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Publications 2022

  1. Asare Y, Shnipova M, Zivkovic L, Schlegl C, Tosato F, Aronova A, Brandhofer M, Strohm L, Beaufort N, Malik R, Weber C, Bernhagen J, Dichgans M. IKKbeta binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses. Signal Transduct Target Ther 2022; 7(1): 355. https://www.ncbi.nlm.nih.gov/pubmed/36257930
  2. Bazioti V, La Rose AM, Maassen S, Bianchi F, de Boer R, Halmos B, Dabral D, Guilbaud E, Flohr-Svendsen A, Groenen AG, Marmolejo-Garza A, Koster MH, Kloosterhuis NJ, Havinga R, Pranger AT, Langelaar-Makkinje M, de Bruin A, van de Sluis B, Kohan AB, Yvan-Charvet L, van den Bogaart G, Westerterp M. T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice. Nat Commun 2022; 13(1): 3799. https://www.ncbi.nlm.nih.gov/pubmed/35778407
  3. Bernhard SM, Adam L, Atef H, Haberli D, Bramer WM, Minder B, Doring Y, Laine JE, Muka T, Rossler J, Baumgartner I. A systematic review of the safety and efficacy of currently used treatment modalities in the treatment of patients with PIK3CA-related overgrowth spectrum. J Vasc Surg Venous Lymphat Disord 2022; 10(2): 527-538 e522. https://www.ncbi.nlm.nih.gov/pubmed/34358672
  4. Bozoglu T, Lee S, Ziegler T, Jurisch V, Maas S, Baehr A, Hinkel R, Hoenig A, Hariharan A, Kim CI, Decker S, Sami H, Koppara T, Oellinger R, Muller OJ, Frank D, Megens R, Nelson P, Weber C, Schnieke A, Sperandio M, Santamaria G, Rad R, Moretti A, Laugwitz KL, Soehnlein O, Ogris M, Kupatt C. Endothelial Retargeting of AAV9 In Vivo. Adv Sci (Weinh) 2022; 9(7): e2103867. https://www.ncbi.nlm.nih.gov/pubmed/35023328
  5. Brandhofer M, Hoffmann A, Blanchet X, Siminkovitch E, Rohlfing AK, El Bounkari O, Nestele JA, Bild A, Kontos C, Hille K, Rohde V, Frohlich A, Golemi J, Gokce O, Krammer C, Scheiermann P, Tsilimparis N, Sachs N, Kempf WE, Maegdefessel L, Otabil MK, Megens RTA, Ippel H, Koenen RR, Luo J, Engelmann B, Mayo KH, Gawaz M, Kapurniotu A, Weber C, von Hundelshausen P, Bernhagen J. Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Cell Mol Life Sci 2022; 79(10): 512. https://www.ncbi.nlm.nih.gov/pubmed/36094626
  6. Carai P, Papageorgiou AP, Van Linthout S, Deckx S, Velthuis S, Lutgens E, Wijnands E, Tschope C, Schmuttermaier C, Kzhyshkowska J, Jones EAV, Heymans S. Stabilin-1 mediates beneficial monocyte recruitment and tolerogenic macrophage programming during CVB3-induced viral myocarditis. J Mol Cell Cardiol 2022; 165: 31-39. https://www.ncbi.nlm.nih.gov/pubmed/34968453
  7. Daugherty A, Hegele RA, Lu HS, Mackman N, Rader DJ, Weber C. Web of Science's Citation Median Metrics Overcome the Major Constraints of the Journal Impact Factor. Arterioscler Thromb Vasc Biol 2022; 42(4): 367-371. https://www.ncbi.nlm.nih.gov/pubmed/35109675
  8. Evans BR, Yerly A, van der Vorst EPC, Baumgartner I, Bernhard SM, Schindewolf M, Doring Y. Inflammatory Mediators in Atherosclerotic Vascular Remodeling. Front Cardiovasc Med 2022; 9: 868934. https://www.ncbi.nlm.nih.gov/pubmed/35600479
  9. Evans PC, Davidson SM, Wojta J, Back M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP, Morawietz H, Osto E, Padro T, Sluimer JC, Tocchetti CG, Van der Heiden K, Vilahur G, Waltenberger J, Weber C. From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22. Cardiovasc Res 2022; 118(13): 2754-2767. https://www.ncbi.nlm.nih.gov/pubmed/35899362
  10. Farina FM, Santovito D, Weber C. Two-Faced Janus: CCR2-Expressing Macrophages and Their Dual Role in Allograft Rejection of the Transplanted Heart. Circulation 2022; 146(8): 639-642. https://www.ncbi.nlm.nih.gov/pubmed/35994560
  11. Farina FM, Serio S, Hall IF, Zani S, Cassanmagnago GA, Climent M, Civilini E, Condorelli G, Quintavalle M, Elia L. The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-kappaB pathway. Eur Heart J 2022; 43(43): 4562-4576. https://www.ncbi.nlm.nih.gov/pubmed/35292818
  12. Faussner A, Deininger MM, Weber C, Steffens S. Direct addition of poly-lysine or poly-ethylenimine to the medium: A simple alternative to plate pre-coating. PLoS One 2022; 17(7): e0260173. https://www.ncbi.nlm.nih.gov/pubmed/35802710
  13. Ferdinandy P, Koller A, Weber C, Wojta J, Waltenberger J. Frontiers in CardioVascular Biomedicine (FCVB) 2022 Budapest is on in person! The excellent programme proves that scientists won against COVID-19. Cardiovasc Res 2022; 118(8): e59-e61. https://www.ncbi.nlm.nih.gov/pubmed/35438746
  14. Friess MC, Kritikos I, Schineis P, Medina-Sanchez JD, Gkountidi AO, Vallone A, Sigmund EC, Schwitter C, Vranova M, Matti C, Arasa J, Saygili Demir C, Bovay E, Proulx ST, Tomura M, Rot A, Legler DF, Petrova TV, Halin C. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. Cell Rep 2022; 38(5): 110334. https://www.ncbi.nlm.nih.gov/pubmed/35108538
  15. Ganesh N, van der Vorst EPC, Spiesshofer J, He S, Burgmaier M, Findeisen H, Lehrke M, Swirski FK, Marx N, Kahles F. Gut immune cells-A novel therapeutical target for cardiovascular disease? Front Cardiovasc Med 2022; 9: 943214. https://www.ncbi.nlm.nih.gov/pubmed/36046186
  16. Gencer S, Doring Y, Jansen Y, Bayasgalan S, Yan Y, Bianchini M, Cimen I, Muller M, Peters LJF, Megens RTA, von Hundelshausen P, Duchene J, Lemnitzer P, Soehnlein O, Weber C, van der Vorst EPC. Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium. Basic Res Cardiol 2022; 117(1): 30. https://www.ncbi.nlm.nih.gov/pubmed/35674847
  17. Georgakis MK, Bernhagen J, Heitman LH, Weber C, Dichgans M. Targeting the CCL2-CCR2 axis for atheroprotection. Eur Heart J 2022; 43(19): 1799-1808. https://www.ncbi.nlm.nih.gov/pubmed/35567558
  18. Giroud M, Jodeleit H, Prentice KJ, Bartelt A. Adipocyte function and the development of cardiometabolic disease. J Physiol 2022; 600(5): 1189-1208. https://www.ncbi.nlm.nih.gov/pubmed/34555180
  19. Guillamat-Prats R, Hering D, Derle A, Rami M, Hardtner C, Santovito D, Rinne P, Bindila L, Hristov M, Pagano S, Vuilleumier N, Schmid S, Janjic A, Enard W, Weber C, Maegdefessel L, Faussner A, Hilgendorf I, Steffens S. GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation. Nat Cardiovasc Res 2022; 1: 1056-1071. https://www.ncbi.nlm.nih.gov/pubmed/36523570
  20. Habenicht LKL, Wang Z, Zhang X, Li Y, Mogler C, Huspenina JS, Schmid RM, Weber C, Mohanta SK, Ma Z, Yin C. The C1q-ApoE complex: A new hallmark pathology of viral hepatitis and nonalcoholic fatty liver disease. Frontiers in Immunology 2022; 13: 970938. https://www.ncbi.nlm.nih.gov/pubmed/36304458
  21. Haghikia A, Zimmermann F, Schumann P, Jasina A, Roessler J, Schmidt D, Heinze P, Kaisler J, Nageswaran V, Aigner A, Ceglarek U, Cineus R, Hegazy AN, van der Vorst EPC, Doring Y, Strauch CM, Nemet I, Tremaroli V, Dwibedi C, Krankel N, Leistner DM, Heimesaat MM, Bereswill S, Rauch G, Seeland U, Soehnlein O, Muller DN, Gold R, Backhed F, Hazen SL, Haghikia A, Landmesser U. Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism. Eur Heart J 2022; 43(6): 518-533. https://www.ncbi.nlm.nih.gov/pubmed/34597388
  22. Hettwer J, Hinterdobler J, Miritsch B, Deutsch MA, Li X, Mauersberger C, Moggio A, Braster Q, Gram H, Robertson AAB, Cooper MA, Gross O, Krane M, Weber C, Koenig W, Soehnlein O, Adamstein NH, Ridker P, Schunkert H, Libby P, Kessler T, Sager HB. Interleukin-1beta suppression dampens inflammatory leucocyte production and uptake in atherosclerosis. Cardiovasc Res 2022; 118(13): 2778-2791. https://www.ncbi.nlm.nih.gov/pubmed/34718444
  23. Heuschkel MA, Babler A, Heyn J, van der Vorst EPC, Steenman M, Gesper M, Kappel BA, Magne D, Goueffic Y, Kramann R, Jahnen-Dechent W, Marx N, Quillard T, Goettsch C. Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro. Front Cardiovasc Med 2022; 9: 959457. https://www.ncbi.nlm.nih.gov/pubmed/36204585
  24. Immler R, Nadolni W, Bertsch A, Morikis V, Rohwedder I, Masgrau-Alsina S, Schroll T, Yevtushenko A, Soehnlein O, Moser M, Gudermann T, Barnea ER, Rehberg M, Simon SI, Zierler S, Pruenster M, Sperandio M. The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation. Cardiovasc Res 2022; 118(5): 1289-1302. https://www.ncbi.nlm.nih.gov/pubmed/33881519
  25. Kahles F, Rau M, Reugels M, Foldenauer AC, Mertens RW, Arrivas MC, Schroder J, Idel P, Moellmann J, van der Vorst EPC, Marx N, Lehrke M. The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury. Cardiovasc Diabetol 2022; 21(1): 18. https://www.ncbi.nlm.nih.gov/pubmed/35123462
  26. Kane J, Jansen M, Hendrix S, Bosmans LA, Beckers L, Tiel CV, Gijbels M, Zelcer N, Vries CJ, von Hundelshausen P, Vervloet M, Eringa E, Horrevoets AJ, Royen NV, Lutgens E. Anti-Galectin-2 Antibody Treatment Reduces Atherosclerotic Plaque Size and Alters Macrophage Polarity. Thromb Haemost 2022; 122(6): 1047-1057. https://www.ncbi.nlm.nih.gov/pubmed/34852377
  27. Karshovska E, Mohibullah R, Zhu M, Zahedi F, Thomas D, Magkrioti C, Geissler C, Megens RTA, Bianchini M, Nazari-Jahantigh M, Ferreiros N, Aidinis V, Schober A. Endothelial ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Increases Atherosclerosis in Female and Male Mice. Arterioscler Thromb Vasc Biol 2022; 42(8): 1023-1036. https://www.ncbi.nlm.nih.gov/pubmed/35708027
  28. Kichi ZA, Natarelli L, Sadeghian S, Boroumand MA, Behmanesh M, Weber C. Orphan GPR26 Counteracts Early Phases of Hyperglycemia-Mediated Monocyte Activation and Is Suppressed in Diabetic Patients. Biomedicines 2022; 10(7). https://www.ncbi.nlm.nih.gov/pubmed/35885041
  29. Kichi ZA, Sabouri SG. Multiple Airy beam generation by a digital micro mirror device. Opt Express 2022; 30(13): 23025-23034. https://www.ncbi.nlm.nih.gov/pubmed/36224991
  30. Kichi ZA, Soltani M, Rezaei M, Shirvani-Farsani Z, Rojhannezhad M. The Emerging Role of EMT-related lncRNAs in Therapy Resistance and their Applications as Biomarkers. Curr Med Chem 2022; 29(26): 4574-4601. https://www.ncbi.nlm.nih.gov/pubmed/35352644
  31. Kleist CJ, Choe CU, Atzler D, Schonhoff M, Boger R, Schwedhelm E, Wicha SG. Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction. Amino Acids 2022; 54(6): 889-896. https://www.ncbi.nlm.nih.gov/pubmed/35618975
  32. Koenen RR, Weber C. Jam-A Unleashed Incites Thromboinflammatory Coronary Artery Disease. JACC Basic Transl Sci 2022; 7(5): 462-464. https://www.ncbi.nlm.nih.gov/pubmed/35663635
  33. Kotschi S, Jung A, Willemsen N, Ofoghi A, Proneth B, Conrad M, Bartelt A. NFE2L1-mediated proteasome function protects from ferroptosis. Mol Metab 2022; 57: 101436. https://www.ncbi.nlm.nih.gov/pubmed/34999280
  34. Kou JJ, Shi JZ, He YY, Hao JJ, Zhang HY, Luo DM, Song JK, Yan Y, Xie XM, Du GH, Pang XB. Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation. Acta Pharmacol Sin 2022; 43(4): 840-849. https://www.ncbi.nlm.nih.gov/pubmed/34267346
  35. Leberzammer J, Agten SM, Blanchet X, Duan R, Ippel H, Megens RTA, Schulz C, Aslani M, Duchene J, Doring Y, Jooss NJ, Zhang P, Brandl R, Stark K, Siess W, Jurk K, Heemskerk JWM, Hackeng TM, Mayo KH, Weber C, von Hundelshausen P. Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood 2022; 139(17): 2691-2705. https://www.ncbi.nlm.nih.gov/pubmed/35313337
  36. Lecour S, Du Pre BC, Botker HE, Brundel B, Daiber A, Davidson SM, Ferdinandy P, Girao H, Gollmann-Tepekoylu C, Gyongyosi M, Hausenloy DJ, Madonna R, Marber M, Perrino C, Pesce M, Schulz R, Sluijter JPG, Steffens S, Van Linthout S, Young ME, Van Laake LW. Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart. Cardiovasc Res 2022; 118(12): 2566-2581. https://www.ncbi.nlm.nih.gov/pubmed/34505881
  37. Lesage A, Marceau F, Gibson C, Loenders B, Katzer W, Ambrosi HD, Saupe J, Faussner A, Pardali E, Knolle J. In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B(2) receptor antagonist in clinical development. Int Immunopharmacol 2022; 105: 108523. https://www.ncbi.nlm.nih.gov/pubmed/35086057
  38. Lip GYH, Rigby A, Weber C. A Rollercoaster Plunge into 2022. Thrombosis and Haemostasis 2022; 122(01): 001-004. https://www.ncbi.nlm.nih.gov/pubmed/35038759
  39. Liu Y, Shi JZ, Jiang R, Liu SF, He YY, van der Vorst EPC, Weber C, Doring Y, Yan Y. Regulatory T Cell-Related Gene Indicators in Pulmonary Hypertension. Front Pharmacol 2022; 13: 908783. https://www.ncbi.nlm.nih.gov/pubmed/35712711
  40. Matta L, de Faria CC, De Oliveira DF, Andrade IS, Lima-Junior NC, Gregorio BM, Takiya CM, Ferreira ACF, Nascimento JHM, de Carvalho DP, Bartelt A, Maciel L, Fortunato RS. Exercise Improves Redox Homeostasis and Mitochondrial Function in White Adipose Tissue. Antioxidants (Basel) 2022; 11(9). https://www.ncbi.nlm.nih.gov/pubmed/36139762
  41. Mauersberger C, Sager HB, Wobst J, Dang TA, Lambrecht L, Koplev S, Stroth M, Bettaga N, Schlossmann J, Wunder F, Friebe A, Björkegren JLM, Dietz L, Maas SL, van der Vorst EPC, Sandner P, Soehnlein O, Schunkert H, Kessler T. Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation. Nature Cardiovascular Research 2022; 1(12): 1174-1186. https://doi.org/10.1038/s44161-022-00175-w
  42. Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, Forstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Erturk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, Eckstein HH, Kleemann R, Habenicht L, Mallat Z, Michel JB, Bernhagen J, Dichgans M, D'Agostino G, Guzik TJ, Olofsson PS, Yin C, Weber C, Lembo G, Carnevale D, Habenicht AJR. Neuroimmune cardiovascular interfaces control atherosclerosis. Nature 2022; 605(7908): 152-159. https://www.ncbi.nlm.nih.gov/pubmed/35477759
  43. Mohanta SK, Weber C, Yin C, Habenicht AJR. The dawn has come for new therapeutics to treat atherosclerosis: Targeting neuroimmune cardiovascular interfaces in artery brain circuits. Clin Transl Med 2022; 12(9): e1040. https://www.ncbi.nlm.nih.gov/pubmed/36052959
  44. Nagy M, van der Meijden PEJ, Glunz J, Schurgers L, Lutgens E, Ten Cate H, Heitmeier S, Spronk HMH. Integrating Mechanisms in Thrombotic Peripheral Arterial Disease. Pharmaceuticals (Basel) 2022; 15(11). https://www.ncbi.nlm.nih.gov/pubmed/36422558
  45. Nardi V, Franchi F, Prasad M, Fatica EM, Alexander MP, Bois MC, Lam J, Singh RJ, Meyer FB, Lanzino G, Xiong Y, Lutgens E, Lerman LO, Lerman A. Uric Acid Expression in Carotid Atherosclerotic Plaque and Serum Uric Acid Are Associated With Cerebrovascular Events. Hypertension 2022; 79(8): 1814-1823. https://www.ncbi.nlm.nih.gov/pubmed/35656807
  46. Natarelli L, Weber C. A Non-Canonical Link between Non-Coding RNAs and Cardiovascular Diseases. Biomedicines 2022; 10(2). https://www.ncbi.nlm.nih.gov/pubmed/35203652
  47. Nitz K, Lacy M, Bianchini M, Wichapong K, Kucukgoze IA, Bonfiglio CA, Migheli R, Wu Y, Burger C, Li Y, Forne I, Ammar C, Janjic A, Mohanta S, Duchene J, Heemskerk JWM, Megens RTA, Schwedhelm E, Huveneers S, Lygate CA, Santovito D, Zimmer R, Imhof A, Weber C, Lutgens E, Atzler D. The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function. Circ Res 2022; 131(8): 701-712. https://www.ncbi.nlm.nih.gov/pubmed/36102188
  48. Ouweneel AB, Reiche ME, Snip OSC, Wever R, van der Wel EJ, Schaftenaar FH, Kauerova S, Lutgens E, Van Eck M, Hoekstra M. Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis. J Cell Sci 2022; 135(5). https://www.ncbi.nlm.nih.gov/pubmed/34698355
  49. Pattarabanjird T, Marshall M, Upadhye A, Srikakulapu P, Garmey JC, Haider A, Taylor AM, Lutgens E, McNamara CA. B-1b Cells Possess Unique bHLH-Driven P62-Dependent Self-Renewal and Atheroprotection. Circ Res 2022; 130(7): 981-993. https://www.ncbi.nlm.nih.gov/pubmed/35209718
  50. Peters LJF, Baaten C, Maas SL, Lu C, Nagy M, Jooss NJ, Bidzhekov K, Santovito D, Moreno-Andres D, Jankowski J, Biessen EAL, Doring Y, Heemskerk JWM, Weber C, Kuijpers MJE, van der Vorst EPC. MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice. Biomedicines 2022; 10(5). https://www.ncbi.nlm.nih.gov/pubmed/35625720
  51. Poelman H, Ippel H, Gurkan B, Boelens R, Vriend G, Veer CV, Lutgens E, Nicolaes GAF. Structural anomalies in a published NMR-derived structure of IRAK-M. J Mol Graph Model 2022; 111: 108061. https://www.ncbi.nlm.nih.gov/pubmed/34837785
  52. Poels K, Schreurs M, Jansen M, Vugts DJ, Seijkens TTP, van Dongen G, Lutgens E, Beaino W. Immuno-PET Imaging of Atherosclerotic Plaques with [(89)Zr]Zr-Anti-CD40 mAb-Proof of Concept. Biology (Basel) 2022; 11(3). https://www.ncbi.nlm.nih.gov/pubmed/35336782
  53. Rot A, Gutjahr JC, Biswas A, Aslani M, Hub E, Thiriot A, von Andrian UH, Megens RTA, Weber C, Duchene J. Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1. Cell Stem Cell 2022; 29(7): 1013-1015. https://www.ncbi.nlm.nih.gov/pubmed/35803222
  54. Santovito D, Weber C. Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease. Nat Rev Cardiol 2022; 19(9): 620-638. https://www.ncbi.nlm.nih.gov/pubmed/35304600
  55. Sauter M, Sauter RJ, Nording H, Lin C, Olbrich M, Autenrieth S, Gleissner C, Thunemann M, Otero N, Lutgens E, Aherrahrou Z, Wolf D, Zender L, Meuth S, Feil R, Langer HF. Apolipoprotein E derived from CD11c(+) cells ameliorates atherosclerosis. iScience 2022; 25(1): 103677. https://www.ncbi.nlm.nih.gov/pubmed/35036868
  56. Schober A, Maleki SS, Nazari-Jahantigh M. Regulatory Non-coding RNAs in Atherosclerosis. Handb Exp Pharmacol 2022; 270: 463-492. https://www.ncbi.nlm.nih.gov/pubmed/33454857
  57. Shah M, He Z, Rauf A, Beikoghli Kalkhoran S, Heiestad CM, Stenslokken KO, Parish CR, Soehnlein O, Arjun S, Davidson SM, Yellon D. Extracellular histones are a target in myocardial ischaemia-reperfusion injury. Cardiovasc Res 2022; 118(4): 1115-1125. https://www.ncbi.nlm.nih.gov/pubmed/33878183
  58. Soppert J, Frisch J, Wirth J, Hemmers C, Boor P, Kramann R, Vondenhoff S, Moellmann J, Lehrke M, Hohl M, van der Vorst EPC, Werner C, Speer T, Maack C, Marx N, Jankowski J, Roma LP, Noels H. A systematic review and meta-analysis of murine models of uremic cardiomyopathy. Kidney Int 2022; 101(2): 256-273. https://www.ncbi.nlm.nih.gov/pubmed/34774555
  59. Steffens S, Nahrendorf M, Madonna R. Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies. Eur Heart J 2022; 43(16): 1533-1541. https://www.ncbi.nlm.nih.gov/pubmed/34897403
  60. Sun T, Li Y, Forstera B, Stanic K, Lu S, Steffens S, Yin C, Erturk A, Megens RTA, Weber C, Habenicht A, Mohanta SK. Tissue Clearing Approaches in Atherosclerosis. Methods Mol Biol 2022; 2419: 747-763. https://www.ncbi.nlm.nih.gov/pubmed/35237999
  61. Tas K, Volta BD, Lindner C, El Bounkari O, Hille K, Tian Y, Puig-Bosch X, Ballmann M, Hornung S, Ortner M, Prem S, Meier L, Rammes G, Haslbeck M, Weber C, Megens RTA, Bernhagen J, Kapurniotu A. Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly. Nat Commun 2022; 13(1): 5004. https://www.ncbi.nlm.nih.gov/pubmed/36008417
  62. Tullemans BME, Fernandez DI, Veninga A, Baaten C, Peters LJF, Aarts MJB, Eble JA, Campello E, Spiezia L, Simioni P, van der Vorst EPC, van der Meijden PEJ, Heemskerk JWM, Kuijpers MJE. Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin. Thromb Haemost 2022; 122(1): 92-104. https://www.ncbi.nlm.nih.gov/pubmed/34130349
  63. van der Velden J, Asselbergs FW, Bakkers J, Batkai S, Bertrand L, Bezzina CR, Bot I, Brundel B, Carrier L, Chamuleau S, Ciccarelli M, Dawson D, Davidson SM, Dendorfer A, Duncker DJ, Eschenhagen T, Fabritz L, Falcao-Pires I, Ferdinandy P, Giacca M, Girao H, Gollmann-Tepekoylu C, Gyongyosi M, Guzik TJ, Hamdani N, Heymans S, Hilfiker A, Hilfiker-Kleiner D, Hoekstra AG, Hulot JS, Kuster DWD, van Laake LW, Lecour S, Leiner T, Linke WA, Lumens J, Lutgens E, Madonna R, Maegdefessel L, Mayr M, van der Meer P, Passier R, Perbellini F, Perrino C, Pesce M, Priori S, Remme CA, Rosenhahn B, Schotten U, Schulz R, Sipido KR, Sluijter JPG, van Steenbeek F, Steffens S, Terracciano CM, Tocchetti CG, Vlasman P, Yeung KK, Zacchigna S, Zwaagman D, Thum T. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res 2022; 118(15): 3016-3051. https://www.ncbi.nlm.nih.gov/pubmed/34999816
  64. Van der Vorst EPC, Biessen EAL. Unwrapped and uNCORked: PPAR-gamma repression in atherosclerosis. Eur Heart J 2022; 43(7): e32-e34. https://www.ncbi.nlm.nih.gov/pubmed/31754688
  65. van der Vorst EPC, Doring Y. How slimming regulatory T cells limit atherosclerosis: Mechanistic insights into T cell lipid metabolism. Atherosclerosis 2022; 362: 23-25. https://www.ncbi.nlm.nih.gov/pubmed/36400604
  66. van der Vorst EPC, Lecour S. Finding the culprit for the failure of the immune clock as time goes by. Cardiovasc Res 2022; 118(13): e88-e90. https://www.ncbi.nlm.nih.gov/pubmed/36065125
  67. Vos WG, Lutgens E, Seijkens TTP. Statins and immune checkpoint inhibitors: a strategy to improve the efficacy of immunotherapy for cancer? Journal for ImmunoTherapy of Cancer 2022; 10(9).
  68. Wang S, Yan Y, Xu WJ, Gong SG, Zhong XJ, An QY, Zhao YL, Liu JM, Wang L, Yuan P, Jiang R. The Role of Glutamine and Glutaminase in Pulmonary Hypertension. Front Cardiovasc Med 2022; 9: 838657. https://www.ncbi.nlm.nih.gov/pubmed/35310969
  69. Wang Z, Zhang X, Zhang C, Li Y, Lu S, Mohanta S, Weber C, Habenicht A, Yin C. Combined Single-Cell RNA and Single-Cell alpha/beta T Cell Receptor Sequencing of the Arterial Wall in Atherosclerosis. Methods Mol Biol 2022; 2419: 727-746. https://www.ncbi.nlm.nih.gov/pubmed/35237998
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Highlights

National Institutes of Allergy and Infectious Diseases, National Institutes of Health

Atherosclerosis: how the body controls the activity of B cells

NATURE CARDIOVASCULAR RESEARCH 2022  ➤ IPEK scientists have identified a protein that is involved in the regulation of immune cells and can curb the development of atherosclerosis.

How antibodies get it wrong

CELL STEM CELL 2022 ➤  IPEK scientists alert to the wrong use of antibodies in scientific publications. In their recent work, they refute a specific study on localization of immune receptor ACKR1.

@LMU

Atherosclerosis: How diseased blood vessels communicate with the brain

NATURE  2022 ➤ IPEK scientists have been able to demonstrate for the first time that nerve signals are exchanged between arteries and the brain in atherosclerosis.

Vectormanzone | Vecteezy.com

Arterial thromboses: innovative treatment approach

BlOOD 2022 ➤ IPEK scientists have shown in an animal model that the CXCL12 messenger could be suitable as a target structure for the treatment of blood-clotting disorders