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Open Access Nature Cardiocascular Research https://www.nature.com/articles/s44161-023-00413-9

New signalling pathway uncovered, shedding fresh light on atherosclerosis

NATURE CARDIOVASCULAR RESEARCH 2024 ➤ IPEK scientists from the Weber and Döring Labs have found new mechanisms involved in the development of inflammatory cardiovascular diseases.

Weber Lab | IPEK

Atherosclerosis: RNA fragment creates prospect for new therapies

SCIENCE TRANSLATIONAL MEDICINE 2023 ➤ IPEK researchers have demonstrated for the first time what role a specific microRNA plays in atherosclerosis – and how it manages to intervene in this signaling…

T cells and atherosclerosis: the good, the bad, and the unknown

NATURE CARDIOVASCULAR RESEARCH 2023 ➤ IPEK scientists describe that atherosclerosis leads to disorders of the immune system, similar to those in known autoimmune diseases. Pairing of single-cell RNA…

How antibodies get it wrong

CELL STEM CELL 2022 ➤ IPEK scientists alert to the wrong use of antibodies in scientific publications. In their recent work, they refute a specific study on localization of immune receptor ACKR1.

@LMU

Atherosclerosis: How diseased blood vessels communicate with the brain

NATURE 2022 ➤ IPEK scientists have been able to demonstrate for the first time that nerve signals are exchanged between arteries and the brain in atherosclerosis.
2024

Bherer C, Eveleigh R, Trajanoska K, St-Cyr J, Paccard A, Nadukkalam Ravindran P, Caron E, Bader Asbah N, McClelland P, Wei C, Baumgartner I, Schindewolf M, Doring Y, Perley D, Lefebvre F, Lepage P, Bourgey M, Bourque G, Ragoussis J, Mooser V, Taliun D. A cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genome. NPJ Genom Med 2024; 9(1): 8.
Bochenek ML, Saar K, Nazari-Jahantigh M, Gogiraju R, Wiedenroth CB, Munzel T, Mayer E, Fink L, Schober A, Hubner N, Guth S, Konstantinides S, Schafer K. Endothelial Overexpression of TGF-beta-Induced Protein Impairs Venous Thrombus Resolution: Possible Role in CTEPH. JACC Basic Transl Sci 2024; 9(1): 100-116.
Chen W, Jin B, Cheng C, Peng H, Zhang X, Tan W, Tang R, Lian X, Diao H, Luo N, Li X, Fan J, Shi J, Yin C, Wang J, Peng S, Yu L, Li J, Wu RQ, Kuang DM, Shi GP, Zhou Y, Wang F, Jiang X. Single-cell profiling reveals kidney CD163(+) dendritic cell participation in human lupus nephritis. Ann Rheum Dis 2024.
Christ A, Maas SL, Jin H, Lu C, Legein B, Wijnands E, Temmerman L, Otten J, Isaacs A, Zenke M, Stoll M, Biessen EAL, van der Vorst EPC. In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naive T cells. Free Radic Biol Med 2024; 210: 406-415.
Dong Y, Kang Z, Zhang Z, Zhang Y, Zhou H, Liu Y, Shuai X, Li J, Yin L, Wang X, Ma Y, Fan H, Jiang F, Lin Z, Ding C, Yun Jin K, Sarapultsev A, Li F, Zhang G, Xie T, Yin C, Cheng X, Luo S, Liu Y, Hu D. Single-cell profile reveals the landscape of cardiac immunity and identifies a cardio-protective Ym-1(hi) neutrophil in myocardial ischemia-reperfusion injury. Sci Bull (Beijing) 2024.
Frenz-Wiessner S, Fairley SD, Buser M, Goek I, Salewskij K, Jonsson G, Illig D, Zu Putlitz B, Petersheim D, Li Y, Chen PH, Kalauz M, Conca R, Sterr M, Geuder J, Mizoguchi Y, Megens RTA, Linder MI, Kotlarz D, Rudelius M, Penninger JM, Marr C, Klein C. Generation of complex bone marrow organoids from human induced pluripotent stem cells. Nat Methods 2024.
Guerra J, Matta L, Bartelt A. Cardiac proteostasis in obesity and cardiovascular disease. Herz 2024.
Jia Y, Cheng L, Yang J, Mao J, Xie Y, Yang X, Zhang X, Wang D, Zhao Z, Schober A, Wei Y. miR-223-3p Prevents Necroptotic Macrophage Death by Targeting Ripk3 in a Negative Feedback Loop and Consequently Ameliorates Advanced Atherosclerosis. Arterioscler Thromb Vasc Biol 2024; 44(1): 218-237.
Kosinski J, Sechi A, Hain J, Villwock S, Ha SA, Hauschulz M, Rose M, Steib F, Ortiz-Bruchle N, Heij L, Maas SL, van der Vorst EPC, Knoesel T, Altendorf-Hofmann A, Simon R, Sauter G, Bednarsch J, Jonigk D, Dahl E. ITIH5 as a multifaceted player in pancreatic cancer suppression, impairing tyrosine kinase signaling, cell adhesion and migration. Mol Oncol 2024.
Lip GYH, Rigby A, Weber C. A Happy New Year 2024 from Thrombosis and Haemostasis! Thromb Haemost 2024; 124(1): 1-3.
Samus M, Rot A. Atypical chemokine receptors in cancer. Cytokine 2024; 176: 156504.
van der Vorst EPC, Kovacic JC. Therapeutic targeting of cell transition: ready for clinical prime-time? Cardiovasc Res 2024.
Wang Y, Panicker IS, Anesi J, Sargisson O, Atchison B, Habenicht AJR. Animal Models, Pathogenesis, and Potential Treatment of Thoracic Aortic Aneurysm. Int J Mol Sci 2024; 25(2).
Weber C, Rigby A, Lip GYH. Thrombosis and Haemostasis 2023 Editors' Choice Papers. Thromb Haemost 2024; 124(1): 80-87.

2023

Aghdassi A, Schwedhelm E, Atzler D, Nauck M, Kuhn JP, Kromrey ML, Volzke H, Felix SB, Dorr M, Ittermann T, Bahls M. The relationship between homoarginine and liver biomarkers: a combination of epidemiological and clinical studies. Sci Rep 2023; 13(1): 5230. https://www.ncbi.nlm.nih.gov/pubmed/36997574
Baretella O, Buser L, Andres C, Haberli D, Lenz A, Doring Y, Baumgartner I, Schindewolf M. Association of sex and cardiovascular risk factors with atherosclerosis distribution pattern in lower extremity peripheral artery disease. Front Cardiovasc Med 2023; 10: 1004003. https://www.ncbi.nlm.nih.gov/pubmed/37441701
Bazioti V, Halmos B, Westerterp M. T-cell Cholesterol Accumulation, Aging, and Atherosclerosis. Current Atherosclerosis Reports 2023; 25(9): 527-534. https://www.ncbi.nlm.nih.gov/pubmed/37395922
Bianchini M, Moller-Ramon Z, Weber C, Megens RTA, Duchene J. Short-Term Western Diet Causes Rapid and Lasting Alterations of Bone Marrow Physiology. Thromb Haemost 2023; 123(11): 1100-1104. https://www.ncbi.nlm.nih.gov/pubmed/37549687
Blanchet X, Weber C, von Hundelshausen P. Chemokine Heteromers and Their Impact on Cellular Function-A Conceptual Framework. Int J Mol Sci 2023; 24(13). https://www.ncbi.nlm.nih.gov/pubmed/37446102
Bochenek ML, Saar K, Nazari-Jahantigh M, Gogiraju R, Wiedenroth CB, Münzel T, Mayer E, Fink L, Schober A, Hübner N, Guth S, Konstantinides S, Schäfer K. Endothelial Overexpression of TGF-β-Induced Protein Impairs Venous Thrombus Resolution. JACC: Basic to Translational Science Epub 2023. https://www.jacc.org/doi/abs/10.1016/j.jacbts.2023.08.005
Bonfiglio CA, Weber C, Atzler D, Lutgens E. Immunotherapy and cardiovascular diseases: novel avenues for immunotherapeutic approaches. QJM 2023; 116(4): 271-278. https://www.ncbi.nlm.nih.gov/pubmed/34293177
Bosmans LA, van Tiel CM, Aarts S, Willemsen L, Baardman J, van Os BW, Toom MD, Beckers L, Ahern DJ, Levels JHM, Jongejan A, Moerland PD, Verberk SGS, den Bossche JV, de Winther M, Weber C, Atzler D, Monaco C, Gerdes N, Shami A, Lutgens E. Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state. Cardiovasc Res 2023; 119(5): 1146-1160. https://www.ncbi.nlm.nih.gov/pubmed/35587037
Christ A, Maas SL, Jin H, Lu C, Legein B, Wijnands E, Temmerman L, Otten J, Isaacs A, Zenke M, Stoll M, Biessen EAL, van der Vorst EPC. In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naive T cells. Free Radic Biol Med 2024; 210: 406-415. https://www.ncbi.nlm.nih.gov/pubmed/38061606
Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou AD, Schubel M, Jobst J, Zhang T, Dorr J, Markl F, Majed L, Muller PJ, May P, Gottschlich A, Tokarew N, Lucke J, Oner A, Schwerdtfeger M, Andreu-Sanz D, Grunmeier R, Seifert M, Michaelides S, Hristov M, Konig LM, Cadilha BL, Mikhaylov O, Anders HJ, Rothenfusser S, Flavell RA, Cerezo-Wallis D, Tejedo C, Soengas MS, Bald T, Huber S, Endres S, Kobold S. T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis. Immunity 2023; 56(1): 143-161 e111. https://www.ncbi.nlm.nih.gov/pubmed/36630913
Brunetta HS, Jung AS, Francisco A, Castilho RF, Mori MA, Bartelt A. IF1 controls UCP1-dependent mitochondrial bioenergetics in brown adipocytes. bioRxiv 2023: 2023.2007.2027.550888. https://www.biorxiv.org/content/biorxiv/early/2023/07/27/2023.07.27.550888.full.pdf
Cimen I, Natarelli L, Abedi Kichi Z, Henderson JM, Farina FM, Briem E, Aslani M, Megens RTA, Jansen Y, Mann-Fallenbuchel E, Gencer S, Duchene J, Nazari-Jahantigh M, van der Vorst EPC, Enard W, Doring Y, Schober A, Santovito D, Weber C. Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice. Sci Transl Med 2023; 15(720): eadf3357. https://www.ncbi.nlm.nih.gov/pubmed/37910599
de Winther MPJ, Back M, Evans P, Gomez D, Goncalves I, Jorgensen HF, Koenen RR, Lutgens E, Norata GD, Osto E, Dib L, Simons M, Stellos K, Yla-Herttuala S, Winkels H, Bochaton-Piallat ML, Monaco C. Translational opportunities of single-cell biology in atherosclerosis. Eur Heart J 2023; 44(14): 1216-1230. https://www.ncbi.nlm.nih.gov/pubmed/36478058
Duan R, Ni Q, Li Y, Zhu M, Li W, Wang P, Yuan K, von Hundelshausen P, Zhu J, Zhang L, Lv L. Lymphocytes, Mean Platelet Volume, and Albumin in Critically Ill COVID-19 Patients with Venous Thromboembolism. Clin Appl Thromb Hemost 2023; 29: 10760296231177676. https://www.ncbi.nlm.nih.gov/pubmed/37229645
Ebert S, Zang L, Ismail N, Otabil M, Frohlich A, Egea V, Acs S, Hoeberg M, Berres ML, Weber C, Moreira JMA, Ries C, Bernhagen J, El Bounkari O. Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation. Cells 2023; 12(14). https://www.ncbi.nlm.nih.gov/pubmed/37508563
Egea V, Megens RTA, Santovito D, Wantha S, Brandl R, Siess W, Khani S, Soehnlein O, Bartelt A, Weber C, Ries C. Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques. Cardiovasc Res 2023; 119(1): 155-166. https://www.ncbi.nlm.nih.gov/pubmed/35238350
Farina FM, Weber C, Santovito D. The emerging landscape of non-conventional RNA functions in atherosclerosis. Atherosclerosis 2023; 374: 74-86. https://www.ncbi.nlm.nih.gov/pubmed/36725418
Ferraro B, Giustetto P, Schengel O, Weckbach LT, Maegdefessel L, Soehnlein O. Longitudinal In Vivo Monitoring of Atheroprogression in Hypercholesterolemic Mice Using Photoacoustic Imaging. Thromb Haemost 2023; 123(5): 545-554. https://www.ncbi.nlm.nih.gov/pubmed/36596447
Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A, Gallo A, Drakos SG, Dimmeler S, Sperandio M, Soehnlein O, Stellos K. The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation. Immunity 2023; 56(5): 979-997 e911. https://www.ncbi.nlm.nih.gov/pubmed/37100060
Gencer S, van der Vorst EPC. Role of G-Protein-Coupled Receptors in Cardiovascular Diseases. Int J Mol Sci 2023; 24(9). https://www.ncbi.nlm.nih.gov/pubmed/37175466
Ghiboub M, Bell M, Sinkeviciute D, Prinjha RK, de Winther MPJ, Harker NR, Tough DF, de Jonge WJ. The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential. Curr Issues Mol Biol 2023; 45(5): 4228-4245. https://www.ncbi.nlm.nih.gov/pubmed/37232738
Gigante B, Levy JH, van Gorp E, Bartoloni A, Bochaton-Piallat ML, Back M, Ten Cate H, Christersson C, Ferreiro JL, Geisler T, Lutgens E, Schulman S, Storey RF, Thachil J, Vilahur G, Liaw PC, Rocca B. Management of patients on antithrombotic therapy with severe infections: a joint clinical consensus statement of the ESC Working Group on Thrombosis, the ESC Working Group on Atherosclerosis and Vascular Biology, and the International Society on Thrombosis and Haemostasis. Eur Heart J 2023; 44(32): 3040-3058. https://www.ncbi.nlm.nih.gov/pubmed/37439553
Giroud M, Kotschi S, Kwon Y, Le Thuc O, Hoffmann A, Gil-Lozano M, Karbiener M, Higareda-Almaraz JC, Khani S, Tews D, Fischer-Posovszky P, Sun W, Dong H, Ghosh A, Wolfrum C, Wabitsch M, Virtanen KA, Bluher M, Nielsen S, Zeigerer A, Garcia-Caceres C, Scheideler M, Herzig S, Bartelt A. The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes. EMBO Rep 2023; 24(10): e57600. https://www.ncbi.nlm.nih.gov/pubmed/37671834
Gomez AM, Bartelt A. Endocrine communication of endoplasmic reticulum stress. Bioessays 2023; 45(8): e2300093. https://www.ncbi.nlm.nih.gov/pubmed/37318317
Gyongyosi M, Alcaide P, Asselbergs FW, Brundel B, Camici GG, Martins PDC, Ferdinandy P, Fontana M, Girao H, Gnecchi M, Gollmann-Tepekoylu C, Kleinbongard P, Krieg T, Madonna R, Paillard M, Pantazis A, Perrino C, Pesce M, Schiattarella GG, Sluijter JPG, Steffens S, Tschope C, Van Linthout S, Davidson SM. Long COVID and the cardiovascular system-elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases. Cardiovasc Res 2023; 119(2): 336-356. https://www.ncbi.nlm.nih.gov/pubmed/35875883
Imamdin A, van der Vorst EPC. Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases. Int J Mol Sci 2023; 24(2). https://www.ncbi.nlm.nih.gov/pubmed/36675065
Kocberber Z, Willemsen N, Bartelt A. The role of proteasome activators PA28alphabeta and PA200 in brown adipocyte differentiation and function. Front Endocrinol (Lausanne) 2023; 14: 1176733. https://www.ncbi.nlm.nih.gov/pubmed/37201100
Kopp EL, Deussen DN, Cuomo R, Lorenz R, Roth DM, Mahata SK, Patel HH. Modeling and Phenotyping Acute and Chronic Type 2 Diabetes Mellitus In Vitro in Rodent Heart and Skeletal Muscle Cells. Cells 2023; 12(24). https://www.ncbi.nlm.nih.gov/pubmed/38132105
Kral M, van der Vorst EPC, Surnov A, Weber C, Doring Y. ILC2-mediated immune crosstalk in chronic (vascular) inflammation. Front Immunol 2023; 14: 1326440. https://www.ncbi.nlm.nih.gov/pubmed/38179045
Krammer C, Yang B, Reichl S, Besson-Girard S, Ji H, Bolini V, Schulte C, Noels H, Schlepckow K, Jocher G, Werner G, Willem M, El Bounkari O, Kapurniotu A, Gokce O, Weber C, Mohanta S, Bernhagen J. Pathways linking aging and atheroprotection in Mif-deficient atherosclerotic mice. FASEB J 2023; 37(3): e22752. https://www.ncbi.nlm.nih.gov/pubmed/36794636
Leberzammer J, von Hundelshausen P. Chemokines, molecular drivers of thromboinflammation and immunothrombosis. Front Immunol 2023; 14: 1276353. https://www.ncbi.nlm.nih.gov/pubmed/37954596
Lemmer IL, Bartelt A. Brown fat has a sweet tooth. Nat Metab 2023; 5(7): 1080-1081. https://www.ncbi.nlm.nih.gov/pubmed/37337121
Lemmer IL, Haas DT, Willemsen N, Kotschi S, Toksöz I, Gjika E, Khani S, Rohm M, Diercksen N, Nguyen PBH, Menden MP, Egu DT, Waschke J, Larsen S, Ma T, Gerhart-Hines Z, Herzig S, Dyar K, Krahmer N, Bartelt A. Nfe2l1-mediated proteasome function controls muscle energy metabolism in obesity. bioRxiv 2023: 2023.2004.2020.537611. https://www.biorxiv.org/content/biorxiv/early/2023/05/15/2023.04.20.537611.full.pdf
Lin C, Mostafa A, Jans A, Wolters JC, Mohamed MR, Van der Vorst EPC, Trautwein C, Bartneck M. Targeting Ligand Independent Tropism of siRNA-LNP by Small Molecules for Directed Therapy of Liver or Myeloid Immune Cells. Adv Healthc Mater 2023: e2202670. https://www.ncbi.nlm.nih.gov/pubmed/36617516
Lip GYH, Rigby A, Weber C. A Happy New Year 2023 from Thrombosis and Haemostasis. Thromb Haemost 2023; 123(1): 1-5. https://www.ncbi.nlm.nih.gov/pubmed/36626897
Louradour J, Ottersberg R, Segiser A, Olejnik A, Martinez-Salazar B, Siegrist M, Egle M, Barbieri M, Nimani S, Alerni N, Doring Y, Odening KE, Longnus S. Simultaneous assessment of mechanical and electrical function in Langendorff-perfused ex-vivo mouse hearts. Front Cardiovasc Med 2023; 10: 1293032. https://www.ncbi.nlm.nih.gov/pubmed/38028448
Maas SL, Donners M, van der Vorst EPC. ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? Int J Mol Sci 2023; 24(8). https://www.ncbi.nlm.nih.gov/pubmed/37108478
Maas SL, Megens RTA, van der Vorst EPC. Ex Vivo Perfusion System to Analyze Chemokine-Driven Leukocyte Adhesion. Methods Mol Biol 2023; 2597: 59-75. https://www.ncbi.nlm.nih.gov/pubmed/36374414
Maas SL, van der Vorst EPC. In Vitro (Trans)Migration Experiment Using Chemokines as Stimulatory Factor. Methods Mol Biol 2023; 2597: 77-87. https://www.ncbi.nlm.nih.gov/pubmed/36374415
Matta L, Blaas L, de Faria CC. From honeymoon to dysfunction: brown fat remodelling in obesity. J Physiol 2023; 601(4): 711-713. https://www.ncbi.nlm.nih.gov/pubmed/36617494
Matta L, Breves C, Fonte Boa L, Domingos AE, Faria CC, Souza I, Correia Lima-Junior N, Rocha APT, Gregorio BM, Carvalho DP, Ferreira ACF, Nascimento JHM, Maciel L, Fortunato RS. Quercetin improves white adipose tissue redox homeostasis in ovariectomized rats. J Endocrinol 2023; 259(2). https://www.ncbi.nlm.nih.gov/pubmed/37566237
Melgrati S, Radice E, Ameti R, Hub E, Thelen S, Pelczar P, Jarrossay D, Rot A, Thelen M. Atlas of the anatomical localization of atypical chemokine receptors in healthy mice. PLoS Biol 2023; 21(5): e3002111. https://www.ncbi.nlm.nih.gov/pubmed/37159457
Mena Gómez A, Bartelt A. Live lean and CRISPR – Engineering metabolism with FGF21 and FNDC5. Clinical and Translational Discovery 2023; 3(5): e230. https://onlinelibrary.wiley.com/doi/abs/10.1002/ctd2.230
Mohanta SK, Sun T, Lu S, Wang Z, Zhang X, Yin C, Weber C, Habenicht AJR. The Impact of the Nervous System on Arteries and the Heart: The Neuroimmune Cardiovascular Circuit Hypothesis. Cells 2023; 12(20). https://www.ncbi.nlm.nih.gov/pubmed/37887328
Mohanta SK, Yin C, Weber C, Godinho-Silva C, Veiga-Fernandes H, Xu QJ, Chang RB, Habenicht AJR. Cardiovascular Brain Circuits. Circ Res 2023; 132(11): 1546-1565. https://www.ncbi.nlm.nih.gov/pubmed/37228235
Mohanta SK, Yin C, Weber C, Habenicht AJR. Neuroimmune cardiovascular interfaces in atherosclerosis. Front Cell Dev Biol 2023; 11: 1117368. https://www.ncbi.nlm.nih.gov/pubmed/36793445
Naeimzadeh Y, Ilbeigi S, Dastsooz H, Rafiee Monjezi M, Mansoori Y, Tabei SMB. Protooncogenic Role of ARHGAP11A and ARHGAP11B in Invasive Ductal Carcinoma: Two Promising Breast Cancer Biomarkers. Biomed Res Int 2023; 2023: 8236853. https://www.ncbi.nlm.nih.gov/pubmed/38046902
Nording H, Baron L, Sauter M, Lubken A, Rawish E, Szepanowski R, von Esebeck J, Sun Y, Emami H, Meusel M, Saraei R, Schanze N, Gorantla SP, von Bubnoff N, Geisler T, von Hundelshausen P, Stellos K, Marquardt J, Sadik CD, Kohl J, Duerschmied D, Kleinschnitz C, Langer HF. Platelets regulate ischemia-induced revascularization and angiogenesis by secretion of growth factor-modulating factors. Blood Adv 2023; 7(21): 6411-6427. https://www.ncbi.nlm.nih.gov/pubmed/37257194
Ofoghi A, Kotschi S, Lemmer IL, Haas DT, Willemsen N, Bayer B, Möller S, Haberecht-Müller S, Krüger E, Krahmer N, Bartelt A. Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis. bioRxiv 2023: 2023.2007.2004.547652. https://www.biorxiv.org/content/biorxiv/early/2023/07/04/2023.07.04.547652.full.pdf
Pan C, Herrero-Fernandez B, Borja Almarcha C, Gomez Bris R, Zorita V, Saez A, Maas SL, Perez-Olivares L, Herrero-Cervera A, Lemnitzer P, van Avondt K, Silvestre-Roig C, Gonzalez-Granado JM, Chevre R, Soehnlein O. Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic Mice. Circulation 2023; 147(9): 774-777. https://www.ncbi.nlm.nih.gov/pubmed/36848415
Pappritz K, Puhl SL, Matz I, Brauer E, Shia YX, El-Shafeey M, Koch SE, Miteva K, Mucha C, Duda GN, Petersen A, Steffens S, Tschope C, Van Linthout S. Sex- and age-related differences in the inflammatory properties of cardiac fibroblasts: impact on the cardiosplenic axis and cardiac fibrosis. Front Cardiovasc Med 2023; 10: 1117419. https://www.ncbi.nlm.nih.gov/pubmed/38054090
Pavlic A, Poelman H, Wasilewski G, Wichapong K, Lux P, Maassen C, Lutgens E, Schurgers LJ, Reutelingsperger CP, Nicolaes GAF. Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. Int J Mol Sci 2023; 24(3). https://www.ncbi.nlm.nih.gov/pubmed/36768348
Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionisio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K. Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity 2023; 56(10): 2325-2341 e2315. https://www.ncbi.nlm.nih.gov/pubmed/37652021
Petrick HL, Pinckaers PJM, Brunetta HS. Ketone body oxidation: glycogen-sparing yet glucose-dependent? J Physiol 2023; 601(12): 2237-2239. https://www.ncbi.nlm.nih.gov/pubmed/37070238
Rakateli L, Huchzermeier R, van der Vorst EPC. AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors. Cells 2023; 12(23). https://www.ncbi.nlm.nih.gov/pubmed/38067179
Rega S, Farina F, Bouhuis S, de Donato S, Chiesa M, Poggio P, Cavallotti L, Bonalumi G, Giambuzzi I, Pompilio G, Perrucci GL. Multi-omics in thoracic aortic aneurysm: the complex road to the simplification. Cell Biosci 2023; 13(1): 131. https://www.ncbi.nlm.nih.gov/pubmed/37475058
Reiche ME, Poels K, Bosmans LA, Vos WG, Van Tiel CM, Gijbels MJJ, Aarts S, Den Toom M, Beckers L, Weber C, Atzler D, Rensen PCN, Kooijman S, Lutgens E. Adipocytes control hematopoiesis and inflammation through CD40 signaling. Haematologica 2023; 108(7): 1873-1885. https://www.ncbi.nlm.nih.gov/pubmed/36475519
Ren L, Li F, Tan X, Fan Y, Ke B, Zhang Y, Jiang H, Jia L, Wang Y, Du J. Abnormal plasma ceramides refine high-risk patients with worsening heart failure. Front Cardiovasc Med 2023; 10: 1185595. https://www.ncbi.nlm.nih.gov/pubmed/37456812
Sachs S, Gotz A, Finan B, Feuchtinger A, DiMarchi RD, Doring Y, Weber C, Tschop MH, Muller TD, Hofmann SM. GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease. Cardiovasc Diabetol 2023; 22(1): 217. https://www.ncbi.nlm.nih.gov/pubmed/37592302
Santovito D, Fan Y, Elia L, Tan JTM, van der Vorst EPC. Editorial: Emerging roles of miRNAs in cardiovascular disease. Front Cardiovasc Med 2023; 10: 1144849. https://www.ncbi.nlm.nih.gov/pubmed/36926041
Santovito D, Steffens S, Barachini S, Madonna R. Autophagy, innate immunity, and cardiac disease. Front Cell Dev Biol 2023; 11: 1149409. https://www.ncbi.nlm.nih.gov/pubmed/37234771
Schonichen C, Montague SJ, Brouns SLN, Burston JJ, Cosemans J, Jurk K, Kehrel BE, Koenen RR, Ni Ainle F, O'Donnell VB, Soehnlein O, Watson SP, Kuijpers MJE, Heemskerk JWM, Nagy M. Antagonistic Roles of Human Platelet Integrin alphaIIbbeta3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow. Arterioscler Thromb Vasc Biol 2023; 43(9): 1700-1712. https://www.ncbi.nlm.nih.gov/pubmed/37409530
Soehnlein O, Doring Y. Beyond association: high neutrophil counts are a causal risk factor for atherosclerotic cardiovascular disease. Eur Heart J 2023; 44(47): 4965-4967. https://www.ncbi.nlm.nih.gov/pubmed/37981833
Steffens S, Schroder K, Kruger M, Maack C, Streckfuss-Bomeke K, Backs J, Backofen R, Baessler B, Devaux Y, Gilsbach R, Heijman J, Knaus J, Kramann R, Linz D, Lister AL, Maatz H, Maegdefessel L, Mayr M, Meder B, Nussbeck SY, Rog-Zielinska EA, Schulz MH, Sickmann A, Yigit G, Kohl P. The challenges of research data management in cardiovascular science: a DGK and DZHK position paper-executive summary. Clin Res Cardiol 2023. https://www.ncbi.nlm.nih.gov/pubmed/37847314
Sun J, Singh P, Shami A, Kluza E, Pan M, Djordjevic D, Michaelsen NB, Kennback C, van der Wel NN, Orho-Melander M, Nilsson J, Formentini I, Conde-Knape K, Lutgens E, Edsfeldt A, Goncalves I. Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture. J Am Coll Cardiol 2023; 81(23): 2213-2227. https://www.ncbi.nlm.nih.gov/pubmed/37286250
Tahamtan A, Samadizadeh S, Salimi V, Natarelli L, Nakstad B. Editorial: miRNAs and inflammation: from biogenesis to therapeutic option. Front Immunol 2023; 14: 1296589. https://www.ncbi.nlm.nih.gov/pubmed/37854607
Thakur M, Junho CVC, Bernhard SM, Schindewolf M, Noels H, Doring Y. NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease. Circ Res 2023; 132(8): 933-949. https://www.ncbi.nlm.nih.gov/pubmed/37053273
Tufanli O, Citir M, Yin C, Van der Vorst EPC, Cimen I. Editorial: The connections of immune metabolic mechanisms with aging-related diseases. Front Cell Dev Biol 2023; 11: 1295264. https://www.ncbi.nlm.nih.gov/pubmed/37829186
Tuleja A, Bernhard S, Hamvas G, Andreoti TA, Rossler J, Boon L, Vikkula M, Kammer R, Haupt F, Doring Y, Baumgartner I. Clinical phenotype of adolescent and adult patients with extracranial vascular malformation. J Vasc Surg Venous Lymphat Disord 2023; 11(5): 1034-1044 e1033. https://www.ncbi.nlm.nih.gov/pubmed/37030445
van der Vorst EPC, Badimon L. The unknown functions of a known protein: the case of coagulation factor XI. Cardiovasc Res 2023; 119(7): e137-e139. https://www.ncbi.nlm.nih.gov/pubmed/37141257
van der Vorst EPC, Maas SL, Theodorou K, Peters LJF, Jin H, Rademakers T, Gijbels MJ, Rousch M, Jansen Y, Weber C, Lehrke M, Lebherz C, Yildiz D, Ludwig A, Bentzon JF, Biessen EAL, Donners M. Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice. Front Cardiovasc Med 2023; 10: 974918. https://www.ncbi.nlm.nih.gov/pubmed/36776254
van Os BW, Kusters PJH, den Toom M, Beckers L, van Tiel CM, Vos WG, de Jong E, Kieser A, van Roomen C, Binder CJ, Reiche ME, de Winther MP, Bosmans LA, Lutgens E. Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis. Front Cardiovasc Med 2023; 10: 1171764. https://www.ncbi.nlm.nih.gov/pubmed/37215541
van Os BW, Vos WG, Bosmans LA, van Tiel CM, Lith SC, den Toom MS, Beckers L, Levels JHM, van Wouw SAE, Zelcer N, Zaal EA, Berkers CR, van der Lest CHA, Helms JB, Weber C, Atzler D, de Winther MPJ, Baardman J, Lutgens E. Hyperlipidaemia elicits an atypical, T helper 1-like CD4(+) T-cell response: a key role for very low-density lipoprotein. Eur Heart J Open 2023; 3(2): oead013. https://www.ncbi.nlm.nih.gov/pubmed/36969380
van Os BW, Vos WG, Bosmans LA, van Tiel CM, Toom MD, Beckers L, Admiraal M, Hoeksema MA, de Winther MP, Lutgens E. CD40L modulates CD4(+) T-cell activation through receptor for activated C kinase 1. Eur J Immunol 2023; 53(12): e2350520. https://www.ncbi.nlm.nih.gov/pubmed/37683186
Wagner JUG, Tombor LS, Malacarne PF, Kettenhausen LM, Panthel J, Kujundzic H, Manickam N, Schmitz K, Cipca M, Stilz KA, Fischer A, Muhly-Reinholz M, Abplanalp WT, John D, Mohanta SK, Weber C, Habenicht AJR, Buchmann GK, Angendohr S, Amin E, Scherschel K, Klocker N, Kelm M, Schuttler D, Clauss S, Gunther S, Boettger T, Braun T, Bar C, Pham MD, Krishnan J, Hille S, Muller OJ, Bozoglu T, Kupatt C, Nardini E, Osmanagic-Myers S, Meyer C, Zeiher AM, Brandes RP, Luxan G, Dimmeler S. Aging impairs the neurovascular interface in the heart. Science 2023; 381(6660): 897-906. https://www.ncbi.nlm.nih.gov/pubmed/37616346
Wang HF, Wang YX, Zhou YP, Wei YP, Yan Y, Zhang ZJ, Jing ZC. Protein O-GlcNAcylation in cardiovascular diseases. Acta Pharmacol Sin 2023; 44(1): 8-18. https://www.ncbi.nlm.nih.gov/pubmed/35817809
Wang Z, Zhang X, Lu S, Zhang C, Ma Z, Su R, Li Y, Sun T, Li Y, Hong M, Deng X, Monjezi MR, Hristov M, Steffens S, Santovito D, Dornmair K, Ley K, Weber C, Mohanta SK, Habenicht AJR, Yin C. Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis. Nat Cardiovasc Res 2023; 2(3): 290-306. https://www.ncbi.nlm.nih.gov/pubmed/37621765
Weber C, Blanchet X, Lip GYH. Thrombosis and Haemostasis 2022 Editors' Choice Papers. Thromb Haemost 2023; 123(1): 123-130. https://www.ncbi.nlm.nih.gov/pubmed/36626900
Weber C, Habenicht AJR, von Hundelshausen P. Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond. Eur Heart J 2023; 44(29): 2672-2681. https://www.ncbi.nlm.nih.gov/pubmed/37210082
Xiao X, Deng X, Zhang G, Liu M, Fu D, Yang P, Li X, Jiang H. Monitoring of the regulatory ability and regulatory state of the autonomic nervous system and its application to the management of hypertensive patients: a study protocol for randomised controlled trials. BMJ Open 2023; 13(6): e063434. https://www.ncbi.nlm.nih.gov/pubmed/37286315
Yerly A, van der Vorst EPC, Baumgartner I, Bernhard SM, Schindewolf M, Doring Y. Sex-specific and hormone-related differences in vascular remodelling in atherosclerosis. Eur J Clin Invest 2023; 53(1): e13885. https://www.ncbi.nlm.nih.gov/pubmed/36219492
Ying Z, van Eenige R, Beerepoot R, Boon MR, Kloosterhuis NJ, van de Sluis B, Bartelt A, Rensen PCN, Kooijman S. Mirabegron-induced brown fat activation does not exacerbate atherosclerosis in mice with a functional hepatic ApoE-LDLR pathway. Pharmacol Res 2023; 187: 106634. https://www.ncbi.nlm.nih.gov/pubmed/36574856
Zhou Y, Schober A. The Year of miR-223: How Platelets Can Kill Cardiomyocytes. Arterioscler Thromb Vasc Biol 2023; 43(2): 231-233. https://www.ncbi.nlm.nih.gov/pubmed/36579642
Ziegler KA, Ahles A, Dueck A, Esfandyari D, Pichler P, Weber K, Kotschi S, Bartelt A, Sinicina I, Graw M, Leonhardt H, Weckbach LT, Massberg S, Schifferer M, Simons M, Hoeher L, Luo J, Erturk A, Schiattarella GG, Sassi Y, Misgeld T, Engelhardt S. Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease. Science 2023; 381(6655): 285-290. https://www.ncbi.nlm.nih.gov/pubmed/37471539

2022

Asare Y, Shnipova M, Zivkovic L, Schlegl C, Tosato F, Aronova A, Brandhofer M, Strohm L, Beaufort N, Malik R, Weber C, Bernhagen J, Dichgans M. IKKbeta binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses. Signal Transduct Target Ther 2022; 7(1): 355. https://www.ncbi.nlm.nih.gov/pubmed/36257930
Bazioti V, La Rose AM, Maassen S, Bianchi F, de Boer R, Halmos B, Dabral D, Guilbaud E, Flohr-Svendsen A, Groenen AG, Marmolejo-Garza A, Koster MH, Kloosterhuis NJ, Havinga R, Pranger AT, Langelaar-Makkinje M, de Bruin A, van de Sluis B, Kohan AB, Yvan-Charvet L, van den Bogaart G, Westerterp M. T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice. Nat Commun 2022; 13(1): 3799. https://www.ncbi.nlm.nih.gov/pubmed/35778407
Bernhard SM, Adam L, Atef H, Haberli D, Bramer WM, Minder B, Doring Y, Laine JE, Muka T, Rossler J, Baumgartner I. A systematic review of the safety and efficacy of currently used treatment modalities in the treatment of patients with PIK3CA-related overgrowth spectrum. J Vasc Surg Venous Lymphat Disord 2022; 10(2): 527-538 e522. https://www.ncbi.nlm.nih.gov/pubmed/34358672
Bozoglu T, Lee S, Ziegler T, Jurisch V, Maas S, Baehr A, Hinkel R, Hoenig A, Hariharan A, Kim CI, Decker S, Sami H, Koppara T, Oellinger R, Muller OJ, Frank D, Megens R, Nelson P, Weber C, Schnieke A, Sperandio M, Santamaria G, Rad R, Moretti A, Laugwitz KL, Soehnlein O, Ogris M, Kupatt C. Endothelial Retargeting of AAV9 In Vivo. Adv Sci (Weinh) 2022; 9(7): e2103867. https://www.ncbi.nlm.nih.gov/pubmed/35023328
Brandhofer M, Hoffmann A, Blanchet X, Siminkovitch E, Rohlfing AK, El Bounkari O, Nestele JA, Bild A, Kontos C, Hille K, Rohde V, Frohlich A, Golemi J, Gokce O, Krammer C, Scheiermann P, Tsilimparis N, Sachs N, Kempf WE, Maegdefessel L, Otabil MK, Megens RTA, Ippel H, Koenen RR, Luo J, Engelmann B, Mayo KH, Gawaz M, Kapurniotu A, Weber C, von Hundelshausen P, Bernhagen J. Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Cell Mol Life Sci 2022; 79(10): 512. https://www.ncbi.nlm.nih.gov/pubmed/36094626
Carai P, Papageorgiou AP, Van Linthout S, Deckx S, Velthuis S, Lutgens E, Wijnands E, Tschope C, Schmuttermaier C, Kzhyshkowska J, Jones EAV, Heymans S. Stabilin-1 mediates beneficial monocyte recruitment and tolerogenic macrophage programming during CVB3-induced viral myocarditis. J Mol Cell Cardiol 2022; 165: 31-39. https://www.ncbi.nlm.nih.gov/pubmed/34968453
Daugherty A, Hegele RA, Lu HS, Mackman N, Rader DJ, Weber C. Web of Science's Citation Median Metrics Overcome the Major Constraints of the Journal Impact Factor. Arterioscler Thromb Vasc Biol 2022; 42(4): 367-371. https://www.ncbi.nlm.nih.gov/pubmed/35109675
Evans BR, Yerly A, van der Vorst EPC, Baumgartner I, Bernhard SM, Schindewolf M, Doring Y. Inflammatory Mediators in Atherosclerotic Vascular Remodeling. Front Cardiovasc Med 2022; 9: 868934. https://www.ncbi.nlm.nih.gov/pubmed/35600479
Evans PC, Davidson SM, Wojta J, Back M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP, Morawietz H, Osto E, Padro T, Sluimer JC, Tocchetti CG, Van der Heiden K, Vilahur G, Waltenberger J, Weber C. From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22. Cardiovasc Res 2022; 118(13): 2754-2767. https://www.ncbi.nlm.nih.gov/pubmed/35899362
Farina FM, Santovito D, Weber C. Two-Faced Janus: CCR2-Expressing Macrophages and Their Dual Role in Allograft Rejection of the Transplanted Heart. Circulation 2022; 146(8): 639-642. https://www.ncbi.nlm.nih.gov/pubmed/35994560
Farina FM, Serio S, Hall IF, Zani S, Cassanmagnago GA, Climent M, Civilini E, Condorelli G, Quintavalle M, Elia L. The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-kappaB pathway. Eur Heart J 2022; 43(43): 4562-4576. https://www.ncbi.nlm.nih.gov/pubmed/35292818
Faussner A, Deininger MM, Weber C, Steffens S. Direct addition of poly-lysine or poly-ethylenimine to the medium: A simple alternative to plate pre-coating. PLoS One 2022; 17(7): e0260173. https://www.ncbi.nlm.nih.gov/pubmed/35802710
Ferdinandy P, Koller A, Weber C, Wojta J, Waltenberger J. Frontiers in CardioVascular Biomedicine (FCVB) 2022 Budapest is on in person! The excellent programme proves that scientists won against COVID-19. Cardiovasc Res 2022; 118(8): e59-e61. https://www.ncbi.nlm.nih.gov/pubmed/35438746
Friess MC, Kritikos I, Schineis P, Medina-Sanchez JD, Gkountidi AO, Vallone A, Sigmund EC, Schwitter C, Vranova M, Matti C, Arasa J, Saygili Demir C, Bovay E, Proulx ST, Tomura M, Rot A, Legler DF, Petrova TV, Halin C. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. Cell Rep 2022; 38(5): 110334. https://www.ncbi.nlm.nih.gov/pubmed/35108538
Ganesh N, van der Vorst EPC, Spiesshofer J, He S, Burgmaier M, Findeisen H, Lehrke M, Swirski FK, Marx N, Kahles F. Gut immune cells-A novel therapeutical target for cardiovascular disease? Front Cardiovasc Med 2022; 9: 943214. https://www.ncbi.nlm.nih.gov/pubmed/36046186
Gencer S, Doring Y, Jansen Y, Bayasgalan S, Yan Y, Bianchini M, Cimen I, Muller M, Peters LJF, Megens RTA, von Hundelshausen P, Duchene J, Lemnitzer P, Soehnlein O, Weber C, van der Vorst EPC. Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium. Basic Res Cardiol 2022; 117(1): 30. https://www.ncbi.nlm.nih.gov/pubmed/35674847
Georgakis MK, Bernhagen J, Heitman LH, Weber C, Dichgans M. Targeting the CCL2-CCR2 axis for atheroprotection. Eur Heart J 2022; 43(19): 1799-1808. https://www.ncbi.nlm.nih.gov/pubmed/35567558
Giroud M, Jodeleit H, Prentice KJ, Bartelt A. Adipocyte function and the development of cardiometabolic disease. J Physiol 2022; 600(5): 1189-1208. https://www.ncbi.nlm.nih.gov/pubmed/34555180
Guillamat-Prats R, Hering D, Derle A, Rami M, Hardtner C, Santovito D, Rinne P, Bindila L, Hristov M, Pagano S, Vuilleumier N, Schmid S, Janjic A, Enard W, Weber C, Maegdefessel L, Faussner A, Hilgendorf I, Steffens S. GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation. Nat Cardiovasc Res 2022; 1: 1056-1071. https://www.ncbi.nlm.nih.gov/pubmed/36523570
Habenicht LKL, Wang Z, Zhang X, Li Y, Mogler C, Huspenina JS, Schmid RM, Weber C, Mohanta SK, Ma Z, Yin C. The C1q-ApoE complex: A new hallmark pathology of viral hepatitis and nonalcoholic fatty liver disease. Frontiers in Immunology 2022; 13: 970938. https://www.ncbi.nlm.nih.gov/pubmed/36304458
Haghikia A, Zimmermann F, Schumann P, Jasina A, Roessler J, Schmidt D, Heinze P, Kaisler J, Nageswaran V, Aigner A, Ceglarek U, Cineus R, Hegazy AN, van der Vorst EPC, Doring Y, Strauch CM, Nemet I, Tremaroli V, Dwibedi C, Krankel N, Leistner DM, Heimesaat MM, Bereswill S, Rauch G, Seeland U, Soehnlein O, Muller DN, Gold R, Backhed F, Hazen SL, Haghikia A, Landmesser U. Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism. Eur Heart J 2022; 43(6): 518-533. https://www.ncbi.nlm.nih.gov/pubmed/34597388
Hettwer J, Hinterdobler J, Miritsch B, Deutsch MA, Li X, Mauersberger C, Moggio A, Braster Q, Gram H, Robertson AAB, Cooper MA, Gross O, Krane M, Weber C, Koenig W, Soehnlein O, Adamstein NH, Ridker P, Schunkert H, Libby P, Kessler T, Sager HB. Interleukin-1beta suppression dampens inflammatory leucocyte production and uptake in atherosclerosis. Cardiovasc Res 2022; 118(13): 2778-2791. https://www.ncbi.nlm.nih.gov/pubmed/34718444
Heuschkel MA, Babler A, Heyn J, van der Vorst EPC, Steenman M, Gesper M, Kappel BA, Magne D, Goueffic Y, Kramann R, Jahnen-Dechent W, Marx N, Quillard T, Goettsch C. Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro. Front Cardiovasc Med 2022; 9: 959457. https://www.ncbi.nlm.nih.gov/pubmed/36204585
Immler R, Nadolni W, Bertsch A, Morikis V, Rohwedder I, Masgrau-Alsina S, Schroll T, Yevtushenko A, Soehnlein O, Moser M, Gudermann T, Barnea ER, Rehberg M, Simon SI, Zierler S, Pruenster M, Sperandio M. The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation. Cardiovasc Res 2022; 118(5): 1289-1302. https://www.ncbi.nlm.nih.gov/pubmed/33881519
Kahles F, Rau M, Reugels M, Foldenauer AC, Mertens RW, Arrivas MC, Schroder J, Idel P, Moellmann J, van der Vorst EPC, Marx N, Lehrke M. The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury. Cardiovasc Diabetol 2022; 21(1): 18. https://www.ncbi.nlm.nih.gov/pubmed/35123462
Kane J, Jansen M, Hendrix S, Bosmans LA, Beckers L, Tiel CV, Gijbels M, Zelcer N, Vries CJ, von Hundelshausen P, Vervloet M, Eringa E, Horrevoets AJ, Royen NV, Lutgens E. Anti-Galectin-2 Antibody Treatment Reduces Atherosclerotic Plaque Size and Alters Macrophage Polarity. Thromb Haemost 2022; 122(6): 1047-1057. https://www.ncbi.nlm.nih.gov/pubmed/34852377
Karshovska E, Mohibullah R, Zhu M, Zahedi F, Thomas D, Magkrioti C, Geissler C, Megens RTA, Bianchini M, Nazari-Jahantigh M, Ferreiros N, Aidinis V, Schober A. Endothelial ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Increases Atherosclerosis in Female and Male Mice. Arterioscler Thromb Vasc Biol 2022; 42(8): 1023-1036. https://www.ncbi.nlm.nih.gov/pubmed/35708027
Kichi ZA, Natarelli L, Sadeghian S, Boroumand MA, Behmanesh M, Weber C. Orphan GPR26 Counteracts Early Phases of Hyperglycemia-Mediated Monocyte Activation and Is Suppressed in Diabetic Patients. Biomedicines 2022; 10(7). https://www.ncbi.nlm.nih.gov/pubmed/35885041
Kichi ZA, Sabouri SG. Multiple Airy beam generation by a digital micro mirror device. Opt Express 2022; 30(13): 23025-23034. https://www.ncbi.nlm.nih.gov/pubmed/36224991
Kichi ZA, Soltani M, Rezaei M, Shirvani-Farsani Z, Rojhannezhad M. The Emerging Role of EMT-related lncRNAs in Therapy Resistance and their Applications as Biomarkers. Curr Med Chem 2022; 29(26): 4574-4601. https://www.ncbi.nlm.nih.gov/pubmed/35352644
Kleist CJ, Choe CU, Atzler D, Schonhoff M, Boger R, Schwedhelm E, Wicha SG. Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction. Amino Acids 2022; 54(6): 889-896. https://www.ncbi.nlm.nih.gov/pubmed/35618975
Koenen RR, Weber C. Jam-A Unleashed Incites Thromboinflammatory Coronary Artery Disease. JACC Basic Transl Sci 2022; 7(5): 462-464. https://www.ncbi.nlm.nih.gov/pubmed/35663635
Kotschi S, Jung A, Willemsen N, Ofoghi A, Proneth B, Conrad M, Bartelt A. NFE2L1-mediated proteasome function protects from ferroptosis. Mol Metab 2022; 57: 101436. https://www.ncbi.nlm.nih.gov/pubmed/34999280
Kou JJ, Shi JZ, He YY, Hao JJ, Zhang HY, Luo DM, Song JK, Yan Y, Xie XM, Du GH, Pang XB. Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation. Acta Pharmacol Sin 2022; 43(4): 840-849. https://www.ncbi.nlm.nih.gov/pubmed/34267346
Leberzammer J, Agten SM, Blanchet X, Duan R, Ippel H, Megens RTA, Schulz C, Aslani M, Duchene J, Doring Y, Jooss NJ, Zhang P, Brandl R, Stark K, Siess W, Jurk K, Heemskerk JWM, Hackeng TM, Mayo KH, Weber C, von Hundelshausen P. Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood 2022; 139(17): 2691-2705. https://www.ncbi.nlm.nih.gov/pubmed/35313337
Lecour S, Du Pre BC, Botker HE, Brundel B, Daiber A, Davidson SM, Ferdinandy P, Girao H, Gollmann-Tepekoylu C, Gyongyosi M, Hausenloy DJ, Madonna R, Marber M, Perrino C, Pesce M, Schulz R, Sluijter JPG, Steffens S, Van Linthout S, Young ME, Van Laake LW. Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart. Cardiovasc Res 2022; 118(12): 2566-2581. https://www.ncbi.nlm.nih.gov/pubmed/34505881
Lesage A, Marceau F, Gibson C, Loenders B, Katzer W, Ambrosi HD, Saupe J, Faussner A, Pardali E, Knolle J. In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B(2) receptor antagonist in clinical development. Int Immunopharmacol 2022; 105: 108523. https://www.ncbi.nlm.nih.gov/pubmed/35086057
Lip GYH, Rigby A, Weber C. A Rollercoaster Plunge into 2022. Thrombosis and Haemostasis 2022; 122(01): 001-004. https://www.ncbi.nlm.nih.gov/pubmed/35038759
Liu Y, Shi JZ, Jiang R, Liu SF, He YY, van der Vorst EPC, Weber C, Doring Y, Yan Y. Regulatory T Cell-Related Gene Indicators in Pulmonary Hypertension. Front Pharmacol 2022; 13: 908783. https://www.ncbi.nlm.nih.gov/pubmed/35712711
Matta L, de Faria CC, De Oliveira DF, Andrade IS, Lima-Junior NC, Gregorio BM, Takiya CM, Ferreira ACF, Nascimento JHM, de Carvalho DP, Bartelt A, Maciel L, Fortunato RS. Exercise Improves Redox Homeostasis and Mitochondrial Function in White Adipose Tissue. Antioxidants (Basel) 2022; 11(9). https://www.ncbi.nlm.nih.gov/pubmed/36139762
Mauersberger C, Sager HB, Wobst J, Dang TA, Lambrecht L, Koplev S, Stroth M, Bettaga N, Schlossmann J, Wunder F, Friebe A, Björkegren JLM, Dietz L, Maas SL, van der Vorst EPC, Sandner P, Soehnlein O, Schunkert H, Kessler T. Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation. Nature Cardiovascular Research 2022; 1(12): 1174-1186. https://doi.org/10.1038/s44161-022-00175-w
Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, Forstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Erturk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, Eckstein HH, Kleemann R, Habenicht L, Mallat Z, Michel JB, Bernhagen J, Dichgans M, D'Agostino G, Guzik TJ, Olofsson PS, Yin C, Weber C, Lembo G, Carnevale D, Habenicht AJR. Neuroimmune cardiovascular interfaces control atherosclerosis. Nature 2022; 605(7908): 152-159. https://www.ncbi.nlm.nih.gov/pubmed/35477759
Mohanta SK, Weber C, Yin C, Habenicht AJR. The dawn has come for new therapeutics to treat atherosclerosis: Targeting neuroimmune cardiovascular interfaces in artery brain circuits. Clin Transl Med 2022; 12(9): e1040. https://www.ncbi.nlm.nih.gov/pubmed/36052959
Nagy M, van der Meijden PEJ, Glunz J, Schurgers L, Lutgens E, Ten Cate H, Heitmeier S, Spronk HMH. Integrating Mechanisms in Thrombotic Peripheral Arterial Disease. Pharmaceuticals (Basel) 2022; 15(11). https://www.ncbi.nlm.nih.gov/pubmed/36422558
Nardi V, Franchi F, Prasad M, Fatica EM, Alexander MP, Bois MC, Lam J, Singh RJ, Meyer FB, Lanzino G, Xiong Y, Lutgens E, Lerman LO, Lerman A. Uric Acid Expression in Carotid Atherosclerotic Plaque and Serum Uric Acid Are Associated With Cerebrovascular Events. Hypertension 2022; 79(8): 1814-1823. https://www.ncbi.nlm.nih.gov/pubmed/35656807
Natarelli L, Weber C. A Non-Canonical Link between Non-Coding RNAs and Cardiovascular Diseases. Biomedicines 2022; 10(2). https://www.ncbi.nlm.nih.gov/pubmed/35203652
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Poelman H, Ippel H, Gurkan B, Boelens R, Vriend G, Veer CV, Lutgens E, Nicolaes GAF. Structural anomalies in a published NMR-derived structure of IRAK-M. J Mol Graph Model 2022; 111: 108061. https://www.ncbi.nlm.nih.gov/pubmed/34837785
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Rot A, Gutjahr JC, Biswas A, Aslani M, Hub E, Thiriot A, von Andrian UH, Megens RTA, Weber C, Duchene J. Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1. Cell Stem Cell 2022; 29(7): 1013-1015. https://www.ncbi.nlm.nih.gov/pubmed/35803222
Santovito D, Weber C. Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease. Nat Rev Cardiol 2022; 19(9): 620-638. https://www.ncbi.nlm.nih.gov/pubmed/35304600
Sauter M, Sauter RJ, Nording H, Lin C, Olbrich M, Autenrieth S, Gleissner C, Thunemann M, Otero N, Lutgens E, Aherrahrou Z, Wolf D, Zender L, Meuth S, Feil R, Langer HF. Apolipoprotein E derived from CD11c(+) cells ameliorates atherosclerosis. iScience 2022; 25(1): 103677. https://www.ncbi.nlm.nih.gov/pubmed/35036868
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Tas K, Volta BD, Lindner C, El Bounkari O, Hille K, Tian Y, Puig-Bosch X, Ballmann M, Hornung S, Ortner M, Prem S, Meier L, Rammes G, Haslbeck M, Weber C, Megens RTA, Bernhagen J, Kapurniotu A. Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly. Nat Commun 2022; 13(1): 5004. https://www.ncbi.nlm.nih.gov/pubmed/36008417
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2021

Abdel Rahman F, d'Almeida S, Zhang T, Asadi M, Bozoglu T, Bongiovanni D, von Scheidt M, Dietzel S, Schwedhelm E, Hinkel R, Laugwitz KL, Kupatt C, Ziegler T. Sphingosine-1-Phosphate Attenuates Lipopolysaccharide-Induced Pericyte Loss via Activation of Rho-A and MRTF-A. Thromb Haemost 2021; 121(3): 341-350. https://www.ncbi.nlm.nih.gov/pubmed/33011963
Alexander Y, Osto E, Schmidt-Trucksass A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Back M, Badimon L, Cosentino F, De Carlo M, Dorobantu M, Harrison DG, Guzik TJ, Hoefer I, Morris PD, Norata GD, Suades R, Taddei S, Vilahur G, Waltenberger J, Weber C, Wilkinson F, Bochaton-Piallat ML, Evans PC. Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis. Cardiovasc Res 2021; 117(1): 29-42. https://www.ncbi.nlm.nih.gov/pubmed/32282914
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vazquez-Martinez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lammermann T, Nourshargh S. Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Immunity 2021; 54(7): 1494-1510 e1497. https://www.ncbi.nlm.nih.gov/pubmed/34033752
Bernlochner I, Klug M, Larasati D, Von Scheidt M, Santovito D, Hristov M, Weber C, Laugwitz KL, Bongiovanni D. Sorting and magnetic-based isolation of reticulated platelets from peripheral blood. Platelets 2021; 32(1): 113-119. https://www.ncbi.nlm.nih.gov/pubmed/32046562
Bosmans LA, Bosch L, Kusters PJH, Lutgens E, Seijkens TTP. The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease. J Cardiovasc Transl Res 2021; 14(1): 13-22. https://www.ncbi.nlm.nih.gov/pubmed/32222950
Bosmans LA, Shami A, Atzler D, Weber C, Goncalves I, Lutgens E. Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis. Vascul Pharmacol 2021; 139: 106884. https://www.ncbi.nlm.nih.gov/pubmed/34102305
Chirivi RGS, van Rosmalen JWG, van der Linden M, Euler M, Schmets G, Bogatkevich G, Kambas K, Hahn J, Braster Q, Soehnlein O, Hoffmann MH, Es H, Raats JMH. Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases. Cell Mol Immunol 2021; 18(6): 1528-1544. https://www.ncbi.nlm.nih.gov/pubmed/32203195
Chondronikola M, Bartelt A, Vidal-Puig A, Virtanen KA. Editorial: Brown Adipose Tissue: From Heat Production in Rodents to Metabolic Health in Humans. Front Endocrinol (Lausanne) 2021; 12: 739065. https://www.ncbi.nlm.nih.gov/pubmed/34381425
Datta-Chaudhuri T, Zanos T, Chang EH, Olofsson PS, Bickel S, Bouton C, Grande D, Rieth L, Aranow C, Bloom O, Mehta AD, Civillico G, Stevens MM, Glowacki E, Bettinger C, Schuettler M, Puleo C, Rennaker R, Mohanta S, Carnevale D, Conde SV, Bonaz B, Chernoff D, Kapa S, Berggren M, Ludwig K, Zanos S, Miller L, Weber D, Yoshor D, Steinman L, Chavan SS, Pavlov VA, Al-Abed Y, Tracey KJ. The Fourth Bioelectronic Medicine Summit "Technology Targeting Molecular Mechanisms": current progress, challenges, and charting the future. Bioelectron Med 2021; 7(1): 7. https://www.ncbi.nlm.nih.gov/pubmed/34024277
Davidson SM, Padro T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J, Weber C. Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart. Cardiovasc Res 2021; 117(10): 2161-2174. https://www.ncbi.nlm.nih.gov/pubmed/34114614
Dickhout A, Kaczor DM, Heinzmann ACA, Brouns SLN, Heemskerk JWM, van Zandvoort M, Koenen RR. Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells. Int J Mol Sci 2021; 22(14). https://www.ncbi.nlm.nih.gov/pubmed/34298951
Dickhout A, Tullemans BME, Heemskerk JWM, Thijssen V, Kuijpers MJE, Koenen RR. Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro. PLoS One 2021; 16(1): e0244736. https://www.ncbi.nlm.nih.gov/pubmed/33411760
Duan R, Goldmann L, Brandl R, Spannagl M, Weber C, Siess W, von Hundelshausen P. Effects of the Btk-Inhibitors Remibrutinib (LOU064) and Rilzabrutinib (PRN1008) With Varying Btk Selectivity Over Tec on Platelet Aggregation and in vitro Bleeding Time. Front Cardiovasc Med 2021; 8: 749022. https://www.ncbi.nlm.nih.gov/pubmed/34631841
Duan R, Goldmann L, Li Y, Weber C, Siess W, von Hundelshausen P. Spontaneous Platelet Aggregation in Blood Is Mediated by FcgammaRIIA Stimulation of Bruton's Tyrosine Kinase. Int J Mol Sci 2021; 23(1). https://www.ncbi.nlm.nih.gov/pubmed/35008508
Egea V, Kessenbrock K, Lawson D, Bartelt A, Weber C, Ries C. Let-7f miRNA regulates SDF-1alpha- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release. Cell Death Dis 2021; 12(6): 516. https://www.ncbi.nlm.nih.gov/pubmed/34016957
Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L, Weber C. The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics. Cardiovasc Res 2021; 117(8): 1814-1822. https://www.ncbi.nlm.nih.gov/pubmed/33744925
Fasolo F, Jin H, Winski G, Chernogubova E, Pauli J, Winter H, Li DY, Glukha N, Bauer S, Metschl S, Wu Z, Koschinsky ML, Reilly M, Pelisek J, Kempf W, Eckstein HH, Soehnlein O, Matic L, Hedin U, Backlund A, Bergmark C, Paloschi V, Maegdefessel L. Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization. Circulation 2021; 144(19): 1567-1583. https://www.ncbi.nlm.nih.gov/pubmed/34647815
Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pircher J, Silvestre-Roig C, Kotini AG, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou EP, Schulz C, Massberg S, Soehnlein O, Ebert B, Levine RL, Reilly MP, Libby P, Wang N, Tall AR. The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Nature 2021; 592(7853): 296-301. https://www.ncbi.nlm.nih.gov/pubmed/33731931
Gencer S, Doring Y, Jansen Y, Bayasgalan S, Schengel O, Muller M, Peters LJF, Weber C, van der Vorst EPC. Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue. Biomedicines 2021; 9(4): 11. https://www.ncbi.nlm.nih.gov/pubmed/33917642
Gencer S, Evans BR, van der Vorst EPC, Doring Y, Weber C. Inflammatory Chemokines in Atherosclerosis. Cells 2021; 10(2). https://www.ncbi.nlm.nih.gov/pubmed/33503867
Georgakis MK, van der Laan SW, Asare Y, Mekke JM, Haitjema S, Schoneveld AH, de Jager SCA, Nurmohamed NS, Kroon J, Stroes ESG, de Kleijn DPV, de Borst GJ, Maegdefessel L, Soehnlein O, Pasterkamp G, Dichgans M. Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability. Arterioscler Thromb Vasc Biol 2021; 41(6): 2038-2048. https://www.ncbi.nlm.nih.gov/pubmed/33827260
Ghiboub M, Elfiky AMI, de Winther MPJ, Harker NR, Tough DF, de Jonge WJ. Selective Targeting of Epigenetic Readers and Histone Deacetylases in Autoimmune and Inflammatory Diseases: Recent Advances and Future Perspectives. J Pers Med 2021; 11(5). https://www.ncbi.nlm.nih.gov/pubmed/33922725
Giroud M, Tsokanos FF, Caratti G, Kotschi S, Khani S, Jouffe C, Vogl ES, Irmler M, Glantschnig C, Gil-Lozano M, Hass D, Khan AA, Garcia MR, Mattijssen F, Maida A, Tews D, Fischer-Posovszky P, Feuchtinger A, Virtanen KA, Beckers J, Wabitsch M, Uhlenhaut H, Bluher M, Tuckermann J, Scheideler M, Bartelt A, Herzig S. HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling. Diabetologia 2021; 64(8): 1850-1865. https://www.ncbi.nlm.nih.gov/pubmed/34014371
Gissler MC, Scherrer P, Anto-Michel N, Pennig J, Hoppe N, Funer L, Hardtner C, Stachon P, Li X, Mitre LS, Marchini T, Madl J, Wadle C, Hilgendorf I, von Zur Muhlen C, Bode C, Weber C, Lutgens E, Wolf D, Gerdes N, Zirlik A, Willecke F. Deficiency of Endothelial CD40 Induces a Stable Plaque Phenotype and Limits Inflammatory Cell Recruitment to Atherosclerotic Lesions in Mice. Thromb Haemost 2021; 121(11): 1530-1540. https://www.ncbi.nlm.nih.gov/pubmed/33618394
Goncalves RLS, Schlame M, Bartelt A, Brand MD, Hotamisligil GS. Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H(2) O(2) production in heart and skeletal muscle mitochondria. FEBS Lett 2021; 595(3): 415-432. https://www.ncbi.nlm.nih.gov/pubmed/33112430
Gutjahr JC, Crawford KS, Jensen DR, Naik P, Peterson FC, Samson GPB, Legler DF, Duchene J, Veldkamp CT, Rot A, Volkman BF. The dimeric form of CXCL12 binds to atypical chemokine receptor 1. Sci Signal 2021; 14(696). https://www.ncbi.nlm.nih.gov/pubmed/34404752
Hall IF, Climent M, Viviani Anselmi C, Papa L, Tragante V, Lambroia L, Farina FM, Kleber ME, Marz W, Biguori C, Condorelli G, Elia L. rs41291957 controls miR-143 and miR-145 expression and impacts coronary artery disease risk. EMBO Mol Med 2021; 13(10): e14060. https://www.ncbi.nlm.nih.gov/pubmed/34551209
He YY, Xie XM, Zhang HD, Ye J, Gencer S, van der Vorst EPC, Doring Y, Weber C, Pang XB, Jing ZC, Yan Y, Han ZY. Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary Hypertension. Front Pharmacol 2021; 12: 753727. https://www.ncbi.nlm.nih.gov/pubmed/34803695
Henderson JM, Weber C, Santovito D. Beyond Self-Recycling: Cell-Specific Role of Autophagy in Atherosclerosis. Cells 2021; 10(3). https://www.ncbi.nlm.nih.gov/pubmed/33799835
Hinkel R, Batkai S, Bahr A, Bozoglu T, Straub S, Borchert T, Viereck J, Howe A, Hornaschewitz N, Oberberger L, Jurisch V, Kozlik-Feldmann R, Freudenthal F, Ziegler T, Weber C, Sperandio M, Engelhardt S, Laugwitz KL, Moretti A, Klymiuk N, Thum T, Kupatt C. AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction. J Am Coll Cardiol 2021; 77(23): 2923-2935. https://www.ncbi.nlm.nih.gov/pubmed/34112319
Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Muller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB. Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. Eur Heart J 2021; 42(39): 4077-4088. https://www.ncbi.nlm.nih.gov/pubmed/34279021
Kassiteridi C, Cole JE, Griseri T, Falck-Hansen M, Goddard ME, Seneviratne AN, Green PA, Park I, Shami AG, Pattarabanjird T, Upadhye A, Taylor AM, Handa A, Channon KM, Lutgens E, McNamara CA, Williams RO, Monaco C. CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Circ Res 2021; 129(2): 280-295. https://www.ncbi.nlm.nih.gov/pubmed/33975450
Kluza E, Beldman TJ, Shami A, Scholl ER, Malinova TS, Grootemaat AE, van der Wel NN, Goncalves I, Huveneers S, Mulder WJM, Lutgens E. Diverse ultrastructural landscape of atherosclerotic endothelium. Atherosclerosis 2021; 339: 35-45. https://www.ncbi.nlm.nih.gov/pubmed/34847419
Koenen RR. Conformation-Crooking CXCL4 to Unravel Autoimmune Heparin-Induced Thrombocytopenia. Thromb Haemost 2021; 121(3): 258-260. https://www.ncbi.nlm.nih.gov/pubmed/33385179
Kou J, Wang M, Shi J, Zhang H, Pu X, Song S, Yang C, Yan Y, Doring Y, Xie X, Pang X. Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation through the Endoplasmic Reticulum Stress Pathway in Apolipoprotein E4 Transgenic Mice. ACS Omega 2021; 6(10): 6654-6662. https://www.ncbi.nlm.nih.gov/pubmed/33748578
Krammer C, Kontos C, Dewor M, Hille K, Dalla Volta B, El Bounkari O, Tas K, Sinitski D, Brandhofer M, Megens RTA, Weber C, Schultz JR, Bernhagen J, Kapurniotu A. A MIF-Derived Cyclopeptide that Inhibits MIF Binding and Atherogenic Signaling via the Chemokine Receptor CXCR2. Chembiochem 2021; 22(6): 1012-1019. https://www.ncbi.nlm.nih.gov/pubmed/33125165
Lacy M, Burger C, Shami A, Ahmadsei M, Winkels H, Nitz K, van Tiel CM, Seijkens TTP, Kusters PJH, Karshovka E, Prange KHM, Wu Y, Brouns SLN, Unterlugauer S, Kuijpers MJE, Reiche ME, Steffens S, Edsfeldt A, Megens RTA, Heemskerk JWM, Goncalves I, Weber C, Gerdes N, Atzler D, Lutgens E. Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nat Commun 2021; 12(1): 3754. https://www.ncbi.nlm.nih.gov/pubmed/34145241
Lee MW, Luo EW, Silvestre-Roig C, Srinivasan Y, Akabori K, Lemnitzer P, Schmidt NW, Lai GH, Santangelo CD, Soehnlein O, Wong GCL. Apolipoprotein Mimetic Peptide Inhibits Neutrophil-Driven Inflammatory Damage via Membrane Remodeling and Suppression of Cell Lysis. ACS Nano 2021; 15(10): 15930-15939. https://www.ncbi.nlm.nih.gov/pubmed/34586780
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Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF, Soehnlein O, Chapman TM. Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists. Eur J Med Chem 2021; 226: 113805. https://www.ncbi.nlm.nih.gov/pubmed/34536667
Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O, Chapman TM. Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation. Eur J Med Chem 2021; 214: 113194. https://www.ncbi.nlm.nih.gov/pubmed/33548634
Marquez AB, van der Vorst EPC, Maas SL. Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential. J Clin Med 2021; 10(17). https://www.ncbi.nlm.nih.gov/pubmed/34501271
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Rossaint J, Thomas K, Mersmann S, Skupski J, Margraf A, Tekath T, Jouvene CC, Dalli J, Hidalgo A, Meuth SG, Soehnlein O, Zarbock A. Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education. J Exp Med 2021; 218(7). https://www.ncbi.nlm.nih.gov/pubmed/34014253
Santovito D, Steffens S. DNA damage and extranuclear DNA sensors: a dangerous duo in atherosclerosis. Eur Heart J 2021; 42(42): 4349-4351. https://www.ncbi.nlm.nih.gov/pubmed/34226940
Santovito D, Toto L, De Nardis V, Marcantonio P, D'Aloisio R, Mastropasqua A, De Cesare D, Bucci M, Paganelli C, Natarelli L, Weber C, Consoli A, Mastropasqua R, Cipollone F. Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes. Sci Rep 2021; 11(1): 4136. https://www.ncbi.nlm.nih.gov/pubmed/33602976
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Schober A, Blay RM, Saboor Maleki S, Zahedi F, Winklmaier AE, Kakar MY, Baatsch IM, Zhu M, Geissler C, Fusco AE, Eberlein A, Li N, Megens RTA, Banafsche R, Kumbrink J, Weber C, Nazari-Jahantigh M. MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions. Circulation 2021; 144(13): 1059-1073. https://www.ncbi.nlm.nih.gov/pubmed/34233454
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Schumacher D, Liehn EA, Singh A, Curaj A, Wijnands E, Lira SA, Tacke F, Jankowski J, Biessen EAL, van der Vorst EPC. CCR6 Deficiency Increases Infarct Size after Murine Acute Myocardial Infarction. Biomedicines 2021; 9(11). https://www.ncbi.nlm.nih.gov/pubmed/34829761
Schumski A, Ortega-Gomez A, Wichapong K, Winter C, Lemnitzer P, Viola JR, Pinilla-Vera M, Folco E, Solis-Mezarino V, Volker-Albert M, Maas SL, Pan C, Perez Olivares L, Winter J, Hackeng T, Karlsson MCI, Zeller T, Imhof A, Baron RM, Nicolaes GAF, Libby P, Maegdefessel L, Kamp F, Benoit M, Doring Y, Soehnlein O. Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion. Circulation 2021; 143(3): 254-266. https://www.ncbi.nlm.nih.gov/pubmed/33167684
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Shami A, Edsfeldt A, Bengtsson E, Nilsson J, Shore AC, Natali A, Khan F, Lutgens E, Goncalves I. Soluble CD40 Levels in Plasma Are Associated with Cardiovascular Disease and in Carotid Plaques with a Vulnerable Phenotype. J Stroke 2021; 23(3): 367-376. https://www.ncbi.nlm.nih.gov/pubmed/34649381
Silvestre-Roig C, Lemnitzer P, Gall J, Schwager S, Toska A, Yvan-Charvet L, Detmar M, Soehnlein O. Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions. Circ Res 2021; 128(2): 284-286. https://www.ncbi.nlm.nih.gov/pubmed/33210556
Soehnlein O, Libby P. Targeting inflammation in atherosclerosis - from experimental insights to the clinic. Nat Rev Drug Discov 2021; 20(8): 589-610. https://www.ncbi.nlm.nih.gov/pubmed/33976384
Soltani-Fard E, Taghvimi S, Abedi Kichi Z, Weber C, Shabaninejad Z, Taheri-Anganeh M, Hossein Khatami S, Mousavi P, Movahedpour A, Natarelli L. Insights into the Function of Regulatory RNAs in Bacteria and Archaea. International Journal of Translational Medicine 2021; 1(3): 403-423. https://www.mdpi.com/2673-8937/1/3/24
Sundararaman SS, Doring Y, van der Vorst EPC. PCSK9: A Multi-Faceted Protein That Is Involved in Cardiovascular Biology. Biomedicines 2021; 9(7). https://www.ncbi.nlm.nih.gov/pubmed/34356856
Sundararaman SS, Peters LJF, Jansen Y, Gencer S, Yan Y, Nazir S, Bonnin Marquez A, Kahles F, Lehrke M, Biessen EAL, Jankowski J, Weber C, Doring Y, van der Vorst EPC. Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe(-/-) mice. Sci Rep 2021; 11(1): 10409. https://www.ncbi.nlm.nih.gov/pubmed/34001955
Sundararaman SS, Peters LJF, Nazir S, Marquez AB, Bouma JE, Bayasgalan S, Doring Y, van der Vorst EPC. PCSK9 Imperceptibly Affects Chemokine Receptor Expression In Vitro and In Vivo. Int J Mol Sci 2021; 22(23). https://www.ncbi.nlm.nih.gov/pubmed/34884827
Sundararaman SS, van der Vorst EPC. Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health. Int J Mol Sci 2021; 22(5). https://www.ncbi.nlm.nih.gov/pubmed/33804544
Tahir S, Steffens S. Nonclassical monocytes in cardiovascular physiology and disease. Am J Physiol Cell Physiol 2021; 320(5): C761-C770. https://www.ncbi.nlm.nih.gov/pubmed/33596150
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Tsokanos FF, Muley C, Khani S, Hass D, Fleming T, Wolff G, Bartelt A, Nawroth P, Herzig S. Methylglyoxal Drives a Distinct, Nonclassical Macrophage Activation Status. Thromb Haemost 2021; 121(11): 1464-1475. https://www.ncbi.nlm.nih.gov/pubmed/33966256
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van der Vorst EPC. c-Kit inhibition: From promising cancer therapy to culprit in atherosclerosis. Atherosclerosis 2021; 324: 115-116. https://www.ncbi.nlm.nih.gov/pubmed/33824002
van der Vorst EPC, Doring Y. Tracing Endothelial CXCR4 May Pave the Way for Localized Lesional Treatment Approaches. Arterioscler Thromb Vasc Biol 2021; 41(2): 837-838. https://www.ncbi.nlm.nih.gov/pubmed/33955781
van der Vorst EPC, Pepe MAA, Peters LJF, Haberbosch M, Jansen Y, Naumann R, Stathopoulos GT, Weber C, Bidzhekov K. Transcriptome signature of miRNA-26b KO mouse model suggests novel targets. BMC Genom Data 2021; 22(1): 23. https://www.ncbi.nlm.nih.gov/pubmed/34193044
van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Perez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R. Prosaposin mediates inflammation in atherosclerosis. Sci Transl Med 2021; 13(584). https://www.ncbi.nlm.nih.gov/pubmed/33692130
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2020

Adrover JM, Aroca-Crevillen A, Crainiciuc G, Ostos F, Rojas-Vega Y, Rubio-Ponce A, Cilloniz C, Bonzon-Kulichenko E, Calvo E, Rico D, Moro MA, Weber C, Lizasoain I, Torres A, Ruiz-Cabello J, Vazquez J, Hidalgo A. Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation. Nat Immunol 2020; 21(2): 135-144. https://www.ncbi.nlm.nih.gov/pubmed/31932813
Aroca-Crevillen A, Adrover JM, Hidalgo A. Circadian Features of Neutrophil Biology. Front Immunol 2020; 11: 576. https://www.ncbi.nlm.nih.gov/pubmed/32346378
Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M. Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability. Circ Res 2020; 127(6): 811-823. https://www.ncbi.nlm.nih.gov/pubmed/32546048
Baardman J, Lutgens E. Regulatory T Cell Metabolism in Atherosclerosis. Metabolites 2020; 10(7): 279. https://www.ncbi.nlm.nih.gov/pubmed/32650487
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Baehr A, Hinkel R, Kupatt C. Statins Make a Difference in Acute Myocardial Infarction: A Revival. J Am Coll Cardiol 2020; 75(12): 1403-1405. https://www.ncbi.nlm.nih.gov/pubmed/32216908
Baehr A, Umansky KB, Bassat E, Jurisch V, Klett K, Bozoglu T, Hornaschewitz N, Solyanik O, Kain D, Ferraro B, Cohen-Rabi R, Krane M, Cyran C, Soehnlein O, Laugwitz KL, Hinkel R, Kupatt C, Tzahor E. Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs. Circulation 2020; 142(9): 868-881. https://www.ncbi.nlm.nih.gov/pubmed/32508131
Ballesteros I, Rubio-Ponce A, Genua M, Lusito E, Kwok I, Fernandez-Calvo G, Khoyratty TE, van Grinsven E, Gonzalez-Hernandez S, Nicolas-Avila JA, Vicanolo T, Maccataio A, Benguria A, Li JL, Adrover JM, Aroca-Crevillen A, Quintana JA, Martin-Salamanca S, Mayo F, Ascher S, Barbiera G, Soehnlein O, Gunzer M, Ginhoux F, Sanchez-Cabo F, Nistal-Villan E, Schulz C, Dopazo A, Reinhardt C, Udalova IA, Ng LG, Ostuni R, Hidalgo A. Co-option of Neutrophil Fates by Tissue Environments. Cell 2020; 183(5): 1282-1297 e1218. https://www.ncbi.nlm.nih.gov/pubmed/33098771
Bartelt A, Weber C. Mitochondrial Ejection for Cardiac Protection: The Macrophage Connection. Cell Metab 2020; 32(4): 512-513. https://www.ncbi.nlm.nih.gov/pubmed/33027673
Bartelt A, Widenmaier SB. Proteostasis in thermogenesis and obesity. Biol Chem 2020; 401(9): 1019-1030. https://www.ncbi.nlm.nih.gov/pubmed/32061163
Bosch L, de Haan JJ, Seijkens TTP, van Tiel CM, Brans MAD, Pasterkamp G, Lutgens E, de Jager SCA. The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular Diseases. Int J Cardiol 2020; 300: 220. https://www.ncbi.nlm.nih.gov/pubmed/31928651
Butt E, Stempfle K, Lister L, Wolf F, Kraft M, Herrmann AB, Viciano CP, Weber C, Hochhaus A, Ernst T, Hoffmann C, Zernecke A, Frietsch JJ. Phosphorylation-Dependent Differences in CXCR4-LASP1-AKT1 Interaction between Breast Cancer and Chronic Myeloid Leukemia. Cells 2020; 9(2): 444. https://www.ncbi.nlm.nih.gov/pubmed/32075106
Chen HJ, Tas SW, de Winther MPJ. Type-I interferons in atherosclerosis. J Exp Med 2020; 217(1). https://www.ncbi.nlm.nih.gov/pubmed/31821440
Cribbs AP, Terlecki-Zaniewicz S, Philpott M, Baardman J, Ahern D, Lindow M, Obad S, Oerum H, Sampey B, Mander PK, Penn H, Wordsworth P, Bowness P, de Winther M, Prinjha RK, Feldmann M, Oppermann U. Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism. Proc Natl Acad Sci U S A 2020; 117(11): 6056-6066. https://www.ncbi.nlm.nih.gov/pubmed/32123118
d'Alessandro E, Becker C, Bergmeier W, Bode C, Bourne JH, Brown H, Buller HR, Ten Cate-Hoek AJ, Ten Cate V, van Cauteren YJM, Cheung YFH, Cleuren A, Coenen D, Crijns H, de Simone I, Dolleman SC, Klein CE, Fernandez DI, Granneman L, van THA, Henke P, Henskens YMC, Huang J, Jennings LK, Jooss N, Karel M, van den Kerkhof D, Klok FA, Kremers B, Lammle B, Leader A, Lundstrom A, Mackman N, Mannucci PM, Maqsood Z, van der Meijden PEJ, van Moorsel M, Moran LA, Morser J, van Mourik M, Navarro S, Neagoe RAI, Olie RH, van Paridon P, Posma J, Provenzale I, Reitsma PH, Scaf B, Schurgers L, Seelig J, Siegbahn A, Siegerink B, Soehnlein O, Soriano EM, Sowa MA, Spronk HMH, Storey RF, Tantiwong C, Veninga A, Wang X, Watson SP, Weitz J, Zeerleder SS, Ten Cate H, Scientific Reviewer C. Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis. Thromb Haemost 2020; 120(4): 538-564. https://www.ncbi.nlm.nih.gov/pubmed/32289858
Daub S, Lutgens E, Munzel T, Daiber A. CD40/CD40L and Related Signaling Pathways in Cardiovascular Health and Disease-The Pros and Cons for Cardioprotection. Int J Mol Sci 2020; 21(22): 8533. https://www.ncbi.nlm.nih.gov/pubmed/33198327
Denisov SS, Heinzmann ACA, Vajen T, Vries MHM, Megens RTA, Suylen D, Koenen RR, Post MJ, Ippel JH, Hackeng TM, Dijkgraaf I. Tick Saliva Protein Evasin-3 Allows for Visualization of Inflammation in Arteries through Interactions with CXC-Type Chemokines Deposited on Activated Endothelium. Bioconjug Chem 2020; 31(3): 948-955. https://www.ncbi.nlm.nih.gov/pubmed/32077689
Depuydt MAC, Prange KHM, Slenders L, Ord T, Elbersen D, Boltjes A, de Jager SCA, Asselbergs FW, de Borst GJ, Aavik E, Lonnberg T, Lutgens E, Glass CK, den Ruijter HM, Kaikkonen MU, Bot I, Slutter B, van der Laan SW, Yla-Herttuala S, Mokry M, Kuiper J, de Winther MPJ, Pasterkamp G. Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics. Circ Res 2020; 127(11): 1437-1455. https://www.ncbi.nlm.nih.gov/pubmed/32981416
Doring Y, Jansen Y, Cimen I, Aslani M, Gencer S, Peters LJF, Duchene J, Weber C, van der Vorst EPC. B-Cell-Specific CXCR4 Protects Against Atherosclerosis Development and Increases Plasma IgM Levels. Circ Res 2020; 126(6): 787-788. https://www.ncbi.nlm.nih.gov/pubmed/32078474
Doring Y, Libby P, Soehnlein O. Neutrophil Extracellular Traps Participate in Cardiovascular Diseases: Recent Experimental and Clinical Insights. Circ Res 2020; 126(9): 1228-1241. https://www.ncbi.nlm.nih.gov/pubmed/32324499
Doring Y, Noels H, van der Vorst E, Weber C. Seeing is repairing: how imaging-based timely interference with CXCR4 could improve repair after myocardial infarction. Eur Heart J 2020; 41(37): 3576-3578. https://www.ncbi.nlm.nih.gov/pubmed/32918455
Dweck MR, Maurovich-Horvat P, Leiner T, Cosyns B, Fayad ZA, Gijsen FJH, Van der Heiden K, Kooi ME, Maehara A, Muller JE, Newby DE, Narula J, Pontone G, Regar E, Serruys PW, van der Steen AFW, Stone PH, Waltenberger JL, Yuan C, Evans PC, Lutgens E, Wentzel JJ, Back M. Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 2020; 21(11): 1177-1183. https://www.ncbi.nlm.nih.gov/pubmed/32887997
Eckardt V, Miller MC, Blanchet X, Duan R, Leberzammer J, Duchene J, Soehnlein O, Megens RT, Ludwig AK, Dregni A, Faussner A, Wichapong K, Ippel H, Dijkgraaf I, Kaltner H, Doring Y, Bidzhekov K, Hackeng TM, Weber C, Gabius HJ, von Hundelshausen P, Mayo KH. Chemokines and galectins form heterodimers to modulate inflammation. EMBO Rep 2020; 21(4): e47852. https://www.ncbi.nlm.nih.gov/pubmed/32080959
Evans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE, Fragiadaki M, Waltenberger J, Weber C, Bochaton-Piallat ML, Back M. Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Cardiovasc Res 2020; 116(14): 2177-2184. https://www.ncbi.nlm.nih.gov/pubmed/32750108
Ferdinandy P, Koller A, Weber C, Waltenberger J. Postponement of Frontiers in Cardiovascular Biomedicine (FCVB) 2020 due to COVID-19: a look forward to 2021. Cardiovasc Res 2020; 116(7): e78-e81. https://www.ncbi.nlm.nih.gov/pubmed/32347928
Franke K, Pillai SY, Hoogenboezem M, Gijbels MJJ, Matlung HL, Geissler J, Olsman H, Pottgens C, van Gorp PJ, Ozsvar-Kozma M, Saito Y, Matozaki T, Kuijpers TW, Hendriks RW, Kraal G, Binder CJ, de Winther MPJ, van den Berg TK. SIRPalpha on Mouse B1 Cells Restricts Lymphoid Tissue Migration and Natural Antibody Production. Front Immunol 2020; 11: 570963. https://www.ncbi.nlm.nih.gov/pubmed/33162986
Gencer S, Lacy M, Atzler D, van der Vorst EPC, Doring Y, Weber C. Immunoinflammatory, Thrombohaemostatic, and Cardiovascular Mechanisms in COVID-19. Thromb Haemost 2020; 120(12): 1629-1641. https://www.ncbi.nlm.nih.gov/pubmed/33124029
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L, Long M, Parry S, Woods R, Hulston C, Benedikter B, Niespolo C, Bazaz R, Francis S, Kiss-Toth E, van Zandvoort M, Schober A, Hellewell P, Evans PC, Ridger V. Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nat Commun 2020; 11(1): 214. https://www.ncbi.nlm.nih.gov/pubmed/31924781
Greiffo FR, Viteri-Alvarez V, Frankenberger M, Dietel D, Ortega-Gomez A, Lee JS, Hilgendorff A, Behr J, Soehnlein O, Eickelberg O, Fernandez IE. CX3CR1-fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases. Eur Respir J 2020; 55(2). https://www.ncbi.nlm.nih.gov/pubmed/31744836
Groeneweg L, Hidalgo A, N AG. Emerging roles of infiltrating granulocytes and monocytes in homeostasis. Cell Mol Life Sci 2020; 77(19): 3823-3830. https://www.ncbi.nlm.nih.gov/pubmed/32248248
Hamid SM, Citir M, Terzi EM, Cimen I, Yildirim Z, Dogan AE, Kocaturk B, Onat UI, Arditi M, Weber C, Traynor-Kaplan A, Schultz C, Erbay E. Inositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth. EMBO Rep 2020; 21(12): e51462. https://www.ncbi.nlm.nih.gov/pubmed/33140520
Hinkel R, Ramanujam D, Kaczmarek V, Howe A, Klett K, Beck C, Dueck A, Thum T, Laugwitz KL, Maegdefessel L, Weber C, Kupatt C, Engelhardt S. AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury. J Am Coll Cardiol 2020; 75(15): 1788-1800. https://www.ncbi.nlm.nih.gov/pubmed/32299591
Karshovska E, Wei Y, Subramanian P, Mohibullah R, Geissler C, Baatsch I, Popal A, Corbalan Campos J, Exner N, Schober A. HIF-1alpha (Hypoxia-Inducible Factor-1alpha) Promotes Macrophage Necroptosis by Regulating miR-210 and miR-383. Arterioscler Thromb Vasc Biol 2020; 40(3): 583-596. https://www.ncbi.nlm.nih.gov/pubmed/31996026
Kessler T, Schunkert H, von Hundelshausen P. Novel Approaches to Fine-Tune Therapeutic Targeting of Platelets in Atherosclerosis: A Critical Appraisal. Thromb Haemost 2020; 120(11): 1492-1504. https://www.ncbi.nlm.nih.gov/pubmed/32772352
Kiouptsi K, Pontarollo G, Todorov H, Braun J, Jackel S, Koeck T, Bayer F, Karwot C, Karpi A, Gerber S, Jansen Y, Wild P, Ruf W, Daiber A, Van Der Vorst E, Weber C, Doring Y, Reinhardt C. Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice. Gut Microbes 2020; 11(6): 1809-1823. https://www.ncbi.nlm.nih.gov/pubmed/32579470
Kontos C, El Bounkari O, Krammer C, Sinitski D, Hille K, Zan C, Yan G, Wang S, Gao Y, Brandhofer M, Megens RTA, Hoffmann A, Pauli J, Asare Y, Gerra S, Bourilhon P, Leng L, Eckstein HH, Kempf WE, Pelisek J, Gokce O, Maegdefessel L, Bucala R, Dichgans M, Weber C, Kapurniotu A, Bernhagen J. Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting. Nat Commun 2020; 11(1): 5981. https://www.ncbi.nlm.nih.gov/pubmed/33239628
Kuznetsova T, Prange KHM, Glass CK, de Winther MPJ. Transcriptional and epigenetic regulation of macrophages in atherosclerosis. Nat Rev Cardiol 2020; 17(4): 216-228. https://www.ncbi.nlm.nih.gov/pubmed/31578516
Lip GYH, Rigby A, Weber C. A Toast to the Last Decade and a Very Happy 2020 from Thrombosis and Haemostasis! Thromb Haemost 2020; 120(1): 1-4. https://www.ncbi.nlm.nih.gov/pubmed/31931535
Lu HS, Schmidt AM, Hegele RA, Mackman N, Rader DJ, Weber C, Daugherty A. Annual Report on Sex in Preclinical Studies: Arteriosclerosis, Thrombosis, and Vascular Biology Publications in 2018. Arterioscler Thromb Vasc Biol 2020; 40(1): e1-e9. https://www.ncbi.nlm.nih.gov/pubmed/31869272
Lutgens E. rs1883832: a CD40 single-nucleotide polymorphism for predicting coronary heart disease in humans. Cardiovasc Res 2020; 116(6): 1095-1096. https://www.ncbi.nlm.nih.gov/pubmed/31722420
Lutgens E, Seijkens TTP. Cancer patients receiving immune checkpoint inhibitor therapy are at an increased risk for atherosclerotic cardiovascular disease. J Immunother Cancer 2020; 8(1). https://www.ncbi.nlm.nih.gov/pubmed/32034065
Marquez AB, Nazir S, van der Vorst EPC. High-Density Lipoprotein Modifications: A Pathological Consequence or Cause of Disease Progression? Biomedicines 2020; 8(12): 549. https://www.ncbi.nlm.nih.gov/pubmed/33260660
Nazir S, Jankowski V, Bender G, Zewinger S, Rye KA, van der Vorst EPC. Interaction between high-density lipoproteins and inflammation: Function matters more than concentration! Adv Drug Deliv Rev 2020; 159: 94-119. https://www.ncbi.nlm.nih.gov/pubmed/33080259
Neele AE, Chen HJ, Gijbels MJJ, van der Velden S, Hoeksema MA, Boshuizen MCS, Van den Bossche J, Tool AT, Matlung HL, van den Berg TK, Lutgens E, de Winther MPJ. Myeloid Ezh2 Deficiency Limits Atherosclerosis Development. Front Immunol 2020; 11: 594603. https://www.ncbi.nlm.nih.gov/pubmed/33574814
Ortega-Gomez A, Soehnlein O. Lack of Proteinase 3 Stabilizes Advanced Atherosclerotic Lesions. Thromb Haemost 2020; 120(6): 994-997. https://www.ncbi.nlm.nih.gov/pubmed/32403136
Peters LJF, Biessen EAL, Hohl M, Weber C, van der Vorst EPC, Santovito D. Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease. Front Physiol 2020; 11: 793. https://www.ncbi.nlm.nih.gov/pubmed/32733281
Peters LJF, Floege J, Biessen EAL, Jankowski J, van der Vorst EPC. MicroRNAs in Chronic Kidney Disease: Four Candidates for Clinical Application. Int J Mol Sci 2020; 21(18). https://www.ncbi.nlm.nih.gov/pubmed/32906849
Poels K, Schnitzler JG, Waissi F, Levels JHM, Stroes ESG, Daemen M, Lutgens E, Pennekamp AM, De Kleijn DPV, Seijkens TTP, Kroon J. Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability. Front Cell Dev Biol 2020; 8: 581641. https://www.ncbi.nlm.nih.gov/pubmed/33282864
Poels K, van Leent MMT, Boutros C, Tissot H, Roy S, Meerwaldt AE, Toner YCA, Reiche ME, Kusters PJH, Malinova T, Huveneers S, Kaufman AE, Mani V, Fayad ZA, de Winther MPJ, Marabelle A, Mulder WJM, Robert C, Seijkens TTP, Lutgens E. Immune Checkpoint Inhibitor Therapy Aggravates T Cell-Driven Plaque Inflammation in Atherosclerosis. JACC CardioOncol 2020; 2(4): 599-610. https://www.ncbi.nlm.nih.gov/pubmed/34396271
Poels K, van Leent MMT, Reiche ME, Kusters PJH, Huveneers S, de Winther MPJ, Mulder WJM, Lutgens E, Seijkens TTP. Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice. Cells 2020; 9(9). https://www.ncbi.nlm.nih.gov/pubmed/32872393
Poels K, Vos WG, Lutgens E, Seijkens TTP. E3 Ubiquitin Ligases as Immunotherapeutic Target in Atherosclerotic Cardiovascular Disease. Front Cardiovasc Med 2020; 7: 106. https://www.ncbi.nlm.nih.gov/pubmed/32582770
Priem B, van Leent MMT, Teunissen AJP, Sofias AM, Mourits VP, Willemsen L, Klein ED, Oosterwijk RS, Meerwaldt AE, Munitz J, Prevot G, Vera Verschuur A, Nauta SA, van Leeuwen EM, Fisher EL, de Jong KAM, Zhao Y, Toner YC, Soultanidis G, Calcagno C, Bomans PHH, Friedrich H, Sommerdijk N, Reiner T, Duivenvoorden R, Zupancic E, Di Martino JS, Kluza E, Rashidian M, Ploegh HL, Dijkhuizen RM, Hak S, Perez-Medina C, Bravo-Cordero JJ, de Winther MPJ, Joosten LAB, van Elsas A, Fayad ZA, Rialdi A, Torre D, Guccione E, Ochando J, Netea MG, Griffioen AW, Mulder WJM. Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition. Cell 2020; 183(3): 786-801 e719. https://www.ncbi.nlm.nih.gov/pubmed/33125893
Puhl SL. Cannabinoid-sensitive receptors in cardiac physiology and ischaemia. Biochim Biophys Acta Mol Cell Res 2020; 1867(3): 118462. https://www.ncbi.nlm.nih.gov/pubmed/30890410
Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts S, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Perez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr 2020; 112(2): 413-426. https://www.ncbi.nlm.nih.gov/pubmed/32320006
Rigby A, Lip GYH, Weber C. Documenting Sex and Sex Differences in Animal Studies. Thromb Haemost 2020; 120(6): 879-882. https://www.ncbi.nlm.nih.gov/pubmed/32369833
Saar-Kovrov V, Donners M, van der Vorst EPC. Shedding of Klotho: Functional Implications in Chronic Kidney Disease and Associated Vascular Disease. Front Cardiovasc Med 2020; 7: 617842. https://www.ncbi.nlm.nih.gov/pubmed/33585584
Sanchez-Diaz M, Nicolas-Avila JA, Cordero MD, Hidalgo A. Mitochondrial Adaptations in the Growing Heart. Trends Endocrinol Metab 2020; 31(4): 308-319. https://www.ncbi.nlm.nih.gov/pubmed/32035734
Santovito D. From Beneficial to Detrimental: How Nicotine Hijacks the Autophagy Machinery. Arterioscler Thromb Vasc Biol 2020; 40(9): 1955-1957. https://www.ncbi.nlm.nih.gov/pubmed/32845772
Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourao A, Blanchet X, Wichapong K, Aslani M, Brunssen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen M, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, Hundelshausen PV, Steffens S, Duchene J, Megens RTA, Sattler M, Weber C. Autophagy unleashes noncanonical microRNA functions. Autophagy 2020; 16(12): 2294-2296. https://www.ncbi.nlm.nih.gov/pubmed/33054575
Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourao A, Blanchet X, Wichapong K, Aslani M, Brunssen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen M, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchene J, Megens RTA, Sattler M, Weber C. Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis. Sci Transl Med 2020; 12(546). https://www.ncbi.nlm.nih.gov/pubmed/32493793
Santovito D, Marcantonio P, Mastroiacovo D, Natarelli L, Mandolini C, De Nardis V, Paganelli C, De Cesare D, Affaitati G, Giamberardino MA, Stellin L, Pinelli M, Weber C, De Blasis G, Occhiuzzi U, Bucci M, Desideri G, Cipollone F. High dose rosuvastatin increases ABCA1 transporter in human atherosclerotic plaques in a cholesterol-independent fashion. Int J Cardiol 2020; 299: 249-253. https://www.ncbi.nlm.nih.gov/pubmed/31409515
Schilperoort M, van den Berg R, Bosmans LA, van Os BW, Dolle MET, Smits NAM, Guichelaar T, van Baarle D, Koemans L, Berbee JFP, Deboer T, Meijer JH, de Vries MR, Vreeken D, van Gils JM, Willems van Dijk K, van Kerkhof LWM, Lutgens E, Biermasz NR, Rensen PCN, Kooijman S. Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice. J Pineal Res 2020; 68(1): e12614. https://www.ncbi.nlm.nih.gov/pubmed/31599473
Schnitzler JG, Hoogeveen RM, Ali L, Prange KHM, Waissi F, van Weeghel M, Bachmann JC, Versloot M, Borrelli MJ, Yeang C, De Kleijn DPV, Houtkooper RH, Koschinsky ML, de Winther MPJ, Groen AK, Witztum JL, Tsimikas S, Stroes ESG, Kroon J. Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation. Circ Res 2020; 126(10): 1346-1359. https://www.ncbi.nlm.nih.gov/pubmed/32160811
Schnitzler JG, Poels K, Stiekema LCA, Yeang C, Tsimikas S, Kroon J, Stroes ESG, Lutgens E, Seijkens TTP. Short-term regulation of hematopoiesis by lipoprotein(a) results in the production of pro-inflammatory monocytes. Int J Cardiol 2020; 315: 81-85. https://www.ncbi.nlm.nih.gov/pubmed/32387421
Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T, Werz O, Chiurchiu V, Azzi A, Dubourdeau M, Gupta SS, Schopohl P, Hoch M, Gjorgevikj D, Khan FM, Brauer D, Tripathi A, Cesnulevicius K, Lescheid D, Schultz M, Sarndahl E, Repsilber D, Kruse R, Sala A, Haeggstrom JZ, Levy BD, Filep JG, Wolkenhauer O. The Atlas of Inflammation Resolution (AIR). Mol Aspects Med 2020; 74: 100894. https://www.ncbi.nlm.nih.gov/pubmed/32893032
Shami A, Atzler D, Bosmans LA, Winkels H, Meiler S, Lacy M, van Tiel C, Ta Megens R, Nitz K, Baardman J, Kusters P, Seijkens T, Buerger C, Janjic A, Riccardi C, Edsfeldt A, Monaco C, Daemen M, de Winther MPJ, Nilsson J, Weber C, Gerdes N, Goncalves I, Lutgens E. Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans. Eur Heart J 2020; 41(31): 2938-2948. https://www.ncbi.nlm.nih.gov/pubmed/32728688
Siess W, Hundelshausen PV, Lorenz R. Selective inhibition of thromboinflammation in COVID-19 by Btk inhibitors. Platelets 2020; 31(8): 989-992. https://www.ncbi.nlm.nih.gov/pubmed/32892684
Silvestre-Roig C, Braster Q, Ortega-Gomez A, Soehnlein O. Neutrophils as regulators of cardiovascular inflammation. Nat Rev Cardiol 2020; 17(6): 327-340. https://www.ncbi.nlm.nih.gov/pubmed/31996800
Steffens S, Van Linthout S, Sluijter JPG, Tocchetti CG, Thum T, Madonna R. Stimulating pro-reparative immune responses to prevent adverse cardiac remodelling: consensus document from the joint 2019 meeting of the ESC Working Groups of cellular biology of the heart and myocardial function. Cardiovasc Res 2020; 116(11): 1850-1862. https://www.ncbi.nlm.nih.gov/pubmed/32396608
Sternkopf M, Nagy M, Baaten C, Kuijpers MJE, Tullemans BME, Wirth J, Theelen W, Mastenbroek TG, Lehrke M, Winnerling B, Baerts L, Marx N, De Meester I, Doring Y, Cosemans J, Daiber A, Steven S, Jankowski J, Heemskerk JWM, Noels H. Native, Intact Glucagon-Like Peptide 1 Is a Natural Suppressor of Thrombus Growth Under Physiological Flow Conditions. Arterioscler Thromb Vasc Biol 2020; 40(3): e65-e77. https://www.ncbi.nlm.nih.gov/pubmed/31893947
Stiekema LCA, Prange KHM, Hoogeveen RM, Verweij SL, Kroon J, Schnitzler JG, Dzobo KE, Cupido AJ, Tsimikas S, Stroes ESG, de Winther MPJ, Bahjat M. Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a). Eur Heart J 2020; 41(24): 2262-2271. https://www.ncbi.nlm.nih.gov/pubmed/32268367
Thiem K, Hoeke G, Zhou E, Hijmans A, Houben T, Boels MG, Mol IM, Lutgens E, Shiri-Sverdlov R, Bussink J, Kanneganti TD, Boon MR, Stienstra R, Tack CJ, Rensen PC, Netea MG, Berbee JF, van Diepen JA. Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions. Diab Vasc Dis Res 2020; 17(1): 1479164119892140. https://www.ncbi.nlm.nih.gov/pubmed/31868000
Tilstam PV, Soppert J, Hemmers C, Harlacher E, Doring Y, van der Vorst EPC, Schulte C, Alampour-Rajabi S, Theelen W, Asare Y, de Winther MPJ, Lawrence T, Bernhagen J, Schober A, Zernecke A, Jankowski J, Weber C, Noels H. Non-activatable mutant of inhibitor of kappa B kinase alpha (IKKalpha) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice. Atherosclerosis 2020; 292: 23-30. https://www.ncbi.nlm.nih.gov/pubmed/31733453
van der Vorst EPC. High-Density Lipoproteins and Apolipoprotein A1. Subcell Biochem 2020; 94: 399-420. https://www.ncbi.nlm.nih.gov/pubmed/32189309
van der Vorst EPC, Biessen EAL, Donners M. Letter by van der Vorst et al Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques". Arterioscler Thromb Vasc Biol 2020; 40(2): e31-e32. https://www.ncbi.nlm.nih.gov/pubmed/31967904
van der Vorst EPC, Daissormont I, Aslani M, Seijkens T, Wijnands E, Lutgens E, Duchene J, Santovito D, Doring Y, Halvorsen B, Aukrust P, Weber C, Hopken UE, Biessen EAL. Interruption of the CXCL13/CXCR5 Chemokine Axis Enhances Plasma IgM Levels and Attenuates Atherosclerosis Development. Thromb Haemost 2020; 120(2): 344-347. https://www.ncbi.nlm.nih.gov/pubmed/31837653
Weber C. The ESC Council on Basic Cardiovascular Science. Eur Heart J 2020; 41(12): 1227-1230. https://www.ncbi.nlm.nih.gov/pubmed/32198920
Weber C, Rigby A, Lip GYH. Thrombosis and Haemostasis 2019 Editor's Choice Papers. Thromb Haemost 2020; 120(1): 184-190. https://www.ncbi.nlm.nih.gov/pubmed/31931536
Willemsen L, de Winther MP. Macrophage subsets in atherosclerosis as defined by single-cell technologies. J Pathol 2020; 250(5): 705-714. https://www.ncbi.nlm.nih.gov/pubmed/32003464
Zernecke A, Winkels H, Cochain C, Williams JW, Wolf D, Soehnlein O, Robbins CS, Monaco C, Park I, McNamara CA, Binder CJ, Cybulsky MI, Scipione CA, Hedrick CC, Galkina EV, Kyaw T, Ghosheh Y, Dinh HQ, Ley K. Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas. Circ Res 2020; 127(3): 402-426. https://www.ncbi.nlm.nih.gov/pubmed/32673538
Zhang D, Ebrahim M, Adler K, Blanchet X, Jamasbi J, Megens RTA, Uhland K, Ungerer M, Munch G, Deckmyn H, Weber C, Elia N, Lorenz R, Siess W. Glycoprotein VI is not a Functional Platelet Receptor for Fibrin Formed in Plasma or Blood. Thromb Haemost 2020; 120(6): 977-993. https://www.ncbi.nlm.nih.gov/pubmed/32492725

2019

Aarts S, Reiche M, den Toom M, Gijbels M, Beckers L, Gerdes N, Lutgens E. Depletion of CD40 on CD11c(+) cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH. Sci Rep 2019; 9(1): 14702. https://www.ncbi.nlm.nih.gov/pubmed/31604965
Aarts SA, Seijkens TT, Kusters PJ, van Tiel CM, Reiche ME, den Toom M, Beckers L, van Roomen CP, de Winther MP, Kooij G, Lutgens E. Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis. J Pathol 2019; 247(4): 471-480. https://www.ncbi.nlm.nih.gov/pubmed/30471110
Adrover JM, Del Fresno C, Crainiciuc G, Cuartero MI, Casanova-Acebes M, Weiss LA, Huerga-Encabo H, Silvestre-Roig C, Rossaint J, Cossio I, Lechuga-Vieco AV, Garcia-Prieto J, Gomez-Parrizas M, Quintana JA, Ballesteros I, Martin-Salamanca S, Aroca-Crevillen A, Chong SZ, Evrard M, Balabanian K, Lopez J, Bidzhekov K, Bachelerie F, Abad-Santos F, Munoz-Calleja C, Zarbock A, Soehnlein O, Weber C, Ng LG, Lopez-Rodriguez C, Sancho D, Moro MA, Ibanez B, Hidalgo A. A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. Immunity 2019; 50(2): 390-402 e310. https://www.ncbi.nlm.nih.gov/pubmed/30709741
Bartelt A, Leipsic J, Weber C. The new age of radiomic risk profiling: perivascular fat at the heart of the matter. Eur Heart J 2019; 40(43): 3544-3546. https://www.ncbi.nlm.nih.gov/pubmed/31605139
Bekkering S, Stiekema LCA, Bernelot Moens S, Verweij SL, Novakovic B, Prange K, Versloot M, Roeters van Lennep JE, Stunnenberg H, de Winther M, Stroes ESG, Joosten LAB, Netea MG, Riksen NP. Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia. Cell Metab 2019; 30(1): 1-2. https://www.ncbi.nlm.nih.gov/pubmed/31204280
Beldman TJ, Malinova TS, Desclos E, Grootemaat AE, Misiak ALS, van der Velden S, van Roomen C, Beckers L, van Veen HA, Krawczyk PM, Hoebe RA, Sluimer JC, Neele AE, de Winther MPJ, van der Wel NN, Lutgens E, Mulder WJM, Huveneers S, Kluza E. Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy. ACS Nano 2019; 13(12): 13759-13774. https://www.ncbi.nlm.nih.gov/pubmed/31268670
Bianchini M, Duchene J, Santovito D, Schloss MJ, Evrard M, Winkels H, Aslani M, Mohanta SK, Horckmans M, Blanchet X, Lacy M, von Hundelshausen P, Atzler D, Habenicht A, Gerdes N, Pelisek J, Ng LG, Steffens S, Weber C, Megens RTA. PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function. Sci Immunol 2019; 4(36). https://www.ncbi.nlm.nih.gov/pubmed/31227596
Bijnen M, van de Gaar J, Vroomen M, Gijbels MJ, de Winther M, Schalkwijk CG, Wouters K. Adipose tissue macrophages do not affect atherosclerosis development in mice. Atherosclerosis 2019; 281: 31-37. https://www.ncbi.nlm.nih.gov/pubmed/30654169
Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueroder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Kockritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death Differ 2019; 26(3): 395-408. https://www.ncbi.nlm.nih.gov/pubmed/30622307
Bollenbach A, Cordts K, Hanff E, Atzler D, Choe CU, Schwedhelm E, Tsikas D. Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans. Anal Biochem 2019; 577: 59-66. https://www.ncbi.nlm.nih.gov/pubmed/31028716
Bongiovanni D, Santamaria G, Klug M, Santovito D, Felicetta A, Hristov M, von Scheidt M, Aslani M, Cibella J, Weber C, Moretti A, Laugwitz KL, Peano C, Bernlochner I. Transcriptome Analysis of Reticulated Platelets Reveals a Prothrombotic Profile. Thromb Haemost 2019; 119(11): 1795-1806. https://www.ncbi.nlm.nih.gov/pubmed/31473989
Bosch L, de Haan J, Seijkens T, van Tiel C, Brans M, Pasterkamp G, Lutgens E, de Jager S. Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure. Int J Cardiol 2019; 279: 141-144. https://www.ncbi.nlm.nih.gov/pubmed/30612848
Brandsma E, Kloosterhuis NJ, Koster M, Dekker DC, Gijbels MJJ, van der Velden S, Rios-Morales M, van Faassen MJR, Loreti MG, de Bruin A, Fu J, Kuipers F, Bakker BM, Westerterp M, de Winther MPJ, Hofker MH, van de Sluis B, Koonen DPY. A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis. Circ Res 2019; 124(1): 94-100. https://www.ncbi.nlm.nih.gov/pubmed/30582442
Busygina K, Denzinger V, Bernlochner I, Weber C, Lorenz R, Siess W. Btk Inhibitors as First Oral Atherothrombosis-Selective Antiplatelet Drugs? Thromb Haemost 2019; 119(8): 1212-1221. https://www.ncbi.nlm.nih.gov/pubmed/31087308
Cassatella MA, Ostberg NK, Tamassia N, Soehnlein O. Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines. Trends Immunol 2019; 40(7): 648-664. https://www.ncbi.nlm.nih.gov/pubmed/31155315
Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdesfessel L, Malin SG. Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability. Circulation 2019; 139(21): 2466-2482. https://www.ncbi.nlm.nih.gov/pubmed/30894016
Chen HJ, Li Yim AYF, Griffith GR, de Jonge WJ, Mannens M, Ferrero E, Henneman P, de Winther MPJ. Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo. Front Immunol 2019; 10: 2887. https://www.ncbi.nlm.nih.gov/pubmed/31921150
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M. Endothelial TGF-beta signalling drives vascular inflammation and atherosclerosis. Nat Metab 2019; 1(9): 912-926. https://www.ncbi.nlm.nih.gov/pubmed/31572976
Ciato D, Li R, Monteserin Garcia JL, Papst L, D'Annunzio S, Hristov M, Tichomirowa MA, Belaya Z, Rozhinskaya L, Buchfelder M, Theodoropoulou M, Paez-Pereda M, Stalla GK. Inhibition of Heat Shock Factor 1 Enhances Repressive Molecular Mechanisms on the POMC Promoter. Neuroendocrinology 2019; 109(4): 362-373. https://www.ncbi.nlm.nih.gov/pubmed/30995664
Cimen I, Yildirim Z, Dogan AE, Yildirim AD, Tufanli O, Onat UI, Nguyen U, Watkins SM, Weber C, Erbay E. Double bond configuration of palmitoleate is critical for atheroprotection. Mol Metab 2019; 28: 58-72. https://www.ncbi.nlm.nih.gov/pubmed/31422082
Cordts K, Grzybowski R, Lezius S, Luneburg N, Atzler D, Neu A, Hornig S, Boger RH, Gerloff C, Magnus T, Thomalla G, Schwedhelm E, Grant PJ, Choe CU. Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies. J Neurol Sci 2019; 397: 156-161. https://www.ncbi.nlm.nih.gov/pubmed/30640152
Cossio I, Lucas D, Hidalgo A. Neutrophils as regulators of the hematopoietic niche. Blood 2019; 133(20): 2140-2148. https://www.ncbi.nlm.nih.gov/pubmed/30898859
Cremer S, Michalik KM, Fischer A, Pfisterer L, Jae N, Winter C, Boon RA, Muhly-Reinholz M, John D, Uchida S, Weber C, Poller W, Gunther S, Braun T, Li DY, Maegdefessel L, Perisic Matic L, Hedin U, Soehnlein O, Zeiher A, Dimmeler S. Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation. Circulation 2019; 139(10): 1320-1334. https://www.ncbi.nlm.nih.gov/pubmed/30586743
de Juan A, Ince LM, Pick R, Chen CS, Molica F, Zuchtriegel G, Wang C, Zhang D, Druzd D, Hessenauer MET, Pelli G, Kolbe I, Oster H, Prophete C, Hergenhan SM, Albrecht U, Ripperger J, Montanez E, Reichel CA, Soehnlein O, Kwak BR, Frenette PS, Scheiermann C. Artery-Associated Sympathetic Innervation Drives Rhythmic Vascular Inflammation of Arteries and Veins. Circulation 2019; 140(13): 1100-1114. https://www.ncbi.nlm.nih.gov/pubmed/31401849
de Winther MPJ, Dallinga-Thie GM. Introduction to the thematic review series on different levels of genetic regulation of cardiovascular disease. Atherosclerosis 2019; 281: 148-149. https://www.ncbi.nlm.nih.gov/pubmed/30658843
de Winther MPJ, Glass CK. Leducq Epigenetics of Atherosclerosis Network. Circ Res 2019; 124(12): 1697-1700. https://www.ncbi.nlm.nih.gov/pubmed/31170047
de Winther MPJ, Lutgens E. The Link between Hematopoiesis and Atherosclerosis. N Engl J Med 2019; 380(19): 1869-1871. https://www.ncbi.nlm.nih.gov/pubmed/31067380
Dekkers KF, Neele AE, Jukema JW, Heijmans BT, de Winther MPJ. Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites. Epigenetics Chromatin 2019; 12(1): 34. https://www.ncbi.nlm.nih.gov/pubmed/31171035
Denisov SS, Ippel JH, Heinzmann ACA, Koenen RR, Ortega-Gomez A, Soehnlein O, Hackeng TM, Dijkgraaf I. Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2. J Biol Chem 2019; 294(33): 12370-12379. https://www.ncbi.nlm.nih.gov/pubmed/31235521
Denzinger V, Busygina K, Jamasbi J, Pekrul I, Spannagl M, Weber C, Lorenz R, Siess W. Optimizing Platelet GPVI Inhibition versus Haemostatic Impairment by the Btk Inhibitors Ibrutinib, Acalabrutinib, ONO/GS-4059, BGB-3111 and Evobrutinib. Thromb Haemost 2019; 119(3): 397-406. https://www.ncbi.nlm.nih.gov/pubmed/30685871
Doring Y, van der Vorst EPC, Duchene J, Jansen Y, Gencer S, Bidzhekov K, Atzler D, Santovito D, Rader DJ, Saleheen D, Weber C. CXCL12 Derived From Endothelial Cells Promotes Atherosclerosis to Drive Coronary Artery Disease. Circulation 2019; 139(10): 1338-1340. https://www.ncbi.nlm.nih.gov/pubmed/30865486
Eckardt V, Weber C, von Hundelshausen P. Glycans and Glycan-Binding Proteins in Atherosclerosis. Thromb Haemost 2019; 119(8): 1265-1273. https://www.ncbi.nlm.nih.gov/pubmed/31266083
Erdogmus S, Storch U, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T, Mederos YSM. Helix 8 is the essential structural motif of mechanosensitive GPCRs. Nat Commun 2019; 10(1): 5784. https://www.ncbi.nlm.nih.gov/pubmed/31857598
Ferraro B, Leoni G, Hinkel R, Ormanns S, Paulin N, Ortega-Gomez A, Viola JR, de Jong R, Bongiovanni D, Bozoglu T, Maas SL, D'Amico M, Kessler T, Zeller T, Hristov M, Reutelingsperger C, Sager HB, Doring Y, Nahrendorf M, Kupatt C, Soehnlein O. Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair. J Am Coll Cardiol 2019; 73(23): 2990-3002. https://www.ncbi.nlm.nih.gov/pubmed/31196457
Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thoele J, Siuda D, Soehnlein O, Wittig I, Heidler J, Weigert A, Fleming I. Myeloid-Specific Deletion of the AMPKalpha2 Subunit Alters Monocyte Protein Expression and Atherogenesis. Int J Mol Sci 2019; 20(12): 3005. https://www.ncbi.nlm.nih.gov/pubmed/31248224
Garcia-Culebras A, Duran-Laforet V, Pena-Martinez C, Moraga A, Ballesteros I, Cuartero MI, de la Parra J, Palma-Tortosa S, Hidalgo A, Corbi AL, Moro MA, Lizasoain I. Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke. Stroke 2019; 50(10): 2922-2932. https://www.ncbi.nlm.nih.gov/pubmed/31451099
Gencer S, van der Vorst EPC, Aslani M, Weber C, Doring Y, Duchene J. Atypical Chemokine Receptors in Cardiovascular Disease. Thromb Haemost 2019; 119(4): 534-541. https://www.ncbi.nlm.nih.gov/pubmed/30716778
Goldmann L, Duan R, Kragh T, Wittmann G, Weber C, Lorenz R, von Hundelshausen P, Spannagl M, Siess W. Oral Bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (FcgammaRIIA): a new option in HIT? Blood Adv 2019; 3(23): 4021-4033. https://www.ncbi.nlm.nih.gov/pubmed/31809536
Gonzalez-Ramos S, Paz-Garcia M, Rius C, Del Monte-Monge A, Rodriguez C, Fernandez-Garcia V, Andres V, Martinez-Gonzalez J, Lasuncion MA, Martin-Sanz P, Soehnlein O, Bosca L. Endothelial NOD1 directs myeloid cell recruitment in atherosclerosis through VCAM-1. FASEB J 2019; 33(3): 3912-3921. https://www.ncbi.nlm.nih.gov/pubmed/30496704
Guillamat Prats R, Rami M, Ring L, Rinne P, Lauer E, Lenglet S, Thomas A, Pagano S, Vuilleumier N, Cravatt BF, Weber C, Faussner A, Steffens S. Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner. Thromb Haemost 2019; 119(2): 348-351. https://www.ncbi.nlm.nih.gov/pubmed/30609444
Guillamat-Prats R, Rami M, Herzig S, Steffens S. Endocannabinoid Signalling in Atherosclerosis and Related Metabolic Complications. Thromb Haemost 2019; 119(4): 567-575. https://www.ncbi.nlm.nih.gov/pubmed/30769363
Hackler E, 3rd, Lew J, Gore MO, Ayers CR, Atzler D, Khera A, Rohatgi A, Lewis A, Neeland I, Omland T, de Lemos JA. Racial Differences in Cardiovascular Biomarkers in the General Population. J Am Heart Assoc 2019; 8(18): e012729. https://www.ncbi.nlm.nih.gov/pubmed/31514563
Hidalgo A, Chilvers ER, Summers C, Koenderman L. The Neutrophil Life Cycle. Trends Immunol 2019; 40(7): 584-597. https://www.ncbi.nlm.nih.gov/pubmed/31153737
Hollander MR, Jansen MF, Hopman L, Dolk E, van de Ven PM, Knaapen P, Horrevoets AJ, Lutgens E, van Royen N. Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single-Domain Llama-Derived Antibody. J Am Heart Assoc 2019; 8(20): e012806. https://www.ncbi.nlm.nih.gov/pubmed/31594443
Hu D, Yin C, Luo S, Habenicht AJR, Mohanta SK. Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity. Front Immunol 2019; 10: 1101. https://www.ncbi.nlm.nih.gov/pubmed/31164888
Joppich M, Weber C, Zimmer R. Using Context-Sensitive Text Mining to Identify miRNAs in Different Stages of Atherosclerosis. Thromb Haemost 2019; 119(8): 1247-1264. https://www.ncbi.nlm.nih.gov/pubmed/31378854
Ketelhuth DFJ, Lutgens E, Back M, Binder CJ, Van den Bossche J, Daniel C, Dumitriu IE, Hoefer I, Libby P, O'Neill L, Weber C, Evans PC. Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovasc Res 2019; 115(9): 1385-1392. https://www.ncbi.nlm.nih.gov/pubmed/31228191
Kiouptsi K, Jackel S, Pontarollo G, Grill A, Kuijpers MJE, Wilms E, Weber C, Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C, Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P, Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der Vorst EPC, Doring Y, Reinhardt C. The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. mBio 2019; 10(5): e02298-02219. https://www.ncbi.nlm.nih.gov/pubmed/31641089
Koenen RR. Lysophosphatidylcholine in Platelet Microvesicles: The Grease for Cardiovascular Disease. Thromb Haemost 2019; 119(8): 1202-1204. https://www.ncbi.nlm.nih.gov/pubmed/31266081
Kornhuber KTI, Seidel H, Pujol C, Meierhofer C, Roschenthaler F, Pressler A, Stockl A, Nagdyman N, Neidenbach RC, von Hundelshausen P, Halle M, Holdenrieder S, Ewert P, Kaemmerer H, Hauser M. Hemostatic abnormalities in adult patients with Marfan syndrome. Cardiovasc Diagn Ther 2019; 9(Suppl 2): S209-S220. https://www.ncbi.nlm.nih.gov/pubmed/31737529
Lacy M, Atzler D, Liu R, de Winther M, Weber C, Lutgens E. Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis. Pharmacol Ther 2019; 193: 50-62. https://www.ncbi.nlm.nih.gov/pubmed/30149100
Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Bluher M, Cypess AM, Kiebish MA, Spite M, Tseng YH. 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metab 2019; 30(4): 768-783 e767. https://www.ncbi.nlm.nih.gov/pubmed/31353262
Lip GYH, Weber C. Thrombosis and Haemostasis Wishes You a Happy New Year Ahead! Thromb Haemost 2019; 119(1): 1-2. https://www.ncbi.nlm.nih.gov/pubmed/30597493
Luque-Martin R, Van den Bossche J, Furze RC, Neele AE, van der Velden S, Gijbels MJJ, van Roomen C, Bernard SG, de Jonge WJ, Rioja I, Prinjha RK, Lewis HD, Mander PK, de Winther MPJ. Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis. Front Pharmacol 2019; 10: 1242. https://www.ncbi.nlm.nih.gov/pubmed/31736752
Lutgens E. Epigenetic Quenching of VSMC Inflammation in CVD: H3K9me2 in Control. Arterioscler Thromb Vasc Biol 2019; 39(11): 2199-2200. https://www.ncbi.nlm.nih.gov/pubmed/31644350
Lutgens E, Atzler D, Doring Y, Duchene J, Steffens S, Weber C. Immunotherapy for cardiovascular disease. Eur Heart J 2019; 40(48): 3937-3946. https://www.ncbi.nlm.nih.gov/pubmed/31121017
Mauler M, Hilgendorf I, Duerschmied D. Response by Mauler et al to Letter Regarding Article, "Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation". Circulation 2019; 140(7): e292-e293. https://www.ncbi.nlm.nih.gov/pubmed/31403846
Meeuwsen JAL, de Vries JJ, van Duijvenvoorde A, van der Velden S, van der Laan SW, van Koeverden ID, van de Weg SM, de Borst GJ, de Winther MPJ, Kuiper J, Pasterkamp G, Hoefer IE, de Jager SCA, Queen of Hearts C. Circulating CD14(+)CD16(-) classical monocytes do not associate with a vulnerable plaque phenotype, and do not predict secondary events in severe atherosclerotic patients. J Mol Cell Cardiol 2019; 127: 260-269. https://www.ncbi.nlm.nih.gov/pubmed/30629987
Nagy M, van Geffen JP, Stegner D, Adams DJ, Braun A, de Witt SM, Elvers M, Geer MJ, Kuijpers MJE, Kunzelmann K, Mori J, Oury C, Pircher J, Pleines I, Poole AW, Senis YA, Verdoold R, Weber C, Nieswandt B, Heemskerk JWM, Baaten C. Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis. Front Cardiovasc Med 2019; 6: 99. https://www.ncbi.nlm.nih.gov/pubmed/31417909
Natarelli L, Weber C. Next-Generation Therapeutic Concepts for Atherosclerosis: Focus on Cell Specificity and Noncoding RNAs. Thromb Haemost 2019; 119(8): 1199-1201. https://www.ncbi.nlm.nih.gov/pubmed/31378853
Neidhart M, Pajak A, Laskari K, Riksen NP, Joosten LAB, Netea MG, Lutgens E, Stroes ESG, Ciurea A, Distler O, Grigorian M, Karouzakis E. Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides. Front Immunol 2019; 10: 791. https://www.ncbi.nlm.nih.gov/pubmed/31037071
Ng LG, Ostuni R, Hidalgo A. Heterogeneity of neutrophils. Nat Rev Immunol 2019; 19(4): 255-265. https://www.ncbi.nlm.nih.gov/pubmed/30816340
Nicorescu I, Dallinga GM, de Winther MPJ, Stroes ESG, Bahjat M. Potential epigenetic therapeutics for atherosclerosis treatment. Atherosclerosis 2019; 281: 189-197. https://www.ncbi.nlm.nih.gov/pubmed/30340764
Nitz K, Lacy M, Atzler D. Amino Acids and Their Metabolism in Atherosclerosis. Arterioscler Thromb Vasc Biol 2019; 39(3): 319-330. https://www.ncbi.nlm.nih.gov/pubmed/30650999
Noels H, Weber C, Koenen RR. Chemokines as Therapeutic Targets in Cardiovascular Disease. Arterioscler Thromb Vasc Biol 2019; 39(4): 583-592. https://www.ncbi.nlm.nih.gov/pubmed/30760014
Onat UI, Yildirim AD, Tufanli O, Cimen I, Kocaturk B, Veli Z, Hamid SM, Shimada K, Chen S, Sin J, Shah PK, Gottlieb RA, Arditi M, Erbay E. Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis. J Am Coll Cardiol 2019; 73(10): 1149-1169. https://www.ncbi.nlm.nih.gov/pubmed/30871699
Paloschi V, Winter H, Viola J, Soehnlein O, Maegdefessel L. Mechanistic Links between Non-Coding RNAs and Myeloid Cell Inflammation in Atherosclerosis. Thromb Haemost 2019; 119(8): 1205-1211. https://www.ncbi.nlm.nih.gov/pubmed/31035303
Pfeiler S, Thakur M, Grunauer P, Megens RTA, Joshi U, Coletti R, Samara V, Muller-Stoy G, Ishikawa-Ankerhold H, Stark K, Klingl A, Frohlich T, Arnold GJ, Wormann S, Bruns CJ, Algul H, Weber C, Massberg S, Engelmann B. CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis. FASEB J 2019; 33(2): 1860-1872. https://www.ncbi.nlm.nih.gov/pubmed/30207797
Pfeiler S, Winkels H, Kelm M, Gerdes N. IL-1 family cytokines in cardiovascular disease. Cytokine 2019; 122: 154215. https://www.ncbi.nlm.nih.gov/pubmed/29198612
Puhl SL, Steffens S. Neutrophils in Post-myocardial Infarction Inflammation: Damage vs. Resolution? Front Cardiovasc Med 2019; 6: 25. https://www.ncbi.nlm.nih.gov/pubmed/30937305
Puhl SL, Weeks KL, Guran A, Ranieri A, Boknik P, Kirchhefer U, Muller FU, Avkiran M. Role of type 2A phosphatase regulatory subunit B56alpha in regulating cardiac responses to beta-adrenergic stimulation in vivo. Cardiovasc Res 2019; 115(3): 519-529. https://www.ncbi.nlm.nih.gov/pubmed/30203051
Rasmuson J, Kenne E, Wahlgren M, Soehnlein O, Lindbom L. Heparinoid sevuparin inhibits Streptococcus-induced vascular leak through neutralizing neutrophil-derived proteins. FASEB J 2019; 33(9): 10443-10452. https://www.ncbi.nlm.nih.gov/pubmed/31216421
Reiche ME, den Toom M, Willemsen L, van Os B, Gijbels MJJ, Gerdes N, Aarts S, Lutgens E. Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction. BMJ Open Diabetes Res Care 2019; 7(1): e000829. https://www.ncbi.nlm.nih.gov/pubmed/31908798
Sager HB, Husser O, Steffens S, Laugwitz KL, Schunkert H, Kastrati A, Ndrepepa G, Kessler T. Time-of-day at symptom onset was not associated with infarct size and long-term prognosis in patients with ST-segment elevation myocardial infarction. J Transl Med 2019; 17(1): 180. https://www.ncbi.nlm.nih.gov/pubmed/31142323
Schloss MJ, Horckmans M, Guillamat-Prats R, Hering D, Lauer E, Lenglet S, Weber C, Thomas A, Steffens S. 2-Arachidonoylglycerol mobilizes myeloid cells and worsens heart function after acute myocardial infarction. Cardiovasc Res 2019; 115(3): 602-613. https://www.ncbi.nlm.nih.gov/pubmed/30295758
Seijkens TTP, Poels K, Meiler S, van Tiel CM, Kusters PJH, Reiche M, Atzler D, Winkels H, Tjwa M, Poelman H, Slutter B, Kuiper J, Gijbels M, Kuivenhoven JA, Matic LP, Paulsson-Berne G, Hedin U, Hansson GK, Nicolaes GAF, Daemen M, Weber C, Gerdes N, de Winther MPJ, Lutgens E. Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death. Eur Heart J 2019; 40(4): 372-382. https://www.ncbi.nlm.nih.gov/pubmed/30452556
Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gomez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, Gonzalez-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature 2019; 569(7755): 236-240. https://www.ncbi.nlm.nih.gov/pubmed/31043745
Silvestre-Roig C, Fridlender ZG, Glogauer M, Scapini P. Neutrophil Diversity in Health and Disease. Trends Immunol 2019; 40(7): 565-583. https://www.ncbi.nlm.nih.gov/pubmed/31160207
Soehnlein O. Neutrophil Research, Quo Vadis? Trends Immunol 2019; 40(7): 561-564. https://www.ncbi.nlm.nih.gov/pubmed/31133465
Steffens S, Weber C. Immunotherapy for Atherosclerosis-Novel Concepts. Thromb Haemost 2019; 119(4): 515-516. https://www.ncbi.nlm.nih.gov/pubmed/30887489
Teixido J, Hidalgo A, Fagerholm S. Editorial: Leukocyte Trafficking in Homeostasis and Disease. Front Immunol 2019; 10: 2560. https://www.ncbi.nlm.nih.gov/pubmed/31736975
Thiem K, Hoeke G, van den Berg S, Hijmans A, Jacobs CWM, Zhou E, Mol IM, Mouktaroudi M, Bussink J, Kanneganti TD, Lutgens E, Stienstra R, Tack CJ, Netea MG, Rensen PCN, Berbee JFP, van Diepen JA. Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice. Sci Rep 2019; 9(1): 4337. https://www.ncbi.nlm.nih.gov/pubmed/30867470
Tunon J, Badimon L, Bochaton-Piallat ML, Cariou B, Daemen MJ, Egido J, Evans PC, Hoefer IE, Ketelhuth DFJ, Lutgens E, Matter CM, Monaco C, Steffens S, Stroes E, Vindis C, Weber C, Back M. Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology. Cardiovasc Res 2019; 115(1): 10-19. https://www.ncbi.nlm.nih.gov/pubmed/30534957
Van Avondt K, Maegdefessel L, Soehnlein O. Therapeutic Targeting of Neutrophil Extracellular Traps in Atherogenic Inflammation. Thromb Haemost 2019; 119(4): 542-552. https://www.ncbi.nlm.nih.gov/pubmed/30731493
Van Avondt K, Nur E, Zeerleder S. Mechanisms of haemolysis-induced kidney injury. Nat Rev Nephrol 2019; 15(11): 671-692. https://www.ncbi.nlm.nih.gov/pubmed/31455889
van Beek AA, Van den Bossche J, Mastroberardino PG, de Winther MPJ, Leenen PJM. Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging? Trends Immunol 2019; 40(2): 113-127. https://www.ncbi.nlm.nih.gov/pubmed/30626541
van der Vorst EPC, Donners M. ADAM8 in the cardiovascular system: An innocent bystander with clinical use? Atherosclerosis 2019; 286: 147-149. https://www.ncbi.nlm.nih.gov/pubmed/31003630
van der Vorst EPC, Mandl M, Muller M, Neideck C, Jansen Y, Hristov M, Gencer S, Peters LJF, Meiler S, Feld M, Geiselhoringer AL, de Jong RJ, Ohnmacht C, Noels H, Soehnlein O, Drechsler M, Weber C, Doring Y. Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions-Brief Report. Arterioscler Thromb Vasc Biol 2019; 39(4): 685-693. https://www.ncbi.nlm.nih.gov/pubmed/30786742
van der Vorst EPC, Peters LJF, Muller M, Gencer S, Yan Y, Weber C, Doring Y. G-Protein Coupled Receptor Targeting on Myeloid Cells in Atherosclerosis. Front Pharmacol 2019; 10: 531. https://www.ncbi.nlm.nih.gov/pubmed/31191301
van der Vorst EPC, Weber C. Novel Features of Monocytes and Macrophages in Cardiovascular Biology and Disease. Arterioscler Thromb Vasc Biol 2019; 39(2): e30-e37. https://www.ncbi.nlm.nih.gov/pubmed/30673349
Varasteh Z, Mohanta S, Li Y, Lopez Armbruster N, Braeuer M, Nekolla SG, Habenicht A, Sager HB, Raes G, Weber W, Hernot S, Schwaiger M. Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using (68)Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques. EJNMMI Res 2019; 9(1): 5. https://www.ncbi.nlm.nih.gov/pubmed/30666513
Varasteh Z, Mohanta S, Robu S, Braeuer M, Li Y, Omidvari N, Topping G, Sun T, Nekolla SG, Richter A, Weber C, Habenicht A, Haberkorn UA, Weber WA. Molecular Imaging of Fibroblast Activity After Myocardial Infarction Using a (68)Ga-Labeled Fibroblast Activation Protein Inhibitor, FAPI-04. J Nucl Med 2019; 60(12): 1743-1749. https://www.ncbi.nlm.nih.gov/pubmed/31405922
Vila-Caballer M, Gonzalez-Granado JM, Zorita V, Abu Nabah YN, Silvestre-Roig C, Del Monte-Monge A, Molina-Sanchez P, Ait-Oufella H, Andres-Manzano MJ, Sanz MJ, Weber C, Kremer L, Gutierrez J, Mallat Z, Andres V. Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. J Mol Cell Cardiol 2019; 132: 154-163. https://www.ncbi.nlm.nih.gov/pubmed/31121182
Weber C, Lip GYH. Thrombosis and Haemostasis 2018 Editor's Choice Papers. Thromb Haemost 2019; 119(1): 183-186. https://www.ncbi.nlm.nih.gov/pubmed/30597513
Welz PS, Zinna VM, Symeonidi A, Koronowski KB, Kinouchi K, Smith JG, Guillen IM, Castellanos A, Furrow S, Aragon F, Crainiciuc G, Prats N, Caballero JM, Hidalgo A, Sassone-Corsi P, Benitah SA. BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis. Cell 2019; 177(6): 1436-1447 e1412. https://www.ncbi.nlm.nih.gov/pubmed/31150620
Wenstedt EF, Verberk SG, Kroon J, Neele AE, Baardman J, Claessen N, Pasaoglu OT, Rademaker E, Schrooten EM, Wouda RD, de Winther MP, Aten J, Vogt L, Van den Bossche J. Salt increases monocyte CCR2 expression and inflammatory responses in humans. JCI Insight 2019; 4(21): e130508. https://www.ncbi.nlm.nih.gov/pubmed/31672939
Wichapong K, Poelman H, Ercig B, Hrdinova J, Liu X, Lutgens E, Nicolaes GA. Rational modulator design by exploitation of protein-protein complex structures. Future Med Chem 2019; 11(9): 1015-1033. https://www.ncbi.nlm.nih.gov/pubmed/31141413
Willemsen L, Neele AE, van der Velden S, Prange KHM, den Toom M, van Roomen C, Reiche ME, Griffith GR, Gijbels MJJ, Lutgens E, de Winther MPJ. Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss. BMJ Open Diabetes Res Care 2019; 7(1): e000751. https://www.ncbi.nlm.nih.gov/pubmed/31798899
Worthmann A, Schlein C, Berbee JFP, Rensen PCN, Heeren J, Bartelt A. Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression. Nutrients 2019; 11(2): 463. https://www.ncbi.nlm.nih.gov/pubmed/30813320
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR. ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med 2019; 25(3): 496-506. https://www.ncbi.nlm.nih.gov/pubmed/30692699

2018

Aarts S, Reiche ME, den Toom M, Beckers L, Gijbels MJJ, Gerdes N, de Winther MPJ, Lutgens E. Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction. PLoS One 2018; 13(8): e0202150. https://www.ncbi.nlm.nih.gov/pubmed/30096208
Ameti R, Melgrati S, Radice E, Cameroni E, Hub E, Thelen S, Rot A, Thelen M. Characterization of a chimeric chemokine as a specific ligand for ACKR3. J Leukoc Biol 2018; 104(2): 391-400. https://www.ncbi.nlm.nih.gov/pubmed/29601107
Atzler D, de Winther MPJ. DARC matter(s) for inflammatory cells. Cardiovasc Res 2018; 114(2): e11-e13. https://www.ncbi.nlm.nih.gov/pubmed/29373721
Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wust RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'Neill L A, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J. A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia. Cell Rep 2018; 25(8): 2044-2052 e2045. https://www.ncbi.nlm.nih.gov/pubmed/30463003
Baaten C, Meacham S, de Witt SM, Feijge MAH, Adams DJ, Akkerman JN, Cosemans J, Grassi L, Jupe S, Kostadima M, Mattheij NJA, Prins MH, Ramirez-Solis R, Soehnlein O, Swieringa F, Weber C, White JK, Ouwehand WH, Heemskerk JWM. A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding. Blood 2018; 132(24): e35-e46. https://www.ncbi.nlm.nih.gov/pubmed/30275110
Bahls M, Atzler D, Markus MRP, Friedrich N, Boger RH, Volzke H, Felix SB, Schwedhelm E, Dorr M. Low-Circulating Homoarginine is Associated with Dilatation and Decreased Function of the Left Ventricle in the General Population. Biomolecules 2018; 8(3): 63. https://www.ncbi.nlm.nih.gov/pubmed/30061520
Baldassarri F, Schwedhelm E, Atzler D, Boger RH, Cordts K, Haller B, Pressler A, Muller S, Suchy C, Wachter R, Dungen HD, Hasenfuss G, Pieske B, Halle M, Edelmann F, Duvinage A. Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction. Biomarkers 2018; 23(6): 540-550. https://www.ncbi.nlm.nih.gov/pubmed/29619838
Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Perez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J. Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance. Immunity 2018; 49(5): 819-828 e816. https://www.ncbi.nlm.nih.gov/pubmed/30413362
Busygina K, Jamasbi J, Seiler T, Deckmyn H, Weber C, Brandl R, Lorenz R, Siess W. Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque-triggered thrombus formation in humans. Blood 2018; 131(24): 2605-2616. https://www.ncbi.nlm.nih.gov/pubmed/29559479
Caporali A, Back M, Daemen MJ, Hoefer IE, Jones EA, Lutgens E, Matter CM, Bochaton-Piallat ML, Siekmann AF, Sluimer JC, Steffens S, Tunon J, Vindis C, Wentzel JJ, Yla-Herttuala S, Evans PC. Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology. Cardiovasc Res 2018; 114(11): 1411-1421. https://www.ncbi.nlm.nih.gov/pubmed/30016405
Casanova-Acebes M, Nicolas-Avila JA, Li JL, Garcia-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, N AG, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A. Neutrophils instruct homeostatic and pathological states in naive tissues. J Exp Med 2018; 215(11): 2778-2795. https://www.ncbi.nlm.nih.gov/pubmed/30282719
Chevre R, Silvestre-Roig C, Soehnlein O. Nutritional Modulation of Innate Immunity: The Fat-Bile-Gut Connection. Trends Endocrinol Metab 2018; 29(10): 686-698. https://www.ncbi.nlm.nih.gov/pubmed/30197155
Curaj A, Wu Z, Rix A, Gresch O, Sternkopf M, Alampour-Rajabi S, Lammers T, van Zandvoort M, Weber C, Koenen RR, Liehn EA, Kiessling F. Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation. Arterioscler Thromb Vasc Biol 2018; 38(1): 40-48. https://www.ncbi.nlm.nih.gov/pubmed/29191926
Daugherty A, Lu HS, Hegele RA, Mackman N, Rader DJ, Schmidt AM, Weber C. Response by Daugherty et al to Letter Regarding Article, "Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the Arteriosclerosis, Thrombosis, and Vascular Biology Council". Arterioscler Thromb Vasc Biol 2018; 38(6): e101-e102. https://www.ncbi.nlm.nih.gov/pubmed/29793996
den Harder AM, de Jong PA, de Groot MCH, Wolterink JM, Budde RPJ, Isgum I, van Solinge WW, Ten Berg MJ, Lutgens E, Veldhuis WB, Haitjema S, Hoefer IE, Leiner T. Commonly available hematological biomarkers are associated with the extent of coronary calcifications. Atherosclerosis 2018; 275: 166-173. https://www.ncbi.nlm.nih.gov/pubmed/29920437
Di Francesco A, Fedrigo M, Santovito D, Natarelli L, Castellani C, De Pascale F, Toscano G, Fraiese A, Feltrin G, Benazzi E, Nocco A, Thiene G, Valente M, Valle G, Schober A, Gerosa G, Angelini A. MicroRNA signatures in cardiac biopsies and detection of allograft rejection. J Heart Lung Transplant 2018; 37(11): 1329-1340. https://www.ncbi.nlm.nih.gov/pubmed/30174164
Dickhout A, Koenen RR. Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks. Front Cardiovasc Med 2018; 5: 113. https://www.ncbi.nlm.nih.gov/pubmed/30186839
Domschke G, Linden F, Pawig L, Hafner A, Akhavanpoor M, Reymann J, Doesch AO, Erbel C, Weber C, Katus HA, Noels H, Erfle H, Gleissner CA, Runz H. Systematic RNA-interference in primary human monocyte-derived macrophages: A high-throughput platform to study foam cell formation. Sci Rep 2018; 8(1): 10516. https://www.ncbi.nlm.nih.gov/pubmed/30002403
Doring Y, van der Vorst EPC. Gouty Offense in Patients With Obstructive Coronary Artery Disease Despite State-of-the-Art Therapy. J Am Heart Assoc 2018; 7(16): e010322. https://www.ncbi.nlm.nih.gov/pubmed/30369331
Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kaab S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A. Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity. EMBO J 2018; 37(12): e98133. https://www.ncbi.nlm.nih.gov/pubmed/29764980
Eikendal ALM, Bots ML, Gohar A, Lutgens E, Hoefer IE, den Ruijter HM, Leiner T. Circulating levels of P-selectin and E-selectin relate to cardiovascular magnetic resonance-derived aortic characteristics in young adults from the general population, a cross-sectional study. J Cardiovasc Magn Reson 2018; 20(1): 54. https://www.ncbi.nlm.nih.gov/pubmed/30068374
Evrard M, Kwok IWH, Chong SZ, Teng KWW, Becht E, Chen J, Sieow JL, Penny HL, Ching GC, Devi S, Adrover JM, Li JLY, Liong KH, Tan L, Poon Z, Foo S, Chua JW, Su IH, Balabanian K, Bachelerie F, Biswas SK, Larbi A, Hwang WYK, Madan V, Koeffler HP, Wong SC, Newell EW, Hidalgo A, Ginhoux F, Ng LG. Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions. Immunity 2018; 48(2): 364-379 e368. https://www.ncbi.nlm.nih.gov/pubmed/29466759
Faller KME, Atzler D, McAndrew DJ, Zervou S, Whittington HJ, Simon JN, Aksentijevic D, Ten Hove M, Choe CU, Isbrandt D, Casadei B, Schneider JE, Neubauer S, Lygate CA. Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine. Cardiovasc Res 2018; 114(3): 417-430. https://www.ncbi.nlm.nih.gov/pubmed/29236952
Girbl T, Lenn T, Perez L, Rolas L, Barkaway A, Thiriot A, Del Fresno C, Lynam E, Hub E, Thelen M, Graham G, Alon R, Sancho D, von Andrian UH, Voisin MB, Rot A, Nourshargh S. Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis. Immunity 2018; 49(6): 1062-1076 e1066. https://www.ncbi.nlm.nih.gov/pubmed/30446388
Gomez-Moreno D, Adrover JM, Hidalgo A. Neutrophils as effectors of vascular inflammation. Eur J Clin Invest 2018; 48 Suppl 2(S2): e12940. https://www.ncbi.nlm.nih.gov/pubmed/29682731
Hinkel R, Klett K, Bahr A, Kupatt C. Thymosin beta4-mediated protective effects in the heart. Expert Opin Biol Ther 2018; 18(sup1): 121-129. https://www.ncbi.nlm.nih.gov/pubmed/30063857
Hoogeveen RM, Nahrendorf M, Riksen NP, Netea MG, de Winther MPJ, Lutgens E, Nordestgaard BG, Neidhart M, Stroes ESG, Catapano AL, Bekkering S. Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases. Eur Heart J 2018; 39(38): 3521-3527. https://www.ncbi.nlm.nih.gov/pubmed/29069365
Horckmans M, Bianchini M, Santovito D, Megens RTA, Springael JY, Negri I, Vacca M, Di Eusanio M, Moschetta A, Weber C, Duchene J, Steffens S. Pericardial Adipose Tissue Regulates Granulopoiesis, Fibrosis, and Cardiac Function After Myocardial Infarction. Circulation 2018; 137(9): 948-960. https://www.ncbi.nlm.nih.gov/pubmed/29167227
Jagschies L, Hirschvogel M, Matallo J, Maier A, Mild K, Brunner H, Hinkel R, Gee MW, Radermacher P, Wildhirt SM, Hafner S. Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model. ASAIO J 2018; 64(4): 480-488. https://www.ncbi.nlm.nih.gov/pubmed/29028694
Kuipers EN, Kantae V, Maarse BCE, van den Berg SM, van Eenige R, Nahon KJ, Reifel-Miller A, Coskun T, de Winther MPJ, Lutgens E, Kooijman S, Harms AC, Hankemeier T, van der Stelt M, Rensen PCN, Boon MR. High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue. Front Physiol 2018; 9: 1913. https://www.ncbi.nlm.nih.gov/pubmed/30687125
Kusters PJH, Lutgens E, Seijkens TTP. Exploring immune checkpoints as potential therapeutic targets in atherosclerosis. Cardiovasc Res 2018; 114(3): 368-377. https://www.ncbi.nlm.nih.gov/pubmed/29309533
Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Perez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R. Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates. Nat Biomed Eng 2018; 2(5): 279-292. https://www.ncbi.nlm.nih.gov/pubmed/30936448
Langin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjoberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schonmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht JM. Consistent success in life-supporting porcine cardiac xenotransplantation. Nature 2018; 564(7736): 430-433. https://www.ncbi.nlm.nih.gov/pubmed/30518863
Leoni G, Soehnlein O. (Re) Solving Repair After Myocardial Infarction. Front Pharmacol 2018; 9: 1342. https://www.ncbi.nlm.nih.gov/pubmed/30534069
Lu HS, Schmidt AM, Hegele RA, Mackman N, Rader DJ, Weber C, Daugherty A. Reporting Sex and Sex Differences in Preclinical Studies. Arterioscler Thromb Vasc Biol 2018; 38(10): e171-e184. https://www.ncbi.nlm.nih.gov/pubmed/30354222
Maas SL, Soehnlein O, Viola JR. Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta. Front Immunol 2018; 9: 2739. https://www.ncbi.nlm.nih.gov/pubmed/30538702
Mederos YSM, Gudermann T, Storch U. Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels. Cells 2018; 7(11): 218. https://www.ncbi.nlm.nih.gov/pubmed/30463370
Natarelli L, Geissler C, Csaba G, Wei Y, Zhu M, di Francesco A, Hartmann P, Zimmer R, Schober A. miR-103 promotes endothelial maladaptation by targeting lncWDR59. Nat Commun 2018; 9(1): 2645. https://www.ncbi.nlm.nih.gov/pubmed/29980665
Neele AE, de Winther MPJ. Repressing the repressor: Ezh2 mediates macrophage activation. J Exp Med 2018; 215(5): 1269-1271. https://www.ncbi.nlm.nih.gov/pubmed/29691302
Neele AE, Gijbels MJJ, van der Velden S, Hoeksema MA, Boshuizen MCS, Prange KHM, Chen HJ, Van den Bossche J, van Roomen C, Shami A, Levels JHM, Kroon J, Lucas T, Dimmeler S, Lutgens E, de Winther MPJ. Myeloid Kdm6b deficiency results in advanced atherosclerosis. Atherosclerosis 2018; 275: 156-165. https://www.ncbi.nlm.nih.gov/pubmed/29908485
Nicolas-Avila JA, Hidalgo A, Ballesteros I. Specialized functions of resident macrophages in brain and heart. J Leukoc Biol 2018; 104(4): 743-756. https://www.ncbi.nlm.nih.gov/pubmed/29947422
Niekamp C, Atzler D, Ojeda FM, Sinning CR, Lackner KJ, Boger RH, Munzel T, Beutel ME, Schmidtmann I, Pfeiffer N, Leuschner A, Blankenberg S, Wild PS, Zeller T, Schwedhelm E, Schnabel RB. Cross-Sectional Associations between Homoarginine, Intermediate Phenotypes, and Atrial Fibrillation in the Community-The Gutenberg Health Study. Biomolecules 2018; 8(3): 86. https://www.ncbi.nlm.nih.gov/pubmed/30200232
Pacher P, Steffens S, Hasko G, Schindler TH, Kunos G. Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly. Nat Rev Cardiol 2018; 15(3): 151-166. https://www.ncbi.nlm.nih.gov/pubmed/28905873
Patel J, Lutgens E. Scientists on the Spot: Esther Lutgens on the immune system and atherosclerosis. Cardiovasc Res 2018; 114(14): e113. https://www.ncbi.nlm.nih.gov/pubmed/30476016
Paulin N, Viola JR, Maas SL, de Jong R, Fernandes-Alnemri T, Weber C, Drechsler M, Doring Y, Soehnlein O. Double-Strand DNA Sensing Aim2 Inflammasome Regulates Atherosclerotic Plaque Vulnerability. Circulation 2018; 138(3): 321-323. https://www.ncbi.nlm.nih.gov/pubmed/30012706
Pfeiler S, Gerdes N. Atherosclerosis: cell biology and lipoproteins - focus on anti-inflammatory therapies. Curr Opin Lipidol 2018; 29(1): 53-55. https://www.ncbi.nlm.nih.gov/pubmed/29298275
Pircher J, Czermak T, Ehrlich A, Eberle C, Gaitzsch E, Margraf A, Grommes J, Saha P, Titova A, Ishikawa-Ankerhold H, Stark K, Petzold T, Stocker T, Weckbach LT, Novotny J, Sperandio M, Nieswandt B, Smith A, Mannell H, Walzog B, Horst D, Soehnlein O, Massberg S, Schulz C. Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation. Nat Commun 2018; 9(1): 1523. https://www.ncbi.nlm.nih.gov/pubmed/29670076
Poller W, Dimmeler S, Heymans S, Zeller T, Haas J, Karakas M, Leistner DM, Jakob P, Nakagawa S, Blankenberg S, Engelhardt S, Thum T, Weber C, Meder B, Hajjar R, Landmesser U. Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives. Eur Heart J 2018; 39(29): 2704-2716. https://www.ncbi.nlm.nih.gov/pubmed/28430919
Rami M, Guillamat-Prats R, Rinne P, Salvermoser M, Ring L, Bianchini M, Blanchet X, Megens RTA, Doring Y, Walzog B, Soehnlein O, Weber C, Faussner A, Steffens S. Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis. Arterioscler Thromb Vasc Biol 2018; 38(5): 1007-1019. https://www.ncbi.nlm.nih.gov/pubmed/29567680
Renz BW, Takahashi R, Tanaka T, Macchini M, Hayakawa Y, Dantes Z, Maurer HC, Chen X, Jiang Z, Westphalen CB, Ilmer M, Valenti G, Mohanta SK, Habenicht AJR, Middelhoff M, Chu T, Nagar K, Tailor Y, Casadei R, Di Marco M, Kleespies A, Friedman RA, Remotti H, Reichert M, Worthley DL, Neumann J, Werner J, Iuga AC, Olive KP, Wang TC. beta2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer. Cancer Cell 2018; 33(1): 75-90 e77. https://www.ncbi.nlm.nih.gov/pubmed/29249692
Rinne P, Guillamat-Prats R, Rami M, Bindila L, Ring L, Lyytikainen LP, Raitoharju E, Oksala N, Lehtimaki T, Weber C, van der Vorst EPC, Steffens S. Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation. Arterioscler Thromb Vasc Biol 2018; 38(11): 2562-2575. https://www.ncbi.nlm.nih.gov/pubmed/30354245
Rinne P, Kadiri JJ, Velasco-Delgado M, Nuutinen S, Viitala M, Hollmen M, Rami M, Savontaus E, Steffens S. Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E(-/-) Mice. Arterioscler Thromb Vasc Biol 2018; 38(2): 313-323. https://www.ncbi.nlm.nih.gov/pubmed/29284608
Rouwet E, Lutgens E. 2016 Jeffrey M. Hoeg Award Lecture. Arterioscler Thromb Vasc Biol 2018; 38(8): 1678-1688. https://www.ncbi.nlm.nih.gov/pubmed/29930003
Salas-Perdomo A, Miro-Mur F, Urra X, Justicia C, Gallizioli M, Zhao Y, Brait VH, Laredo C, Tudela R, Hidalgo A, Chamorro A, Planas AM. T Cells Prevent Hemorrhagic Transformation in Ischemic Stroke by P-Selectin Binding. Arterioscler Thromb Vasc Biol 2018; 38(8): 1761-1771. https://www.ncbi.nlm.nih.gov/pubmed/29903733
Salvermoser M, Pick R, Weckbach LT, Zehrer A, Lohr P, Drechsler M, Sperandio M, Soehnlein O, Walzog B. Myosin 1f is specifically required for neutrophil migration in 3D environments during acute inflammation. Blood 2018; 131(17): 1887-1898. https://www.ncbi.nlm.nih.gov/pubmed/29487067
Schmitz C, Noels H, El Bounkari O, Straussfeld E, Megens RTA, Sternkopf M, Alampour-Rajabi S, Krammer C, Tilstam PV, Gerdes N, Burger C, Kapurniotu A, Bucala R, Jankowski J, Weber C, Bernhagen J. Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis. FASEB J 2018; 32(8): 4428-4443. https://www.ncbi.nlm.nih.gov/pubmed/29543531
Schonhoff M, Weineck G, Hoppe J, Hornig S, Cordts K, Atzler D, Gerloff C, Boger R, Neu A, Schwedhelm E, Choe CU. Cognitive performance of 20 healthy humans supplemented with L-homoarginine for 4 weeks. J Clin Neurosci 2018; 50: 237-241. https://www.ncbi.nlm.nih.gov/pubmed/29396070
Schumski A, Winter C, Doring Y, Soehnlein O. The Ins and Outs of Myeloid Cells in Atherosclerosis. J Innate Immun 2018; 10(5-6): 479-486. https://www.ncbi.nlm.nih.gov/pubmed/29669334
Seijkens TTP, Lutgens E. Cardiovascular oncology: exploring the effects of targeted cancer therapies on atherosclerosis. Curr Opin Lipidol 2018; 29(5): 381-388. https://www.ncbi.nlm.nih.gov/pubmed/30074493
Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts S, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slutter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol 2018; 71(5): 527-542. https://www.ncbi.nlm.nih.gov/pubmed/29406859
Soehnlein O. [Atherothrombosis : Novel therapeutic strategies]. Herz 2018; 43(2): 103-108. https://www.ncbi.nlm.nih.gov/pubmed/29236146
Soehnlein O. Decision shaping neutrophil-platelet interplay in inflammation: From physiology to intervention. Eur J Clin Invest 2018; 48(2). https://www.ncbi.nlm.nih.gov/pubmed/29226390
Soehnlein O, Bazioti V, Westerterp M. A Pad 4 Plaque Erosion. Circ Res 2018; 123(1): 6-8. https://www.ncbi.nlm.nih.gov/pubmed/29929967
Steven S, Dib M, Hausding M, Kashani F, Oelze M, Kroller-Schon S, Hanf A, Daub S, Roohani S, Gramlich Y, Lutgens E, Schulz E, Becker C, Lackner KJ, Kleinert H, Knosalla C, Niesler B, Wild PS, Munzel T, Daiber A. CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice. Cardiovasc Res 2018; 114(2): 312-323. https://www.ncbi.nlm.nih.gov/pubmed/29036612
Stocker TJ, Pircher J, Skenderi A, Ehrlich A, Eberle C, Megens RTA, Petzold T, Zhang Z, Walzog B, Muller-Taubenberger A, Weber C, Massberg S, Ishikawa-Ankerhold H, Schulz C. The Actin Regulator Coronin-1A Modulates Platelet Shape Change and Consolidates Arterial Thrombosis. Thromb Haemost 2018; 118(12): 2098-2111. https://www.ncbi.nlm.nih.gov/pubmed/30453345
Trevino-Villarreal JH, Reynolds JS, Bartelt A, Langston PK, MacArthur MR, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace LE, Mejia P, Trocha K, Kajitani GS, Longchamp A, Harputlugil E, Gathungu R, Bird SS, Bullock AD, Figenshau RS, Andriole GL, Thompson A, Heeren J, Ozaki CK, Kristal BS, Fontana L, Mitchell JR. Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms. JCI Insight 2018; 3(21): e99470. https://www.ncbi.nlm.nih.gov/pubmed/30385734
Tunon J, Back M, Badimon L, Bochaton-Piallat ML, Cariou B, Daemen MJ, Egido J, Evans PC, Francis SE, Ketelhuth DF, Lutgens E, Matter CM, Monaco C, Steffens S, Stroes E, Vindis C, Weber C, Hoefer IE, Atherosclerosis ESCWGo, Vascular B. Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice. Eur J Prev Cardiol 2018; 25(9): 948-955. https://www.ncbi.nlm.nih.gov/pubmed/29759006
Vajen T, Koenen RR, Werner I, Staudt M, Projahn D, Curaj A, Sonmez TT, Simsekyilmaz S, Schumacher D, Mollmann J, Hackeng TM, Hundelshausen PV, Weber C, Liehn EA. Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis. Sci Rep 2018; 8(1): 10647. https://www.ncbi.nlm.nih.gov/pubmed/30006564
van der Tuin SJL, Li Z, Berbee JFP, Verkouter I, Ringnalda LE, Neele AE, van Klinken JB, Rensen SS, Fu J, de Winther MPJ, Groen AK, Rensen PCN, Willems van Dijk K, Wang Y. Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80(+)Clec4f(+)Vsig4(+)Ly6C(-) Kupffer Cell Subsets. J Am Heart Assoc 2018; 7(6): e008105. https://www.ncbi.nlm.nih.gov/pubmed/29525783
van der Vorst EPC, Weber C, Donners M. A Disintegrin and Metalloproteases (ADAMs) in Cardiovascular, Metabolic and Inflammatory Diseases: Aspects for Theranostic Approaches. Thromb Haemost 2018; 118(7): 1167-1175. https://www.ncbi.nlm.nih.gov/pubmed/29874690
van der Vorst EPC, de Jong RJ, Donners M. Message in a Microbottle: Modulation of Vascular Inflammation and Atherosclerosis by Extracellular Vesicles. Front Cardiovasc Med 2018; 5: 2. https://www.ncbi.nlm.nih.gov/pubmed/29404342
van der Vorst EPC, Doring Y. Resistin keeps its Janus face. Int J Cardiol 2018; 272: 47-48. https://www.ncbi.nlm.nih.gov/pubmed/30180984
van der Vorst EPC, Weber C. Metabolomic profiling of atherosclerotic plaques: towards improved cardiovascular risk stratification. Eur Heart J 2018; 39(24): 2311-2313. https://www.ncbi.nlm.nih.gov/pubmed/29562256
Vinketova capital Ka C, Karagyozov I, Koleva V, Hristov M, Mourdjeva M, Sperandio M, Oreshkova T. Progesterone and cyclic adenosine monophosphate down-regulate CD90 in the stromal cells of human decidua. In vitro evidence and in situ findings. Am J Reprod Immunol 2018; 80(5): e13043. https://www.ncbi.nlm.nih.gov/pubmed/30151982
Viola JR, Lemnitzer P, Paulin N, Drechsler M, Nazari-Jahantigh M, Maas S, De Jong RJ, Winter J, Schober A, Weber C, Atabai K, Soehnlein O. Deletion of MFGE8 Inhibits Neointima Formation upon Arterial Damage. Thromb Haemost 2018; 118(7): 1340-1342. https://www.ncbi.nlm.nih.gov/pubmed/29864782
Wang W, Liu W, Fidler T, Wang Y, Tang Y, Woods B, Welch C, Cai B, Silvestre-Roig C, Ai D, Yang YG, Hidalgo A, Soehnlein O, Tabas I, Levine RL, Tall AR, Wang N. Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 (V617F) Mice. Circ Res 2018; 123(11): e35-e47. https://www.ncbi.nlm.nih.gov/pubmed/30571460
Wei Y, Corbalan-Campos J, Gurung R, Natarelli L, Zhu M, Exner N, Erhard F, Greulich F, Geissler C, Uhlenhaut NH, Zimmer R, Schober A. Dicer in Macrophages Prevents Atherosclerosis by Promoting Mitochondrial Oxidative Metabolism. Circulation 2018; 138(18): 2007-2020. https://www.ncbi.nlm.nih.gov/pubmed/29748186
Wei Y, Zhu M, Schober A. Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer. Int J Mol Sci 2018; 19(6): 1756. https://www.ncbi.nlm.nih.gov/pubmed/29899293
Williams JW, Martel C, Potteaux S, Esaulova E, Ingersoll MA, Elvington A, Saunders BT, Huang LH, Habenicht AJ, Zinselmeyer BH, Randolph GJ. Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic Plaques-Brief Report. Arterioscler Thromb Vasc Biol 2018; 38(8): 1702-1710. https://www.ncbi.nlm.nih.gov/pubmed/29903736
Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelman H, Schumski A, Winter J, Drechsler M, de Jong R, Immler R, Sperandio M, Hristov M, Zeller T, Nicolaes GAF, Weber C, Viola JR, Hidalgo A, Scheiermann C, Soehnlein O. Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis. Cell Metab 2018; 28(1): 175-182 e175. https://www.ncbi.nlm.nih.gov/pubmed/29861387
Winter C, Soehnlein O. The potential of chronopharmacology for treatment of atherosclerosis. Curr Opin Lipidol 2018; 29(5): 368-374. https://www.ncbi.nlm.nih.gov/pubmed/30063471
Winter C, Soehnlein O, Maegdefessel L. TIMPing the Aorta: Smooth Muscle Cell-Specific Deletion of BMAL1 Limits Murine Abdominal Aortic Aneurysm Development. Arterioscler Thromb Vasc Biol 2018; 38(5): 982-983. https://www.ncbi.nlm.nih.gov/pubmed/29695531
Zhou Z, Schober A, Nazari-Jahantigh M. Dicer promotes endothelial recovery and limits lesion formation after vascular injury through miR-126-5p. Int J Cardiol 2018; 273: 199-202. https://www.ncbi.nlm.nih.gov/pubmed/30213595
Ziegler T, Bahr A, Howe A, Klett K, Husada W, Weber C, Laugwitz KL, Kupatt C, Hinkel R. Tbeta4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs. Mol Ther 2018; 26(7): 1706-1714. https://www.ncbi.nlm.nih.gov/pubmed/29929787
Ziegler T, Hinkel R, Kupatt C. Induced pluripotent stem cell derived cardiac models: effects of Thymosin beta4. Expert Opin Biol Ther 2018; 18(sup1): 111-120. https://www.ncbi.nlm.nih.gov/pubmed/30063852

2017

A-Gonzalez N, Quintana JA, Garcia-Silva S, Mazariegos M, Gonzalez de la Aleja A, Nicolas-Avila JA, Walter W, Adrover JM, Crainiciuc G, Kuchroo VK, Rothlin CV, Peinado H, Castrillo A, Ricote M, Hidalgo A. Phagocytosis imprints heterogeneity in tissue-resident macrophages. J Exp Med 2017; 214(5): 1281-96. https://www.ncbi.nlm.nih.gov/pubmed/28432199
Aarts S, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen P, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E. Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. J Neuroinflammation 2017; 14(1): 105. https://www.ncbi.nlm.nih.gov/pubmed/28494768
Aarts S, Seijkens TTP, van Dorst KJF, Dijkstra CD, Kooij G, Lutgens E. The CD40-CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Front Immunol 2017; 8: 1791. https://www.ncbi.nlm.nih.gov/pubmed/29312317
Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, de Winther MP, Noels H, Bernhagen J. Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A 2017; 114(13): E2766-E75. https://www.ncbi.nlm.nih.gov/pubmed/28292897
Atzler D, McAndrew DJ, Cordts K, Schneider JE, Zervou S, Schwedhelm E, Neubauer S, Lygate CA. Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure. Circulation 2017; 135(4): 400-2. https://www.ncbi.nlm.nih.gov/pubmed/28115416
Bamberg F, Hetterich H, Rospleszcz S, Lorbeer R, Auweter SD, Schlett CL, Schafnitzel A, Bayerl C, Schindler A, Saam T, Muller-Peltzer K, Sommer W, Zitzelsberger T, Machann J, Ingrisch M, Selder S, Rathmann W, Heier M, Linkohr B, Meisinger C, Weber C, Ertl-Wagner B, Massberg S, Reiser MF, Peters A. Subclinical Disease Burden as Assessed by Whole-Body MRI in Subjects With Prediabetes, Subjects With Diabetes, and Normal Control Subjects From the General Population: The KORA-MRI Study. Diabetes 2017; 66(1): 158-69. https://www.ncbi.nlm.nih.gov/pubmed/27999110
Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T. CD40-signalling abrogates induction of RORgammat(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis. Nat Commun 2017; 8: 14715. https://www.ncbi.nlm.nih.gov/pubmed/28276457
Beldman TJ, Senders ML, Alaarg A, Perez-Medina C, Tang J, Zhao Y, Fay F, Deichmoller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E. Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis. ACS Nano 2017; 11(6): 5785-99. https://www.ncbi.nlm.nih.gov/pubmed/28463501
Bermudez B, Dahl TB, Medina I, Groeneweg M, Holm S, Montserrat-de la Paz S, Rousch M, Otten J, Herias V, Varela LM, Ranheim T, Yndestad A, Ortega-Gomez A, Abia R, Nagy L, Aukrust P, Muriana FJG, Halvorsen B, Biessen EAL. Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARgamma-Dependent Monocyte Differentiation and Function. Arterioscler Thromb Vasc Biol 2017; 37(6): 1157-67. https://www.ncbi.nlm.nih.gov/pubmed/28408371
Bernelot Moens SJ, Neele AE, Kroon J, van der Valk FM, Van den Bossche J, Hoeksema MA, Hoogeveen RM, Schnitzler JG, Baccara-Dinet MT, Manvelian G, de Winther MPJ, Stroes ESG. PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia. Eur Heart J 2017; 38(20): 1584-93. https://www.ncbi.nlm.nih.gov/pubmed/28329114
Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D. Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes. Eur Heart J 2017; 38(4): 292-301. https://www.ncbi.nlm.nih.gov/pubmed/28182242
Cheng HS, Besla R, Li A, Chen Z, Shikatani EA, Nazari-Jahantigh M, Hammoutene A, Nguyen MA, Geoffrion M, Cai L, Khyzha N, Li T, MacParland SA, Husain M, Cybulsky MI, Boulanger CM, Temel RE, Schober A, Rayner KJ, Robbins CS, Fish JE. Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a. Circ Res 2017; 121(4): 354-67. https://www.ncbi.nlm.nih.gov/pubmed/28637783
de Jong R, Leoni G, Drechsler M, Soehnlein O. The advantageous role of annexin A1 in cardiovascular disease. Cell Adh Migr 2017; 11(3): 261-74. https://www.ncbi.nlm.nih.gov/pubmed/27860536
de Jong RJ, Paulin N, Lemnitzer P, Viola JR, Winter C, Ferraro B, Grommes J, Weber C, Reutelingsperger C, Drechsler M, Soehnlein O. Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report. Arterioscler Thromb Vasc Biol 2017; 37(2): 312-5. https://www.ncbi.nlm.nih.gov/pubmed/28062503
Degen H, Borst O, Ziegler M, Mojica Munoz AK, Jamasbi J, Walker B, Gobel S, Fassbender J, Adler K, Brandl R, Munch G, Lorenz R, Siess W, Gawaz M, Ungerer M. ADPase CD39 Fused to Glycoprotein VI-Fc Boosts Local Antithrombotic Effects at Vascular Lesions. J Am Heart Assoc 2017; 6(8): e005991. https://www.ncbi.nlm.nih.gov/pubmed/28751543
Doring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schroder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gabel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C. Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies. Circulation 2017; 136(4): 388-403. https://www.ncbi.nlm.nih.gov/pubmed/28450349
Doring Y, Soehnlein O, Weber C. Neutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis. Circ Res 2017; 120(4): 736-43. https://www.ncbi.nlm.nih.gov/pubmed/28209798
Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K, Caamano J, Rulicke T, Moss P, Megens RTA, von Andrian UH, Hidalgo A, Weber C, Rot A. Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. Nat Immunol 2017; 18(7): 753-61. https://www.ncbi.nlm.nih.gov/pubmed/28553950
Enamorado M, Iborra S, Priego E, Cueto FJ, Quintana JA, Martinez-Cano S, Mejias-Perez E, Esteban M, Melero I, Hidalgo A, Sancho D. Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells. Nat Commun 2017; 8: 16073. https://www.ncbi.nlm.nih.gov/pubmed/28714465
Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S, Thompson AAR, Jo H, Weber C, Ridger V, Schober A, Evans PC. Mechanical Activation of Hypoxia-Inducible Factor 1alpha Drives Endothelial Dysfunction at Atheroprone Sites. Arterioscler Thromb Vasc Biol 2017; 37(11): 2087-101. https://www.ncbi.nlm.nih.gov/pubmed/28882872
Ferrari E, Lutgens E, Weber C, Gerdes N. Atherosclerosis: cell biology and lipoproteins focus on epigenetic modification and macrophage biology. Curr Opin Lipidol 2017; 28(2): 220-1. https://www.ncbi.nlm.nih.gov/pubmed/28272157
Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J. Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Oncotarget 2017; 8(22): 35542-57. https://www.ncbi.nlm.nih.gov/pubmed/28415767
Hakimzadeh N, Pinas VA, Molenaar G, de Waard V, Lutgens E, van Eck-Smit BLF, de Bruin K, Piek JJ, Eersels JLH, Booij J, Verberne HJ, Windhorst AD. Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques. PLoS One 2017; 12(11): e0187767. https://www.ncbi.nlm.nih.gov/pubmed/29190653
Horckmans M, Ring L, Duchene J, Santovito D, Schloss MJ, Drechsler M, Weber C, Soehnlein O, Steffens S. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype. Eur Heart J 2017; 38(3): 187-97. https://www.ncbi.nlm.nih.gov/pubmed/28158426
Hyafil F, Pelisek J, Laitinen I, Schottelius M, Mohring M, Doring Y, van der Vorst EP, Kallmayer M, Steiger K, Poschenrieder A, Notni J, Fischer J, Baumgartner C, Rischpler C, Nekolla SG, Weber C, Eckstein HH, Wester HJ, Schwaiger M. Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer (68)Ga-Pentixafor for PET. J Nucl Med 2017; 58(3): 499-506. https://www.ncbi.nlm.nih.gov/pubmed/27789718
Jamasbi J, Ayabe K, Goto S, Nieswandt B, Peter K, Siess W. Platelet receptors as therapeutic targets: Past, present and future. Thromb Haemost 2017; 117(7): 1249-57. https://www.ncbi.nlm.nih.gov/pubmed/28597906
Jung C, Lichtenauer M, Strodthoff D, Winkels H, Wernly B, Burger C, Kamchybekov U, Lutgens E, Figulla HR, Gerdes N. Alterations in systemic levels of Th1, Th2, and Th17 cytokines in overweight adolescents and obese mice. Pediatr Diabetes 2017; 18(8): 714-21. https://www.ncbi.nlm.nih.gov/pubmed/27597513
Krishnasamy K, Limbourg A, Kapanadze T, Gamrekelashvili J, Beger C, Hager C, Lozanovski VJ, Falk CS, Napp LC, Bauersachs J, Mack M, Haller H, Weber C, Adams RH, Limbourg FP. Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia. Nat Commun 2017; 8(1): 952. https://www.ncbi.nlm.nih.gov/pubmed/29038527
Kusters P, Seijkens T, Burger C, Legein B, Winkels H, Gijbels M, Barthels C, Bennett R, Beckers L, Atzler D, Biessen E, Brocker T, Weber C, Gerdes N, Lutgens E. Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption. Am J Pathol 2017; 187(12): 2912-9. https://www.ncbi.nlm.nih.gov/pubmed/28935569
Ley K, Gerdes N, Winkels H. ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis. Arterioscler Thromb Vasc Biol 2017; 37(5): 764-77. https://www.ncbi.nlm.nih.gov/pubmed/28360089
Li JL, Zarbock A, Hidalgo A. Platelets as autonomous drones for hemostatic and immune surveillance. J Exp Med 2017; 214(8): 2193-204. https://www.ncbi.nlm.nih.gov/pubmed/28720569
Lip GY, Weber C. A happy and prosperous New Year 2017 with "Thrombosis and Haemostasis" .... and our 60(th) Anniversary! Thromb Haemost 2017; 117(1): 1-2. https://www.ncbi.nlm.nih.gov/pubmed/28066853
Lip GYH, Weber C. Thrombosis and Haemostasis: Past, present and future. Thromb Haemost 2017; 117(7): 1217-8. https://www.ncbi.nlm.nih.gov/pubmed/30457155
Maffia P, Doring Y, Biessen EA, Mallat Z. Commentary: Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. Front Immunol 2017; 8: 140. https://www.ncbi.nlm.nih.gov/pubmed/28243244
Mitroulis I, Chen LS, Singh RP, Kourtzelis I, Economopoulou M, Kajikawa T, Troullinaki M, Ziogas A, Ruppova K, Hosur K, Maekawa T, Wang B, Subramanian P, Tonn T, Verginis P, von Bonin M, Wobus M, Bornhauser M, Grinenko T, Di Scala M, Hidalgo A, Wielockx B, Hajishengallis G, Chavakis T. Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J Clin Invest 2017; 127(10): 3624-39. https://www.ncbi.nlm.nih.gov/pubmed/28846069
Mojica Munoz AK, Jamasbi J, Uhland K, Degen H, Munch G, Ungerer M, Brandl R, Megens R, Weber C, Lorenz R, Siess W. Recombinant GPVI-Fc added to single or dual antiplatelet therapy in vitro prevents plaque-induced platelet thrombus formation. Thromb Haemost 2017; 117(8): 1651-9. https://www.ncbi.nlm.nih.gov/pubmed/28569920
Neele AE, Prange KH, Hoeksema MA, van der Velden S, Lucas T, Dimmeler S, Lutgens E, Van den Bossche J, de Winther MP. Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells. Epigenomics 2017; 9(4): 383-91. https://www.ncbi.nlm.nih.gov/pubmed/28322580
Newland SA, Mohanta S, Clement M, Taleb S, Walker JA, Nus M, Sage AP, Yin C, Hu D, Kitt LL, Finigan AJ, Rodewald HR, Binder CJ, McKenzie ANJ, Habenicht AJ, Mallat Z. Type-2 innate lymphoid cells control the development of atherosclerosis in mice. Nat Commun 2017; 8: 15781. https://www.ncbi.nlm.nih.gov/pubmed/28589929
Nicolaou A, Zhao Z, Northoff BH, Sass K, Herbst A, Kohlmaier A, Chalaris A, Wolfrum C, Weber C, Steffens S, Rose-John S, Teupser D, Holdt LM. Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice. Arterioscler Thromb Vasc Biol 2017; 37(2): 247-57. https://www.ncbi.nlm.nih.gov/pubmed/28062509
Nicolas-Avila JA, Adrover JM, Hidalgo A. Neutrophils in Homeostasis, Immunity, and Cancer. Immunity 2017; 46(1): 15-28. https://www.ncbi.nlm.nih.gov/pubmed/28099862
Paulin N, Doring Y, Kooijman S, Blanchet X, Viola JR, de Jong R, Mandl M, Hendrikse J, Schiener M, von Hundelshausen P, Vogt A, Weber C, Bdeir K, Hofmann SM, Rensen PCN, Drechsler M, Soehnlein O. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance. EBioMedicine 2017; 16: 204-11. https://www.ncbi.nlm.nih.gov/pubmed/28111237
Pellico J, Lechuga-Vieco AV, Almarza E, Hidalgo A, Mesa-Nunez C, Fernandez-Barahona I, Quintana JA, Bueren J, Enriquez JA, Ruiz-Cabello J, Herranz F. In vivo imaging of lung inflammation with neutrophil-specific (68)Ga nano-radiotracer. Sci Rep 2017; 7(1): 13242. https://www.ncbi.nlm.nih.gov/pubmed/29038592
Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, Hilgarth R, O'Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A. Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling. J Clin Invest 2017; 127(9): 3510-20. https://www.ncbi.nlm.nih.gov/pubmed/28783045
Rademakers T, van der Vorst EP, Daissormont IT, Otten JJ, Theodorou K, Theelen TL, Gijbels M, Anisimov A, Nurmi H, Lindeman JH, Schober A, Heeneman S, Alitalo K, Biessen EA. Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis. Sci Rep 2017; 7: 45263. https://www.ncbi.nlm.nih.gov/pubmed/28349940
Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat ML, Boilard E, Buzas EI, Caporali A, Dignat-George F, Evans PC, Lacroix R, Lutgens E, Ketelhuth DFJ, Nieuwland R, Toti F, Tunon J, Weber C, Hoefer IE. Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. Thromb Haemost 2017; 117(7): 1296-316. https://www.ncbi.nlm.nih.gov/pubmed/28569921
Rinne P, Rami M, Nuutinen S, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikainen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimaki T, Weber C, Steffens S. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. Circulation 2017; 136(1): 83-97. https://www.ncbi.nlm.nih.gov/pubmed/28450348
Rowinska Z, Koeppel TA, Sanati M, Schelzig H, Jankowski J, Weber C, Zernecke A, Liehn EA. Role of the CX3C chemokine receptor CX3CR1 in the pathogenesis of atherosclerosis after aortic transplantation. PLoS One 2017; 12(2): e0170644. https://www.ncbi.nlm.nih.gov/pubmed/28234900
Santovito D. Fat or fit: The big oxymoron of (metabolically) healthy obesity. Atherosclerosis 2017; 262: 143-5. https://www.ncbi.nlm.nih.gov/pubmed/28499608
Santovito D, Weber C. Atherosclerosis revisited from a clinical perspective: still an inflammatory disease? Thromb Haemost 2017; 117(2): 231-7. https://www.ncbi.nlm.nih.gov/pubmed/27975102
Santovito D, Weber C. Zooming in on microRNAs for refining cardiovascular risk prediction in secondary prevention. Eur Heart J 2017; 38(7): 524-8. https://www.ncbi.nlm.nih.gov/pubmed/27371715
Schloss MJ, Hilby M, Nitz K, Guillamat Prats R, Ferraro B, Leoni G, Soehnlein O, Kessler T, He W, Luckow B, Horckmans M, Weber C, Duchene J, Steffens S. Ly6C(high) Monocytes Oscillate in the Heart During Homeostasis and After Myocardial Infarction-Brief Report. Arterioscler Thromb Vasc Biol 2017; 37(9): 1640-5. https://www.ncbi.nlm.nih.gov/pubmed/28663258
Soehnlein O, Silvestre-Roig C. Basic research: Standardizing animal atherosclerosis studies to improve reproducibility. Nat Rev Cardiol 2017; 14(10): 574-5. https://www.ncbi.nlm.nih.gov/pubmed/28880022
Soehnlein O, Steffens S, Hidalgo A, Weber C. Neutrophils as protagonists and targets in chronic inflammation. Nat Rev Immunol 2017; 17(4): 248-61. https://www.ncbi.nlm.nih.gov/pubmed/28287106
Steffens S, Winter C, Schloss MJ, Hidalgo A, Weber C, Soehnlein O. Circadian Control of Inflammatory Processes in Atherosclerosis and Its Complications. Arterioscler Thromb Vasc Biol 2017; 37(6): 1022-8. https://www.ncbi.nlm.nih.gov/pubmed/28450299
Theodorou K, van der Vorst EPC, Gijbels MJ, Wolfs IMJ, Jeurissen M, Theelen TL, Sluimer JC, Wijnands E, Cleutjens JP, Li Y, Jansen Y, Weber C, Ludwig A, Bentzon JF, Bartsch JW, Biessen EAL, Donners M. Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression. Sci Rep 2017; 7(1): 11670. https://www.ncbi.nlm.nih.gov/pubmed/28916789
Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Cimen I, Walter P, Weber C, Erbay E. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A 2017; 114(8): E1395-E404. https://www.ncbi.nlm.nih.gov/pubmed/28137856
van den Berg SM, van Dam AD, Kusters PJH, Beckers L, den Toom M, van der Velden S, Van den Bossche J, van Die I, Boon MR, Rensen PCN, Lutgens E, de Winther MPJ. Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils. J Mol Endocrinol 2017; 59(3): 245-55. https://www.ncbi.nlm.nih.gov/pubmed/28694301
van den Berg SM, van Dam AD, Rensen PC, de Winther MP, Lutgens E. Immune Modulation of Brown(ing) Adipose Tissue in Obesity. Endocr Rev 2017; 38(1): 46-68. https://www.ncbi.nlm.nih.gov/pubmed/27849358
van der Vorst EP, Zhao Z, Rami M, Holdt LM, Teupser D, Steffens S, Weber C. Contrasting effects of myeloid and endothelial ADAM17 on atherosclerosis development. Thromb Haemost 2017; 117(3): 644-6. https://www.ncbi.nlm.nih.gov/pubmed/28004058
van der Vorst EPC, Maas SL, Ortega-Gomez A, Hameleers JMM, Bianchini M, Asare Y, Soehnlein O, Doring Y, Weber C, Megens RTA. Functional ex-vivo Imaging of Arterial Cellular Recruitment and Lipid Extravasation. Bio Protoc 2017; 7(12): e2344. https://www.ncbi.nlm.nih.gov/pubmed/28890907
van der Vorst EPC, Theodorou K, Biessen EAL, Donners M. HDL and macrophages: explaining the clinical failures and advancing HDL-based therapeutics in cardiovascular diseases? Expert Rev Cardiovasc Ther 2017; 15(5): 343-4. https://www.ncbi.nlm.nih.gov/pubmed/28349717
van der Vorst EPC, Theodorou K, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LFA, Tas SW, Wolfs IMJ, Kuijpers MJE, Gijbels MJ, Schalkwijk CG, Koonen DPY, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, de Winther MPJ, Biessen EAL, Donners M. High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-kappaB/STAT1-IRF1 Signaling. Cell Metab 2017; 25(1): 197-207. https://www.ncbi.nlm.nih.gov/pubmed/27866837
Varasteh Z, Hyafil F, Anizan N, Diallo D, Aid-Launais R, Mohanta S, Li Y, Braeuer M, Steiger K, Vigne J, Qin Z, Nekolla SG, Fabre JE, Doring Y, Le Guludec D, Habenicht A, Vera DR, Schwaiger M. Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using (111)In-tilmanocept. EJNMMI Res 2017; 7(1): 40. https://www.ncbi.nlm.nih.gov/pubmed/28470406
von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, Doring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C. Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Sci Transl Med 2017; 9(384). https://www.ncbi.nlm.nih.gov/pubmed/28381538
Weber C, Badimon L, Mach F, van der Vorst EPC. Therapeutic strategies for atherosclerosis and atherothrombosis: Past, present and future. Thromb Haemost 2017; 117(7): 1258-64. https://www.ncbi.nlm.nih.gov/pubmed/28594053
Weber C, Lip GY. Editors' Choice 2016 papers in Thrombosis and Haemostasis. Thromb Haemost 2017; 117(1): 204-6. https://www.ncbi.nlm.nih.gov/pubmed/28066852
Weber C, von Hundelshausen P. CANTOS Trial Validates the Inflammatory Pathogenesis of Atherosclerosis: Setting the Stage for a New Chapter in Therapeutic Targeting. Circ Res 2017; 121(10): 1119-21. https://www.ncbi.nlm.nih.gov/pubmed/29074528
Winkels H, Meiler S, Lievens D, Engel D, Spitz C, Burger C, Beckers L, Dandl A, Reim S, Ahmadsei M, Hartwig H, Holdt LM, Hristov M, Megens RTA, Schmitt MM, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N. CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice. Eur Heart J 2017; 38(48): 3590-9. https://www.ncbi.nlm.nih.gov/pubmed/29045618
Wolf D, Bukosza N, Engel D, Poggi M, Jehle F, Anto Michel N, Chen YC, Colberg C, Hoppe N, Dufner B, Boon L, Blankenbach H, Hilgendorf I, von Zur Muhlen C, Reinohl J, Sommer B, Marchini T, Febbraio MA, Weber C, Bode C, Peter K, Lutgens E, Zirlik A. Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO). Thromb Haemost 2017; 117(2): 325-38. https://www.ncbi.nlm.nih.gov/pubmed/27853810
Wu Z, Rademakers T, Kiessling F, Vogt M, Westein E, Weber C, Megens RTA, van Zandvoort M. Multi-photon microscopy in cardiovascular research. Methods 2017; 130: 79-89. https://www.ncbi.nlm.nih.gov/pubmed/28434997
Xu Y, Wang Y, Yan S, Zhou Y, Yang Q, Pan Y, Zeng X, An X, Liu Z, Wang L, Xu J, Cao Y, Fulton DJ, Weintraub NL, Bagi Z, Hoda MN, Wang X, Li Q, Hong M, Jiang X, Boison D, Weber C, Wu C, Huo Y. Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis. EMBO Mol Med 2017; 9(9): 1263-78. https://www.ncbi.nlm.nih.gov/pubmed/28751580
Yin C, Mohanta S, Maffia P, Habenicht AJ. Editorial: Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity. Front Immunol 2017; 8: 228. https://www.ncbi.nlm.nih.gov/pubmed/28321222
Zahedi F, Nazari-Jahantigh M, Zhou Z, Subramanian P, Wei Y, Grommes J, Offermanns S, Steffens S, Weber C, Schober A. Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. Cell Mol Life Sci 2017; 74(2): 359-72. https://www.ncbi.nlm.nih.gov/pubmed/27622243
Zhao Z, Vajen T, Karshovska E, Dickhout A, Schmitt MM, Megens RTA, von Hundelshausen P, Koeppel TA, Hackeng TM, Weber C, Koenen RR. Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice. J Cell Mol Med 2017; 21(8): 1523-31. https://www.ncbi.nlm.nih.gov/pubmed/28211187
Zhu M, Wei Y, Geissler C, Abschlag K, Corbalan Campos J, Hristov M, Mollmann J, Lehrke M, Karshovska E, Schober A. Hyperlipidemia-Induced MicroRNA-155-5p Improves beta-Cell Function by Targeting Mafb. Diabetes 2017; 66(12): 3072-84. https://www.ncbi.nlm.nih.gov/pubmed/28970282
Ziegler T, Kraus M, Husada W, Gesenhues F, Jiang Q, Pinkenburg O, Trenkwalder T, Laugwitz KL, le Noble F, Weber C, Kupatt C, Hinkel R. Steerable Induction of the Thymosin beta4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization. Hum Gene Ther 2017; 29(12): 1407-1415. https://www.ncbi.nlm.nih.gov/pubmed/28726522

2016

Alam A, Leoni G, Quiros M, Wu H, Desai C, Nishio H, Jones RM, Nusrat A, Neish AS. The microenvironment of injured murine gut elicits a local pro-restitutive microbiota. Nat Microbiol 2016; 1: 15021. https://www.ncbi.nlm.nih.gov/pubmed/27571978
Braster Q, Silvestre Roig C, Hartwig H, Beckers L, den Toom M, Doring Y, Daemen MJ, Lutgens E, Soehnlein O. Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice. PLoS One 2016; 11(10): e0163922. https://www.ncbi.nlm.nih.gov/pubmed/27701440
Braster Q, Silvestre-Roig C, Hartwig H, Kusters P, Aarts S, den Toom M, Gallo RL, Weber C, Lutgens E, Soehnlein O. Cathelicidin regulates myeloid cell accumulation in adipose tissue and promotes insulin resistance during obesity. Thromb Haemost 2016; 115(6): 1237-9. https://www.ncbi.nlm.nih.gov/pubmed/26939624
Campa CC, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, Ghigo A, Camporeale A, Di Savino A, Martini M, Perino A, Megens RT, Kurz AR, Scheiermann C, Sperandio M, Gamba A, Hirsch E. Rac signal adaptation controls neutrophil mobilization from the bone marrow. Sci Signal 2016; 9(459): ra124. https://www.ncbi.nlm.nih.gov/pubmed/27999173
Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Renia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med 2016; 213(11): 2293-314. https://www.ncbi.nlm.nih.gov/pubmed/27811056
Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EPC, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T. Author response: Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. eLife Sciences Publications, Ltd 2016.
Daugherty A, Hegele RA, Mackman N, Rader DJ, Schmidt AM, Weber C. Complying With the National Institutes of Health Guidelines and Principles for Rigor and Reproducibility: Refutations. Arterioscler Thromb Vasc Biol 2016; 36(7): 1303-4. https://www.ncbi.nlm.nih.gov/pubmed/27335467
de Jong R, Leoni G, Drechsler M, Soehnlein O. The advantageous role of annexin A1 in cardiovascular disease. Cell Adh Migr 2017; 11(3): 261-74. https://www.ncbi.nlm.nih.gov/pubmed/27860536
Deppe J, Popp T, Egea V, Steinritz D, Schmidt A, Thiermann H, Weber C, Ries C. Impairment of hypoxia-induced HIF-1alpha signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol 2016; 90(5): 1141-50. https://www.ncbi.nlm.nih.gov/pubmed/26082309
Deppe J, Steinritz D, Santovito D, Egea V, Schmidt A, Weber C, Ries C. Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia. Toxicol Lett 2016; 244: 81-7. https://www.ncbi.nlm.nih.gov/pubmed/26383628
Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Muller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sanchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Doring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Kohrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Hofmann SM, Yang B, Tschop MH, DiMarchi R, Muller TD. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell 2016; 167(3): 843-57 e14. https://www.ncbi.nlm.nih.gov/pubmed/27720451
Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseno CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP. Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nat Commun 2016; 7: 12597. https://www.ncbi.nlm.nih.gov/pubmed/27576369
Gerdes N, Seijkens T, Lievens D, Kuijpers MJ, Winkels H, Projahn D, Hartwig H, Beckers L, Megens RT, Boon L, Noelle RJ, Soehnlein O, Heemskerk JW, Weber C, Lutgens E. Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes. Arterioscler Thromb Vasc Biol 2016; 36(3): 482-90. https://www.ncbi.nlm.nih.gov/pubmed/26821950
Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T. MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease. Circulation 2016; 134(24): 1973-90. https://www.ncbi.nlm.nih.gov/pubmed/27780851
Hartmann P, Zhou Z, Natarelli L, Wei Y, Nazari-Jahantigh M, Zhu M, Grommes J, Steffens S, Weber C, Schober A. Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nat Commun 2016; 7: 10521. https://www.ncbi.nlm.nih.gov/pubmed/26837267
Hibender S, Franken R, van Roomen C, Ter Braake A, van der Made I, Schermer EE, Gunst Q, van den Hoff MJ, Lutgens E, Pinto YM, Groenink M, Zwinderman AH, Mulder BJ, de Vries CJ, de Waard V. Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model. Arterioscler Thromb Vasc Biol 2016; 36(8): 1618-26. https://www.ncbi.nlm.nih.gov/pubmed/27283746
Hu D, Yin C, Mohanta SK, Weber C, Habenicht AJ. Preparation of Single Cell Suspensions from Mouse Aorta. Bio Protoc 2016; 6(11): e1832. https://www.ncbi.nlm.nih.gov/pubmed/27335895
Jamasbi J, Megens RT, Bianchini M, Uhland K, Munch G, Ungerer M, Sherman S, Faussner A, Brandl R, John C, Buchner J, Weber C, Lorenz R, Elia N, Siess W. Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation. JACC Basic Transl Sci 2016; 1(3): 131-42. https://www.ncbi.nlm.nih.gov/pubmed/27766315
Jansen MF, Hollander MR, van Royen N, Horrevoets AJ, Lutgens E. CD40 in coronary artery disease: a matter of macrophages? Basic Res Cardiol 2016; 111(4): 38. https://www.ncbi.nlm.nih.gov/pubmed/27146510
Leiva M, Hidalgo A. Bidirectional dialog in the haematopoietic niche. Cell Cycle 2016; 15(8): 1027-8. https://www.ncbi.nlm.nih.gov/pubmed/27097370
Leiva M, Quintana JA, Ligos JM, Hidalgo A. Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFbeta availability. Nat Commun 2016; 7: 10222. https://www.ncbi.nlm.nih.gov/pubmed/26742601
Li J, McArdle S, Gholami A, Kimura T, Wolf D, Gerhardt T, Miller J, Weber C, Ley K. CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis. Circ Res 2016; 118(10): 1540-52. https://www.ncbi.nlm.nih.gov/pubmed/27021296
Lip GYH, Weber C. May your New Year be happy and prosperous with “Thrombosis and Haemostasis”. Thrombosis and Haemostasis 2016; 115(01): 1-2. http://dx.doi.org/10.1160/th15-11-0912
Mahl C, Egea V, Megens RT, Pitsch T, Santovito D, Weber C, Ries C. RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/beta-catenin signaling in human mesenchymal stem cells. Cell Mol Life Sci 2016; 73(7): 1489-501. https://www.ncbi.nlm.nih.gov/pubmed/26459448
Martinez-Moreno M, Leiva M, Aguilera-Montilla N, Sevilla-Movilla S, Isern de Val S, Arellano-Sanchez N, Gutierrez NC, Maldonado R, Martinez-Lopez J, Buno I, Garcia-Marco JA, Sanchez-Mateos P, Hidalgo A, Garcia-Pardo A, Teixido J. In vivo adhesion of malignant B cells to bone marrow microvasculature is regulated by alpha4beta1 cytoplasmic-binding proteins. Leukemia 2016; 30(4): 861-72. https://www.ncbi.nlm.nih.gov/pubmed/26658839
Meiler S, Smeets E, Winkels H, Shami A, Pascutti MF, Nolte MA, Beckers L, Weber C, Gerdes N, Lutgens E. Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report. Arterioscler Thromb Vasc Biol 2016; 36(9): 1748-52. https://www.ncbi.nlm.nih.gov/pubmed/27444204
Mohanta S, Yin C, Weber C, Hu D, Habenicht AJ. Aorta Atherosclerosis Lesion Analysis in Hyperlipidemic Mice. Bio Protoc 2016; 6(11): e1833. https://www.ncbi.nlm.nih.gov/pubmed/27366759
Muhlstedt S, Ghadge SK, Duchene J, Qadri F, Jarve A, Vilianovich L, Popova E, Pohlmann A, Niendorf T, Boye P, Ozcelik C, Bader M. Cardiomyocyte-derived CXCL12 is not involved in cardiogenesis but plays a crucial role in myocardial infarction. J Mol Med (Berl) 2016; 94(9): 1005-14. https://www.ncbi.nlm.nih.gov/pubmed/27251706
Nus M, Martinez-Poveda B, MacGrogan D, Chevre R, D'Amato G, Sbroggio M, Rodriguez C, Martinez-Gonzalez J, Andres V, Hidalgo A, de la Pompa JL. Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis. Cardiovasc Res 2016; 112(2): 568-80. https://www.ncbi.nlm.nih.gov/pubmed/27496872
Ortega-Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong RJ, Megens RT, Jamasbi J, Doring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O. Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment. Circulation 2016; 134(16): 1176-88. https://www.ncbi.nlm.nih.gov/pubmed/27660294
Petzold T, Thienel M, Konrad I, Schubert I, Regenauer R, Hoppe B, Lorenz M, Eckart A, Chandraratne S, Lennerz C, Kolb C, Braun D, Jamasbi J, Brandl R, Braun S, Siess W, Schulz C, Massberg S. Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis. Sci Transl Med 2016; 8(367): 367ra168. https://www.ncbi.nlm.nih.gov/pubmed/27903864
Rajasekaran D, Groning S, Schmitz C, Zierow S, Drucker N, Bakou M, Kohl K, Mertens A, Lue H, Weber C, Xiao A, Luker G, Kapurniotu A, Lolis E, Bernhagen J. Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE. J Biol Chem 2016; 291(30): 15881-95. https://www.ncbi.nlm.nih.gov/pubmed/27226569
Santovito D, Egea V, Weber C. Small but smart: MicroRNAs orchestrate atherosclerosis development and progression. Biochim Biophys Acta 2016; 1861(12 Pt B): 2075-86. https://www.ncbi.nlm.nih.gov/pubmed/26738655
Schaftenaar F, Frodermann V, Kuiper J, Lutgens E. Atherosclerosis: the interplay between lipids and immune cells. Curr Opin Lipidol 2016; 27(3): 209-15. https://www.ncbi.nlm.nih.gov/pubmed/27031276
Schloss MJ, Horckmans M, Nitz K, Duchene J, Drechsler M, Bidzhekov K, Scheiermann C, Weber C, Soehnlein O, Steffens S. The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment. EMBO Mol Med 2016; 8(8): 937-48. https://www.ncbi.nlm.nih.gov/pubmed/27226028
Schmohl J, Santovito D, Guenther T, Sutanto W, Kroell T, Salih H, Pitsch T, Egea V, Weber C, Schmetzer H, Ries C. Expression of surface-associated 82kDa-proMMP-9 in primary acute leukemia blast cells inversely correlates with patients' risk. Exp Hematol 2016; 44(5): 358-62 e5. https://www.ncbi.nlm.nih.gov/pubmed/26845021
Schober A, Weber C. Mechanisms of MicroRNAs in Atherosclerosis. Annu Rev Pathol 2016; 11(1): 583-616. https://www.ncbi.nlm.nih.gov/pubmed/27193456
Silvestre-Roig C, Hidalgo A, Soehnlein O. Neutrophil heterogeneity: implications for homeostasis and pathogenesis. Blood 2016; 127(18): 2173-81. https://www.ncbi.nlm.nih.gov/pubmed/27002116
Simsekyilmaz S, Liehn EA, Weinandy S, Schreiber F, Megens RT, Theelen W, Smeets R, Jockenhovel S, Gries T, Moller M, Klee D, Weber C, Zernecke A. Targeting In-Stent-Stenosis with RGD- and CXCL1-Coated Mini-Stents in Mice. PLoS One 2016; 11(5): e0155829. https://www.ncbi.nlm.nih.gov/pubmed/27192172
Soehnlein O. Monocytes Chat With Atherosclerotic Lesions. Arterioscler Thromb Vasc Biol 2016; 36(9): 1720-1. https://www.ncbi.nlm.nih.gov/pubmed/27559145
Spitz C, Winkels H, Burger C, Weber C, Lutgens E, Hansson GK, Gerdes N. Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential. Cell Mol Life Sci 2016; 73(5): 901-22. https://www.ncbi.nlm.nih.gov/pubmed/26518635
Spronck B, Megens RT, Reesink KD, Delhaas T. A method for three-dimensional quantification of vascular smooth muscle orientation: application in viable murine carotid arteries. Biomech Model Mechanobiol 2016; 15(2): 419-32. https://www.ncbi.nlm.nih.gov/pubmed/26174758
Srikakulapu P, Hu D, Yin C, Mohanta SK, Bontha SV, Peng L, Beer M, Weber C, McNamara CA, Grassia G, Maffia P, Manz RA, Habenicht AJ. Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice. Arterioscler Thromb Vasc Biol 2016; 36(6): 1174-85. https://www.ncbi.nlm.nih.gov/pubmed/27102965
Steffens S. M1 signature mediators in atheroma-derived single cell secretome of symptomatic plaques. Thromb Haemost 2016; 115(5): 871. https://www.ncbi.nlm.nih.gov/pubmed/27052888
Tilgner J, von Trotha KT, Gombert A, Jacobs MJ, Drechsler M, Doring Y, Soehnlein O, Grommes J. Aspirin, but Not Tirofiban Displays Protective Effects in Endotoxin Induced Lung Injury. PLoS One 2016; 11(9): e0161218. https://www.ncbi.nlm.nih.gov/pubmed/27583400
van Dam AD, Bekkering S, Crasborn M, van Beek L, van den Berg SM, Vrieling F, Joosten SA, van Harmelen V, de Winther MPJ, Lutjohann D, Lutgens E, Boon MR, Riksen NP, Rensen PCN, Berbee JFP. BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice. Atherosclerosis 2016; 251: 6-14. https://www.ncbi.nlm.nih.gov/pubmed/27232458
Viola J, Soehnlein O. Atherosclerosis - A matter of unresolved inflammation. Semin Immunol 2015; 27(3): 184-93. https://www.ncbi.nlm.nih.gov/pubmed/25865626
Viola JR, Lemnitzer P, Jansen Y, Csaba G, Winter C, Neideck C, Silvestre-Roig C, Dittmar G, Doring Y, Drechsler M, Weber C, Zimmer R, Cenac N, Soehnlein O. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. Circ Res 2016; 119(9): 1030-8. https://www.ncbi.nlm.nih.gov/pubmed/27531933
Weber C, Doring Y, Noels H. Potential cell-specific functions of CXCR4 in atherosclerosis. Hamostaseologie 2016; 36(2): 97-102. https://www.ncbi.nlm.nih.gov/pubmed/25586789
Weber C, Shantsila E, Hristov M, Caligiuri G, Guzik T, Heine GH, Hoefer IE, Monaco C, Peter K, Rainger E, Siegbahn A, Steffens S, Wojta J, Lip GY. Role and analysis of monocyte subsets in cardiovascular disease. Joint consensus document of the European Society of Cardiology (ESC) Working Groups "Atherosclerosis & Vascular Biology" and "Thrombosis". Thromb Haemost 2016; 116(4): 626-37. https://www.ncbi.nlm.nih.gov/pubmed/27412877
Wei Y, Schober A. MicroRNA regulation of macrophages in human pathologies. Cell Mol Life Sci 2016; 73(18): 3473-95. https://www.ncbi.nlm.nih.gov/pubmed/27137182
Wichapong K, Alard JE, Ortega-Gomez A, Weber C, Hackeng TM, Soehnlein O, Nicolaes GA. Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1). J Med Chem 2016; 59(9): 4289-301. https://www.ncbi.nlm.nih.gov/pubmed/26871718
Yin C, Mohanta SK, Srikakulapu P, Weber C, Habenicht AJ. Artery Tertiary Lymphoid Organs: Powerhouses of Atherosclerosis Immunity. Front Immunol 2016; 7: 387. https://www.ncbi.nlm.nih.gov/pubmed/27777573
Ziegler T, Horstkotte M, Lange P, Ng J, Bongiovanni D, Hinkel R, Laugwitz KL, Sperandio M, Horstkotte J, Kupatt C. Endothelial RAGE exacerbates acute postischaemic cardiac inflammation. Thromb Haemost 2016; 116(2): 300-8. https://www.ncbi.nlm.nih.gov/pubmed/27412300

2015

Ahmadsei M, Lievens D, Weber C, von Hundelshausen P, Gerdes N. Immune-mediated and lipid-mediated platelet function in atherosclerosis. Curr Opin Lipidol 2015; 26(5): 438-48. https://www.ncbi.nlm.nih.gov/pubmed/26270811
Akhtar S, Hartmann P, Karshovska E, Rinderknecht FA, Subramanian P, Gremse F, Grommes J, Jacobs M, Kiessling F, Weber C, Steffens S, Schober A. Endothelial Hypoxia-Inducible Factor-1alpha Promotes Atherosclerosis and Monocyte Recruitment by Upregulating MicroRNA-19a. Hypertension 2015; 66(6): 1220-6. https://www.ncbi.nlm.nih.gov/pubmed/26483345
Alampour-Rajabi S, El Bounkari O, Rot A, Muller-Newen G, Bachelerie F, Gawaz M, Weber C, Schober A, Bernhagen J. MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis. FASEB J 2015; 29(11): 4497-511. https://www.ncbi.nlm.nih.gov/pubmed/26139098
Alard JE, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RT, Leoni G, Ferraro B, Rossaint J, Paulin N, Ng J, Ippel H, Suylen D, Hinkel R, Blanchet X, Gaillard F, D'Amico M, von Hundelshausen P, Zarbock A, Scheiermann C, Hackeng TM, Steffens S, Kupatt C, Nicolaes GA, Weber C, Soehnlein O. Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. Sci Transl Med 2015; 7(317): 317ra196. https://www.ncbi.nlm.nih.gov/pubmed/26659570
Azghandi S, Prell C, van der Laan SW, Schneider M, Malik R, Berer K, Gerdes N, Pasterkamp G, Weber C, Haffner C, Dichgans M. Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1. Stroke 2015; 46(1): 197-202. https://www.ncbi.nlm.nih.gov/pubmed/25388417
Back M, Weber C, Lutgens E. Regulation of atherosclerotic plaque inflammation. J Intern Med 2015; 278(5): 462-82. https://www.ncbi.nlm.nih.gov/pubmed/25823439
Bernlochner I, Goedel A, Plischke C, Schupke S, Haller B, Schulz C, Mayer K, Morath T, Braun S, Schunkert H, Siess W, Kastrati A, Laugwitz KL. Impact of immature platelets on platelet response to ticagrelor and prasugrel in patients with acute coronary syndrome. Eur Heart J 2015; 36(45): 3202-10. https://www.ncbi.nlm.nih.gov/pubmed/26216931
Burger C, Weber C, Lutgens E, Gerdes N. Atherosclerosis: cell biology and lipoproteins-focus on CD40 signaling, PCSK9, and novel animal models. Curr Opin Lipidol 2015; 26(3): 245-6. https://www.ncbi.nlm.nih.gov/pubmed/25950709
Curaj A, Wu Z, Fokong S, Liehn EA, Weber C, Burlacu A, Lammers T, van Zandvoort M, Kiessling F. Noninvasive molecular ultrasound monitoring of vessel healing after intravascular surgical procedures in a preclinical setup. Arterioscler Thromb Vasc Biol 2015; 35(6): 1366-73. https://www.ncbi.nlm.nih.gov/pubmed/25838431
Doring Y. Not growth but death: GM-CSF/IL-23 axis drives atherosclerotic plaque vulnerability by enhancing macrophage and DC apoptosis. Circ Res 2015; 116(2): 222-4. https://www.ncbi.nlm.nih.gov/pubmed/25593270
Doring Y, Drechsler M, Soehnlein O, Weber C. Neutrophils in atherosclerosis: from mice to man. Arterioscler Thromb Vasc Biol 2015; 35(2): 288-95. https://www.ncbi.nlm.nih.gov/pubmed/25147339
Drechsler M, de Jong R, Rossaint J, Viola JR, Leoni G, Wang JM, Grommes J, Hinkel R, Kupatt C, Weber C, Doring Y, Zarbock A, Soehnlein O. Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment. Circ Res 2015; 116(5): 827-35. https://www.ncbi.nlm.nih.gov/pubmed/25520364
Drechsler M, Duchene J, Soehnlein O. Chemokines control mobilization, recruitment, and fate of monocytes in atherosclerosis. Arterioscler Thromb Vasc Biol 2015; 35(5): 1050-5. https://www.ncbi.nlm.nih.gov/pubmed/25792446
Duchene J, von Hundelshausen P. Platelet-derived chemokines in atherosclerosis. Hamostaseologie 2015; 35(2): 137-41. https://www.ncbi.nlm.nih.gov/pubmed/25592448
Hartmann P, Schober A, Weber C. Chemokines and microRNAs in atherosclerosis. Cell Mol Life Sci 2015; 72(17): 3253-66. https://www.ncbi.nlm.nih.gov/pubmed/26001902
Hartwig H, Silvestre Roig C, Daemen M, Lutgens E, Soehnlein O. Neutrophils in atherosclerosis. A brief overview. Hamostaseologie 2015; 35(2): 121-7. https://www.ncbi.nlm.nih.gov/pubmed/25385255
Hartwig H, Silvestre-Roig C, Hendrikse J, Beckers L, Paulin N, Van der Heiden K, Braster Q, Drechsler M, Daemen MJ, Lutgens E, Soehnlein O. Atherosclerotic Plaque Destabilization in Mice: A Comparative Study. PLoS One 2015; 10(10): e0141019. https://www.ncbi.nlm.nih.gov/pubmed/26492161
Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C. Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model. J Am Coll Cardiol 2015; 66(2): 154-65. https://www.ncbi.nlm.nih.gov/pubmed/26160631
Hoefer IE, Steffens S, Ala-Korpela M, Back M, Badimon L, Bochaton-Piallat ML, Boulanger CM, Caligiuri G, Dimmeler S, Egido J, Evans PC, Guzik T, Kwak BR, Landmesser U, Mayr M, Monaco C, Pasterkamp G, Tunon J, Weber C, Atherosclerosis ESCWG, Vascular B. Novel methodologies for biomarker discovery in atherosclerosis. Eur Heart J 2015; 36(39): 2635-42. https://www.ncbi.nlm.nih.gov/pubmed/26049157
Hristov M, Weber C. Myocardial infarction and inflammation: lost in the biomarker labyrinth. Circ Res 2015; 116(5): 781-3. https://www.ncbi.nlm.nih.gov/pubmed/25722440
Hu D, Mohanta SK, Yin C, Peng L, Ma Z, Srikakulapu P, Grassia G, MacRitchie N, Dever G, Gordon P, Burton FL, Ialenti A, Sabir SR, McInnes IB, Brewer JM, Garside P, Weber C, Lehmann T, Teupser D, Habenicht L, Beer M, Grabner R, Maffia P, Weih F, Habenicht AJ. Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin beta Receptors. Immunity 2015; 42(6): 1100-15. https://www.ncbi.nlm.nih.gov/pubmed/26084025
Ippel H, Miller MC, Berbis MA, Suylen D, Andre S, Hackeng TM, Canada FJ, Weber C, Gabius HJ, Jimenez-Barbero J, Mayo KH. (1)H, (13)C, and (15)N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3. Biomol NMR Assign 2015; 9(1): 59-63. https://www.ncbi.nlm.nih.gov/pubmed/24504927
Jamasbi J, Megens RT, Bianchini M, Munch G, Ungerer M, Faussner A, Sherman S, Walker A, Goyal P, Jung S, Brandl R, Weber C, Lorenz R, Farndale R, Elia N, Siess W. Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies. J Am Coll Cardiol 2015; 65(22): 2404-15. https://www.ncbi.nlm.nih.gov/pubmed/26046734
Karshovska E, Zhao Z, Blanchet X, Schmitt MM, Bidzhekov K, Soehnlein O, von Hundelshausen P, Mattheij NJ, Cosemans JM, Megens RT, Koeppel TA, Schober A, Hackeng TM, Weber C, Koenen RR. Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice. Circ Res 2015; 116(4): 587-99. https://www.ncbi.nlm.nih.gov/pubmed/25472975
Klapproth S, Sperandio M, Pinheiro EM, Prunster M, Soehnlein O, Gertler FB, Fassler R, Moser M. Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired beta2 integrin function in mice. Blood 2015; 126(25): 2704-12. https://www.ncbi.nlm.nih.gov/pubmed/26337492
Kornmann LM, Zernecke A, Curfs DM, Janssen BJ, Weber C, de Winther MP, Reneman RS, Hoeks AP, Reesink KD. Echogenic perfluorohexane-loaded macrophages adhere in vivo to activated vascular endothelium in mice, an explorative study. Cardiovasc Ultrasound 2015; 13: 1. https://www.ncbi.nlm.nih.gov/pubmed/25567641
Kuijpers MJ, Mattheij NJ, Cipolla L, van Geffen JP, Lawrence T, Donners MM, Boon L, Lievens D, Torti M, Noels H, Gerdes N, Cosemans JM, Lutgens E, Heemskerk JW. Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase beta, and Not Via CD40 and IkappaB Kinase alpha. Arterioscler Thromb Vasc Biol 2015; 35(6): 1374-81. https://www.ncbi.nlm.nih.gov/pubmed/25908768
Kusters PJH, Lutgens E. Cytokines and Immune Responses in Murine Atherosclerosis. In: Methods in Molecular Biology. Springer New York 2015; pp. 17-40.
Legein B, Janssen EM, Theelen TL, Gijbels MJ, Walraven J, Klarquist JS, Hennies CM, Wouters K, Seijkens TT, Wijnands E, Sluimer JC, Lutgens E, Zenke M, Hildner K, Biessen EA, Temmerman L. Ablation of CD8alpha(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice. Sci Rep 2015; 5: 15414. https://www.ncbi.nlm.nih.gov/pubmed/26486587
Leoni G, Neumann PA, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Farokhzad OC, Neish AS, Nusrat A. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest 2015; 125(3): 1215-27. https://www.ncbi.nlm.nih.gov/pubmed/25664854
Leoni G, Neumann PA, Sumagin R, Denning TL, Nusrat A. Wound repair: role of immune-epithelial interactions. Mucosal Immunol 2015; 8(5): 959-68. https://www.ncbi.nlm.nih.gov/pubmed/26174765
Lichtenauer M, Franz M, Fritzenwanger M, Figulla HR, Gerdes N, Jung C. Elevated plasma levels of interleukin-12p40 and interleukin-16 in overweight adolescents. Biomed Res Int 2015; 2015: 940910. https://www.ncbi.nlm.nih.gov/pubmed/25710036
Lip GY, Weber C. A happy new year from Thrombosis and Haemostasis. A 5 year reflection from the editorial team. Thromb Haemost 2015; 113(1): 1-2. https://www.ncbi.nlm.nih.gov/pubmed/25567473
Lundeberg E, Van Der Does AM, Kenne E, Soehnlein O, Lindbom L. Assessing large-vessel endothelial permeability using near-infrared fluorescence imaging--brief report. Arterioscler Thromb Vasc Biol 2015; 35(4): 783-6. https://www.ncbi.nlm.nih.gov/pubmed/25675996
Mandl M, Drechsler M, Jansen Y, Neideck C, Noels H, Faussner A, Soehnlein O, Weber C, Doring Y. Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation. PLoS One 2015; 10(8): e0134176. https://www.ncbi.nlm.nih.gov/pubmed/26252890
Mandolini C, Santovito D, Marcantonio P, Buttitta F, Bucci M, Ucchino S, Mezzetti A, Cipollone F. Identification of microRNAs 758 and 33b as potential modulators of ABCA1 expression in human atherosclerotic plaques. Nutr Metab Cardiovasc Dis 2015; 25(2): 202-9. https://www.ncbi.nlm.nih.gov/pubmed/25445880
Medina I, Cougoule C, Drechsler M, Bermudez B, Koenen RR, Sluimer J, Wolfs I, Doring Y, Herias V, Gijbels M, Bot I, de Jager S, Weber C, Cleutjens J, van Berkel TJC, Sikkink KJ, Mocsai A, Maridonneau-Parini I, Soehnlein O, Biessen EAL. Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility. Circulation 2015; 132(6): 490-501. https://www.ncbi.nlm.nih.gov/pubmed/26068045
Megens RT, Bianchini M, Schmitt MM, Weber C. Optical imaging innovations for atherosclerosis research: multiphoton microscopy and optical nanoscopy. Arterioscler Thromb Vasc Biol 2015; 35(6): 1339-46. https://www.ncbi.nlm.nih.gov/pubmed/25908769
Megens RTA, Soehnlein O. Intravital Microscopy for Atherosclerosis Research. In: Methods in Molecular Biology. Springer New York 2015; pp. 41-60.
Molica F, Morel S, Kwak BR, Rohner-Jeanrenaud F, Steffens S. Adipokines at the crossroad between obesity and cardiovascular disease. Thromb Haemost 2015; 113(3): 553-66. https://www.ncbi.nlm.nih.gov/pubmed/25338625
Natarelli L, Schober A. MicroRNAs and the response to injury in atherosclerosis. Hamostaseologie 2015; 35(2): 142-50. https://www.ncbi.nlm.nih.gov/pubmed/25612846
Nazari-Jahantigh M, Egea V, Schober A, Weber C. MicroRNA-specific regulatory mechanisms in atherosclerosis. J Mol Cell Cardiol 2015; 89(Pt A): 35-41. https://www.ncbi.nlm.nih.gov/pubmed/25450610
Njock MS, Cheng HS, Dang LT, Nazari-Jahantigh M, Lau AC, Boudreau E, Roufaiel M, Cybulsky MI, Schober A, Fish JE. Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs. Blood 2015; 125(20): 3202-12. https://www.ncbi.nlm.nih.gov/pubmed/25838349
Pawig L, Klasen C, Weber C, Bernhagen J, Noels H. Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives. Front Immunol 2015; 6: 429. https://www.ncbi.nlm.nih.gov/pubmed/26347749
Renz M, Otten C, Faurobert E, Rudolph F, Zhu Y, Boulday G, Duchene J, Mickoleit M, Dietrich AC, Ramspacher C, Steed E, Manet-Dupe S, Benz A, Hassel D, Vermot J, Huisken J, Tournier-Lasserve E, Felbor U, Sure U, Albiges-Rizo C, Abdelilah-Seyfried S. Regulation of beta1 integrin-Klf2-mediated angiogenesis by CCM proteins. Dev Cell 2015; 32(2): 181-90. https://www.ncbi.nlm.nih.gov/pubmed/25625207
Santovito D, Egea V, Weber C. DNA methylation and epigenetics: exploring the terra incognita of the atherosclerotic landscape. Eur Heart J 2015; 36(16): 956-8. https://www.ncbi.nlm.nih.gov/pubmed/25527822
Santovito D, Weber C. Fibronectin extradomain A: balancing atherosclerotic plaque burden and stability. Thromb Haemost 2015; 114(1): 4. https://www.ncbi.nlm.nih.gov/pubmed/26062571
Schober A, Nazari-Jahantigh M, Weber C. MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis. Nat Rev Cardiol 2015; 12(6): 361-74. https://www.ncbi.nlm.nih.gov/pubmed/25855604
Selle J, Asare Y, Kohncke J, Alampour-Rajabi S, Shagdarsuren G, Klos A, Weber C, Jankowski J, Shagdarsuren E. Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice. Thromb Haemost 2015; 114(4): 848-58. https://www.ncbi.nlm.nih.gov/pubmed/26084965
Soehnlein O. (Re)solving atherosclerosis. Sci Transl Med 2015; 7(275): 275fs7. https://www.ncbi.nlm.nih.gov/pubmed/25695998
Soehnlein O, Ortega-Gomez A, Doring Y, Weber C. Neutrophil-macrophage interplay in atherosclerosis: protease-mediated cytokine processing versus NET release. Thromb Haemost 2015; 114(4): 866-7. https://www.ncbi.nlm.nih.gov/pubmed/26310276
Steffens S, Pacher P. The activated endocannabinoid system in atherosclerosis: driving force or protective mechanism? Curr Drug Targets 2015; 16(4): 334-41. https://www.ncbi.nlm.nih.gov/pubmed/25469884
Stoppe C, Rex S, Goetzenich A, Kraemer S, Emontzpohl C, Soppert J, Averdunk L, Sun Y, Rossaint R, Lue H, Huang C, Song Y, Pantouris G, Lolis E, Leng L, Schulte W, Bucala R, Weber C, Bernhagen J. Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients. Antioxid Redox Signal 2015; 23(11): 865-79. https://www.ncbi.nlm.nih.gov/pubmed/26234719
van Dam AD, Nahon KJ, Kooijman S, van den Berg SM, Kanhai AA, Kikuchi T, Heemskerk MM, van Harmelen V, Lombes M, van den Hoek AM, de Winther MP, Lutgens E, Guigas B, Rensen PC, Boon MR. Salsalate activates brown adipose tissue in mice. Diabetes 2015; 64(5): 1544-54. https://www.ncbi.nlm.nih.gov/pubmed/25475439
van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond) 2015; 39(5): 782-90. https://www.ncbi.nlm.nih.gov/pubmed/25394307
van der Vorst EP, Doring Y, Weber C. Chemokines and their receptors in Atherosclerosis. J Mol Med (Berl) 2015; 93(9): 963-71. https://www.ncbi.nlm.nih.gov/pubmed/26175090
van der Vorst EP, Doring Y, Weber C. MIF and CXCL12 in Cardiovascular Diseases: Functional Differences and Similarities. Front Immunol 2015; 6: 373. https://www.ncbi.nlm.nih.gov/pubmed/26257740
van der Vorst EP, Doring Y, Weber C. Chemokines. Arterioscler Thromb Vasc Biol 2015; 35(11): e52-6. https://www.ncbi.nlm.nih.gov/pubmed/26490276
Viola J, Soehnlein O. Atherosclerosis - A matter of unresolved inflammation. Semin Immunol 2015; 27(3): 184-93. https://www.ncbi.nlm.nih.gov/pubmed/25865626
von Hundelshausen P, Oexle K, Bidzhekov K, Schmitt MM, Hristov M, Blanchet X, Kaemmerer H, Matyas G, Meitinger T, Weber C. Recurrent spontaneous coronary dissections in a patient with a de novo fibrillin-1 mutation without Marfan syndrome. Thromb Haemost 2015; 113(3): 668-70. https://www.ncbi.nlm.nih.gov/pubmed/25519456
Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med 2015; 21(7): 820-6. https://www.ncbi.nlm.nih.gov/pubmed/26099046
Weber C, Hristov M. Atherogenesis and inflammation. From cellular mediators to regulatory mechanisms of inflammation in atherosclerosis. Hamostaseologie 2015; 35(2): 99, 101. https://www.ncbi.nlm.nih.gov/pubmed/25943077
Weber C, Lip GY. Editors' Choice papers in Thrombosis and Haemostasis. Thromb Haemost 2015; 113(1): 217-20. https://www.ncbi.nlm.nih.gov/pubmed/25567474
Wei Y, Zhu M, Corbalan-Campos J, Heyll K, Weber C, Schober A. Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microRNA-155 on atherosclerosis. Arterioscler Thromb Vasc Biol 2015; 35(4): 796-803. https://www.ncbi.nlm.nih.gov/pubmed/25810298
Wertenbruch S, Drescher H, Grossarth V, Kroy D, Giebeler A, Erschfeld S, Heinrichs D, Soehnlein O, Trautwein C, Brandenburg LO, Streetz K. The Anti-Microbial Peptide LL-37/CRAMP Is Elevated in Patients with Liver Diseases and Acts as a Protective Factor during Mouse Liver Injury. Digestion 2015; 91(4): 307-17. https://www.ncbi.nlm.nih.gov/pubmed/25998843
Wirtz TH, Tillmann S, Strussmann T, Kraemer S, Heemskerk JW, Grottke O, Gawaz M, von Hundelshausen P, Bernhagen J. Platelet-derived MIF: a novel platelet chemokine with distinct recruitment properties. Atherosclerosis 2015; 239(1): 1-10. https://www.ncbi.nlm.nih.gov/pubmed/25561410
Yamano T, Nedjic J, Hinterberger M, Steinert M, Koser S, Pinto S, Gerdes N, Lutgens E, Ishimaru N, Busslinger M, Brors B, Kyewski B, Klein L. Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction. Immunity 2015; 42(6): 1048-61. https://www.ncbi.nlm.nih.gov/pubmed/26070482
Yin C, Mohanta S, Ma Z, Weber C, Hu D, Weih F, Habenicht A. Generation of Aorta Transcript Atlases of Wild-Type and Apolipoprotein E-null Mice by Laser Capture Microdissection-Based mRNA Expression Microarrays. In: Methods in Molecular Biology. Springer New York 2015; pp. 297-308.
Zarzycka B, Nicolaes GA, Lutgens E. Targeting the adaptive immune system: new strategies in the treatment of atherosclerosis. Expert Rev Clin Pharmacol 2015; 8(3): 297-313. https://www.ncbi.nlm.nih.gov/pubmed/25843158
Zarzycka B, Seijkens T, Nabuurs SB, Ritschel T, Grommes J, Soehnlein O, Schrijver R, van Tiel CM, Hackeng TM, Weber C, Giehler F, Kieser A, Lutgens E, Vriend G, Nicolaes GA. Discovery of small molecule CD40-TRAF6 inhibitors. J Chem Inf Model 2015; 55(2): 294-307. https://www.ncbi.nlm.nih.gov/pubmed/25622654
Zirlik A, Lutgens E. An inflammatory link in atherosclerosis and obesity. Co-stimulatory molecules. Hamostaseologie 2015; 35(3): 272-8. https://www.ncbi.nlm.nih.gov/pubmed/26225729

2014

Aoqui C, Chmielewski S, Scherer E, Eissler R, Sollinger D, Heid I, Braren R, Schmaderer C, Megens RT, Weber C, Heemann U, Tschop M, Baumann M. Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet. Cardiovasc Diabetol 2014; 13: 31. https://www.ncbi.nlm.nih.gov/pubmed/24490784
Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest 2014; 124(5): 2136-46. https://www.ncbi.nlm.nih.gov/pubmed/24743145
Blanchet X, Cesarek K, Brandt J, Herwald H, Teupser D, Kuchenhoff H, Karshovska E, Mause SF, Siess W, Wasmuth H, Soehnlein O, Koenen RR, Weber C, von Hundelshausen P. Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome. Thromb Haemost 2014; 112(6): 1277-87. https://www.ncbi.nlm.nih.gov/pubmed/25183015
Brantl SA, Khandoga AL, Siess W. Mechanism of platelet activation induced by endocannabinoids in blood and plasma. Platelets 2014; 25(3): 151-61. https://www.ncbi.nlm.nih.gov/pubmed/23789792
Brantl SA, Khandoga AL, Siess W. Activation of platelets by the endocannabinoids 2-arachidonoylglycerol and virodhamine is mediated by their conversion to arachidonic acid and thromboxane A2, not by activation of cannabinoid receptors. Platelets 2014; 25(6): 465-6. https://www.ncbi.nlm.nih.gov/pubmed/24102401
Chatzigeorgiou A, Chung KJ, Garcia-Martin R, Alexaki VI, Klotzsche-von Ameln A, Phieler J, Sprott D, Kanczkowski W, Tzanavari T, Bdeir M, Bergmann S, Cartellieri M, Bachmann M, Nikolakopoulou P, Androutsellis-Theotokis A, Siegert G, Bornstein SR, Muders MH, Boon L, Karalis KP, Lutgens E, Chavakis T. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology 2014; 60(4): 1196-210. https://www.ncbi.nlm.nih.gov/pubmed/24845056
Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte KM, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T, Lutgens E. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A 2014; 111(7): 2686-91. https://www.ncbi.nlm.nih.gov/pubmed/24492375
Chevre R, Gonzalez-Granado JM, Megens RT, Sreeramkumar V, Silvestre-Roig C, Molina-Sanchez P, Weber C, Soehnlein O, Hidalgo A, Andres V. High-resolution imaging of intravascular atherogenic inflammation in live mice. Circ Res 2014; 114(5): 770-9. https://www.ncbi.nlm.nih.gov/pubmed/24366169
de Winther MP, Lutgens E. MiR-92a: at the heart of lipid-driven endothelial dysfunction. Circ Res 2014; 114(3): 399-401. https://www.ncbi.nlm.nih.gov/pubmed/24481837
Doring Y, Noels H, Mandl M, Kramp B, Neideck C, Lievens D, Drechsler M, Megens RT, Tilstam PV, Langer M, Hartwig H, Theelen W, Marth JD, Sperandio M, Soehnlein O, Weber C. Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication. Circ Res 2014; 114(6): 976-81. https://www.ncbi.nlm.nih.gov/pubmed/24425712
Doring Y, Pawig L, Weber C, Noels H. The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease. Front Physiol 2014; 5: 212. https://www.ncbi.nlm.nih.gov/pubmed/24966838
Doring Y, Soehnlein O, Weber C. Neutrophils cast NETs in atherosclerosis: employing peptidylarginine deiminase as a therapeutic target. Circ Res 2014; 114(6): 931-4. https://www.ncbi.nlm.nih.gov/pubmed/24625721
Duarte Campos DF, Vogt M, Lindner M, Kirsten A, Weber M, Megens RT, Pyta J, Zenke M, Van Zandvoort M, Fischer H. Two-photon laser scanning microscopy as a useful tool for imaging and evaluating macrophage-, IL-4 activated macrophage- and osteoclast-based in vitro degradation of beta-tricalcium phosphate bone substitute material. Microsc Res Tech 2014; 77(2): 143-52. https://www.ncbi.nlm.nih.gov/pubmed/24282165
Giebeler A, Streetz KL, Soehnlein O, Neumann U, Wang JM, Brandenburg LO. Deficiency of formyl peptide receptor 1 and 2 is associated with increased inflammation and enhanced liver injury after LPS-stimulation. PLoS One 2014; 9(6): e100522. https://www.ncbi.nlm.nih.gov/pubmed/24956481
Hartmann P, Schober A, Weber C. MicroRNA-155 and macrophages: a fatty liaison. Cardiovasc Res 2014; 103(1): 5-6. https://www.ncbi.nlm.nih.gov/pubmed/24907979
Hartwig H, Drechsler M, Lievens D, Kramp B, von Hundelshausen P, Lutgens E, Weber C, Doring Y, Soehnlein O. Platelet-derived PF4 reduces neutrophil apoptosis following arterial occlusion. Thromb Haemost 2014; 111(3): 562-4. https://www.ncbi.nlm.nih.gov/pubmed/24258616
Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Muller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C. MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2. Nat Commun 2014; 5(1): 3970. https://www.ncbi.nlm.nih.gov/pubmed/24910328
Hoeksema MA, Gijbels MJ, Van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stoger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJ, Biessen EA, Daemen MJ, Lutgens E, de Winther MP. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol Med 2014; 6(9): 1124-32. https://www.ncbi.nlm.nih.gov/pubmed/25007801
Jaczewska J, Abdulreda MH, Yau CY, Schmitt MM, Schubert I, Berggren PO, Weber C, Koenen RR, Moy VT, Wojcikiewicz EP. TNF-alpha and IFN-gamma promote lymphocyte adhesion to endothelial junctional regions facilitating transendothelial migration. J Leukoc Biol 2014; 95(2): 265-74. https://www.ncbi.nlm.nih.gov/pubmed/24072879
Kapopara PR, von Felden J, Soehnlein O, Wang Y, Napp LC, Sonnenschein K, Wollert KC, Schieffer B, Gaestel M, Bauersachs J, Bavendiek U. Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodelling and promotes endothelial healing after arterial injury. Thromb Haemost 2014; 112(6): 1264-76. https://www.ncbi.nlm.nih.gov/pubmed/25120198
Kwak BR, Back M, Bochaton-Piallat ML, Caligiuri G, Daemen MJ, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ, Evans PC. Biomechanical factors in atherosclerosis: mechanisms and clinical implications. Eur Heart J 2014; 35(43): 3013-20, 20a-20d. https://www.ncbi.nlm.nih.gov/pubmed/25230814
Li X, Zhu M, Penfold ME, Koenen RR, Thiemann A, Heyll K, Akhtar S, Koyadan S, Wu Z, Gremse F, Kiessling F, van Zandvoort M, Schall TJ, Weber C, Schober A. Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue. Circulation 2014; 129(11): 1244-53. https://www.ncbi.nlm.nih.gov/pubmed/24374972
Lip GYH, Weber C. A very happy new year 2014 from Thrombosis and Haemostasis! Reflections on the past, the present and the future 2014; 111(01): 1-2. http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1608911
Lutgens E. CD40-CD40L: a Janus-faced interaction. Thromb Haemost 2014; 112(2): 223. https://www.ncbi.nlm.nih.gov/pubmed/25007918
Mandl M, Schmitz S, Weber C, Hristov M. Characterization of the CD14++CD16+ monocyte population in human bone marrow. PLoS One 2014; 9(11): e112140. https://www.ncbi.nlm.nih.gov/pubmed/25369328
Mastropasqua R, Toto L, Cipollone F, Santovito D, Carpineto P, Mastropasqua L. Role of microRNAs in the modulation of diabetic retinopathy. Prog Retin Eye Res 2014; 43: 92-107. https://www.ncbi.nlm.nih.gov/pubmed/25128741
Merres J, Hoss J, Albrecht LJ, Kress E, Soehnlein O, Jansen S, Pufe T, Tauber SC, Brandenburg LO. Role of the cathelicidin-related antimicrobial peptide in inflammation and mortality in a mouse model of bacterial meningitis. J Innate Immun 2014; 6(2): 205-18. https://www.ncbi.nlm.nih.gov/pubmed/23969854
Mion F, D'Inca F, Danelli L, Toffoletto B, Guarnotta C, Frossi B, Burocchi A, Rigoni A, Gerdes N, Lutgens E, Tripodo C, Colombo MP, Rivera J, Vitale G, Pucillo CE. Mast cells control the expansion and differentiation of IL-10-competent B cells. J Immunol 2014; 193(9): 4568-79. https://www.ncbi.nlm.nih.gov/pubmed/25267976
Mohanta SK, Yin C, Peng L, Srikakulapu P, Bontha V, Hu D, Weih F, Weber C, Gerdes N, Habenicht AJ. Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis. Circ Res 2014; 114(11): 1772-87. https://www.ncbi.nlm.nih.gov/pubmed/24855201
Natarelli L, Schober A. Janus-faced role of Kruppel-like factor 2-dependent regulation of microRNAs in endothelial proliferation. Arterioscler Thromb Vasc Biol 2014; 34(8): 1605-6. https://www.ncbi.nlm.nih.gov/pubmed/25031325
Nencioni A, da Silva RF, Fraga-Silva RA, Steffens S, Fabre M, Bauer I, Caffa I, Magnone M, Sociali G, Quercioli A, Pelli G, Lenglet S, Galan K, Burger F, Vazquez Calvo S, Bertolotto M, Bruzzone S, Ballestrero A, Patrone F, Dallegri F, Santos RA, Stergiopulos N, Mach F, Vuilleumier N, Montecucco F. Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice. Thromb Haemost 2014; 111(2): 308-22. https://www.ncbi.nlm.nih.gov/pubmed/24196571
Noels H, Zhou B, Tilstam PV, Theelen W, Li X, Pawig L, Schmitz C, Akhtar S, Simsekyilmaz S, Shagdarsuren E, Schober A, Adams RH, Bernhagen J, Liehn EA, Doring Y, Weber C. Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol 2014; 34(6): 1209-20. https://www.ncbi.nlm.nih.gov/pubmed/24723559
Oldekamp S, Pscheidl S, Kress E, Soehnlein O, Jansen S, Pufe T, Wang JM, Tauber SC, Brandenburg LO. Lack of formyl peptide receptor 1 and 2 leads to more severe inflammation and higher mortality in mice with of pneumococcal meningitis. Immunology 2014; 143(3): 447-61. https://www.ncbi.nlm.nih.gov/pubmed/24863484
Popp T, Steinritz D, Breit A, Deppe J, Egea V, Schmidt A, Gudermann T, Weber C, Ries C. Wnt5a/beta-catenin signaling drives calcium-induced differentiation of human primary keratinocytes. J Invest Dermatol 2014; 134(8): 2183-91. https://www.ncbi.nlm.nih.gov/pubmed/24658506
Projahn D, Simsekyilmaz S, Singh S, Kanzler I, Kramp BK, Langer M, Burlacu A, Bernhagen J, Klee D, Zernecke A, Hackeng TM, Groll J, Weber C, Liehn EA, Koenen RR. Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction. J Cell Mol Med 2014; 18(5): 790-800. https://www.ncbi.nlm.nih.gov/pubmed/24512349
Rassaf T, Weber C, Bernhagen J. Macrophage migration inhibitory factor in myocardial ischaemia/reperfusion injury. Cardiovasc Res 2014; 102(2): 321-8. https://www.ncbi.nlm.nih.gov/pubmed/24675723
Richter R, Jochheim-Richter A, Ciuculescu F, Kollar K, Seifried E, Forssmann U, Verzijl D, Smit MJ, Blanchet X, von Hundelshausen P, Weber C, Forssmann WG, Henschler R. Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells. Stem Cells Dev 2014; 23(16): 1959-74. https://www.ncbi.nlm.nih.gov/pubmed/24708339
Ries C. Cytokine functions of TIMP-1. Cell Mol Life Sci 2014; 71(4): 659-72. https://www.ncbi.nlm.nih.gov/pubmed/23982756
Ring L, Neth P, Weber C, Steffens S, Faussner A. beta-Catenin-dependent pathway activation by both promiscuous "canonical" WNT3a-, and specific "noncanonical" WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency. Cell Signal 2014; 26(2): 260-7. https://www.ncbi.nlm.nih.gov/pubmed/24269653
Rossaint J, Herter JM, Van Aken H, Napirei M, Doring Y, Weber C, Soehnlein O, Zarbock A. Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation. Blood 2014; 123(16): 2573-84. https://www.ncbi.nlm.nih.gov/pubmed/24335230
Santovito D, De Nardis V, Marcantonio P, Mandolini C, Paganelli C, Vitale E, Buttitta F, Bucci M, Mezzetti A, Consoli A, Cipollone F. Plasma exosome microRNA profiling unravels a new potential modulator of adiponectin pathway in diabetes: effect of glycemic control. J Clin Endocrinol Metab 2014; 99(9): E1681-5. https://www.ncbi.nlm.nih.gov/pubmed/24937531
Schiener M, Hossann M, Viola JR, Ortega-Gomez A, Weber C, Lauber K, Lindner LH, Soehnlein O. Nanomedicine-based strategies for treatment of atherosclerosis. Trends Mol Med 2014; 20(5): 271-81. https://www.ncbi.nlm.nih.gov/pubmed/24594264
Schmitt MM, Fraemohs L, Hackeng TM, Weber C, Koenen RR. Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution. Atherosclerosis 2014; 234(2): 254-64. https://www.ncbi.nlm.nih.gov/pubmed/24704627
Schmitt MM, Megens RT, Zernecke A, Bidzhekov K, van den Akker NM, Rademakers T, van Zandvoort MA, Hackeng TM, Koenen RR, Weber C. Endothelial junctional adhesion molecule-a guides monocytes into flow-dependent predilection sites of atherosclerosis. Circulation 2014; 129(1): 66-76. https://www.ncbi.nlm.nih.gov/pubmed/24065611
Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RT, Heyll K, Noels H, Hristov M, Wang S, Kiessling F, Olson EN, Weber C. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med 2014; 20(4): 368-76. https://www.ncbi.nlm.nih.gov/pubmed/24584117
Seijkens T, Hoeksema MA, Beckers L, Smeets E, Meiler S, Levels J, Tjwa M, de Winther MP, Lutgens E. Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis. FASEB J 2014; 28(5): 2202-13. https://www.ncbi.nlm.nih.gov/pubmed/24481967
Seijkens T, Kusters P, Chatzigeorgiou A, Chavakis T, Lutgens E. Immune cell crosstalk in obesity: a key role for costimulation? Diabetes 2014; 63(12): 3982-91. https://www.ncbi.nlm.nih.gov/pubmed/25414012
Silvestre-Roig C, de Winther MP, Weber C, Daemen MJ, Lutgens E, Soehnlein O. Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies. Circ Res 2014; 114(1): 214-26. https://www.ncbi.nlm.nih.gov/pubmed/24385514
Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A. Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation 2014; 129(5): 598-606. https://www.ncbi.nlm.nih.gov/pubmed/24201302
Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A. Response to letter regarding article "Role of extracellular RNA in atherosclerotic plaque formation in mice". Circulation 2014; 130(16): e144-5. https://www.ncbi.nlm.nih.gov/pubmed/25311624
Soehnlein O. Macrophages shine bright. Blood 2014; 124(15): 2320-2. https://www.ncbi.nlm.nih.gov/pubmed/25301333
Soehnlein O. The ABC of Thrombopoiesis. Arterioscler Thromb Vasc Biol 2014; 34(4): 700-1. https://www.ncbi.nlm.nih.gov/pubmed/24665122
Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nacher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi MD, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A. Neutrophils scan for activated platelets to initiate inflammation. Science 2014; 346(6214): 1234-8. https://www.ncbi.nlm.nih.gov/pubmed/25477463
Steffens S. Fine tuning effector and regulatory T-cell dynamics: a novel tool for plaque regression? Cardiovasc Res 2014; 102(1): 3-5. https://www.ncbi.nlm.nih.gov/pubmed/24556952
Tilstam PV, Gijbels MJ, Habbeddine M, Cudejko C, Asare Y, Theelen W, Zhou B, Doring Y, Drechsler M, Pawig L, Simsekyilmaz S, Koenen RR, de Winther MP, Lawrence T, Bernhagen J, Zernecke A, Weber C, Noels H. Bone marrow-specific knock-in of a non-activatable Ikkalpha kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice. PLoS One 2014; 9(2): e87452. https://www.ncbi.nlm.nih.gov/pubmed/24498325
von Hundelshausen P, Schmitt MM. Platelets and their chemokines in atherosclerosis-clinical applications. Front Physiol 2014; 5: 294. https://www.ncbi.nlm.nih.gov/pubmed/25152735
Wan M, Soehnlein O, Tang X, van der Does AM, Smedler E, Uhlen P, Lindbom L, Agerberth B, Haeggstrom JZ. Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo. FASEB J 2014; 28(8): 3456-67. https://www.ncbi.nlm.nih.gov/pubmed/24736410
Weber C, Lip GYH. Editors’ Choice papers in Thrombosis and Haemostasis. Thromb Haemost 2014; 111(01): 183-188. http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1608912
Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I. Rubbing salt into wounded endothelium: sodium potentiates proatherogenic effects of TNF-alpha under non-uniform shear stress. Thromb Haemost 2014; 112(1): 183-95. https://www.ncbi.nlm.nih.gov/pubmed/24573382
Wildhagen KC, Garcia de Frutos P, Reutelingsperger CP, Schrijver R, Areste C, Ortega-Gomez A, Deckers NM, Hemker HC, Soehnlein O, Nicolaes GA. Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood 2014; 123(7): 1098-101. https://www.ncbi.nlm.nih.gov/pubmed/24264231
Wildhagen KC, Schrijver R, Beckers L, ten Cate H, Reutelingsperger CP, Lutgens E, Nicolaes GA. Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis. PLoS One 2014; 9(7): e101446. https://www.ncbi.nlm.nih.gov/pubmed/25032959
Winkels H, Weber C, Lutgens E, Gerdes N. Atherosclerosis: cell biology and lipoproteins focus on iNKT cells and CD40/CD40L in atherosclerosis and metabolic disorders. Curr Opin Lipidol 2014; 25(5): 408-9. https://www.ncbi.nlm.nih.gov/pubmed/25186203
Zernecke A, Weber C. Chemokines in atherosclerosis: proceedings resumed. Arterioscler Thromb Vasc Biol 2014; 34(4): 742-50. https://www.ncbi.nlm.nih.gov/pubmed/24436368

2013

Akhtar S, Gremse F, Kiessling F, Weber C, Schober A. CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice. Arterioscler Thromb Vasc Biol 2013; 33(4): 679-686. https://www.ncbi.nlm.nih.gov/pubmed/23393393
Asare Y, Shagdarsuren E, Schmid JA, Tilstam PV, Grommes J, El Bounkari O, Schutz AK, Weber C, de Winther MP, Noels H, Bernhagen J. Endothelial CSN5 impairs NF-kappaB activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions. Thromb Haemost 2013; 110(1): 141-152. https://www.ncbi.nlm.nih.gov/pubmed/23636414
Badr Eslam R, Lang IM, Koppensteiner R, Calatzis A, Panzer S, Gremmel T. Residual platelet activation through protease-activated receptors (PAR)-1 and -4 in patients on P2Y12 inhibitors. Int J Cardiol 2013; 168(1): 403-406. https://www.ncbi.nlm.nih.gov/pubmed/23041015
Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele ST, Hamulyak K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EA, Spronk HM, ten Cate H. Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner. PLoS One 2013; 8(2): e55784. https://www.ncbi.nlm.nih.gov/pubmed/23409043
Bras G, Bochenska O, Rapala-Kozik M, Guevara-Lora I, Faussner A, Kamysz W, Kozik A. Release of biologically active kinin peptides, Met-Lys-bradykinin and Leu-Met-Lys-bradykinin from human kininogens by two major secreted aspartic proteases of Candida parapsilosis. Peptides 2013; 48: 114-123. https://www.ncbi.nlm.nih.gov/pubmed/23954712
Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chevre R, N AG, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell 2013; 153(5): 1025-1035. https://www.ncbi.nlm.nih.gov/pubmed/23706740
Doring Y, Weber C, Soehnlein O. Footprints of neutrophil extracellular traps as predictors of cardiovascular risk. Arterioscler Thromb Vasc Biol 2013; 33(8): 1735-1736. https://www.ncbi.nlm.nih.gov/pubmed/23818484
Drechsler M, Soehnlein O. The complexity of arterial classical monocyte recruitment. J Innate Immun 2013; 5(4): 358-366. https://www.ncbi.nlm.nih.gov/pubmed/23571485
Drechsler M, Soehnlein O, Weber C. Nitric oxide-donating statins upgrade the benefits of lipid-lowering in vascular inflammation by desensitizing neutrophil activation: editorial to: "Nitric oxide-donating atorvastatin attenuates neutrophil recruitment during vascular inflammation independent of changes in plasma cholesterol" by R. Baetta et al. Cardiovasc Drugs Ther 2013; 27(3): 183-185. https://www.ncbi.nlm.nih.gov/pubmed/23440356
Fujita B, Strodthoff D, Fritzenwanger M, Pfeil A, Ferrari M, Goebel B, Figulla HR, Gerdes N, Jung C. Altered red blood cell distribution width in overweight adolescents and its association with markers of inflammation. Pediatr Obes 2013; 8(5): 385-391. https://www.ncbi.nlm.nih.gov/pubmed/23239558
Gerdes N, Winkels H, Weber C. Atherosclerosis: cell biology and lipoproteins-focus on anti-inflammatory mechanisms as therapeutic options. Curr Opin Lipidol 2013; 24(2): 187-188. https://www.ncbi.nlm.nih.gov/pubmed/23481233
Ghosh M, van den Akker NM, Wijnands KA, Poeze M, Weber C, McQuade LE, Pluth MD, Lippard SJ, Post MJ, Molin DG, van Zandvoort MA. Specific visualization of nitric oxide in the vasculature with two-photon microscopy using a copper based fluorescent probe. PLoS One 2013; 8(9): e75331. https://www.ncbi.nlm.nih.gov/pubmed/24086509
Goyal P, Pandey D, Brunnert D, Hammer E, Zygmunt M, Siess W. Cofilin oligomer formation occurs in vivo and is regulated by cofilin phosphorylation. PLoS One 2013; 8(8): e71769. https://www.ncbi.nlm.nih.gov/pubmed/23951242
Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stoger L, Wijnands E, Janssen BJ, Creemers EE, Pinto YM, Grimm D, Schurmann N, Vigorito E, Thum T, Stassen F, Yin X, Mayr M, de Windt LJ, Lutgens E, Wouters K, de Winther MP, Zacchigna S, Giacca M, van Bilsen M, Papageorgiou AP, Schroen B. Macrophage microRNA-155 promotes cardiac hypertrophy and failure. Circulation 2013; 128(13): 1420-1432. https://www.ncbi.nlm.nih.gov/pubmed/23956210
Kanzler I, Tuchscheerer N, Steffens G, Simsekyilmaz S, Konschalla S, Kroh A, Simons D, Asare Y, Schober A, Bucala R, Weber C, Bernhagen J, Liehn EA. Differential roles of angiogenic chemokines in endothelial progenitor cell-induced angiogenesis. Basic Res Cardiol 2013; 108(1): 310. https://www.ncbi.nlm.nih.gov/pubmed/23184390
Karshovska E, Weber C, von Hundelshausen P. Platelet chemokines in health and disease. Thromb Haemost 2013; 110(5): 894-902. https://www.ncbi.nlm.nih.gov/pubmed/23783401
Klingenberg R, Gerdes N, Badeau RM, Gistera A, Strodthoff D, Ketelhuth DF, Lundberg AM, Rudling M, Nilsson SK, Olivecrona G, Zoller S, Lohmann C, Luscher TF, Jauhiainen M, Sparwasser T, Hansson GK. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 2013; 123(3): 1323-1334. https://www.ncbi.nlm.nih.gov/pubmed/23426179
Kozik A, Faussner A, Blonska B, Guevara-Lora I. Kinin-generating cellular model obtained from human glioblastoma cell line U-373. Acta Biochimica Polonica 2013; 60(3). http://dx.doi.org/10.18388/abp.2013_1985
Kramp BK, Megens RT, Sarabi A, Winkler S, Projahn D, Weber C, Koenen RR, von Hundelshausen P. Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment. Thromb Haemost 2013; 110(4): 795-806. https://www.ncbi.nlm.nih.gov/pubmed/23925484
Kumar N, Ippel H, Weber C, Hackeng T, Mayo KH. Protein lysine-Nzeta alkylation and O-phosphorylation mediated by DTT-generated reactive oxygen species. Protein Sci 2013; 22(3): 327-346. https://www.ncbi.nlm.nih.gov/pubmed/23315912
Langer HF, Weber C, Gawaz M. The platelet--thrombosis and beyond. Thromb Haemost 2013; 110(5): 857-858. https://www.ncbi.nlm.nih.gov/pubmed/24108387
Legein B, Temmerman L, Biessen EA, Lutgens E. Inflammation and immune system interactions in atherosclerosis. Cell Mol Life Sci 2013; 70(20): 3847-3869. https://www.ncbi.nlm.nih.gov/pubmed/23430000
Lenglet S, Thomas A, Soehnlein O, Montecucco F, Burger F, Pelli G, Galan K, Cravatt B, Staub C, Steffens S. Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. Arterioscler Thromb Vasc Biol 2013; 33(2): 215-223. https://www.ncbi.nlm.nih.gov/pubmed/23241405
Leschner J, Wennerberg G, Feierler J, Bermudez M, Welte B, Kalatskaya I, Wolber G, Faussner A. Interruption of the ionic lock in the bradykinin B2 receptor results in constitutive internalization and turns several antagonists into strong agonists. J Pharmacol Exp Ther 2013; 344(1): 85-95. https://www.ncbi.nlm.nih.gov/pubmed/23086229
Liehn EA, Kanzler I, Konschalla S, Kroh A, Simsekyilmaz S, Sonmez TT, Bucala R, Bernhagen J, Weber C. Compartmentalized protective and detrimental effects of endogenous macrophage migration-inhibitory factor mediated by CXCR2 in a mouse model of myocardial ischemia/reperfusion. Arterioscler Thromb Vasc Biol 2013; 33(9): 2180-2186. https://www.ncbi.nlm.nih.gov/pubmed/23868943
Lievens D, Habets KL, Robertson AK, Laouar Y, Winkels H, Rademakers T, Beckers L, Wijnands E, Boon L, Mosaheb M, Ait-Oufella H, Mallat Z, Flavell RA, Rudling M, Binder CJ, Gerdes N, Biessen EA, Weber C, Daemen MJ, Kuiper J, Lutgens E. Abrogated transforming growth factor beta receptor II (TGFbetaRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis. Eur Heart J 2013; 34(48): 3717-3727. https://www.ncbi.nlm.nih.gov/pubmed/22613345
Lundberg AM, Ketelhuth DF, Johansson ME, Gerdes N, Liu S, Yamamoto M, Akira S, Hansson GK. Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis. Cardiovasc Res 2013; 99(2): 364-373. https://www.ncbi.nlm.nih.gov/pubmed/23417039
Manthey HD, Cochain C, Barnsteiner S, Karshovska E, Pelisek J, Koch M, Chaudhari SM, Busch M, Eckstein HH, Weber C, Koenen RR, Zernecke A. CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice. Thromb Haemost 2013; 110(6): 1267-1277. https://www.ncbi.nlm.nih.gov/pubmed/24114205
Molica F, Burger F, Thomas A, Staub C, Tailleux A, Staels B, Pelli G, Zimmer A, Cravatt B, Matter CM, Pacher P, Steffens S. Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation. J Lipid Res 2013; 54(5): 1360-1368. https://www.ncbi.nlm.nih.gov/pubmed/23479425
Nakahata AM, Mayer B, Neth P, Hansen D, Sampaio MU, Oliva ML. Blocking the proliferation of human tumor cell lines by peptidase inhibitors from Bauhinia seeds. Planta Med 2013; 79(3-4): 227-235. https://www.ncbi.nlm.nih.gov/pubmed/23345168
Neth P, Nazari-Jahantigh M, Schober A, Weber C. MicroRNAs in flow-dependent vascular remodelling. Cardiovasc Res 2013; 99(2): 294-303. https://www.ncbi.nlm.nih.gov/pubmed/23612583
Oral H, Kanzler I, Tuchscheerer N, Curaj A, Simsekyilmaz S, Sonmez TT, Radu E, Postea O, Weber C, Schuh A, Liehn EA. CXC chemokine KC fails to induce neutrophil infiltration and neoangiogenesis in a mouse model of myocardial infarction. J Mol Cell Cardiol 2013; 60: 1-7. https://www.ncbi.nlm.nih.gov/pubmed/23598282
Ortega-Gomez A, Perretti M, Soehnlein O. Resolution of inflammation: an integrated view. EMBO Mol Med 2013; 5(5): 661-674. https://www.ncbi.nlm.nih.gov/pubmed/23592557
Petzold T, Ruppert R, Pandey D, Barocke V, Meyer H, Lorenz M, Zhang L, Siess W, Massberg S, Moser M. beta1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse. Blood 2013; 122(15): 2723-2731. https://www.ncbi.nlm.nih.gov/pubmed/24004668
Poti F, Gualtieri F, Sacchi S, Weissen-Plenz G, Varga G, Brodde M, Weber C, Simoni M, Nofer JR. KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol 2013; 33(7): 1505-1512. https://www.ncbi.nlm.nih.gov/pubmed/23640484
Preissner KT, Weber C. Go with the flow: the passion for vascular biology research. Highlights from IVBM 2012. Thromb Haemost 2013; 109(3): 366-367. https://www.ncbi.nlm.nih.gov/pubmed/23407867
Schaffer S, Tandon R, Zipse H, Siess W, Schmidt A, Jamasbi J, Karshovska E, Steglich W, Lorenz R. Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages. Biochem Pharmacol 2013; 86(2): 279-285. https://www.ncbi.nlm.nih.gov/pubmed/23665353
Seijkens T, Kusters P, Engel D, Lutgens E. CD40-CD40L: linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications. Diab Vasc Dis Res 2013; 10(2): 115-122. https://www.ncbi.nlm.nih.gov/pubmed/22965071
Smeets E, Meiler S, Lutgens E. Lymphocytic tumor necrosis factor receptor superfamily co-stimulatory molecules in the pathogenesis of atherosclerosis. Curr Opin Lipidol 2013; 24(6): 518-524. https://www.ncbi.nlm.nih.gov/pubmed/24184937
Soehnlein O. Myeloid cells in traffic. J Innate Immun 2013; 5(4): 301-303. https://www.ncbi.nlm.nih.gov/pubmed/23594523
Soehnlein O, Drechsler M, Doring Y, Lievens D, Hartwig H, Kemmerich K, Ortega-Gomez A, Mandl M, Vijayan S, Projahn D, Garlichs CD, Koenen RR, Hristov M, Lutgens E, Zernecke A, Weber C. Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes. EMBO Mol Med 2013; 5(3): 471-481. https://www.ncbi.nlm.nih.gov/pubmed/23417922
Soehnlein O, Swirski FK. Hypercholesterolemia links hematopoiesis with atherosclerosis. Trends Endocrinol Metab 2013; 24(3): 129-136. https://www.ncbi.nlm.nih.gov/pubmed/23228326
Strodthoff D, Lundberg AM, Agardh HE, Ketelhuth DF, Paulsson-Berne G, Arner P, Hansson GK, Gerdes N. Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice. Arterioscler Thromb Vasc Biol 2013; 33(6): 1189-1196. https://www.ncbi.nlm.nih.gov/pubmed/23520162
Strussmann T, Tillmann S, Wirtz T, Bucala R, von Hundelshausen P, Bernhagen J. Platelets are a previously unrecognised source of MIF. Thromb Haemost 2013; 110(5): 1004-1013. https://www.ncbi.nlm.nih.gov/pubmed/23846621
von Hundelshausen P, Weber C. [Chronic inflammation and atherosclerosis]. Dtsch Med Wochenschr 2013; 138(37): 1839-1844. https://www.ncbi.nlm.nih.gov/pubmed/24006166
Wantha S, Alard JE, Megens RT, van der Does AM, Doring Y, Drechsler M, Pham CT, Wang MW, Wang JM, Gallo RL, von Hundelshausen P, Lindbom L, Hackeng T, Weber C, Soehnlein O. Neutrophil-derived cathelicidin promotes adhesion of classical monocytes. Circ Res 2013; 112(5): 792-801. https://www.ncbi.nlm.nih.gov/pubmed/23283724
Weber C. MicroRNAs: from basic mechanisms to clinical application in cardiovascular medicine. Arterioscler Thromb Vasc Biol 2013; 33(2): 168-169. https://www.ncbi.nlm.nih.gov/pubmed/23325472
Weber C, Lip GYH. Editors’ Choice papers in Thrombosis and Haemostasis. Thrombosis and Haemostasis 2013; 109(01): 170-173. http://dx.doi.org/10.1055/s-0037-1609008
Weber C, Lip GYH. A Happy New Year 2013 for Thrombosis and Haemostasis …. Thrombosis and Haemostasis 2013; 109(01): 1-2. http://dx.doi.org/10.1055/s-0037-1609007
Wei Y, Nazari-Jahantigh M, Chan L, Zhu M, Heyll K, Corbalan-Campos J, Hartmann P, Thiemann A, Weber C, Schober A. The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis. Circulation 2013; 127(15): 1609-1619. https://www.ncbi.nlm.nih.gov/pubmed/23513069
Wei Y, Nazari-Jahantigh M, Neth P, Weber C, Schober A. MicroRNA-126, -145, and -155: a therapeutic triad in atherosclerosis? Arterioscler Thromb Vasc Biol 2013; 33(3): 449-454. https://www.ncbi.nlm.nih.gov/pubmed/23324496
Wei Y, Schober A, Weber C. Pathogenic arterial remodeling: the good and bad of microRNAs. Am J Physiol Heart Circ Physiol 2013; 304(8): H1050-1059. https://www.ncbi.nlm.nih.gov/pubmed/23396454
Wu Z, Curaj A, Fokong S, Liehn EA, Weber C, Lammers T, Kiessling F, Zandvoort van M. Rhodamine-loaded intercellular adhesion molecule-1-targeted microbubbles for dual-modality imaging under controlled shear stresses. Circ Cardiovasc Imaging 2013; 6(6): 974-981. https://www.ncbi.nlm.nih.gov/pubmed/24036383
Yla-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PW, Waltenberger J, Weber C, Tokgozoglu L, Atherosclerosis ESCWGo, Vascular B. Stabilization of atherosclerotic plaques: an update. Eur Heart J 2013; 34(42): 3251-3258. https://www.ncbi.nlm.nih.gov/pubmed/23966311
Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, Rohwedder I, Hinkel R, Gross L, Lee S, Hu J, Soehnlein O, Franz WM, Sperandio M, Pohl U, Thomas M, Weber C, Augustin HG, Fassler R, Deutsch U, Kupatt C. Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest 2013; 123(8): 3436-3445. https://www.ncbi.nlm.nih.gov/pubmed/23863629
Zimmermann R, Krueger J, Filipovic MR, Ivanovic-Burmazovic I, Calatzis A, Weiss DR, Eckstein R. A detailed examination of platelet function inhibition by nitric oxide in platelet-rich plasma and whole blood. Clin Lab 2013; 59(5-6): 629-638. https://www.ncbi.nlm.nih.gov/pubmed/23865363

2012

Bampalis VG, Brantl SA, Siess W. Why and how to eliminate spontaneous platelet aggregation in blood measured by multiple electrode aggregometry. J Thromb Haemost 2012; 10(8): 1710-1714. https://www.ncbi.nlm.nih.gov/pubmed/22712617
Bidzhekov K, Gan L, Denecke B, Rostalsky A, Hristov M, Koeppel TA, Zernecke A, Weber C. microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans. Thromb Haemost 2012; 107(4): 619-625. https://www.ncbi.nlm.nih.gov/pubmed/22370758
Blanchet X, Langer M, Weber C, Koenen RR, von Hundelshausen P. Touch of chemokines. Front Immunol 2012; 3: 175. https://www.ncbi.nlm.nih.gov/pubmed/22807925
Bras G, Bochenska O, Rapala-Kozik M, Guevara-Lora I, Faussner A, Kozik A. Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg(9)-Met-Lys-bradykinin. Biol Chem 2012; 393(8): 829-839. https://www.ncbi.nlm.nih.gov/pubmed/22944684
Brauner R, Johannes C, Ploessl F, Bracher F, Lorenz RL. Phytosterols reduce cholesterol absorption by inhibition of 27-hydroxycholesterol generation, liver X receptor alpha activation, and expression of the basolateral sterol exporter ATP-binding cassette A1 in Caco-2 enterocytes. J Nutr 2012; 142(6): 981-989. https://www.ncbi.nlm.nih.gov/pubmed/22535758
Cardilo-Reis L, Gruber S, Schreier SM, Drechsler M, Papac-Milicevic N, Weber C, Wagner O, Stangl H, Soehnlein O, Binder CJ. Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype. EMBO Mol Med 2012; 4(10): 1072-1086. https://www.ncbi.nlm.nih.gov/pubmed/23027612
Djafarzadeh R, Sauter M, Notohamiprodjo S, Noessner E, Goyal P, Siess W, Wornle M, Ribeiro A, Himmelein S, Sitter T, Nelson PJ. Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells. PLoS One 2012; 7(4): e33963. https://www.ncbi.nlm.nih.gov/pubmed/22558080
Doring Y, Drechsler M, Wantha S, Kemmerich K, Lievens D, Vijayan S, Gallo RL, Weber C, Soehnlein O. Lack of neutrophil-derived CRAMP reduces atherosclerosis in mice. Circ Res 2012; 110(8): 1052-1056. https://www.ncbi.nlm.nih.gov/pubmed/22394519
Doring Y, Manthey HD, Drechsler M, Lievens D, Megens RT, Soehnlein O, Busch M, Manca M, Koenen RR, Pelisek J, Daemen MJ, Lutgens E, Zenke M, Binder CJ, Weber C, Zernecke A. Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. Circulation 2012; 125(13): 1673-1683. https://www.ncbi.nlm.nih.gov/pubmed/22388324
Doring Y, Noels H, Weber C. The use of high-throughput technologies to investigate vascular inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol 2012; 32(2): 182-195. https://www.ncbi.nlm.nih.gov/pubmed/22258901
Doring Y, Soehnlein O, Drechsler M, Shagdarsuren E, Chaudhari SM, Meiler S, Hartwig H, Hristov M, Koenen RR, Hieronymus T, Zenke M, Weber C, Zernecke A. Hematopoietic interferon regulatory factor 8-deficiency accelerates atherosclerosis in mice. Arterioscler Thromb Vasc Biol 2012; 32(7): 1613-1623. https://www.ncbi.nlm.nih.gov/pubmed/22556330
Doring Y, Zernecke A. Plasmacytoid dendritic cells in atherosclerosis. Front Physiol 2012; 3: 230. https://www.ncbi.nlm.nih.gov/pubmed/22754539
Egea V, Schober A, Weber C. Circulating miRNAs: messengers on the move in cardiovascular disease. Thromb Haemost 2012; 108(4): 590-591. https://www.ncbi.nlm.nih.gov/pubmed/22955179
Egea V, Zahler S, Rieth N, Neth P, Popp T, Kehe K, Jochum M, Ries C. Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A 2012; 109(6): E309-316. https://www.ncbi.nlm.nih.gov/pubmed/22223664
Faussner A, Schussler S, Feierler J, Bermudez M, Pfeifer J, Schnatbaum K, Tradler T, Jochum M, Wolber G, Gibson C. Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist. Br J Pharmacol 2012; 167(4): 839-853. https://www.ncbi.nlm.nih.gov/pubmed/22646218
Grismayer B, Sato S, Kopitz C, Ries C, Soelch S, Schmitt M, Baretton G, Kruger A, Luther T, Kotzsch M, Magdolen V. Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes. Biol Chem 2012; 393(12): 1449-1455. https://www.ncbi.nlm.nih.gov/pubmed/23667902
Grommes J, Alard JE, Drechsler M, Wantha S, Morgelin M, Kuebler WM, Jacobs M, von Hundelshausen P, Markart P, Wygrecka M, Preissner KT, Hackeng TM, Koenen RR, Weber C, Soehnlein O. Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury. Am J Respir Crit Care Med 2012; 185(6): 628-636. https://www.ncbi.nlm.nih.gov/pubmed/22246174
Grommes J, Morgelin M, Soehnlein O. Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment. Eur Respir J 2012; 40(2): 416-423. https://www.ncbi.nlm.nih.gov/pubmed/22267758
Grommes J, Vijayan S, Drechsler M, Hartwig H, Morgelin M, Dembinski R, Jacobs M, Koeppel TA, Binnebosel M, Weber C, Soehnlein O. Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation. PLoS One 2012; 7(6): e38917. https://www.ncbi.nlm.nih.gov/pubmed/22701728
Hamesch K, Subramanian P, Li X, Dembowsky K, Chevalier E, Weber C, Schober A. The CXCR4 antagonist POL5551 is equally effective as sirolimus in reducing neointima formation without impairing re-endothelialisation. Thromb Haemost 2012; 107(2): 356-368. https://www.ncbi.nlm.nih.gov/pubmed/22234341
Hristov M, Schmitz S, Nauwelaers F, Weber C. A flow cytometric protocol for enumeration of endothelial progenitor cells and monocyte subsets in human blood. J Immunol Methods 2012; 381(1-2): 9-13. https://www.ncbi.nlm.nih.gov/pubmed/22537800
Kamchybekov U, Figulla HR, Gerdes N, Jung C. Macrophage migration inhibitory factor is elevated in obese adolescents. Arch Physiol Biochem 2012; 118(4): 204-209. https://www.ncbi.nlm.nih.gov/pubmed/22676646
Kanzler I, Liehn EA, Koenen RR, Weber C. Anti-inflammatory therapeutic approaches to reduce acute atherosclerotic complications. Curr Pharm Biotechnol 2012; 13(1): 37-45. https://www.ncbi.nlm.nih.gov/pubmed/21470163
Karshovska E, Weber C. Atherosclerosis: cell biology and lipoproteins--new mechanistic links in atherosclerosis: chemokines mediating the effects of lipids, platelets and dendritic cells. Curr Opin Lipidol 2012; 23(4): 400-401. https://www.ncbi.nlm.nih.gov/pubmed/22801391
Koenen R, Weber C. Chemokines and Their Receptors as Therapeutic Targets in Atherosclerosis. In: Atherosclerosis: Treatment and Prevention. Pan Stanford Publishing; 2012: 1-30. http://dx.doi.org/10.1201/b13723-2
Kolben T, Perobner I, Fernsebner K, Lechner F, Geissler C, Ruiz-Heinrich L, Capovilla S, Jochum M, Neth P. Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells. Biol Chem 2012; 393(12): 1433-1447. https://www.ncbi.nlm.nih.gov/pubmed/23152409
Liehn EA, Bucur O, Weber C. Role of microparticles as messengers enhancing stem cell activity after genetic engineering. Circ Res 2012; 111(3): 265-267. https://www.ncbi.nlm.nih.gov/pubmed/22821904
Lip GYH, Weber C. Welcome to a new year in Thrombosis and Haemostasis…. Thrombosis and Haemostasis 2012; 107(01): 1-2. http://dx.doi.org/10.1055/s-0037-1608982
Lutgens E, Leiner T, Weber C. RANK(L)-ing biomarkers as surrogates for coronary calcium score. Thromb Haemost 2012; 107(1): 3. https://www.ncbi.nlm.nih.gov/pubmed/22159710
Matusik P, Guzik B, Weber C, Guzik TJ. Do we know enough about the immune pathogenesis of acute coronary syndromes to improve clinical practice? Thromb Haemost 2012; 108(3): 443-456. https://www.ncbi.nlm.nih.gov/pubmed/22872109
Megens RT, Vijayan S, Lievens D, Doring Y, van Zandvoort MA, Grommes J, Weber C, Soehnlein O. Presence of luminal neutrophil extracellular traps in atherosclerosis. Thromb Haemost 2012; 107(3): 597-598. https://www.ncbi.nlm.nih.gov/pubmed/22318427
Nazari-Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen RR, Heyll K, Gremse F, Kiessling F, Grommes J, Weber C, Schober A. MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Invest 2012; 122(11): 4190-4202. https://www.ncbi.nlm.nih.gov/pubmed/23041630
Nazari-Jahantigh M, Wei Y, Schober A. The role of microRNAs in arterial remodelling. Thromb Haemost 2012; 107(4): 611-618. https://www.ncbi.nlm.nih.gov/pubmed/22371089
Noels H, Bernhagen J, Weber C. MIF in Atherosclerosis. In: The MIF Handbook. WORLD SCIENTIFIC; 2012: 321-345. http://dx.doi.org/10.1142/9789814335362_0017
Perobner I, Karow M, Jochum M, Neth P. LRP6 mediates Wnt/beta-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells. Int J Biochem Cell Biol 2012; 44(11): 1970-1982. https://www.ncbi.nlm.nih.gov/pubmed/22871567
Postea O, Vasina EM, Cauwenberghs S, Projahn D, Liehn EA, Lievens D, Theelen W, Kramp BK, Butoi ED, Soehnlein O, Heemskerk JW, Ludwig A, Weber C, Koenen RR. Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia. Arterioscler Thromb Vasc Biol 2012; 32(5): 1186-1193. https://www.ncbi.nlm.nih.gov/pubmed/22383701
Poti F, Costa S, Bergonzini V, Galletti M, Pignatti E, Weber C, Simoni M, Nofer JR. Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R(-)/(-)) mice. Vascul Pharmacol 2012; 57(1): 56-64. https://www.ncbi.nlm.nih.gov/pubmed/22459073
Projahn D, Koenen RR. Platelets: key players in vascular inflammation. J Leukoc Biol 2012; 92(6): 1167-1175. https://www.ncbi.nlm.nih.gov/pubmed/22923486
Raffetseder U, Liehn EA, Weber C, Mertens PR. Role of cold shock Y-box protein-1 in inflammation, atherosclerosis and organ transplant rejection. Eur J Cell Biol 2012; 91(6-7): 567-575. https://www.ncbi.nlm.nih.gov/pubmed/21943779
Redondo S, Gonzalez-Rocafort A, Navarro-Dorado J, Ramajo M, Hristov M, Gordillo-Moscoso A, Reguillo F, Carnero M, Martinez-Gonzalez J, Rodriguez E, Weber C, Tejerina T. Decreased pre-surgical CD34+/CD144+ cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patients. J Cardiothorac Surg 2012; 7: 2. https://www.ncbi.nlm.nih.gov/pubmed/22214418
Rohwedder I, Montanez E, Beckmann K, Bengtsson E, Duner P, Nilsson J, Soehnlein O, Fassler R. Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation. EMBO Mol Med 2012; 4(7): 564-576. https://www.ncbi.nlm.nih.gov/pubmed/22514136
Rowinska Z, Zander S, Zernecke A, Jacobs M, Langer S, Weber C, Merx MW, Koeppel TA. Non- invasive in vivo analysis of a murine aortic graft using high resolution ultrasound microimaging. Eur J Radiol 2012; 81(2): 244-249. https://www.ncbi.nlm.nih.gov/pubmed/21334152
Schober A, Siess W. Lysophosphatidic acid in atherosclerotic diseases. Br J Pharmacol 2012; 167(3): 465-482. https://www.ncbi.nlm.nih.gov/pubmed/22568609
Schuh A, Kroh A, Konschalla S, Liehn EA, Sobota RM, Biessen EA, Bot I, Sonmez TT, Schober A, Marx N, Weber C, Sasse A. Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing SDF-1 in a rat model. J Cell Mol Med 2012; 16(10): 2311-2320. https://www.ncbi.nlm.nih.gov/pubmed/22288686
Schuh A, Sasse A, Konschalla S, Kroh A, Merx MW, Weber C, Liehn EA. Repetitive transplantation of different cell types sequentially improves heart function after infarction. J Cell Mol Med 2012; 16(7): 1640-1647. https://www.ncbi.nlm.nih.gov/pubmed/22050647
Schwartz V, Kruttgen A, Weis J, Weber C, Ostendorf T, Lue H, Bernhagen J. Role for CD74 and CXCR4 in clathrin-dependent endocytosis of the cytokine MIF. Eur J Cell Biol 2012; 91(6-7): 435-449. https://www.ncbi.nlm.nih.gov/pubmed/22014447
Soehnlein O. Multiple roles for neutrophils in atherosclerosis. Circ Res 2012; 110(6): 875-888. https://www.ncbi.nlm.nih.gov/pubmed/22427325
Soehnlein O, Weber C. Neutrophils and their granule proteins in the treatment of athero-sclerosis. In: Atherosclerosis: Treatment and Prevention. Pan Stanford Publishing; 2012: 1-30. http://dx.doi.org/10.1201/b13723-2
Stoger JL, Gijbels MJ, van der Velden S, Manca M, van der Loos CM, Biessen EA, Daemen MJ, Lutgens E, de Winther MP. Distribution of macrophage polarization markers in human atherosclerosis. Atherosclerosis 2012; 225(2): 461-468. https://www.ncbi.nlm.nih.gov/pubmed/23078881
Van de Vijver P, Schmitt M, Suylen D, Scheer L, Thomassen MC, Schurgers LJ, Griffin JH, Koenen RR, Hackeng TM. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S. J Am Chem Soc 2012; 134(47): 19318-19321. https://www.ncbi.nlm.nih.gov/pubmed/23066897
Weber C, Lip GYH. Highlights and hot topics from 2011 in Thrombosis and Haemostasis. Thrombosis and Haemostasis 2012; 107(01): 196-199. http://dx.doi.org/10.1055/s-0037-1608981
Zernecke A, Weber C. Improving the treatment of atherosclerosis by linking anti-inflammatory and lipid modulating strategies. Heart 2012; 98(21): 1600-1606. https://www.ncbi.nlm.nih.gov/pubmed/23086996

2011

Bampalis VG, Dwivedi S, Shai E, Brandl R, Varon D, Siess W. Effect of 5-HT2A receptor antagonists on human platelet activation in blood exposed to physiologic stimuli and atherosclerotic plaque. J Thromb Haemost 2011; 9(10): 2112-2115. https://www.ncbi.nlm.nih.gov/pubmed/21848639
Butoi ED, Gan AM, Manduteanu I, Stan D, Calin M, Pirvulescu M, Koenen RR, Weber C, Simionescu M. Cross talk between smooth muscle cells and monocytes/activated monocytes via CX3CL1/CX3CR1 axis augments expression of pro-atherogenic molecules. Biochim Biophys Acta 2011; 1813(12): 2026-2035. https://www.ncbi.nlm.nih.gov/pubmed/21888931
Daissormont IT, Christ A, Temmerman L, Sampedro Millares S, Seijkens T, Manca M, Rousch M, Poggi M, Boon L, van der Loos C, Daemen M, Lutgens E, Halvorsen B, Aukrust P, Janssen E, Biessen EA. Plasmacytoid dendritic cells protect against atherosclerosis by tuning T-cell proliferation and activity. Circ Res 2011; 109(12): 1387-1395. https://www.ncbi.nlm.nih.gov/pubmed/22021930
de Jager SC, Bermudez B, Bot I, Koenen RR, Bot M, Kavelaars A, de Waard V, Heijnen CJ, Muriana FJ, Weber C, van Berkel TJ, Kuiper J, Lee SJ, Abia R, Biessen EA. Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis. J Exp Med 2011; 208(2): 217-225. https://www.ncbi.nlm.nih.gov/pubmed/21242297
Douma K, Megens RT, van Zandvoort MA. Optical molecular imaging of atherosclerosis using nanoparticles: shedding new light on the darkness. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2011; 3(4): 376-388. https://www.ncbi.nlm.nih.gov/pubmed/21448988
Drechsler M, Doring Y, Megens RT, Soehnlein O. Neutrophilic granulocytes - promiscuous accelerators of atherosclerosis. Thromb Haemost 2011; 106(5): 839-848. https://www.ncbi.nlm.nih.gov/pubmed/22012406
Engel D, Beckers L, Wijnands E, Seijkens T, Lievens D, Drechsler M, Gerdes N, Soehnlein O, Daemen MJ, Stan RV, Biessen EA, Lutgens E. Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response. FASEB J 2011; 25(11): 3838-3848. https://www.ncbi.nlm.nih.gov/pubmed/21795505
Frithiof R, Soehnlein O, Eriksson S, Fenhammar J, Hjelmqvist H, Lindbom L, Rundgren M. The effects of isoflurane anesthesia and mechanical ventilation on renal function during endotoxemia. Acta Anaesthesiol Scand 2011; 55(4): 401-410. https://www.ncbi.nlm.nih.gov/pubmed/21391922
Gerdes N, Zhu L, Ersoy M, Hermansson A, Hjemdahl P, Hu H, Hansson GK, Li N. Platelets regulate CD4(+) T-cell differentiation via multiple chemokines in humans. Thromb Haemost 2011; 106(2): 353-362. https://www.ncbi.nlm.nih.gov/pubmed/21655676
Gerdes N, Zirlik A. Co-stimulatory molecules in and beyond co-stimulation - tipping the balance in atherosclerosis? Thromb Haemost 2011; 106(5): 804-813. https://www.ncbi.nlm.nih.gov/pubmed/21979444
Goyal P, Behring A, Kumar A, Siess W. STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells. PLoS One 2011; 6(1): e16249. https://www.ncbi.nlm.nih.gov/pubmed/21283756
Grommes J, Soehnlein O. Contribution of neutrophils to acute lung injury. Mol Med 2011; 17(3-4): 293-307. https://www.ncbi.nlm.nih.gov/pubmed/21046059
Heinrichs D, Knauel M, Offermanns C, Berres ML, Nellen A, Leng L, Schmitz P, Bucala R, Trautwein C, Weber C, Bernhagen J, Wasmuth HE. Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74. Proc Natl Acad Sci U S A 2011; 108(42): 17444-17449. https://www.ncbi.nlm.nih.gov/pubmed/21969590
Hristov M, Weber C. Differential role of monocyte subsets in atherosclerosis. Thromb Haemost 2011; 106(5): 757-762. https://www.ncbi.nlm.nih.gov/pubmed/21901241
Khandoga AL, Pandey D, Welsch U, Brandl R, Siess W. GPR92/LPA(5) lysophosphatidate receptor mediates megakaryocytic cell shape change induced by human atherosclerotic plaques. Cardiovasc Res 2011; 90(1): 157-164. https://www.ncbi.nlm.nih.gov/pubmed/21106562
Koenen RR, Weber C. Chemokines: established and novel targets in atherosclerosis. EMBO Mol Med 2011; 3(12): 713-725. https://www.ncbi.nlm.nih.gov/pubmed/22038924
Kraemer S, Lue H, Zernecke A, Kapurniotu A, Andreetto E, Frank R, Lennartz B, Weber C, Bernhagen J. MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism. FASEB J 2011; 25(3): 894-906. https://www.ncbi.nlm.nih.gov/pubmed/21106938
Kramp BK, Sarabi A, Koenen RR, Weber C. Heterophilic chemokine receptor interactions in chemokine signaling and biology. Exp Cell Res 2011; 317(5): 655-663. https://www.ncbi.nlm.nih.gov/pubmed/21146524
Kuijpers MJ, Megens RT, Nikookhesal E, Feijge MA, De Mey JG, oude Egbrink MG, van Giezen JJ, Heemskerk JW. Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y(1)(2) antagonist ticagrelor. Thromb Haemost 2011; 106(6): 1179-1188. https://www.ncbi.nlm.nih.gov/pubmed/22071958
Liehn EA, Tuchscheerer N, Kanzler I, Drechsler M, Fraemohs L, Schuh A, Koenen RR, Zander S, Soehnlein O, Hristov M, Grigorescu G, Urs AO, Leabu M, Bucur I, Merx MW, Zernecke A, Ehling J, Gremse F, Lammers T, Kiessling F, Bernhagen J, Schober A, Weber C. Double-edged role of the CXCL12/CXCR4 axis in experimental myocardial infarction. J Am Coll Cardiol 2011; 58(23): 2415-2423. https://www.ncbi.nlm.nih.gov/pubmed/22115649
Lievens D, von Hundelshausen P. Platelets in atherosclerosis. Thromb Haemost 2011; 106(5): 827-838. https://www.ncbi.nlm.nih.gov/pubmed/22012554
Lip GY, Weber C. Clinical and basic science articles from Thrombosis and Haemostasis. Thromb Haemost 2011; 105(1): 202-205. https://www.ncbi.nlm.nih.gov/pubmed/21249716
Lutgens E, Binder CJ. Immunology of atherosclerosis. Thromb Haemost 2011; 106(5): 755-756. https://www.ncbi.nlm.nih.gov/pubmed/22011700
Megens RT, Kemmerich K, Pyta J, Weber C, Soehnlein O. Intravital imaging of phagocyte recruitment. Thromb Haemost 2011; 105(5): 802-810. https://www.ncbi.nlm.nih.gov/pubmed/21437362
Megens RT, Soehnlein O. Seeing is believing: an update on modalities to image inflammation in vivo. Thromb Haemost 2011; 105(5): 774-775. https://www.ncbi.nlm.nih.gov/pubmed/21437354
Noels H, Weber C. Catching up with important players in atherosclerosis: type I interferons and neutrophils. Curr Opin Lipidol 2011; 22(2): 144-145. https://www.ncbi.nlm.nih.gov/pubmed/21415605
Poggi M, Engel D, Christ A, Beckers L, Wijnands E, Boon L, Driessen A, Cleutjens J, Weber C, Gerdes N, Lutgens E. CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice. Arterioscler Thromb Vasc Biol 2011; 31(10): 2251-2260. https://www.ncbi.nlm.nih.gov/pubmed/21817098
Rana OR, Saygili E, Gemein C, Zink MD, Buhr A, Saygili E, Mischke K, Nolte KW, Weis J, Weber C, Marx N, Schauerte P. Chronic electrical neuronal stimulation increases cardiac parasympathetic tone by eliciting neurotrophic effects. Circ Res 2011; 108(10): 1209-1219. https://www.ncbi.nlm.nih.gov/pubmed/21441135
Reitsma S, Oude Egbrink MG, Heijnen VV, Megens RT, Engels W, Vink H, Slaaf DW, van Zandvoort MA. Endothelial glycocalyx thickness and platelet-vessel wall interactions during atherogenesis. Thromb Haemost 2011; 106(5): 939-946. https://www.ncbi.nlm.nih.gov/pubmed/21901228
Sarabi A, Kramp BK, Drechsler M, Hackeng TM, Soehnlein O, Weber C, Koenen RR, Von Hundelshausen P. CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment. J Thromb Haemost 2011; 9(1): 209-219. https://www.ncbi.nlm.nih.gov/pubmed/20961394
Saygili E, Schauerte P, Pekassa M, Saygili E, Rackauskas G, Schwinger RH, Weis J, Weber C, Marx N, Rana OR. Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion. Cell Mol Neurobiol 2011; 31(1): 17-25. https://www.ncbi.nlm.nih.gov/pubmed/20683769
Schober A, Hristov M, Kofler S, Forbrig R, Lohr B, Heussen N, Zhe Z, Akhtar S, Schumann U, Krotz F, Leibig M, Konig A, Kaczmarek I, Reichart B, Klauss V, Weber C, Sohn HY. CD34+CD140b+ cells and circulating CXCL12 correlate with the angiographically assessed severity of cardiac allograft vasculopathy. Eur Heart J 2011; 32(4): 476-484. https://www.ncbi.nlm.nih.gov/pubmed/21036775
Schober A, Weber C. Bone marrow-derived smooth muscle cells are breaking bad in atherogenesis. Arterioscler Thromb Vasc Biol 2011; 31(6): 1258-1259. https://www.ncbi.nlm.nih.gov/pubmed/21593459
Schober LJ, Khandoga AL, Dwivedi S, Penz SM, Maruyama T, Brandl R, Siess W. The role of PGE(2) in human atherosclerotic plaque on platelet EP(3) and EP(4) receptor activation and platelet function in whole blood. J Thromb Thrombolysis 2011; 32(2): 158-166. https://www.ncbi.nlm.nih.gov/pubmed/21424266
Simons D, Grieb G, Hristov M, Pallua N, Weber C, Bernhagen J, Steffens G. Hypoxia-induced endothelial secretion of macrophage migration inhibitory factor and role in endothelial progenitor cell recruitment. J Cell Mol Med 2011; 15(3): 668-678. https://www.ncbi.nlm.nih.gov/pubmed/20178462
Soehnlein O, Wantha S, Simsekyilmaz S, Doring Y, Megens RT, Mause SF, Drechsler M, Smeets R, Weinandy S, Schreiber F, Gries T, Jockenhoevel S, Moller M, Vijayan S, van Zandvoort MA, Agerberth B, Pham CT, Gallo RL, Hackeng TM, Liehn EA, Zernecke A, Klee D, Weber C. Neutrophil-derived cathelicidin protects from neointimal hyperplasia. Sci Transl Med 2011; 3(103): 103ra198. https://www.ncbi.nlm.nih.gov/pubmed/21974936
Vasina EM, Cauwenberghs S, Feijge MA, Heemskerk JW, Weber C, Koenen RR. Microparticles from apoptotic platelets promote resident macrophage differentiation. Cell Death Dis 2011; 2(9): e211. https://www.ncbi.nlm.nih.gov/pubmed/21956548
Vonend O, Ockenfels N, Gao X, Allolio B, Lang K, Mai K, Quack I, Saleh A, Degenhart C, Seufert J, Seiler L, Beuschlein F, Quinkler M, Podrabsky P, Bidlingmaier M, Lorenz R, Reincke M, Rump LC, German Conn's R. Adrenal venous sampling: evaluation of the German Conn's registry. Hypertension 2011; 57(5): 990-995. https://www.ncbi.nlm.nih.gov/pubmed/21383311
Weber C, Lip G. Commencing 2011 with Thrombosis and Haemostasis – and looking to the future. Thrombosis and Haemostasis 2011; 105(01): 1-2. http://dx.doi.org/10.1055/s-0037-1609003
Weber C, Meiler S, Doring Y, Koch M, Drechsler M, Megens RT, Rowinska Z, Bidzhekov K, Fecher C, Ribechini E, van Zandvoort MA, Binder CJ, Jelinek I, Hristov M, Boon L, Jung S, Korn T, Lutz MB, Forster I, Zenke M, Hieronymus T, Junt T, Zernecke A. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest 2011; 121(7): 2898-2910. https://www.ncbi.nlm.nih.gov/pubmed/21633167
Weber C, Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 2011; 17(11): 1410-1422. https://www.ncbi.nlm.nih.gov/pubmed/22064431
Weber C, Soehnlein O. ApoE controls the interface linking lipids and inflammation in atherosclerosis. J Clin Invest 2011; 121(10): 3825-3827. https://www.ncbi.nlm.nih.gov/pubmed/21968109
Wildhagen KC, Lutgens E, Loubele ST, ten Cate H, Nicolaes GA. The structure-function relationship of activated protein C. Lessons from natural and engineered mutations. Thromb Haemost 2011; 106(6): 1034-1045. https://www.ncbi.nlm.nih.gov/pubmed/22072231
Yla-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PW, Waltenberger J, Weber C, Tokgozoglu L. Stabilisation of atherosclerotic plaques. Position paper of the European Society of Cardiology (ESC) Working Group on atherosclerosis and vascular biology. Thromb Haemost 2011; 106(1): 1-19. https://www.ncbi.nlm.nih.gov/pubmed/21670845
Zhou Z, Subramanian P, Sevilmis G, Globke B, Soehnlein O, Karshovska E, Megens R, Heyll K, Chun J, Saulnier-Blache JS, Reinholz M, van Zandvoort M, Weber C, Schober A. Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium. Cell Metab 2011; 13(5): 592-600. https://www.ncbi.nlm.nih.gov/pubmed/21531341

2010

Bai L, Beckers L, Wijnands E, Lutgens SP, Herias MV, Saftig P, Daemen MJ, Cleutjens K, Lutgens E, Biessen EA, Heeneman S. Cathepsin K gene disruption does not affect murine aneurysm formation. Atherosclerosis 2010; 209(1): 96-103. https://www.ncbi.nlm.nih.gov/pubmed/19775691
Bampalis VG, Khandoga AL, Siess W. Fluoxetine inhibition of 5-HT-potentiated platelet aggregation in whole blood. Thromb Haemost 2010; 104(6): 1272-4. https://www.ncbi.nlm.nih.gov/pubmed/20806122
Berres ML, Koenen RR, Rueland A, Zaldivar MM, Heinrichs D, Sahin H, Schmitz P, Streetz KL, Berg T, Gassler N, Weiskirchen R, Proudfoot A, Weber C, Trautwein C, Wasmuth HE. Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. J Clin Invest 2010; 120(11): 4129-40. https://www.ncbi.nlm.nih.gov/pubmed/20978355
Braunersreuther V, Pellieux C, Pelli G, Burger F, Steffens S, Montessuit C, Weber C, Proudfoot A, Mach F, Arnaud C. Chemokine CCL5/RANTES inhibition reduces myocardial reperfusion injury in atherosclerotic mice. J Mol Cell Cardiol 2010; 48(4): 789-98. https://www.ncbi.nlm.nih.gov/pubmed/19665464
Drechsler M, Megens RT, van Zandvoort M, Weber C, Soehnlein O. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation 2010; 122(18): 1837-45. https://www.ncbi.nlm.nih.gov/pubmed/20956207
Dwivedi S, Pandey D, Khandoga AL, Brandl R, Siess W. Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque. J Transl Med 2010; 8: 128. https://www.ncbi.nlm.nih.gov/pubmed/21134286
Felker P, Sere K, Lin Q, Becker C, Hristov M, Hieronymus T, Zenke M. TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells. J Immunol 2010; 185(9): 5326-35. https://www.ncbi.nlm.nih.gov/pubmed/20881193
Gerdes N. From bystander to commander: how smooth muscle cells promote lymphoid tissue neogenesis. Arterioscler Thromb Vasc Biol 2010; 30(3): 393-4. https://www.ncbi.nlm.nih.gov/pubmed/20139359
Goossens P, Gijbels MJ, Zernecke A, Eijgelaar W, Vergouwe MN, van der Made I, Vanderlocht J, Beckers L, Buurman WA, Daemen MJ, Kalinke U, Weber C, Lutgens E, de Winther MP. Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. Cell Metab 2010; 12(2): 142-53. https://www.ncbi.nlm.nih.gov/pubmed/20674859
Hristov M, Gumbel D, Lutgens E, Zernecke A, Weber C. Soluble CD40 ligand impairs the function of peripheral blood angiogenic outgrowth cells and increases neointimal formation after arterial injury. Circulation 2010; 121(2): 315-24. https://www.ncbi.nlm.nih.gov/pubmed/20048211
Hristov M, Leyendecker T, Schuhmann C, von Hundelshausen P, Heussen N, Kehmeier E, Krotz F, Sohn HY, Klauss V, Weber C. Circulating monocyte subsets and cardiovascular risk factors in coronary artery disease. Thromb Haemost 2010; 104(2): 412-4. https://www.ncbi.nlm.nih.gov/pubmed/20431842
Jung C, Gerdes N, Fritzenwanger M, Figulla HR. Circulating levels of interleukin-1 family cytokines in overweight adolescents. Mediators Inflamm 2010; 2010: 958403. https://www.ncbi.nlm.nih.gov/pubmed/20169140
Kenne E, Soehnlein O, Genove G, Rotzius P, Eriksson EE, Lindbom L. Immune cell recruitment to inflammatory loci is impaired in mice deficient in basement membrane protein laminin alpha4. J Leukoc Biol 2010; 88(3): 523-8. https://www.ncbi.nlm.nih.gov/pubmed/20483922
Koenen RR, Weber C. Therapeutic targeting of chemokine interactions in atherosclerosis. Nat Rev Drug Discov 2010; 9(2): 141-53. https://www.ncbi.nlm.nih.gov/pubmed/20118962
Koenen RR, Weber C. Platelet-derived chemokines in vascular remodeling and atherosclerosis. Semin Thromb Hemost 2010; 36(2): 163-9. https://www.ncbi.nlm.nih.gov/pubmed/20414831
Liehn EA, Piccinini AM, Koenen RR, Soehnlein O, Adage T, Fatu R, Curaj A, Popescu A, Zernecke A, Kungl AJ, Weber C. A new monocyte chemotactic protein-1/chemokine CC motif ligand-2 competitor limiting neointima formation and myocardial ischemia/reperfusion injury in mice. J Am Coll Cardiol 2010; 56(22): 1847-57. https://www.ncbi.nlm.nih.gov/pubmed/21087715
Lievens D, Gerdes N, Schober A, Weber C. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol 2010; 21(3): 284-5. https://www.ncbi.nlm.nih.gov/pubmed/20463476
Lievens D, Zernecke A, Seijkens T, Soehnlein O, Beckers L, Munnix IC, Wijnands E, Goossens P, van Kruchten R, Thevissen L, Boon L, Flavell RA, Noelle RJ, Gerdes N, Biessen EA, Daemen MJ, Heemskerk JW, Weber C, Lutgens E. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood 2010; 116(20): 4317-27. https://www.ncbi.nlm.nih.gov/pubmed/20705757
Linder A, Soehnlein O, Akesson P. Roles of heparin-binding protein in bacterial infections. J Innate Immun 2010; 2(5): 431-8. https://www.ncbi.nlm.nih.gov/pubmed/20505311
Loges S, Schmidt T, Tjwa M, van Geyte K, Lievens D, Lutgens E, Vanhoutte D, Borgel D, Plaisance S, Hoylaerts M, Luttun A, Dewerchin M, Jonckx B, Carmeliet P. Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6. Blood 2010; 115(11): 2264-73. https://www.ncbi.nlm.nih.gov/pubmed/19965679
Lutgens E, Lievens D, Beckers L, Wijnands E, Soehnlein O, Zernecke A, Seijkens T, Engel D, Cleutjens J, Keller AM, Naik SH, Boon L, Oufella HA, Mallat Z, Ahonen CL, Noelle RJ, de Winther MP, Daemen MJ, Biessen EA, Weber C. Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med 2010; 207(2): 391-404. https://www.ncbi.nlm.nih.gov/pubmed/20100871
Mause SF, Ritzel E, Liehn EA, Hristov M, Bidzhekov K, Muller-Newen G, Soehnlein O, Weber C. Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury. Circulation 2010; 122(5): 495-506. https://www.ncbi.nlm.nih.gov/pubmed/20644015
Mause SF, Weber C. Microparticles: protagonists of a novel communication network for intercellular information exchange. Circ Res 2010; 107(9): 1047-57. https://www.ncbi.nlm.nih.gov/pubmed/21030722
Mause SF, Weber C, Sampol J, Dignat-George F. New horizons in vascular biology and thrombosis: Highlights from EMVBM 2009. Thromb Haemost 2010; 104(3): 421-3. https://www.ncbi.nlm.nih.gov/pubmed/20694282
Meuwese MC, Broekhuizen LN, Kuikhoven M, Heeneman S, Lutgens E, Gijbels MJ, Nieuwdorp M, Peutz CJ, Stroes ES, Vink H, van den Berg BM. Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice. PLoS One 2010; 5(12): e14262. https://www.ncbi.nlm.nih.gov/pubmed/21170388
Noels H, Weber C. Fractalkine as an important target of aspirin in the prevention of atherogenesis : Editorial to: "Aspirin inhibits fractalkine expression in atherosclerotic plaques and reduces atherosclerosis in ApoE gene knockout mice" by H. Liu et al. Cardiovasc Drugs Ther 2010; 24(1): 1-3. https://www.ncbi.nlm.nih.gov/pubmed/20033269
Penz SM, Bernlochner I, Toth O, Lorenz R, Calatzis A, Siess W. Selective and rapid monitoring of dual platelet inhibition by aspirin and P2Y12 antagonists by using multiple electrode aggregometry. Thromb J 2010; 8: 9. https://www.ncbi.nlm.nih.gov/pubmed/20465804
Preissner K, Lip G, Weber C. Editor´s choice articles 2008–2009. Thrombosis and Haemostasis 2017; 103(01): 3-6. http://dx.doi.org/10.1055/s-0037-1608916
Rana OR, Schauerte P, Kluttig R, Schroder JW, Koenen RR, Weber C, Nolte KW, Weis J, Hoffmann R, Marx N, Saygili E. Acetylcholine as an age-dependent non-neuronal source in the heart. Auton Neurosci 2010; 156(1-2): 82-9. https://www.ncbi.nlm.nih.gov/pubmed/20510655
Reininger AJ, Bernlochner I, Penz SM, Ravanat C, Smethurst P, Farndale RW, Gachet C, Brandl R, Siess W. A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol 2010; 55(11): 1147-58. https://www.ncbi.nlm.nih.gov/pubmed/20223370
Ren M, Guo Q, Guo L, Lenz M, Qian F, Koenen RR, Xu H, Schilling AB, Weber C, Ye RD, Dinner AR, Tang WJ. Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme. EMBO J 2010; 29(23): 3952-66. https://www.ncbi.nlm.nih.gov/pubmed/20959807
Rotzius P, Thams S, Soehnlein O, Kenne E, Tseng CN, Bjorkstrom NK, Malmberg KJ, Lindbom L, Eriksson EE. Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice. Am J Pathol 2010; 177(1): 493-500. https://www.ncbi.nlm.nih.gov/pubmed/20472897
Saygili E, Schauerte P, Kuppers F, Heck L, Weis J, Weber C, Schwinger RH, Hoffmann R, Schroder JW, Marx N, Rana OR. Electrical stimulation of sympathetic neurons induces autocrine/paracrine effects of NGF mediated by TrkA. J Mol Cell Cardiol 2010; 49(1): 79-87. https://www.ncbi.nlm.nih.gov/pubmed/20138055
Schober LJ, Khandoga AL, Penz SM, Siess W. The EP3-agonist sulprostone, but not prostaglandin E2 potentiates platelet aggregation in human blood. Thromb Haemost 2010; 103(6): 1268-9. https://www.ncbi.nlm.nih.gov/pubmed/20431854
Schreinemachers MC, Doorschodt BM, Florquin S, van den Bergh Weerman MA, Zernecke A, Idu MM, Tolba RH, van Gulik TM. Pulsatile perfusion preservation of warm ischaemia-damaged experimental kidney grafts. Br J Surg 2010; 97(3): 349-58. https://www.ncbi.nlm.nih.gov/pubmed/20095019
Schwarz N, Pruessmeyer J, Hess FM, Dreymueller D, Pantaler E, Koelsch A, Windoffer R, Voss M, Sarabi A, Weber C, Sechi AS, Uhlig S, Ludwig A. Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1. Cell Mol Life Sci 2010; 67(24): 4233-48. https://www.ncbi.nlm.nih.gov/pubmed/20559678
Seijkens T, Engel D, Tjwa M, Lutgens E. The role of CD154 in haematopoietic development. Thromb Haemost 2010; 104(4): 693-701. https://www.ncbi.nlm.nih.gov/pubmed/20694278
Shagdarsuren E, Bidzhekov K, Mause SF, Simsekyilmaz S, Polakowski T, Hawlisch H, Gessner JE, Zernecke A, Weber C. C5a receptor targeting in neointima formation after arterial injury in atherosclerosis-prone mice. Circulation 2010; 122(10): 1026-36. https://www.ncbi.nlm.nih.gov/pubmed/20733098
Soehnlein O, Eriksson S, Hjelmqvist H, Andersson A, Morgelin M, Lindbom L, Rundgren M, Frithiof R. Anesthesia aggravates lung damage and precipitates hypotension in endotoxemic sheep. Shock 2010; 34(4): 412-9. https://www.ncbi.nlm.nih.gov/pubmed/20844413
Soehnlein O, Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol 2010; 10(6): 427-39. https://www.ncbi.nlm.nih.gov/pubmed/20498669
Subramanian P, Karshovska E, Reinhard P, Megens RT, Zhou Z, Akhtar S, Schumann U, Li X, van Zandvoort M, Ludin C, Weber C, Schober A. Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation. Circ Res 2010; 107(1): 96-105. https://www.ncbi.nlm.nih.gov/pubmed/20360252
Subramanian P, Schober A. Neointima formation after vascular injury: is it all about CD39? Thromb Haemost 2010; 103(2): 257-8. https://www.ncbi.nlm.nih.gov/pubmed/20076840
van Triest HJ, Megens RT, van Assen HC, ter Haar Romeny BM, van Zandvoort MA. Arterial radius estimation from microscopic data using a new algorithm for circle parameter estimation. J Biomed Opt 2010; 15(2): 026012. https://www.ncbi.nlm.nih.gov/pubmed/20459257
Vasina E, Heemskerk JW, Weber C, Koenen RR. Platelets and platelet-derived microparticles in vascular inflammatory disease. Inflamm Allergy Drug Targets 2010; 9(5): 346-54. https://www.ncbi.nlm.nih.gov/pubmed/21054257
Weber C. Far from the heart: Receptor cross-talk in remote conditioning. Nat Med 2010; 16(7): 760-2. https://www.ncbi.nlm.nih.gov/pubmed/20613755
Weber C. Obstacles and options in the quest for drug candidates against vascular disease. Thromb Haemost 2010; 104(1): 1-3. https://www.ncbi.nlm.nih.gov/pubmed/20508900
Weber C, Lip GY. Moving forward with a new editorial team for Thrombosis and Haemostasis. Thromb Haemost 2010; 103(1): 1-2. https://www.ncbi.nlm.nih.gov/pubmed/20062942
Weber C, Schober A, Zernecke A. MicroRNAs in arterial remodelling, inflammation and atherosclerosis. Curr Drug Targets 2010; 11(8): 950-6. https://www.ncbi.nlm.nih.gov/pubmed/20415650
Wiesner C, Faix J, Himmel M, Bentzien F, Linder S. KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophages. Blood 2010; 116(9): 1559-69. https://www.ncbi.nlm.nih.gov/pubmed/20505159
Zaldivar MM, Pauels K, von Hundelshausen P, Berres ML, Schmitz P, Bornemann J, Kowalska MA, Gassler N, Streetz KL, Weiskirchen R, Trautwein C, Weber C, Wasmuth HE. CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis. Hepatology 2010; 51(4): 1345-53. https://www.ncbi.nlm.nih.gov/pubmed/20162727
Zernecke A, Weber C. Chemokines in the vascular inflammatory response of atherosclerosis. Cardiovasc Res 2010; 86(2): 192-201. https://www.ncbi.nlm.nih.gov/pubmed/20007309
Zimmermann HW, Seidler S, Nattermann J, Gassler N, Hellerbrand C, Zernecke A, Tischendorf JJ, Luedde T, Weiskirchen R, Trautwein C, Tacke F. Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One 2010; 5(6): e11049. https://www.ncbi.nlm.nih.gov/pubmed/20548789

2009

Doorschodt BM, Schreinemachers MC, Florquin S, Lai W, Sitzia M, Zernecke A, Tolba RH. Evaluation of a novel system for hypothermic oxygenated pulsatile perfusion preservation. Int J Artif Organs 2009; 32(10): 728-738. https://www.ncbi.nlm.nih.gov/pubmed/19943234
Goetzenich A, Hatam N, Zernecke A, Weber C, Czarnotta T, Autschbach R, Christiansen S. Alteration of matrix metalloproteinases in selective left ventricular adriamycin-induced cardiomyopathy in the pig. J Heart Lung Transplant 2009; 28(10): 1087-1093. https://www.ncbi.nlm.nih.gov/pubmed/19782292
Hristov M, Schmitz S, Schuhmann C, Leyendecker T, von Hundelshausen P, Krotz F, Sohn HY, Nauwelaers FA, Weber C. An optimized flow cytometry protocol for analysis of angiogenic monocytes and endothelial progenitor cells in peripheral blood. Cytometry A 2009; 75(10): 848-853. https://www.ncbi.nlm.nih.gov/pubmed/19739088
Hristov M, Weber C. Progenitor cell trafficking in the vascular wall. J Thromb Haemost 2009; 7 Suppl 1: 31-34. https://www.ncbi.nlm.nih.gov/pubmed/19630763
Karlmark KR, Weiskirchen R, Zimmermann HW, Gassler N, Ginhoux F, Weber C, Merad M, Luedde T, Trautwein C, Tacke F. Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 2009; 50(1): 261-274. https://www.ncbi.nlm.nih.gov/pubmed/19554540
Koenen RR, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, Reiss K, Sarabi A, Lindbom L, Hackeng TM, Weber C, Ludwig A. Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases. Blood 2009; 113(19): 4799-4809. https://www.ncbi.nlm.nih.gov/pubmed/19258599
Koenen RR, von Hundelshausen P, Nesmelova IV, Zernecke A, Liehn EA, Sarabi A, Kramp BK, Piccinini AM, Paludan SR, Kowalska MA, Kungl AJ, Hackeng TM, Mayo KH, Weber C. Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. Nat Med 2009; 15(1): 97-103. https://www.ncbi.nlm.nih.gov/pubmed/19122657
Landsman L, Bar-On L, Zernecke A, Kim KW, Krauthgamer R, Shagdarsuren E, Lira SA, Weissman IL, Weber C, Jung S. CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood 2009; 113(4): 963-972. https://www.ncbi.nlm.nih.gov/pubmed/18971423
Lievens D, Eijgelaar WJ, Biessen EA, Daemen MJ, Lutgens E. The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost 2009; 102(2): 206-214. https://www.ncbi.nlm.nih.gov/pubmed/19652870
Malycha F, Eggermann T, Hristov M, Schena FP, Mertens PR, Zerres K, Floege J, Eitner F. No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy patients. Nephrol Dial Transplant 2009; 24(1): 321-324. https://www.ncbi.nlm.nih.gov/pubmed/18840896
Matthijsen RA, de Winther MP, Kuipers D, van der Made I, Weber C, Herias MV, Gijbels MJ, Buurman WA. Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 2009; 119(16): 2188-2195. https://www.ncbi.nlm.nih.gov/pubmed/19380618
Mause SF, Weber C. Intrusion through the fragile back door: immature plaque microvessels as entry portals for leukocytes and erythrocytes in atherosclerosis. J Am Coll Cardiol 2009; 53(17): 1528-1531. https://www.ncbi.nlm.nih.gov/pubmed/19389563
Noels H, Bernhagen J, Weber C. Macrophage migration inhibitory factor: a noncanonical chemokine important in atherosclerosis. Trends Cardiovasc Med 2009; 19(3): 76-86. https://www.ncbi.nlm.nih.gov/pubmed/19679264
Noels H, Somers R, Liu H, Ye H, Du MQ, De Wolf-Peeters C, Marynen P, Baens M. Auto-ubiquitination-induced degradation of MALT1-API2 prevents BCL10 destabilization in t(11;18)(q21;q21)-positive MALT lymphoma. PLoS One 2009; 4(3): e4822. https://www.ncbi.nlm.nih.gov/pubmed/19279678
Quast T, Tappertzhofen B, Schild C, Grell J, Czeloth N, Forster R, Alon R, Fraemohs L, Dreck K, Weber C, Lammermann T, Sixt M, Kolanus W. Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. Blood 2009; 113(23): 5801-5810. https://www.ncbi.nlm.nih.gov/pubmed/19346499
Raffetseder U, Rauen T, Djudjaj S, Kretzler M, En-Nia A, Tacke F, Zimmermann HW, Nelson PJ, Frye BC, Floege J, Stefanidis I, Weber C, Mertens PR. Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1. Kidney Int 2009; 75(2): 185-196. https://www.ncbi.nlm.nih.gov/pubmed/18800033
Rana OR, Saygili E, Meyer C, Gemein C, Kruttgen A, Andrzejewski MG, Ludwig A, Schotten U, Schwinger RH, Weber C, Weis J, Mischke K, Rassaf T, Kelm M, Schauerte P. Regulation of nerve growth factor in the heart: the role of the calcineurin-NFAT pathway. J Mol Cell Cardiol 2009; 46(4): 568-578. https://www.ncbi.nlm.nih.gov/pubmed/19150448
Saygili E, Rana OR, Meyer C, Gemein C, Andrzejewski MG, Ludwig A, Weber C, Schotten U, Kruttgen A, Weis J, Schwinger RH, Mischke K, Rassaf T, Kelm M, Schauerte P. The angiotensin-calcineurin-NFAT pathway mediates stretch-induced up-regulation of matrix metalloproteinases-2/-9 in atrial myocytes. Basic Res Cardiol 2009; 104(4): 435-448. https://www.ncbi.nlm.nih.gov/pubmed/19148693
Schroder K, Kohnen A, Aicher A, Liehn EA, Buchse T, Stein S, Weber C, Dimmeler S, Brandes RP. NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells. Circ Res 2009; 105(6): 537-544. https://www.ncbi.nlm.nih.gov/pubmed/19679834
Schuh A, Liehn EA, Sasse A, Schneider R, Neuss S, Weber C, Kelm M, Merx MW. Improved left ventricular function after transplantation of microspheres and fibroblasts in a rat model of myocardial infarction. Basic Res Cardiol 2009; 104(4): 403-411. https://www.ncbi.nlm.nih.gov/pubmed/19139948
Schwartz V, Lue H, Kraemer S, Korbiel J, Krohn R, Ohl K, Bucala R, Weber C, Bernhagen J. A functional heteromeric MIF receptor formed by CD74 and CXCR4. FEBS Lett 2009; 583(17): 2749-2757. https://www.ncbi.nlm.nih.gov/pubmed/19665027
Segerer S, Johnson Z, Rek A, Baltus T, von Hundelshausen P, Kungl AJ, Proudfoot AE, Weber C, Nelson PJ. The basic residue cluster (55)KKWVR(59) in CCL5 is required for in vivo biologic function. Mol Immunol 2009; 46(13): 2533-2538. https://www.ncbi.nlm.nih.gov/pubmed/19524301
Shagdarsuren E, Djalali-Talab Y, Aurrand-Lions M, Bidzhekov K, Liehn EA, Imhof BA, Weber C, Zernecke A. Importance of junctional adhesion molecule-C for neointimal hyperplasia and monocyte recruitment in atherosclerosis-prone mice-brief report. Arterioscler Thromb Vasc Biol 2009; 29(8): 1161-1163. https://www.ncbi.nlm.nih.gov/pubmed/19520977
Soehnlein O. An elegant defense: how neutrophils shape the immune response. Trends Immunol 2009; 30(11): 511-512. https://www.ncbi.nlm.nih.gov/pubmed/19709929
Soehnlein O. Direct and alternative antimicrobial mechanisms of neutrophil-derived granule proteins. J Mol Med (Berl) 2009; 87(12): 1157-1164. https://www.ncbi.nlm.nih.gov/pubmed/19641860
Soehnlein O, Drechsler M, Hristov M, Weber C. Functional alterations of myeloid cell subsets in hyperlipidaemia: relevance for atherosclerosis. J Cell Mol Med 2009; 13(11-12): 4293-4303. https://www.ncbi.nlm.nih.gov/pubmed/19900213
Soehnlein O, Lindbom L. Neutrophil-derived azurocidin alarms the immune system. J Leukoc Biol 2009; 85(3): 344-351. https://www.ncbi.nlm.nih.gov/pubmed/18955543
Soehnlein O, Lindbom L, Weber C. Mechanisms underlying neutrophil-mediated monocyte recruitment. Blood 2009; 114(21): 4613-4623. https://www.ncbi.nlm.nih.gov/pubmed/19696199
Soehnlein O, Weber C. Myeloid cells in atherosclerosis: initiators and decision shapers. Semin Immunopathol 2009; 31(1): 35-47. https://www.ncbi.nlm.nih.gov/pubmed/19238385
Soehnlein O, Weber C, Lindbom L. Neutrophil granule proteins tune monocytic cell function. Trends Immunol 2009; 30(11): 538-546. https://www.ncbi.nlm.nih.gov/pubmed/19699683
Soehnlein O, Zernecke A, Weber C. Neutrophils launch monocyte extravasation by release of granule proteins. Thromb Haemost 2009; 102(2): 198-205. https://www.ncbi.nlm.nih.gov/pubmed/19652869
Taylor J, Weber C. European Perspectives - Spotlight: Christian Weber, MD, FESC - FESC Aiming to Selectively Target Platelet Chemokine Heteromers and Macrophage Migration Inhibitory Factor Receptors to Diagnose, Treat, and Prevent Atherosclerosis. Circulation 2009; 119(24): f139-f141. https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.109.192208
Taylor J, Weber C. European Perspectives - Team 2009: Institute for Molecular Cardiovascular Research, Aachen, Germany. Circulation 2009; 119(24): f142-f143. https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.109.192208
Taylor J, Weber C. European Perspectives - Initiatives in cardiovascular Research: the Euregio Cardiovascular Research School. Circulation 2009; 119(24): f144. https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.109.192208
Tjwa M, Moons L, Lutgens E. Pleiotropic role of growth arrest-specific gene 6 in atherosclerosis. Curr Opin Lipidol 2009; 20(5): 386-392. https://www.ncbi.nlm.nih.gov/pubmed/19644365
von Hundelshausen P, Koenen RR, Weber C. Platelet-mediated enhancement of leukocyte adhesion. Microcirculation 2009; 16(1): 84-96. https://www.ncbi.nlm.nih.gov/pubmed/19115139
Weber C. Frontiers of vascular biology: mechanisms of inflammation and immunoregulation during arterial remodelling. Thromb Haemost 2009; 102(2): 188-190. https://www.ncbi.nlm.nih.gov/pubmed/19652867
Weber C. Monozyten und Leukozyten. In: Pötzsch B, Madlener K, eds. Hämostaseologie. Berlin, Heidelberg: Springer Berlin Heidelberg; 2010: 105-111. https://doi.org/10.1007/978-3-642-01544-1_13
Wojcikiewicz EP, Koenen RR, Fraemohs L, Minkiewicz J, Azad H, Weber C, Moy VT. LFA-1 binding destabilizes the JAM-A homophilic interaction during leukocyte transmigration. Biophys J 2009; 96(1): 285-293. https://www.ncbi.nlm.nih.gov/pubmed/18849408
Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, Hristov M, Koppel T, Jahantigh MN, Lutgens E, Wang S, Olson EN, Schober A, Weber C. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal 2009; 2(100): ra81. https://www.ncbi.nlm.nih.gov/pubmed/19996457
Zouggari Y, Ait-Oufella H, Waeckel L, Vilar J, Loinard C, Cochain C, Recalde A, Duriez M, Levy BI, Lutgens E, Mallat Z, Silvestre JS. Regulatory T cells modulate postischemic neovascularization. Circulation 2009; 120(14): 1415-1425. https://www.ncbi.nlm.nih.gov/pubmed/19770391

2008

Buccione R, Gimona M, Linder S. FEBS workshop: invadopodia podosomes and focal adhesions in tissue invasion. Eur J Cell Biol 2008; 87(8-9): 457-750. https://www.sciencedirect.com/journal/european-journal-of-cell-biology/vol/87/issue/8
Dragomir E, Manduteanu I, Calin M, Gan AM, Stan D, Koenen RR, Weber C, Simionescu M. High glucose conditions induce upregulation of fractalkine and monocyte chemotactic protein-1 in human smooth muscle cells. Thromb Haemost 2008; 100(6): 1155-1165. https://www.ncbi.nlm.nih.gov/pubmed/19132243
Gimona M, Buccione R, Courtneidge SA, Linder S. Assembly and biological role of podosomes and invadopodia. Curr Opin Cell Biol 2008; 20(2): 235-41. https://www.ncbi.nlm.nih.gov/pubmed/18337078
Khandoga AL, Fujiwara Y, Goyal P, Pandey D, Tsukahara R, Bolen A, Guo H, Wilke N, Liu J, Valentine WJ, Durgam GG, Miller DD, Jiang G, Prestwich GD, Tigyi G, Siess W. Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin. Platelets 2008; 19(6): 415-27. https://www.ncbi.nlm.nih.gov/pubmed/18925509
Krump-Konvalinkova V, Chwalla I, Siess W. FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression. Biochem Biophys Res Commun 2008; 370(4): 603-8. https://www.ncbi.nlm.nih.gov/pubmed/18402775
Reichel CA, Rehberg M, Bihari P, Moser CM, Linder S, Khandoga A, Krombach F. Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus specificity and a critical role in collagen IV remodeling. J Leukoc Biol 2008; 83(4): 864-74. https://www.ncbi.nlm.nih.gov/pubmed/18174361
Rode S, Rubic T, Lorenz RL. alpha-Tocopherol disturbs macrophage LXRalpha regulation of ABCA1/G1 and cholesterol handling. Biochem Biophys Res Commun 2008; 369(3): 868-72. https://www.ncbi.nlm.nih.gov/pubmed/18328805
Schulz C, Konrad I, Sauer S, Orschiedt L, Koellnberger M, Lorenz R, Walter U, Massberg S. Effect of chronic treatment with acetylsalicylic acid and clopidogrel on atheroprogression and atherothrombosis in ApoE-deficient mice in vivo. Thromb Haemost 2008; 99(1): 190-5. https://www.ncbi.nlm.nih.gov/pubmed/18217153
Schulz C, Penz S, Hoffmann C, Langer H, Gillitzer A, Schneider S, Brandl R, Seidl S, Massberg S, Pichler B, Kremmer E, Stellos K, Schonberger T, Siess W, Gawaz M. Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo. Basic Res Cardiol 2008; 103(4): 356-67. https://www.ncbi.nlm.nih.gov/pubmed/18431526
Thal D, Xavier CP, Rosentreter A, Linder S, Friedrichs B, Waha A, Pietsch T, Stumpf M, Noegel A, Clemen C. Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy. J Pathol 2008; 214(4): 415-24. https://www.ncbi.nlm.nih.gov/pubmed/18189330
Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hengst L, Hofmann F, Feil R. Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells. Mol Biol Cell 2008; 19(10): 4434-41. https://www.ncbi.nlm.nih.gov/pubmed/18685080

2007

Chellaiah MA, Kuppuswamy D, Lasky L, Linder S. Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorption. J Biol Chem 2007; 282(13): 10104-16. https://www.ncbi.nlm.nih.gov/pubmed/17283076
Erl W. Atorvastatin-induced downregulation of survivin and vascular smooth muscle cell apoptosis: a causal relationship in restenosis? Cardiovasc Drugs Ther 2007; 21(3): 141-4. https://www.ncbi.nlm.nih.gov/pubmed/17486302
Kumar A, Tyagi NK, Goyal P, Pandey D, Siess W, Kinne RK. Sodium-independent low-affinity D-glucose transport by human sodium/D-glucose cotransporter 1: critical role of tryptophan 561. Biochemistry 2007; 46(10): 2758-66. https://www.ncbi.nlm.nih.gov/pubmed/17288452
Linder S. The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol 2007; 17(3): 107-17. https://www.ncbi.nlm.nih.gov/pubmed/17275303
Newill H, Loske R, Wagner J, Johannes C, Lorenz RL, Lehmann L. Oxidation products of stigmasterol interfere with the action of the female sex hormone 17beta-estradiol in cultured human breast and endometrium cell lines. Mol Nutr Food Res 2007; 51(7): 888-98. https://www.ncbi.nlm.nih.gov/pubmed/17579897
Pandey D, Goyal P, Siess W. Lysophosphatidic acid stimulation of platelets rapidly induces Ca2+-dependent dephosphorylation of cofilin that is independent of dense granule secretion and aggregation. Blood Cells Mol Dis 2007; 38(3): 269-79. https://www.ncbi.nlm.nih.gov/pubmed/17321765
Penz SM, Reininger AJ, Toth O, Deckmyn H, Brandl R, Siess W. Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques. Thromb Haemost 2007; 97(3): 435-43. https://www.ncbi.nlm.nih.gov/pubmed/17334511
Trasak C, Zenner G, Vogel A, Yuksekdag G, Rost R, Haase I, Fischer M, Israel L, Imhof A, Linder S, Schleicher M, Aepfelbacher M. Yersinia protein kinase YopO is activated by a novel G-actin binding process. J Biol Chem 2007; 282(4): 2268-77. https://www.ncbi.nlm.nih.gov/pubmed/17121817
Tyagi NK, Kumar A, Goyal P, Pandey D, Siess W, Kinne RK. D-Glucose-recognition and phlorizin-binding sites in human sodium/D-glucose cotransporter 1 (hSGLT1): a tryptophan scanning study. Biochemistry 2007; 46(47): 13616-28. https://www.ncbi.nlm.nih.gov/pubmed/17983207

2006

Daub K, Langer H, Seizer P, Stellos K, May AE, Goyal P, Bigalke B, Schonberger T, Geisler T, Siegel-Axel D, Oostendorp RA, Lindemann S, Gawaz M. Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells. FASEB J 2006; 20(14): 2559-2561. https://www.ncbi.nlm.nih.gov/pubmed/17077283
Goyal P, Pandey D, Siess W. Phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells. J Biol Chem 2006; 281(35): 25223-25230. https://www.ncbi.nlm.nih.gov/pubmed/16820362
Gringel A, Walz D, Rosenberger G, Minden A, Kutsche K, Kopp P, Linder S. PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation. J Cell Physiol 2006; 209(2): 568-579. https://www.ncbi.nlm.nih.gov/pubmed/16897755
Kopp P, Lammers R, Aepfelbacher M, Woehlke G, Rudel T, Machuy N, Steffen W, Linder S. The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages. Mol Biol Cell 2006; 17(6): 2811-2823. https://www.ncbi.nlm.nih.gov/pubmed/16554367
Linder S. Proceedings of the Adhesion Meeting, Munich, Germany, April 28-30, 2005. Eur J Cell Biol 2006; 85(3-4): 143-332. https://www.ncbi.nlm.nih.gov/pubmed/16546555
Massberg S, Konrad I, Schurzinger K, Lorenz M, Schneider S, Zohlnhoefer D, Hoppe K, Schiemann M, Kennerknecht E, Sauer S, Schulz C, Kerstan S, Rudelius M, Seidl S, Sorge F, Langer H, Peluso M, Goyal P, Vestweber D, Emambokus NR, Busch DH, Frampton J, Gawaz M. Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med 2006; 203(5): 1221-1233. https://www.ncbi.nlm.nih.gov/pubmed/16618794
Pandey D, Goyal P, Bamburg JR, Siess W. Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets. Blood 2006; 107(2): 575-583. https://www.ncbi.nlm.nih.gov/pubmed/16219803
Pfrommer CA, Erl W, Weber PC. Docosahexaenoic acid induces ciap1 mRNA and protects human endothelial cells from stress-induced apoptosis. Am J Physiol Heart Circ Physiol 2006; 290(6): H2178-2186. https://www.ncbi.nlm.nih.gov/pubmed/16473961
Rubic T, Lorenz RL. Downregulated CD36 and oxLDL uptake and stimulated ABCA1/G1 and cholesterol efflux as anti-atherosclerotic mechanisms of interleukin-10. Cardiovasc Res 2006; 69(2): 527-535. https://www.ncbi.nlm.nih.gov/pubmed/16336952
Schroder A, Schroder B, Roppenser B, Linder S, Sinha B, Fassler R, Aepfelbacher M. Staphylococcus aureus fibronectin binding protein-A induces motile attachment sites and complex actin remodeling in living endothelial cells. Mol Biol Cell 2006; 17(12): 5198-5210. https://www.ncbi.nlm.nih.gov/pubmed/17021255
Siess W. Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein. Pathophysiol Haemost Thromb 2006; 35(3-4): 292-304. https://www.ncbi.nlm.nih.gov/pubmed/16877878
Toth O, Calatzis A, Penz S, Losonczy H, Siess W. Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood. Thromb Haemost 2006; 96(6): 781-788. https://www.ncbi.nlm.nih.gov/pubmed/17139373
Ussar S, Wang HV, Linder S, Fassler R, Moser M. The Kindlins: subcellular localization and expression during murine development. Exp Cell Res 2006; 312(16): 3142-3151. https://www.ncbi.nlm.nih.gov/pubmed/16876785
Weber GF, Gaertner FC, Erl W, Janssen KP, Blechert B, Holzmann B, Weighardt H, Essler M. IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase. J Immunol 2006; 177(11): 8266-8272. https://www.ncbi.nlm.nih.gov/pubmed/17114505

2005

Bu DX, Erl W, de Martin R, Hansson GK, Yan ZQ. IKKbeta-dependent NF-kappaB pathway controls vascular inflammation and intimal hyperplasia. FASEB J 2005; 19(10): 1293-5. https://www.ncbi.nlm.nih.gov/pubmed/15939736
Durgam GG, Virag T, Walker MD, Tsukahara R, Yasuda S, Liliom K, van Meeteren LA, Moolenaar WH, Wilke N, Siess W, Tigyi G, Miller DD. Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. J Med Chem 2005; 48(15): 4919-30. https://www.ncbi.nlm.nih.gov/pubmed/16033271
Erl W. Statin-induced vascular smooth muscle cell apoptosis: a possible role in the prevention of restenosis? Curr Drug Targets Cardiovasc Haematol Disord 2005; 5(2): 135-44. https://www.ncbi.nlm.nih.gov/pubmed/15853755
Gimona M, Grashoff C, Kopp P. Oktoberfest for adhesion structures. EMBO Rep 2005; 6(10): 922-6. https://www.ncbi.nlm.nih.gov/pubmed/16170307
Gopfert MS, Siedler F, Siess W, Sellmayer A. Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation. J Vasc Res 2005; 42(2): 120-32. https://www.ncbi.nlm.nih.gov/pubmed/15665547
Goyal P, Pandey D, Behring A, Siess W. Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283. J Biol Chem 2005; 280(30): 27569-77. https://www.ncbi.nlm.nih.gov/pubmed/15923181
Kim HJ, Vosseler CA, Weber PC, Erl W. Docosahexaenoic acid induces apoptosis in proliferating human endothelial cells. J Cell Physiol 2005; 204(3): 881-8. https://www.ncbi.nlm.nih.gov/pubmed/15795939
Krump-Konvalinkova V, Yasuda S, Rubic T, Makarova N, Mages J, Erl W, Vosseler C, Kirkpatrick CJ, Tigyi G, Siess W. Stable knock-down of the sphingosine 1-phosphate receptor S1P1 influences multiple functions of human endothelial cells. Arterioscler Thromb Vasc Biol 2005; 25(3): 546-52. https://www.ncbi.nlm.nih.gov/pubmed/15618544
Linder S. Understanding cell-matrix contacts with the help of nucleofection. Amexa Newsletter 2005; 6(11).
Linder S, Kopp P. Podosomes at a glance. J Cell Sci 2005; 118(Pt 10): 2079-82. https://www.ncbi.nlm.nih.gov/pubmed/15890982
Osiak AE, Zenner G, Linder S. Subconfluent endothelial cells form podosomes downstream of cytokine and RhoGTPase signaling. Exp Cell Res 2005; 307(2): 342-53. https://www.ncbi.nlm.nih.gov/pubmed/15894313
Penz S, Reininger AJ, Brandl R, Goyal P, Rabie T, Bernlochner I, Rother E, Goetz C, Engelmann B, Smethurst PA, Ouwehand WH, Farndale R, Nieswandt B, Siess W. Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI. FASEB J 2005; 19(8): 898-909. https://www.ncbi.nlm.nih.gov/pubmed/15923400
Tyagi NK, Goyal P, Kumar A, Pandey D, Siess W, Kinne RK. High-yield functional expression of human sodium/d-glucose cotransporter1 in Pichia pastoris and characterization of ligand-induced conformational changes as studied by tryptophan fluorescence. Biochemistry 2005; 44(47): 15514-24. https://www.ncbi.nlm.nih.gov/pubmed/16300400