Publications 2021
- Abdel Rahman F, d'Almeida S, Zhang T, Asadi M, Bozoglu T, Bongiovanni D, von Scheidt M, Dietzel S, Schwedhelm E, Hinkel R, Laugwitz KL, Kupatt C, Ziegler T. Sphingosine-1-Phosphate Attenuates Lipopolysaccharide-Induced Pericyte Loss via Activation of Rho-A and MRTF-A. Thromb Haemost 2021; 121(3): 341-350. https://www.ncbi.nlm.nih.gov/pubmed/33011963
- Alexander Y, Osto E, Schmidt-Trucksass A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Back M, Badimon L, Cosentino F, De Carlo M, Dorobantu M, Harrison DG, Guzik TJ, Hoefer I, Morris PD, Norata GD, Suades R, Taddei S, Vilahur G, Waltenberger J, Weber C, Wilkinson F, Bochaton-Piallat ML, Evans PC. Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis. Cardiovasc Res 2021; 117(1): 29-42. https://www.ncbi.nlm.nih.gov/pubmed/32282914
- Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vazquez-Martinez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lammermann T, Nourshargh S. Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Immunity 2021; 54(7): 1494-1510 e1497. https://www.ncbi.nlm.nih.gov/pubmed/34033752
- Bernlochner I, Klug M, Larasati D, Von Scheidt M, Santovito D, Hristov M, Weber C, Laugwitz KL, Bongiovanni D. Sorting and magnetic-based isolation of reticulated platelets from peripheral blood. Platelets 2021; 32(1): 113-119. https://www.ncbi.nlm.nih.gov/pubmed/32046562
- Bosmans LA, Bosch L, Kusters PJH, Lutgens E, Seijkens TTP. The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease. J Cardiovasc Transl Res 2021; 14(1): 13-22. https://www.ncbi.nlm.nih.gov/pubmed/32222950
- Bosmans LA, Shami A, Atzler D, Weber C, Goncalves I, Lutgens E. Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis. Vascul Pharmacol 2021; 139: 106884. https://www.ncbi.nlm.nih.gov/pubmed/34102305
- Chirivi RGS, van Rosmalen JWG, van der Linden M, Euler M, Schmets G, Bogatkevich G, Kambas K, Hahn J, Braster Q, Soehnlein O, Hoffmann MH, Es H, Raats JMH. Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases. Cell Mol Immunol 2021; 18(6): 1528-1544. https://www.ncbi.nlm.nih.gov/pubmed/32203195
- Chondronikola M, Bartelt A, Vidal-Puig A, Virtanen KA. Editorial: Brown Adipose Tissue: From Heat Production in Rodents to Metabolic Health in Humans. Front Endocrinol (Lausanne) 2021; 12: 739065. https://www.ncbi.nlm.nih.gov/pubmed/34381425
- Datta-Chaudhuri T, Zanos T, Chang EH, Olofsson PS, Bickel S, Bouton C, Grande D, Rieth L, Aranow C, Bloom O, Mehta AD, Civillico G, Stevens MM, Glowacki E, Bettinger C, Schuettler M, Puleo C, Rennaker R, Mohanta S, Carnevale D, Conde SV, Bonaz B, Chernoff D, Kapa S, Berggren M, Ludwig K, Zanos S, Miller L, Weber D, Yoshor D, Steinman L, Chavan SS, Pavlov VA, Al-Abed Y, Tracey KJ. The Fourth Bioelectronic Medicine Summit "Technology Targeting Molecular Mechanisms": current progress, challenges, and charting the future. Bioelectron Med 2021; 7(1): 7. https://www.ncbi.nlm.nih.gov/pubmed/34024277
- Davidson SM, Padro T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J, Weber C. Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart. Cardiovasc Res 2021; 117(10): 2161-2174. https://www.ncbi.nlm.nih.gov/pubmed/34114614
- Dickhout A, Kaczor DM, Heinzmann ACA, Brouns SLN, Heemskerk JWM, van Zandvoort M, Koenen RR. Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells. Int J Mol Sci 2021; 22(14). https://www.ncbi.nlm.nih.gov/pubmed/34298951
- Dickhout A, Tullemans BME, Heemskerk JWM, Thijssen V, Kuijpers MJE, Koenen RR. Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro. PLoS One 2021; 16(1): e0244736. https://www.ncbi.nlm.nih.gov/pubmed/33411760
- Duan R, Goldmann L, Brandl R, Spannagl M, Weber C, Siess W, von Hundelshausen P. Effects of the Btk-Inhibitors Remibrutinib (LOU064) and Rilzabrutinib (PRN1008) With Varying Btk Selectivity Over Tec on Platelet Aggregation and in vitro Bleeding Time. Front Cardiovasc Med 2021; 8: 749022. https://www.ncbi.nlm.nih.gov/pubmed/34631841
- Duan R, Goldmann L, Li Y, Weber C, Siess W, von Hundelshausen P. Spontaneous Platelet Aggregation in Blood Is Mediated by FcgammaRIIA Stimulation of Bruton's Tyrosine Kinase. Int J Mol Sci 2021; 23(1). https://www.ncbi.nlm.nih.gov/pubmed/35008508
- Egea V, Kessenbrock K, Lawson D, Bartelt A, Weber C, Ries C. Let-7f miRNA regulates SDF-1alpha- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release. Cell Death Dis 2021; 12(6): 516. https://www.ncbi.nlm.nih.gov/pubmed/34016957
- Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L, Weber C. The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics. Cardiovasc Res 2021; 117(8): 1814-1822. https://www.ncbi.nlm.nih.gov/pubmed/33744925
- Fasolo F, Jin H, Winski G, Chernogubova E, Pauli J, Winter H, Li DY, Glukha N, Bauer S, Metschl S, Wu Z, Koschinsky ML, Reilly M, Pelisek J, Kempf W, Eckstein HH, Soehnlein O, Matic L, Hedin U, Backlund A, Bergmark C, Paloschi V, Maegdefessel L. Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization. Circulation 2021; 144(19): 1567-1583. https://www.ncbi.nlm.nih.gov/pubmed/34647815
- Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pircher J, Silvestre-Roig C, Kotini AG, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou EP, Schulz C, Massberg S, Soehnlein O, Ebert B, Levine RL, Reilly MP, Libby P, Wang N, Tall AR. The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Nature 2021; 592(7853): 296-301. https://www.ncbi.nlm.nih.gov/pubmed/33731931
- Gencer S, Doring Y, Jansen Y, Bayasgalan S, Schengel O, Muller M, Peters LJF, Weber C, van der Vorst EPC. Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue. Biomedicines 2021; 9(4): 11. https://www.ncbi.nlm.nih.gov/pubmed/33917642
- Gencer S, Evans BR, van der Vorst EPC, Doring Y, Weber C. Inflammatory Chemokines in Atherosclerosis. Cells 2021; 10(2). https://www.ncbi.nlm.nih.gov/pubmed/33503867
- Georgakis MK, van der Laan SW, Asare Y, Mekke JM, Haitjema S, Schoneveld AH, de Jager SCA, Nurmohamed NS, Kroon J, Stroes ESG, de Kleijn DPV, de Borst GJ, Maegdefessel L, Soehnlein O, Pasterkamp G, Dichgans M. Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability. Arterioscler Thromb Vasc Biol 2021; 41(6): 2038-2048. https://www.ncbi.nlm.nih.gov/pubmed/33827260
- Ghiboub M, Elfiky AMI, de Winther MPJ, Harker NR, Tough DF, de Jonge WJ. Selective Targeting of Epigenetic Readers and Histone Deacetylases in Autoimmune and Inflammatory Diseases: Recent Advances and Future Perspectives. J Pers Med 2021; 11(5). https://www.ncbi.nlm.nih.gov/pubmed/33922725
- Giroud M, Tsokanos FF, Caratti G, Kotschi S, Khani S, Jouffe C, Vogl ES, Irmler M, Glantschnig C, Gil-Lozano M, Hass D, Khan AA, Garcia MR, Mattijssen F, Maida A, Tews D, Fischer-Posovszky P, Feuchtinger A, Virtanen KA, Beckers J, Wabitsch M, Uhlenhaut H, Bluher M, Tuckermann J, Scheideler M, Bartelt A, Herzig S. HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling. Diabetologia 2021; 64(8): 1850-1865. https://www.ncbi.nlm.nih.gov/pubmed/34014371
- Gissler MC, Scherrer P, Anto-Michel N, Pennig J, Hoppe N, Funer L, Hardtner C, Stachon P, Li X, Mitre LS, Marchini T, Madl J, Wadle C, Hilgendorf I, von Zur Muhlen C, Bode C, Weber C, Lutgens E, Wolf D, Gerdes N, Zirlik A, Willecke F. Deficiency of Endothelial CD40 Induces a Stable Plaque Phenotype and Limits Inflammatory Cell Recruitment to Atherosclerotic Lesions in Mice. Thromb Haemost 2021; 121(11): 1530-1540. https://www.ncbi.nlm.nih.gov/pubmed/33618394
- Goncalves RLS, Schlame M, Bartelt A, Brand MD, Hotamisligil GS. Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H(2) O(2) production in heart and skeletal muscle mitochondria. FEBS Lett 2021; 595(3): 415-432. https://www.ncbi.nlm.nih.gov/pubmed/33112430
- Gutjahr JC, Crawford KS, Jensen DR, Naik P, Peterson FC, Samson GPB, Legler DF, Duchene J, Veldkamp CT, Rot A, Volkman BF. The dimeric form of CXCL12 binds to atypical chemokine receptor 1. Sci Signal 2021; 14(696). https://www.ncbi.nlm.nih.gov/pubmed/34404752
- Hall IF, Climent M, Viviani Anselmi C, Papa L, Tragante V, Lambroia L, Farina FM, Kleber ME, Marz W, Biguori C, Condorelli G, Elia L. rs41291957 controls miR-143 and miR-145 expression and impacts coronary artery disease risk. EMBO Mol Med 2021; 13(10): e14060. https://www.ncbi.nlm.nih.gov/pubmed/34551209
- He YY, Xie XM, Zhang HD, Ye J, Gencer S, van der Vorst EPC, Doring Y, Weber C, Pang XB, Jing ZC, Yan Y, Han ZY. Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary Hypertension. Front Pharmacol 2021; 12: 753727. https://www.ncbi.nlm.nih.gov/pubmed/34803695
- Henderson JM, Weber C, Santovito D. Beyond Self-Recycling: Cell-Specific Role of Autophagy in Atherosclerosis. Cells 2021; 10(3). https://www.ncbi.nlm.nih.gov/pubmed/33799835
- Hinkel R, Batkai S, Bahr A, Bozoglu T, Straub S, Borchert T, Viereck J, Howe A, Hornaschewitz N, Oberberger L, Jurisch V, Kozlik-Feldmann R, Freudenthal F, Ziegler T, Weber C, Sperandio M, Engelhardt S, Laugwitz KL, Moretti A, Klymiuk N, Thum T, Kupatt C. AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction. J Am Coll Cardiol 2021; 77(23): 2923-2935. https://www.ncbi.nlm.nih.gov/pubmed/34112319
- Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Muller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB. Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. Eur Heart J 2021; 42(39): 4077-4088. https://www.ncbi.nlm.nih.gov/pubmed/34279021
- Kassiteridi C, Cole JE, Griseri T, Falck-Hansen M, Goddard ME, Seneviratne AN, Green PA, Park I, Shami AG, Pattarabanjird T, Upadhye A, Taylor AM, Handa A, Channon KM, Lutgens E, McNamara CA, Williams RO, Monaco C. CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Circ Res 2021; 129(2): 280-295. https://www.ncbi.nlm.nih.gov/pubmed/33975450
- Kluza E, Beldman TJ, Shami A, Scholl ER, Malinova TS, Grootemaat AE, van der Wel NN, Goncalves I, Huveneers S, Mulder WJM, Lutgens E. Diverse ultrastructural landscape of atherosclerotic endothelium. Atherosclerosis 2021; 339: 35-45. https://www.ncbi.nlm.nih.gov/pubmed/34847419
- Koenen RR. Conformation-Crooking CXCL4 to Unravel Autoimmune Heparin-Induced Thrombocytopenia. Thromb Haemost 2021; 121(3): 258-260. https://www.ncbi.nlm.nih.gov/pubmed/33385179
- Kou J, Wang M, Shi J, Zhang H, Pu X, Song S, Yang C, Yan Y, Doring Y, Xie X, Pang X. Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation through the Endoplasmic Reticulum Stress Pathway in Apolipoprotein E4 Transgenic Mice. ACS Omega 2021; 6(10): 6654-6662. https://www.ncbi.nlm.nih.gov/pubmed/33748578
- Krammer C, Kontos C, Dewor M, Hille K, Dalla Volta B, El Bounkari O, Tas K, Sinitski D, Brandhofer M, Megens RTA, Weber C, Schultz JR, Bernhagen J, Kapurniotu A. A MIF-Derived Cyclopeptide that Inhibits MIF Binding and Atherogenic Signaling via the Chemokine Receptor CXCR2. Chembiochem 2021; 22(6): 1012-1019. https://www.ncbi.nlm.nih.gov/pubmed/33125165
- Lacy M, Burger C, Shami A, Ahmadsei M, Winkels H, Nitz K, van Tiel CM, Seijkens TTP, Kusters PJH, Karshovka E, Prange KHM, Wu Y, Brouns SLN, Unterlugauer S, Kuijpers MJE, Reiche ME, Steffens S, Edsfeldt A, Megens RTA, Heemskerk JWM, Goncalves I, Weber C, Gerdes N, Atzler D, Lutgens E. Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nat Commun 2021; 12(1): 3754. https://www.ncbi.nlm.nih.gov/pubmed/34145241
- Lee MW, Luo EW, Silvestre-Roig C, Srinivasan Y, Akabori K, Lemnitzer P, Schmidt NW, Lai GH, Santangelo CD, Soehnlein O, Wong GCL. Apolipoprotein Mimetic Peptide Inhibits Neutrophil-Driven Inflammatory Damage via Membrane Remodeling and Suppression of Cell Lysis. ACS Nano 2021; 15(10): 15930-15939. https://www.ncbi.nlm.nih.gov/pubmed/34586780
- Lemmer IL, Willemsen N, Hilal N, Bartelt A. A guide to understanding endoplasmic reticulum stress in metabolic disorders. Mol Metab 2021; 47: 101169. https://www.ncbi.nlm.nih.gov/pubmed/33484951
- Lesch S, Blumenberg V, Stoiber S, Gottschlich A, Ogonek J, Cadilha BL, Dantes Z, Rataj F, Dorman K, Lutz J, Karches CH, Heise C, Kurzay M, Larimer BM, Grassmann S, Rapp M, Nottebrock A, Kruger S, Tokarew N, Metzger P, Hoerth C, Benmebarek MR, Dhoqina D, Grunmeier R, Seifert M, Oener A, Umut O, Joaquina S, Vimeux L, Tran T, Hank T, Baba T, Huynh D, Megens RTA, Janssen KP, Jastroch M, Lamp D, Ruehland S, Di Pilato M, Pruessmann JN, Thomas M, Marr C, Ormanns S, Reischer A, Hristov M, Tartour E, Donnadieu E, Rothenfusser S, Duewell P, Konig LM, Schnurr M, Subklewe M, Liss AS, Halama N, Reichert M, Mempel TR, Endres S, Kobold S. T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours. Nat Biomed Eng 2021; 5(11): 1246-1260. https://www.ncbi.nlm.nih.gov/pubmed/34083764
- Lip GYH, Rigby A, Weber C. Looking Back on 2020, Looking Forward to 2021. Thromb Haemost 2021; 121(1): 1-3. https://www.ncbi.nlm.nih.gov/pubmed/33477196
- Lutgens E, Joffre J, van Os B, Ait-Oufella H. Targeting cytokines and immune checkpoints in atherosclerosis with monoclonal antibodies. Atherosclerosis 2021; 335: 98-109. https://www.ncbi.nlm.nih.gov/pubmed/34593238
- Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF, Soehnlein O, Chapman TM. Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists. Eur J Med Chem 2021; 226: 113805. https://www.ncbi.nlm.nih.gov/pubmed/34536667
- Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O, Chapman TM. Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation. Eur J Med Chem 2021; 214: 113194. https://www.ncbi.nlm.nih.gov/pubmed/33548634
- Marquez AB, van der Vorst EPC, Maas SL. Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential. J Clin Med 2021; 10(17). https://www.ncbi.nlm.nih.gov/pubmed/34501271
- Muley C, Bartelt A. Fuse your mitochondria, lose appetite: an anorexic, anti-obesity sphingolipid. EMBO Mol Med 2021; 13(8): e14618. https://www.ncbi.nlm.nih.gov/pubmed/34288516
- Muley C, Kotschi S, Bartelt A. Role of Ubiquilins for Brown Adipocyte Proteostasis and Thermogenesis. Front Endocrinol (Lausanne) 2021; 12: 739021. https://www.ncbi.nlm.nih.gov/pubmed/34650520
- Natarelli L, Parca L, Mazza T, Weber C, Virgili F, Fratantonio D. MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2. Noncoding RNA 2021; 7(1). https://www.ncbi.nlm.nih.gov/pubmed/33670580
- Natarelli L, Virgili F, Weber C. SARS-CoV-2, Cardiovascular Diseases, and Noncoding RNAs: A Connected Triad. Int J Mol Sci 2021; 22(22). https://www.ncbi.nlm.nih.gov/pubmed/34830125
- Nording H, Baron L, Haberthur D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, Meusel M, Meyer-Saraei R, Hlushchuk R, Sedding D, Borst O, Eitel I, Karsten CM, Feil R, Pichler B, Erdmann J, Verschoor A, Chavakis E, Chavakis T, von Hundelshausen P, Kohl J, Gawaz M, Langer HF. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun 2021; 12(1): 3352. https://www.ncbi.nlm.nih.gov/pubmed/34099640
- Perrino C, Ferdinandy P, Botker HE, Brundel B, Collins P, Davidson SM, den Ruijter HM, Engel FB, Gerdts E, Girao H, Gyongyosi M, Hausenloy DJ, Lecour S, Madonna R, Marber M, Murphy E, Pesce M, Regitz-Zagrosek V, Sluijter JPG, Steffens S, Gollmann-Tepekoylu C, Van Laake LW, Van Linthout S, Schulz R, Ytrehus K. Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res 2021; 117(2): 367-385. https://www.ncbi.nlm.nih.gov/pubmed/32484892
- Pesce M, Agostoni P, Botker HE, Brundel B, Davidson SM, Caterina R, Ferdinandy P, Girao H, Gyongyosi M, Hulot JS, Lecour S, Perrino C, Schulz R, Sluijter JP, Steffens S, Tancevski I, Gollmann-Tepekoylu C, Tschope C, Linthout SV, Madonna R. COVID-19-related cardiac complications from clinical evidences to basic mechanisms: opinion paper of the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res 2021; 117(10): 2148-2160. https://www.ncbi.nlm.nih.gov/pubmed/34117887
- Peters LJF, Jans A, Bartneck M, van der Vorst EPC. Immunomodulatory Nanomedicine for the Treatment of Atherosclerosis. J Clin Med 2021; 10(14). https://www.ncbi.nlm.nih.gov/pubmed/34300351
- Poels K, Neppelenbroek SIM, Kersten MJ, Antoni ML, Lutgens E, Seijkens TTP. Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem. J Immunother Cancer 2021; 9(6). https://www.ncbi.nlm.nih.gov/pubmed/34168005
- Puhl SL, Hilby M, Kohlhaas M, Keidel LM, Jansen Y, Hristov M, Schindler J, Maack C, Steffens S. Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodelling. Sci Rep 2021; 11(1): 14385. https://www.ncbi.nlm.nih.gov/pubmed/34257332
- Reiche ME, Lutgens E. Lose the helpers... get 'remote' regulators! Cardiovasc Res 2021; 117(3): 635-636. https://www.ncbi.nlm.nih.gov/pubmed/32637996
- Reilly NA, Lutgens E, Kuiper J, Heijmans BT, Jukema JW. Effects of fatty acids on T cell function: role in atherosclerosis. Nat Rev Cardiol 2021; 18(12): 824-837. https://www.ncbi.nlm.nih.gov/pubmed/34253911
- Rossaint J, Thomas K, Mersmann S, Skupski J, Margraf A, Tekath T, Jouvene CC, Dalli J, Hidalgo A, Meuth SG, Soehnlein O, Zarbock A. Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education. J Exp Med 2021; 218(7). https://www.ncbi.nlm.nih.gov/pubmed/34014253
- Santovito D, Steffens S. DNA damage and extranuclear DNA sensors: a dangerous duo in atherosclerosis. Eur Heart J 2021; 42(42): 4349-4351. https://www.ncbi.nlm.nih.gov/pubmed/34226940
- Santovito D, Toto L, De Nardis V, Marcantonio P, D'Aloisio R, Mastropasqua A, De Cesare D, Bucci M, Paganelli C, Natarelli L, Weber C, Consoli A, Mastropasqua R, Cipollone F. Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes. Sci Rep 2021; 11(1): 4136. https://www.ncbi.nlm.nih.gov/pubmed/33602976
- Santovito D, Weber C. Not all myocardial infarctions are created equal: The potential of circulating microRNAs to discern coronary artery dissection. EBioMedicine 2021; 67: 103366. https://www.ncbi.nlm.nih.gov/pubmed/33965874
- Schindler L, Zwissler L, Krammer C, Hendgen-Cotta U, Rassaf T, Hampton MB, Dickerhof N, Bernhagen J. Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells. J Leukoc Biol 2021; 110(5): 893-905. https://www.ncbi.nlm.nih.gov/pubmed/33565160
- Schlein C, Fischer AW, Sass F, Worthmann A, Todter K, Jaeckstein MY, Behrens J, Lynes MD, Kiebish MA, Narain NR, Bussberg V, Darkwah A, Jespersen NZ, Nielsen S, Scheele C, Schweizer M, Braren I, Bartelt A, Tseng YH, Heeren J, Scheja L. Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. Cell Rep 2021; 34(2): 108624. https://www.ncbi.nlm.nih.gov/pubmed/33440156
- Schmohl J, Moebius S, Guenther T, Pepeldjyika E, Seidel CL, Sutanto W, Schuster F, Kraemer D, Salih H, Hartmann A, Tischer J, Ries C, Schmetzer H. Expression of Surface-associated 82 kDa proMMP-9 in Lymphatic Leukemia Blast Cells Differentially Correlates With Prognosis. Anticancer Res 2021; 41(8): 3891-3898. https://www.ncbi.nlm.nih.gov/pubmed/34281851
- Schober A, Blay RM, Saboor Maleki S, Zahedi F, Winklmaier AE, Kakar MY, Baatsch IM, Zhu M, Geissler C, Fusco AE, Eberlein A, Li N, Megens RTA, Banafsche R, Kumbrink J, Weber C, Nazari-Jahantigh M. MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions. Circulation 2021; 144(13): 1059-1073. https://www.ncbi.nlm.nih.gov/pubmed/34233454
- Schoeps B, Eckfeld C, Prokopchuk O, Bottcher J, Haussler D, Steiger K, Demir IE, Knolle P, Soehnlein O, Jenne DE, Hermann CD, Kruger A. TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer. Cancer Res 2021; 81(13): 3568-3579. https://www.ncbi.nlm.nih.gov/pubmed/33941611
- Schumacher D, Curaj A, Simsekyilmaz S, Schober A, Liehn EA, Mause SF. miR155 Deficiency Reduces Myofibroblast Density but Fails to Improve Cardiac Function after Myocardial Infarction in Dyslipidemic Mouse Model. Int J Mol Sci 2021; 22(11). https://www.ncbi.nlm.nih.gov/pubmed/34067440
- Schumacher D, Liehn EA, Singh A, Curaj A, Wijnands E, Lira SA, Tacke F, Jankowski J, Biessen EAL, van der Vorst EPC. CCR6 Deficiency Increases Infarct Size after Murine Acute Myocardial Infarction. Biomedicines 2021; 9(11). https://www.ncbi.nlm.nih.gov/pubmed/34829761
- Schumski A, Ortega-Gomez A, Wichapong K, Winter C, Lemnitzer P, Viola JR, Pinilla-Vera M, Folco E, Solis-Mezarino V, Volker-Albert M, Maas SL, Pan C, Perez Olivares L, Winter J, Hackeng T, Karlsson MCI, Zeller T, Imhof A, Baron RM, Nicolaes GAF, Libby P, Maegdefessel L, Kamp F, Benoit M, Doring Y, Soehnlein O. Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion. Circulation 2021; 143(3): 254-266. https://www.ncbi.nlm.nih.gov/pubmed/33167684
- Sebag SC, Zhang Z, Qian Q, Li M, Zhu Z, Harata M, Li W, Zingman LV, Liu L, Lira VA, Potthoff MJ, Bartelt A, Yang L. ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue. Cell Rep 2021; 37(7): 110003. https://www.ncbi.nlm.nih.gov/pubmed/34788615
- Shami A, Edsfeldt A, Bengtsson E, Nilsson J, Shore AC, Natali A, Khan F, Lutgens E, Goncalves I. Soluble CD40 Levels in Plasma Are Associated with Cardiovascular Disease and in Carotid Plaques with a Vulnerable Phenotype. J Stroke 2021; 23(3): 367-376. https://www.ncbi.nlm.nih.gov/pubmed/34649381
- Silvestre-Roig C, Lemnitzer P, Gall J, Schwager S, Toska A, Yvan-Charvet L, Detmar M, Soehnlein O. Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions. Circ Res 2021; 128(2): 284-286. https://www.ncbi.nlm.nih.gov/pubmed/33210556
- Soehnlein O, Libby P. Targeting inflammation in atherosclerosis - from experimental insights to the clinic. Nat Rev Drug Discov 2021; 20(8): 589-610. https://www.ncbi.nlm.nih.gov/pubmed/33976384
- Soltani-Fard E, Taghvimi S, Abedi Kichi Z, Weber C, Shabaninejad Z, Taheri-Anganeh M, Hossein Khatami S, Mousavi P, Movahedpour A, Natarelli L. Insights into the Function of Regulatory RNAs in Bacteria and Archaea. International Journal of Translational Medicine 2021; 1(3): 403-423. https://www.mdpi.com/2673-8937/1/3/24
- Sundararaman SS, Doring Y, van der Vorst EPC. PCSK9: A Multi-Faceted Protein That Is Involved in Cardiovascular Biology. Biomedicines 2021; 9(7). https://www.ncbi.nlm.nih.gov/pubmed/34356856
- Sundararaman SS, Peters LJF, Jansen Y, Gencer S, Yan Y, Nazir S, Bonnin Marquez A, Kahles F, Lehrke M, Biessen EAL, Jankowski J, Weber C, Doring Y, van der Vorst EPC. Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe(-/-) mice. Sci Rep 2021; 11(1): 10409. https://www.ncbi.nlm.nih.gov/pubmed/34001955
- Sundararaman SS, Peters LJF, Nazir S, Marquez AB, Bouma JE, Bayasgalan S, Doring Y, van der Vorst EPC. PCSK9 Imperceptibly Affects Chemokine Receptor Expression In Vitro and In Vivo. Int J Mol Sci 2021; 22(23). https://www.ncbi.nlm.nih.gov/pubmed/34884827
- Sundararaman SS, van der Vorst EPC. Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health. Int J Mol Sci 2021; 22(5). https://www.ncbi.nlm.nih.gov/pubmed/33804544
- Tahir S, Steffens S. Nonclassical monocytes in cardiovascular physiology and disease. Am J Physiol Cell Physiol 2021; 320(5): C761-C770. https://www.ncbi.nlm.nih.gov/pubmed/33596150
- Thakur M, Evans B, Schindewolf M, Baumgartner I, Doring Y. Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases. Cells 2021; 10(7). https://www.ncbi.nlm.nih.gov/pubmed/34359859
- Totzeck M, Lutgens E, Neilan TG. Are we underestimating the potential for cardiotoxicity related to immune checkpoint inhibitors? Eur Heart J 2021; 42(16): 1632-1635. https://www.ncbi.nlm.nih.gov/pubmed/33291139
- Tsokanos FF, Muley C, Khani S, Hass D, Fleming T, Wolff G, Bartelt A, Nawroth P, Herzig S. Methylglyoxal Drives a Distinct, Nonclassical Macrophage Activation Status. Thromb Haemost 2021; 121(11): 1464-1475. https://www.ncbi.nlm.nih.gov/pubmed/33966256
- Tullemans BME, Karel MFA, Leopold V, Ten Brink MS, Baaten C, Maas SL, de Vos AF, Eble JA, Nijziel MR, van der Vorst EPC, Cosemans J, Heemskerk JWM, Claushuis TAM, Kuijpers MJE. Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function. EJHaem 2021; 2(4): 685-699. https://www.ncbi.nlm.nih.gov/pubmed/35845214
- van der Bruggen MM, Reesink KD, Spronck PJM, Bitsch N, Hameleers J, Megens RTA, Schalkwijk CG, Delhaas T, Spronck B. An integrated set-up for ex vivo characterisation of biaxial murine artery biomechanics under pulsatile conditions. Sci Rep 2021; 11(1): 2671. https://www.ncbi.nlm.nih.gov/pubmed/33514757
- van der Laan KWF, Reesink KD, van der Bruggen MM, Jaminon AMG, Schurgers LJ, Megens RTA, Huberts W, Delhaas T, Spronck B. Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy. Front Physiol 2021; 12: 814434. https://www.ncbi.nlm.nih.gov/pubmed/35095571
- van der Vorst EPC. c-Kit inhibition: From promising cancer therapy to culprit in atherosclerosis. Atherosclerosis 2021; 324: 115-116. https://www.ncbi.nlm.nih.gov/pubmed/33824002
- van der Vorst EPC, Doring Y. Tracing Endothelial CXCR4 May Pave the Way for Localized Lesional Treatment Approaches. Arterioscler Thromb Vasc Biol 2021; 41(2): 837-838. https://www.ncbi.nlm.nih.gov/pubmed/33955781
- van der Vorst EPC, Pepe MAA, Peters LJF, Haberbosch M, Jansen Y, Naumann R, Stathopoulos GT, Weber C, Bidzhekov K. Transcriptome signature of miRNA-26b KO mouse model suggests novel targets. BMC Genom Data 2021; 22(1): 23. https://www.ncbi.nlm.nih.gov/pubmed/34193044
- van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Perez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R. Prosaposin mediates inflammation in atherosclerosis. Sci Transl Med 2021; 13(584). https://www.ncbi.nlm.nih.gov/pubmed/33692130
- van Niekerk E, Botha Le Roux S, Atzler D, Schwedhelm E, Boger RH, van Rooyen JM, Moss SJ, Mels CMC. Blood pressure and nitric oxide synthesis capacity in physically active and inactive groups: the SABPA study. J Hum Hypertens 2021; 35(4): 325-333. https://www.ncbi.nlm.nih.gov/pubmed/32382032
- van Os B, Lutgens E. SPARCing the clot. Blood 2021; 137(11): 1441-1442. https://www.ncbi.nlm.nih.gov/pubmed/33734343
- Varasteh Z, De Rose F, Mohanta S, Li Y, Zhang X, Miritsch B, Scafetta G, Yin C, Sager HB, Glasl S, Gorpas D, Habenicht AJR, Ntziachristos V, Weber WA, Bartolazzi A, Schwaiger M, D'Alessandria C. Imaging atherosclerotic plaques by targeting Galectin-3 and activated macrophages using ((89)Zr)-DFO- Galectin3-F(ab')(2) mAb. Theranostics 2021; 11(4): 1864-1876. https://www.ncbi.nlm.nih.gov/pubmed/33408786
- von Hundelshausen P, Lorenz R, Siess W, Weber C. Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT): Targeting Pathomechanisms with Bruton Tyrosine Kinase Inhibitors. Thromb Haemost 2021; 121(11): 1395-1399. https://www.ncbi.nlm.nih.gov/pubmed/33851389
- von Hundelshausen P, Siess W. Bleeding by Bruton Tyrosine Kinase-Inhibitors: Dependency on Drug Type and Disease. Cancers (Basel) 2021; 13(5). https://www.ncbi.nlm.nih.gov/pubmed/33806595
- von Hundelshausen P, Wichapong K, Gabius HJ, Mayo KH. The marriage of chemokines and galectins as functional heterodimers. Cell Mol Life Sci 2021; 78(24): 8073-8095. https://www.ncbi.nlm.nih.gov/pubmed/34767039
- Weber C, Rigby A, Lip GYH. Thrombosis and Haemostasis 2020 Editors' Choice Papers. Thromb Haemost 2021; 121(1): 109-114. https://www.ncbi.nlm.nih.gov/pubmed/33477198
- Weber C, von Hundelshausen P, Siess W. VITT after ChAdOx1 nCoV-19 Vaccination. N Engl J Med 2021; 385(23): 2203-2204. https://www.ncbi.nlm.nih.gov/pubmed/34731556
- Werth K, Hub E, Gutjahr JC, Bosjnak B, Zheng X, Bubke A, Russo S, Rot A, Forster R. Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp. Cell Rep 2021; 36(2): 109346. https://www.ncbi.nlm.nih.gov/pubmed/34260918
- Wichapong K, Silvestre-Roig C, Braster Q, Schumski A, Soehnlein O, Nicolaes GAF. Structure-based peptide design targeting intrinsically disordered proteins: Novel histone H4 and H2A peptidic inhibitors. Comput Struct Biotechnol J 2021; 19: 934-948. https://www.ncbi.nlm.nih.gov/pubmed/33598107
- Yan Y, Thakur M, van der Vorst EPC, Weber C, Doring Y. Targeting the chemokine network in atherosclerosis. Atherosclerosis 2021; 330: 95-106. https://www.ncbi.nlm.nih.gov/pubmed/34247863
- Yang Y, Tetti M, Vohra T, Adolf C, Seissler J, Hristov M, Belavgeni A, Bidlingmaier M, Linkermann A, Mulatero P, Beuschlein F, Reincke M, Williams TA. BEX1 Is Differentially Expressed in Aldosterone-Producing Adenomas and Protects Human Adrenocortical Cells From Ferroptosis. Hypertension 2021; 77(5): 1647-1658. https://www.ncbi.nlm.nih.gov/pubmed/33745298
- Yola IM, Moser C, Duncan MS, Schwedhelm E, Atzler D, Maas R, Hannemann J, Boger RH, Vasan RS, Xanthakis V. Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study. PLoS One 2021; 16(9): e0254577. https://www.ncbi.nlm.nih.gov/pubmed/34492019