-executive summary. Clin Res Cardiol 2024

  45. Streckfuss-Bomeke K, Krankel N, Maack C, Schnabel RB, Zelarayan LC, Frey N, Jezzard P, Kruger M, Lachmann N, Lutz S, Noack C, Schoger E, Schroder K, Sommerfeld LC, Steffens S, Winkels H, Wurtz C, Zeller T, Rog-Zielinska EA, Kohl P. Physiologists as medical scientists: An early warning from the German academic system. Physiol Rep 2024

  46. Strohm L, Daiber A, Ubbens H, Krishnankutty R, Oelze M, Kuntic M, Hahad O, Klein V, Hoefer IE, von Kriegsheim A, Kleinert H, Atzler D, Lurz P, Weber C, Wild PS, Munzel T, Knosalla C, Lutgens E, Daub S. Role of inflammatory signaling pathways involving the CD40-CD40L-TRAF cascade in diabetes and hypertension-insights from animal and human studies. Basic Res Cardiol 2024
  47. Sun T, Monjezi MR, Xu X, Yin C, Habenicht AJR, Mohanta SK. Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis. J Vis Exp 2024
  48. Takaoka M, Zhao X, Lim HY, Magnussen CG, Ang O, Suffee N, Schrank PR, Ong WS, Tsiantoulas D, Sommer F, Mohanta SK, Harrison J, Meng Y, Laurans L, Wu F, Lu Y, Masters L, Newland SA, Denti L, Hong M, Chajadine M, Juonala M, Koskinen JS, Kahonen M, Pahkala K, Rovio SP, Mykkanen J, Thomson R, Kaisho T, Habenicht AJR, Clement M, Tedgui A, Ait-Oufella H, Zhao TX, Nus M, Ruhrberg C, Taleb S, Williams JW, Raitakari OT, Angeli V, Mallat Z. Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis. Nature 2024
  49. Teuwen JTJ, van der Vorst EPC, Maas SL. Navigating the Maze of Kinases: CaMK-like Family Protein Kinases and Their Role in Atherosclerosis. Int J Mol Sci 2024
  50. van der Vorst EPC, Rydén M. The double-edged impact of obesity on cancer risk and treatment response: implications for atherosclerosis? Cardiovasc Res. 2024 
  51. van der Vorst EPC, Kovacic JC. Therapeutic targeting of cell transition: ready for clinical prime-time? Cardiovasc Res 2024
  52. Vos WG, van Os BW, den Toom M, Beckers L, van Roomen C, van Tiel CM, Mohapatra BC, Band H, Nitz K, Weber C, Atzler D, de Winther MPJ, Bosmans LA, Lutgens E, Seijkens TTP. T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation. Front Immunol 2024
  53. Wang Y, Panicker IS, Anesi J, Sargisson O, Atchison B, Habenicht AJR. Animal Models, Pathogenesis, and Potential Treatment of Thoracic Aortic Aneurysm. Int J Mol Sci 2024
  54. Wang Y, Li G, Chen B, Shakir G, Volz M, van der Vorst EPC, Maas SL, Geiger M, Jethwa C, Bartelt A, Li Z, Wettich J, Sachs N, Maegdefessel L, Nazari Jahantigh M, Hristov M, Lacy M, Lutz B, Weber C, Herzig S, Guillamat Prats R, Steffens S. Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner. Cardiovasc Res 2024
  55. Wallach I, ..., Blanchet X, ..., Heifets A. AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep 2024
  56. Wang Y, Fang Y, Habenicht AJR, Golledge J, Giovannucci EL, Ceriello A. Postprandial Plasma Glucose With a Fasting Time of 4-7.9 h Is Positively Associated With Cancer Mortality in US Adults. Diabetes Metab Res Rev 2024
  57. Weber C, Rigby A, Lip GYH. Thrombosis and Haemostasis 2023 Editors' Choice Papers. Thromb Haemost 2024

  58. Wu Y, Avcilar-Kücükgöze I, Santovito D, Atzler D. Amino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular Disease. Biomolecules 2024

  59. Zhang Y, Liu G, Zeng Q, Wu W, Lei K, Zhang C, Tang M, Zhang Y, Xiang X, Tan L, Cui R, Qin S, Song X, Yin C, Chen Z, Kuang M. CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis. Cancer Cell 2024

  60. Zhang X, van der Vorst EPC. High-Density Lipoprotein Modifications: Causes and Functional Consequences in Type 2 Diabetes Mellitus. Cells 2024

  61. Zhao D, Han C, Mammadova-Bach E, Watanabe-Kusunoki K, Honda TSB, Li Y, Li C, Li Q, Long H, Lyubenov L, Shi C, Santovito D, Weber C, Boor P, Droste P, Parikh S, Shapiro J, De Chiara L, Carangelo G, Romagnani P, Klussmann S, Vater A, Anders H-J. Inhibition of complement factor C5a or C5aR for cholesterol crystal embolism-related vascular thrombosis with microvascular injury and its consequences. Kidney Internat 2024

Highlights

Knocking Out Assumptions: Hidden Challenges in Transgenic Mouse Models

17 Oct 2024 | News | Publication

JLB 2024 ➤ IPEK scientists from the Duchene Lab have published critical findings on the limitations of genetic research using knockout mice.

Oxidative stress: how protein recycling protects against cell death

15 Oct 2024 | News | Publication

CELL DEATH & DIFF 2024 ➤ IPEK scientists from the Bartelt Lab  have discovered a new molecular switch that protects against cell death.

Brown fat: how cells generate heat by burning calories

16 Sep 2024 | News | Publication

EMBO JOURNAL 2024 ➤ IPEK scientists from the Bartelt Lab have have discovered a new switch that controls thermogenesis in mitochondria.

New signalling pathway uncovered, shedding fresh light on atherosclerosis

22 Jan 2024 | News | Publication

NATURE CARDIOV. RES. 2024 ➤ IPEK scientists from the Weber and Döring Labs have found new mechanisms involved in the development of inflammatory cardiovascular diseases.