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Publications 2023

  1. Aghdassi A, Schwedhelm E, Atzler D, Nauck M, Kuhn JP, Kromrey ML, Volzke H, Felix SB, Dorr M, Ittermann T, Bahls M. The relationship between homoarginine and liver biomarkers: a combination of epidemiological and clinical studies. Sci Rep 2023; 13(1): 5230. https://www.ncbi.nlm.nih.gov/pubmed/36997574
  2. Baretella O, Buser L, Andres C, Haberli D, Lenz A, Doring Y, Baumgartner I, Schindewolf M. Association of sex and cardiovascular risk factors with atherosclerosis distribution pattern in lower extremity peripheral artery disease. Front Cardiovasc Med 2023; 10: 1004003. https://www.ncbi.nlm.nih.gov/pubmed/37441701
  3. Bazioti V, Halmos B, Westerterp M. T-cell Cholesterol Accumulation, Aging, and Atherosclerosis. Current Atherosclerosis Reports 2023; 25(9): 527-534. https://www.ncbi.nlm.nih.gov/pubmed/37395922
  4. Bianchini M, Moller-Ramon Z, Weber C, Megens RTA, Duchene J. Short-Term Western Diet Causes Rapid and Lasting Alterations of Bone Marrow Physiology. Thromb Haemost 2023; 123(11): 1100-1104. https://www.ncbi.nlm.nih.gov/pubmed/37549687
  5. Blanchet X, Weber C, von Hundelshausen P. Chemokine Heteromers and Their Impact on Cellular Function-A Conceptual Framework. Int J Mol Sci 2023; 24(13). https://www.ncbi.nlm.nih.gov/pubmed/37446102
  6. Bochenek ML, Saar K, Nazari-Jahantigh M, Gogiraju R, Wiedenroth CB, Münzel T, Mayer E, Fink L, Schober A, Hübner N, Guth S, Konstantinides S, Schäfer K. Endothelial Overexpression of TGF-β-Induced Protein Impairs Venous Thrombus Resolution. JACC: Basic to Translational Science Epub 2023. https://www.jacc.org/doi/abs/10.1016/j.jacbts.2023.08.005
  7. Bonfiglio CA, Weber C, Atzler D, Lutgens E. Immunotherapy and cardiovascular diseases: novel avenues for immunotherapeutic approaches. QJM 2023; 116(4): 271-278. https://www.ncbi.nlm.nih.gov/pubmed/34293177
  8. Bosmans LA, van Tiel CM, Aarts S, Willemsen L, Baardman J, van Os BW, Toom MD, Beckers L, Ahern DJ, Levels JHM, Jongejan A, Moerland PD, Verberk SGS, den Bossche JV, de Winther M, Weber C, Atzler D, Monaco C, Gerdes N, Shami A, Lutgens E. Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state. Cardiovasc Res 2023; 119(5): 1146-1160. https://www.ncbi.nlm.nih.gov/pubmed/35587037
  9. Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou AD, Schubel M, Jobst J, Zhang T, Dorr J, Markl F, Majed L, Muller PJ, May P, Gottschlich A, Tokarew N, Lucke J, Oner A, Schwerdtfeger M, Andreu-Sanz D, Grunmeier R, Seifert M, Michaelides S, Hristov M, Konig LM, Cadilha BL, Mikhaylov O, Anders HJ, Rothenfusser S, Flavell RA, Cerezo-Wallis D, Tejedo C, Soengas MS, Bald T, Huber S, Endres S, Kobold S. T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis. Immunity 2023; 56(1): 143-161 e111. https://www.ncbi.nlm.nih.gov/pubmed/36630913
  10. Cimen I, Natarelli L, Abedi Kichi Z, Henderson JM, Farina FM, Briem E, Aslani M, Megens RTA, Jansen Y, Mann-Fallenbuchel E, Gencer S, Duchene J, Nazari-Jahantigh M, van der Vorst EPC, Enard W, Doring Y, Schober A, Santovito D, Weber C. Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice. Sci Transl Med 2023; 15(720): eadf3357. https://www.ncbi.nlm.nih.gov/pubmed/37910599
  11. de Winther MPJ, Back M, Evans P, Gomez D, Goncalves I, Jorgensen HF, Koenen RR, Lutgens E, Norata GD, Osto E, Dib L, Simons M, Stellos K, Yla-Herttuala S, Winkels H, Bochaton-Piallat ML, Monaco C. Translational opportunities of single-cell biology in atherosclerosis. Eur Heart J 2023; 44(14): 1216-1230. https://www.ncbi.nlm.nih.gov/pubmed/36478058
  12. Duan R, Ni Q, Li Y, Zhu M, Li W, Wang P, Yuan K, von Hundelshausen P, Zhu J, Zhang L, Lv L. Lymphocytes, Mean Platelet Volume, and Albumin in Critically Ill COVID-19 Patients with Venous Thromboembolism. Clin Appl Thromb Hemost 2023; 29: 10760296231177676. https://www.ncbi.nlm.nih.gov/pubmed/37229645
  13. Ebert S, Zang L, Ismail N, Otabil M, Frohlich A, Egea V, Acs S, Hoeberg M, Berres ML, Weber C, Moreira JMA, Ries C, Bernhagen J, El Bounkari O. Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation. Cells 2023; 12(14). https://www.ncbi.nlm.nih.gov/pubmed/37508563
  14. Egea V, Megens RTA, Santovito D, Wantha S, Brandl R, Siess W, Khani S, Soehnlein O, Bartelt A, Weber C, Ries C. Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques. Cardiovasc Res 2023; 119(1): 155-166. https://www.ncbi.nlm.nih.gov/pubmed/35238350
  15. Farina FM, Weber C, Santovito D. The emerging landscape of non-conventional RNA functions in atherosclerosis. Atherosclerosis 2023; 374: 74-86. https://www.ncbi.nlm.nih.gov/pubmed/36725418
  16. Ferraro B, Giustetto P, Schengel O, Weckbach LT, Maegdefessel L, Soehnlein O. Longitudinal In Vivo Monitoring of Atheroprogression in Hypercholesterolemic Mice Using Photoacoustic Imaging. Thromb Haemost 2023; 123(5): 545-554. https://www.ncbi.nlm.nih.gov/pubmed/36596447
  17. Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A, Gallo A, Drakos SG, Dimmeler S, Sperandio M, Soehnlein O, Stellos K. The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation. Immunity 2023; 56(5): 979-997 e911. https://www.ncbi.nlm.nih.gov/pubmed/37100060
  18. Gencer S, van der Vorst EPC. Role of G-Protein-Coupled Receptors in Cardiovascular Diseases. Int J Mol Sci 2023; 24(9). https://www.ncbi.nlm.nih.gov/pubmed/37175466
  19. Ghiboub M, Bell M, Sinkeviciute D, Prinjha RK, de Winther MPJ, Harker NR, Tough DF, de Jonge WJ. The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential. Curr Issues Mol Biol 2023; 45(5): 4228-4245. https://www.ncbi.nlm.nih.gov/pubmed/37232738
  20. Gigante B, Levy JH, van Gorp E, Bartoloni A, Bochaton-Piallat ML, Back M, Ten Cate H, Christersson C, Ferreiro JL, Geisler T, Lutgens E, Schulman S, Storey RF, Thachil J, Vilahur G, Liaw PC, Rocca B. Management of patients on antithrombotic therapy with severe infections: a joint clinical consensus statement of the ESC Working Group on Thrombosis, the ESC Working Group on Atherosclerosis and Vascular Biology, and the International Society on Thrombosis and Haemostasis. Eur Heart J 2023; 44(32): 3040-3058. https://www.ncbi.nlm.nih.gov/pubmed/37439553
  21. Giroud M, Kotschi S, Kwon Y, Le Thuc O, Hoffmann A, Gil-Lozano M, Karbiener M, Higareda-Almaraz JC, Khani S, Tews D, Fischer-Posovszky P, Sun W, Dong H, Ghosh A, Wolfrum C, Wabitsch M, Virtanen KA, Bluher M, Nielsen S, Zeigerer A, Garcia-Caceres C, Scheideler M, Herzig S, Bartelt A. The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes. EMBO Rep 2023; 24(10): e57600. https://www.ncbi.nlm.nih.gov/pubmed/37671834
  22. Gomez AM, Bartelt A. Endocrine communication of endoplasmic reticulum stress. Bioessays 2023; 45(8): e2300093. https://www.ncbi.nlm.nih.gov/pubmed/37318317
  23. Gyongyosi M, Alcaide P, Asselbergs FW, Brundel B, Camici GG, Martins PDC, Ferdinandy P, Fontana M, Girao H, Gnecchi M, Gollmann-Tepekoylu C, Kleinbongard P, Krieg T, Madonna R, Paillard M, Pantazis A, Perrino C, Pesce M, Schiattarella GG, Sluijter JPG, Steffens S, Tschope C, Van Linthout S, Davidson SM. Long COVID and the cardiovascular system-elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases. Cardiovasc Res 2023; 119(2): 336-356. https://www.ncbi.nlm.nih.gov/pubmed/35875883
  24. Imamdin A, van der Vorst EPC. Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases. Int J Mol Sci 2023; 24(2). https://www.ncbi.nlm.nih.gov/pubmed/36675065
  25. Kocberber Z, Willemsen N, Bartelt A. The role of proteasome activators PA28alphabeta and PA200 in brown adipocyte differentiation and function. Front Endocrinol (Lausanne) 2023; 14: 1176733. https://www.ncbi.nlm.nih.gov/pubmed/37201100
  26. Kopp EL, Deussen DN, Cuomo R, Lorenz R, Roth DM, Mahata SK, Patel HH. Modeling and Phenotyping Acute and Chronic Type 2 Diabetes Mellitus In Vitro in Rodent Heart and Skeletal Muscle Cells. Cells 2023; 12(24). https://www.ncbi.nlm.nih.gov/pubmed/38132105
  27. Kral M, van der Vorst EPC, Surnov A, Weber C, Doring Y. ILC2-mediated immune crosstalk in chronic (vascular) inflammation. Front Immunol 2023; 14: 1326440. https://www.ncbi.nlm.nih.gov/pubmed/38179045
  28. Krammer C, Yang B, Reichl S, Besson-Girard S, Ji H, Bolini V, Schulte C, Noels H, Schlepckow K, Jocher G, Werner G, Willem M, El Bounkari O, Kapurniotu A, Gokce O, Weber C, Mohanta S, Bernhagen J. Pathways linking aging and atheroprotection in Mif-deficient atherosclerotic mice. FASEB J 2023; 37(3): e22752. https://www.ncbi.nlm.nih.gov/pubmed/36794636
  29. Leberzammer J, von Hundelshausen P. Chemokines, molecular drivers of thromboinflammation and immunothrombosis. Front Immunol 2023; 14: 1276353. https://www.ncbi.nlm.nih.gov/pubmed/37954596
  30. Lemmer IL, Bartelt A. Brown fat has a sweet tooth. Nat Metab 2023; 5(7): 1080-1081. https://www.ncbi.nlm.nih.gov/pubmed/37337121
  31. Lemmer IL, Haas DT, Willemsen N, Kotschi S, Toksöz I, Gjika E, Khani S, Rohm M, Diercksen N, Nguyen PBH, Menden MP, Egu DT, Waschke J, Larsen S, Ma T, Gerhart-Hines Z, Herzig S, Dyar K, Krahmer N, Bartelt A. Nfe2l1-mediated proteasome function controls muscle energy metabolism in obesity. bioRxiv 2023: 2023.2004.2020.537611. https://www.biorxiv.org/content/biorxiv/early/2023/05/15/2023.04.20.537611.full.pdf
  32. Lin C, Mostafa A, Jans A, Wolters JC, Mohamed MR, Van der Vorst EPC, Trautwein C, Bartneck M. Targeting Ligand Independent Tropism of siRNA-LNP by Small Molecules for Directed Therapy of Liver or Myeloid Immune Cells. Adv Healthc Mater 2023: e2202670. https://www.ncbi.nlm.nih.gov/pubmed/36617516
  33. Lip GYH, Rigby A, Weber C. A Happy New Year 2023 from Thrombosis and Haemostasis. Thromb Haemost 2023; 123(1): 1-5. https://www.ncbi.nlm.nih.gov/pubmed/36626897
  34. Louradour J, Ottersberg R, Segiser A, Olejnik A, Martinez-Salazar B, Siegrist M, Egle M, Barbieri M, Nimani S, Alerni N, Doring Y, Odening KE, Longnus S. Simultaneous assessment of mechanical and electrical function in Langendorff-perfused ex-vivo mouse hearts. Front Cardiovasc Med 2023; 10: 1293032. https://www.ncbi.nlm.nih.gov/pubmed/38028448
  35. Maas SL, Donners M, van der Vorst EPC. ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? Int J Mol Sci 2023; 24(8). https://www.ncbi.nlm.nih.gov/pubmed/37108478
  36. Maas SL, Megens RTA, van der Vorst EPC. Ex Vivo Perfusion System to Analyze Chemokine-Driven Leukocyte Adhesion. Methods Mol Biol 2023; 2597: 59-75. https://www.ncbi.nlm.nih.gov/pubmed/36374414
  37. Maas SL, van der Vorst EPC. In Vitro (Trans)Migration Experiment Using Chemokines as Stimulatory Factor. Methods Mol Biol 2023; 2597: 77-87. https://www.ncbi.nlm.nih.gov/pubmed/36374415
  38. Matta L, Blaas L, de Faria CC. From honeymoon to dysfunction: brown fat remodelling in obesity. J Physiol 2023; 601(4): 711-713. https://www.ncbi.nlm.nih.gov/pubmed/36617494
  39. Matta L, Breves C, Fonte Boa L, Domingos AE, Faria CC, Souza I, Correia Lima-Junior N, Rocha APT, Gregorio BM, Carvalho DP, Ferreira ACF, Nascimento JHM, Maciel L, Fortunato RS. Quercetin improves white adipose tissue redox homeostasis in ovariectomized rats. J Endocrinol 2023; 259(2). https://www.ncbi.nlm.nih.gov/pubmed/37566237
  40. Melgrati S, Radice E, Ameti R, Hub E, Thelen S, Pelczar P, Jarrossay D, Rot A, Thelen M. Atlas of the anatomical localization of atypical chemokine receptors in healthy mice. PLoS Biol 2023; 21(5): e3002111. https://www.ncbi.nlm.nih.gov/pubmed/37159457
  41. Mena Gómez A, Bartelt A. Live lean and CRISPR – Engineering metabolism with FGF21 and FNDC5. Clinical and Translational Discovery 2023; 3(5): e230. https://onlinelibrary.wiley.com/doi/abs/10.1002/ctd2.230
  42. Mohanta SK, Sun T, Lu S, Wang Z, Zhang X, Yin C, Weber C, Habenicht AJR. The Impact of the Nervous System on Arteries and the Heart: The Neuroimmune Cardiovascular Circuit Hypothesis. Cells 2023; 12(20). https://www.ncbi.nlm.nih.gov/pubmed/37887328
  43. Mohanta SK, Yin C, Weber C, Godinho-Silva C, Veiga-Fernandes H, Xu QJ, Chang RB, Habenicht AJR. Cardiovascular Brain Circuits. Circ Res 2023; 132(11): 1546-1565. https://www.ncbi.nlm.nih.gov/pubmed/37228235
  44. Mohanta SK, Yin C, Weber C, Habenicht AJR. Neuroimmune cardiovascular interfaces in atherosclerosis. Front Cell Dev Biol 2023; 11: 1117368. https://www.ncbi.nlm.nih.gov/pubmed/36793445
  45. Naeimzadeh Y, Ilbeigi S, Dastsooz H, Rafiee Monjezi M, Mansoori Y, Tabei SMB. Protooncogenic Role of ARHGAP11A and ARHGAP11B in Invasive Ductal Carcinoma: Two Promising Breast Cancer Biomarkers. Biomed Res Int 2023; 2023: 8236853. https://www.ncbi.nlm.nih.gov/pubmed/38046902
  46. Nording H, Baron L, Sauter M, Lubken A, Rawish E, Szepanowski R, von Esebeck J, Sun Y, Emami H, Meusel M, Saraei R, Schanze N, Gorantla SP, von Bubnoff N, Geisler T, von Hundelshausen P, Stellos K, Marquardt J, Sadik CD, Kohl J, Duerschmied D, Kleinschnitz C, Langer HF. Platelets regulate ischemia-induced revascularization and angiogenesis by secretion of growth factor-modulating factors. Blood Adv 2023; 7(21): 6411-6427. https://www.ncbi.nlm.nih.gov/pubmed/37257194
  47. Pan C, Herrero-Fernandez B, Borja Almarcha C, Gomez Bris R, Zorita V, Saez A, Maas SL, Perez-Olivares L, Herrero-Cervera A, Lemnitzer P, van Avondt K, Silvestre-Roig C, Gonzalez-Granado JM, Chevre R, Soehnlein O. Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic Mice. Circulation 2023; 147(9): 774-777. https://www.ncbi.nlm.nih.gov/pubmed/36848415
  48. Pappritz K, Puhl SL, Matz I, Brauer E, Shia YX, El-Shafeey M, Koch SE, Miteva K, Mucha C, Duda GN, Petersen A, Steffens S, Tschope C, Van Linthout S. Sex- and age-related differences in the inflammatory properties of cardiac fibroblasts: impact on the cardiosplenic axis and cardiac fibrosis. Front Cardiovasc Med 2023; 10: 1117419. https://www.ncbi.nlm.nih.gov/pubmed/38054090
  49. Pavlic A, Poelman H, Wasilewski G, Wichapong K, Lux P, Maassen C, Lutgens E, Schurgers LJ, Reutelingsperger CP, Nicolaes GAF. Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. Int J Mol Sci 2023; 24(3). https://www.ncbi.nlm.nih.gov/pubmed/36768348
  50. Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionisio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K. Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity 2023; 56(10): 2325-2341 e2315. https://www.ncbi.nlm.nih.gov/pubmed/37652021
  51. Petrick HL, Pinckaers PJM, Brunetta HS. Ketone body oxidation: glycogen-sparing yet glucose-dependent? J Physiol 2023; 601(12): 2237-2239. https://www.ncbi.nlm.nih.gov/pubmed/37070238
  52. Rakateli L, Huchzermeier R, van der Vorst EPC. AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors. Cells 2023; 12(23). https://www.ncbi.nlm.nih.gov/pubmed/38067179
  53. Rega S, Farina F, Bouhuis S, de Donato S, Chiesa M, Poggio P, Cavallotti L, Bonalumi G, Giambuzzi I, Pompilio G, Perrucci GL. Multi-omics in thoracic aortic aneurysm: the complex road to the simplification. Cell Biosci 2023; 13(1): 131. https://www.ncbi.nlm.nih.gov/pubmed/37475058
  54. Reiche ME, Poels K, Bosmans LA, Vos WG, Van Tiel CM, Gijbels MJJ, Aarts S, Den Toom M, Beckers L, Weber C, Atzler D, Rensen PCN, Kooijman S, Lutgens E. Adipocytes control hematopoiesis and inflammation through CD40 signaling. Haematologica 2023; 108(7): 1873-1885. https://www.ncbi.nlm.nih.gov/pubmed/36475519
  55. Ren L, Li F, Tan X, Fan Y, Ke B, Zhang Y, Jiang H, Jia L, Wang Y, Du J. Abnormal plasma ceramides refine high-risk patients with worsening heart failure. Front Cardiovasc Med 2023; 10: 1185595. https://www.ncbi.nlm.nih.gov/pubmed/37456812
  56. Sachs S, Gotz A, Finan B, Feuchtinger A, DiMarchi RD, Doring Y, Weber C, Tschop MH, Muller TD, Hofmann SM. GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease. Cardiovasc Diabetol 2023; 22(1): 217. https://www.ncbi.nlm.nih.gov/pubmed/37592302
  57. Santovito D, Fan Y, Elia L, Tan JTM, van der Vorst EPC. Editorial: Emerging roles of miRNAs in cardiovascular disease. Front Cardiovasc Med 2023; 10: 1144849. https://www.ncbi.nlm.nih.gov/pubmed/36926041
  58. Santovito D, Steffens S, Barachini S, Madonna R. Autophagy, innate immunity, and cardiac disease. Front Cell Dev Biol 2023; 11: 1149409. https://www.ncbi.nlm.nih.gov/pubmed/37234771
  59. Schonichen C, Montague SJ, Brouns SLN, Burston JJ, Cosemans J, Jurk K, Kehrel BE, Koenen RR, Ni Ainle F, O'Donnell VB, Soehnlein O, Watson SP, Kuijpers MJE, Heemskerk JWM, Nagy M. Antagonistic Roles of Human Platelet Integrin alphaIIbbeta3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow. Arterioscler Thromb Vasc Biol 2023; 43(9): 1700-1712. https://www.ncbi.nlm.nih.gov/pubmed/37409530
  60. Soehnlein O, Doring Y. Beyond association: high neutrophil counts are a causal risk factor for atherosclerotic cardiovascular disease. Eur Heart J 2023; 44(47): 4965-4967. https://www.ncbi.nlm.nih.gov/pubmed/37981833
  61. Steffens S, Schroder K, Kruger M, Maack C, Streckfuss-Bomeke K, Backs J, Backofen R, Baessler B, Devaux Y, Gilsbach R, Heijman J, Knaus J, Kramann R, Linz D, Lister AL, Maatz H, Maegdefessel L, Mayr M, Meder B, Nussbeck SY, Rog-Zielinska EA, Schulz MH, Sickmann A, Yigit G, Kohl P. The challenges of research data management in cardiovascular science: a DGK and DZHK position paper-executive summary. Clin Res Cardiol 2023. https://www.ncbi.nlm.nih.gov/pubmed/37847314
  62. Sun J, Singh P, Shami A, Kluza E, Pan M, Djordjevic D, Michaelsen NB, Kennback C, van der Wel NN, Orho-Melander M, Nilsson J, Formentini I, Conde-Knape K, Lutgens E, Edsfeldt A, Goncalves I. Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture. J Am Coll Cardiol 2023; 81(23): 2213-2227. https://www.ncbi.nlm.nih.gov/pubmed/37286250
  63. Tahamtan A, Samadizadeh S, Salimi V, Natarelli L, Nakstad B. Editorial: miRNAs and inflammation: from biogenesis to therapeutic option. Front Immunol 2023; 14: 1296589. https://www.ncbi.nlm.nih.gov/pubmed/37854607
  64. Thakur M, Junho CVC, Bernhard SM, Schindewolf M, Noels H, Doring Y. NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease. Circ Res 2023; 132(8): 933-949. https://www.ncbi.nlm.nih.gov/pubmed/37053273
  65. Tufanli O, Citir M, Yin C, Van der Vorst EPC, Cimen I. Editorial: The connections of immune metabolic mechanisms with aging-related diseases. Front Cell Dev Biol 2023; 11: 1295264. https://www.ncbi.nlm.nih.gov/pubmed/37829186
  66. Tuleja A, Bernhard S, Hamvas G, Andreoti TA, Rossler J, Boon L, Vikkula M, Kammer R, Haupt F, Doring Y, Baumgartner I. Clinical phenotype of adolescent and adult patients with extracranial vascular malformation. J Vasc Surg Venous Lymphat Disord 2023; 11(5): 1034-1044 e1033. https://www.ncbi.nlm.nih.gov/pubmed/37030445
  67. van der Vorst EPC, Badimon L. The unknown functions of a known protein: the case of coagulation factor XI. Cardiovasc Res 2023; 119(7): e137-e139. https://www.ncbi.nlm.nih.gov/pubmed/37141257
  68. van der Vorst EPC, Maas SL, Theodorou K, Peters LJF, Jin H, Rademakers T, Gijbels MJ, Rousch M, Jansen Y, Weber C, Lehrke M, Lebherz C, Yildiz D, Ludwig A, Bentzon JF, Biessen EAL, Donners M. Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice. Front Cardiovasc Med 2023; 10: 974918. https://www.ncbi.nlm.nih.gov/pubmed/36776254
  69. van Os BW, Kusters PJH, den Toom M, Beckers L, van Tiel CM, Vos WG, de Jong E, Kieser A, van Roomen C, Binder CJ, Reiche ME, de Winther MP, Bosmans LA, Lutgens E. Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis. Front Cardiovasc Med 2023; 10: 1171764. https://www.ncbi.nlm.nih.gov/pubmed/37215541
  70. van Os BW, Vos WG, Bosmans LA, van Tiel CM, Lith SC, den Toom MS, Beckers L, Levels JHM, van Wouw SAE, Zelcer N, Zaal EA, Berkers CR, van der Lest CHA, Helms JB, Weber C, Atzler D, de Winther MPJ, Baardman J, Lutgens E. Hyperlipidaemia elicits an atypical, T helper 1-like CD4(+) T-cell response: a key role for very low-density lipoprotein. Eur Heart J Open 2023; 3(2): oead013. https://www.ncbi.nlm.nih.gov/pubmed/36969380
  71. van Os BW, Vos WG, Bosmans LA, van Tiel CM, Toom MD, Beckers L, Admiraal M, Hoeksema MA, de Winther MP, Lutgens E. CD40L modulates CD4(+) T-cell activation through receptor for activated C kinase 1. Eur J Immunol 2023; 53(12): e2350520. https://www.ncbi.nlm.nih.gov/pubmed/37683186
  72. Wagner JUG, Tombor LS, Malacarne PF, Kettenhausen LM, Panthel J, Kujundzic H, Manickam N, Schmitz K, Cipca M, Stilz KA, Fischer A, Muhly-Reinholz M, Abplanalp WT, John D, Mohanta SK, Weber C, Habenicht AJR, Buchmann GK, Angendohr S, Amin E, Scherschel K, Klocker N, Kelm M, Schuttler D, Clauss S, Gunther S, Boettger T, Braun T, Bar C, Pham MD, Krishnan J, Hille S, Muller OJ, Bozoglu T, Kupatt C, Nardini E, Osmanagic-Myers S, Meyer C, Zeiher AM, Brandes RP, Luxan G, Dimmeler S. Aging impairs the neurovascular interface in the heart. Science 2023; 381(6660): 897-906. https://www.ncbi.nlm.nih.gov/pubmed/37616346
  73. Wang HF, Wang YX, Zhou YP, Wei YP, Yan Y, Zhang ZJ, Jing ZC. Protein O-GlcNAcylation in cardiovascular diseases. Acta Pharmacol Sin 2023; 44(1): 8-18. https://www.ncbi.nlm.nih.gov/pubmed/35817809
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Highlights

Atherosclerosis: RNA fragment creates prospect for new therapies

1 Nov 2023 | News | Publication

SCIENCE TRANSL.MED 2023 ➤ IPEK researchers have demonstrated for the first time what role a specific microRNA plays in atherosclerosis – and how it manages to intervene in this signaling pathway.

T cells and atherosclerosis: the good, the bad, and the unknown

NATURE CARDIOVASCULAR RESEARCH 2023  ➤ IPEK scientists describe that atherosclerosis leads to disorders of the immune system, similar to those in known autoimmune diseases. Pairing of single-cell RNA…