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Publications 2021

  1. Abdel Rahman F, d'Almeida S, Zhang T, Asadi M, Bozoglu T, Bongiovanni D, von Scheidt M, Dietzel S, Schwedhelm E, Hinkel R, Laugwitz KL, Kupatt C, Ziegler T. Sphingosine-1-Phosphate Attenuates Lipopolysaccharide-Induced Pericyte Loss via Activation of Rho-A and MRTF-A. Thromb Haemost 2021; 121(3): 341-350. https://www.ncbi.nlm.nih.gov/pubmed/33011963
  2. Alexander Y, Osto E, Schmidt-Trucksass A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Back M, Badimon L, Cosentino F, De Carlo M, Dorobantu M, Harrison DG, Guzik TJ, Hoefer I, Morris PD, Norata GD, Suades R, Taddei S, Vilahur G, Waltenberger J, Weber C, Wilkinson F, Bochaton-Piallat ML, Evans PC. Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis. Cardiovasc Res 2021; 117(1): 29-42. https://www.ncbi.nlm.nih.gov/pubmed/32282914
  3. Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vazquez-Martinez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lammermann T, Nourshargh S. Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Immunity 2021; 54(7): 1494-1510 e1497. https://www.ncbi.nlm.nih.gov/pubmed/34033752
  4. Bernlochner I, Klug M, Larasati D, Von Scheidt M, Santovito D, Hristov M, Weber C, Laugwitz KL, Bongiovanni D. Sorting and magnetic-based isolation of reticulated platelets from peripheral blood. Platelets 2021; 32(1): 113-119. https://www.ncbi.nlm.nih.gov/pubmed/32046562
  5. Bosmans LA, Bosch L, Kusters PJH, Lutgens E, Seijkens TTP. The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease. J Cardiovasc Transl Res 2021; 14(1): 13-22. https://www.ncbi.nlm.nih.gov/pubmed/32222950
  6. Bosmans LA, Shami A, Atzler D, Weber C, Goncalves I, Lutgens E. Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis. Vascul Pharmacol 2021; 139: 106884. https://www.ncbi.nlm.nih.gov/pubmed/34102305
  7. Chirivi RGS, van Rosmalen JWG, van der Linden M, Euler M, Schmets G, Bogatkevich G, Kambas K, Hahn J, Braster Q, Soehnlein O, Hoffmann MH, Es H, Raats JMH. Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases. Cell Mol Immunol 2021; 18(6): 1528-1544. https://www.ncbi.nlm.nih.gov/pubmed/32203195
  8. Chondronikola M, Bartelt A, Vidal-Puig A, Virtanen KA. Editorial: Brown Adipose Tissue: From Heat Production in Rodents to Metabolic Health in Humans. Front Endocrinol (Lausanne) 2021; 12: 739065. https://www.ncbi.nlm.nih.gov/pubmed/34381425
  9. Datta-Chaudhuri T, Zanos T, Chang EH, Olofsson PS, Bickel S, Bouton C, Grande D, Rieth L, Aranow C, Bloom O, Mehta AD, Civillico G, Stevens MM, Glowacki E, Bettinger C, Schuettler M, Puleo C, Rennaker R, Mohanta S, Carnevale D, Conde SV, Bonaz B, Chernoff D, Kapa S, Berggren M, Ludwig K, Zanos S, Miller L, Weber D, Yoshor D, Steinman L, Chavan SS, Pavlov VA, Al-Abed Y, Tracey KJ. The Fourth Bioelectronic Medicine Summit "Technology Targeting Molecular Mechanisms": current progress, challenges, and charting the future. Bioelectron Med 2021; 7(1): 7. https://www.ncbi.nlm.nih.gov/pubmed/34024277
  10. Davidson SM, Padro T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J, Weber C. Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart. Cardiovasc Res 2021; 117(10): 2161-2174. https://www.ncbi.nlm.nih.gov/pubmed/34114614
  11. Dickhout A, Kaczor DM, Heinzmann ACA, Brouns SLN, Heemskerk JWM, van Zandvoort M, Koenen RR. Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells. Int J Mol Sci 2021; 22(14). https://www.ncbi.nlm.nih.gov/pubmed/34298951
  12. Dickhout A, Tullemans BME, Heemskerk JWM, Thijssen V, Kuijpers MJE, Koenen RR. Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro. PLoS One 2021; 16(1): e0244736. https://www.ncbi.nlm.nih.gov/pubmed/33411760
  13. Duan R, Goldmann L, Brandl R, Spannagl M, Weber C, Siess W, von Hundelshausen P. Effects of the Btk-Inhibitors Remibrutinib (LOU064) and Rilzabrutinib (PRN1008) With Varying Btk Selectivity Over Tec on Platelet Aggregation and in vitro Bleeding Time. Front Cardiovasc Med 2021; 8: 749022. https://www.ncbi.nlm.nih.gov/pubmed/34631841
  14. Duan R, Goldmann L, Li Y, Weber C, Siess W, von Hundelshausen P. Spontaneous Platelet Aggregation in Blood Is Mediated by FcgammaRIIA Stimulation of Bruton's Tyrosine Kinase. Int J Mol Sci 2021; 23(1). https://www.ncbi.nlm.nih.gov/pubmed/35008508
  15. Egea V, Kessenbrock K, Lawson D, Bartelt A, Weber C, Ries C. Let-7f miRNA regulates SDF-1alpha- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release. Cell Death Dis 2021; 12(6): 516. https://www.ncbi.nlm.nih.gov/pubmed/34016957
  16. Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L, Weber C. The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics. Cardiovasc Res 2021; 117(8): 1814-1822. https://www.ncbi.nlm.nih.gov/pubmed/33744925
  17. Fasolo F, Jin H, Winski G, Chernogubova E, Pauli J, Winter H, Li DY, Glukha N, Bauer S, Metschl S, Wu Z, Koschinsky ML, Reilly M, Pelisek J, Kempf W, Eckstein HH, Soehnlein O, Matic L, Hedin U, Backlund A, Bergmark C, Paloschi V, Maegdefessel L. Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization. Circulation 2021; 144(19): 1567-1583. https://www.ncbi.nlm.nih.gov/pubmed/34647815
  18. Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pircher J, Silvestre-Roig C, Kotini AG, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou EP, Schulz C, Massberg S, Soehnlein O, Ebert B, Levine RL, Reilly MP, Libby P, Wang N, Tall AR. The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Nature 2021; 592(7853): 296-301. https://www.ncbi.nlm.nih.gov/pubmed/33731931
  19. Gencer S, Doring Y, Jansen Y, Bayasgalan S, Schengel O, Muller M, Peters LJF, Weber C, van der Vorst EPC. Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue. Biomedicines 2021; 9(4): 11. https://www.ncbi.nlm.nih.gov/pubmed/33917642
  20. Gencer S, Evans BR, van der Vorst EPC, Doring Y, Weber C. Inflammatory Chemokines in Atherosclerosis. Cells 2021; 10(2). https://www.ncbi.nlm.nih.gov/pubmed/33503867
  21. Georgakis MK, van der Laan SW, Asare Y, Mekke JM, Haitjema S, Schoneveld AH, de Jager SCA, Nurmohamed NS, Kroon J, Stroes ESG, de Kleijn DPV, de Borst GJ, Maegdefessel L, Soehnlein O, Pasterkamp G, Dichgans M. Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability. Arterioscler Thromb Vasc Biol 2021; 41(6): 2038-2048. https://www.ncbi.nlm.nih.gov/pubmed/33827260
  22. Ghiboub M, Elfiky AMI, de Winther MPJ, Harker NR, Tough DF, de Jonge WJ. Selective Targeting of Epigenetic Readers and Histone Deacetylases in Autoimmune and Inflammatory Diseases: Recent Advances and Future Perspectives. J Pers Med 2021; 11(5). https://www.ncbi.nlm.nih.gov/pubmed/33922725
  23. Giroud M, Tsokanos FF, Caratti G, Kotschi S, Khani S, Jouffe C, Vogl ES, Irmler M, Glantschnig C, Gil-Lozano M, Hass D, Khan AA, Garcia MR, Mattijssen F, Maida A, Tews D, Fischer-Posovszky P, Feuchtinger A, Virtanen KA, Beckers J, Wabitsch M, Uhlenhaut H, Bluher M, Tuckermann J, Scheideler M, Bartelt A, Herzig S. HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling. Diabetologia 2021; 64(8): 1850-1865. https://www.ncbi.nlm.nih.gov/pubmed/34014371
  24. Gissler MC, Scherrer P, Anto-Michel N, Pennig J, Hoppe N, Funer L, Hardtner C, Stachon P, Li X, Mitre LS, Marchini T, Madl J, Wadle C, Hilgendorf I, von Zur Muhlen C, Bode C, Weber C, Lutgens E, Wolf D, Gerdes N, Zirlik A, Willecke F. Deficiency of Endothelial CD40 Induces a Stable Plaque Phenotype and Limits Inflammatory Cell Recruitment to Atherosclerotic Lesions in Mice. Thromb Haemost 2021; 121(11): 1530-1540. https://www.ncbi.nlm.nih.gov/pubmed/33618394
  25. Goncalves RLS, Schlame M, Bartelt A, Brand MD, Hotamisligil GS. Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H(2) O(2) production in heart and skeletal muscle mitochondria. FEBS Lett 2021; 595(3): 415-432. https://www.ncbi.nlm.nih.gov/pubmed/33112430
  26. Gutjahr JC, Crawford KS, Jensen DR, Naik P, Peterson FC, Samson GPB, Legler DF, Duchene J, Veldkamp CT, Rot A, Volkman BF. The dimeric form of CXCL12 binds to atypical chemokine receptor 1. Sci Signal 2021; 14(696). https://www.ncbi.nlm.nih.gov/pubmed/34404752
  27. Hall IF, Climent M, Viviani Anselmi C, Papa L, Tragante V, Lambroia L, Farina FM, Kleber ME, Marz W, Biguori C, Condorelli G, Elia L. rs41291957 controls miR-143 and miR-145 expression and impacts coronary artery disease risk. EMBO Mol Med 2021; 13(10): e14060. https://www.ncbi.nlm.nih.gov/pubmed/34551209
  28. He YY, Xie XM, Zhang HD, Ye J, Gencer S, van der Vorst EPC, Doring Y, Weber C, Pang XB, Jing ZC, Yan Y, Han ZY. Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary Hypertension. Front Pharmacol 2021; 12: 753727. https://www.ncbi.nlm.nih.gov/pubmed/34803695
  29. Henderson JM, Weber C, Santovito D. Beyond Self-Recycling: Cell-Specific Role of Autophagy in Atherosclerosis. Cells 2021; 10(3). https://www.ncbi.nlm.nih.gov/pubmed/33799835
  30. Hinkel R, Batkai S, Bahr A, Bozoglu T, Straub S, Borchert T, Viereck J, Howe A, Hornaschewitz N, Oberberger L, Jurisch V, Kozlik-Feldmann R, Freudenthal F, Ziegler T, Weber C, Sperandio M, Engelhardt S, Laugwitz KL, Moretti A, Klymiuk N, Thum T, Kupatt C. AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction. J Am Coll Cardiol 2021; 77(23): 2923-2935. https://www.ncbi.nlm.nih.gov/pubmed/34112319
  31. Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Muller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB. Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. Eur Heart J 2021; 42(39): 4077-4088. https://www.ncbi.nlm.nih.gov/pubmed/34279021
  32. Kassiteridi C, Cole JE, Griseri T, Falck-Hansen M, Goddard ME, Seneviratne AN, Green PA, Park I, Shami AG, Pattarabanjird T, Upadhye A, Taylor AM, Handa A, Channon KM, Lutgens E, McNamara CA, Williams RO, Monaco C. CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Circ Res 2021; 129(2): 280-295. https://www.ncbi.nlm.nih.gov/pubmed/33975450
  33. Kluza E, Beldman TJ, Shami A, Scholl ER, Malinova TS, Grootemaat AE, van der Wel NN, Goncalves I, Huveneers S, Mulder WJM, Lutgens E. Diverse ultrastructural landscape of atherosclerotic endothelium. Atherosclerosis 2021; 339: 35-45. https://www.ncbi.nlm.nih.gov/pubmed/34847419
  34. Koenen RR. Conformation-Crooking CXCL4 to Unravel Autoimmune Heparin-Induced Thrombocytopenia. Thromb Haemost 2021; 121(3): 258-260. https://www.ncbi.nlm.nih.gov/pubmed/33385179
  35. Kou J, Wang M, Shi J, Zhang H, Pu X, Song S, Yang C, Yan Y, Doring Y, Xie X, Pang X. Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation through the Endoplasmic Reticulum Stress Pathway in Apolipoprotein E4 Transgenic Mice. ACS Omega 2021; 6(10): 6654-6662. https://www.ncbi.nlm.nih.gov/pubmed/33748578
  36. Krammer C, Kontos C, Dewor M, Hille K, Dalla Volta B, El Bounkari O, Tas K, Sinitski D, Brandhofer M, Megens RTA, Weber C, Schultz JR, Bernhagen J, Kapurniotu A. A MIF-Derived Cyclopeptide that Inhibits MIF Binding and Atherogenic Signaling via the Chemokine Receptor CXCR2. Chembiochem 2021; 22(6): 1012-1019. https://www.ncbi.nlm.nih.gov/pubmed/33125165
  37. Lacy M, Burger C, Shami A, Ahmadsei M, Winkels H, Nitz K, van Tiel CM, Seijkens TTP, Kusters PJH, Karshovka E, Prange KHM, Wu Y, Brouns SLN, Unterlugauer S, Kuijpers MJE, Reiche ME, Steffens S, Edsfeldt A, Megens RTA, Heemskerk JWM, Goncalves I, Weber C, Gerdes N, Atzler D, Lutgens E. Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nat Commun 2021; 12(1): 3754. https://www.ncbi.nlm.nih.gov/pubmed/34145241
  38. Lee MW, Luo EW, Silvestre-Roig C, Srinivasan Y, Akabori K, Lemnitzer P, Schmidt NW, Lai GH, Santangelo CD, Soehnlein O, Wong GCL. Apolipoprotein Mimetic Peptide Inhibits Neutrophil-Driven Inflammatory Damage via Membrane Remodeling and Suppression of Cell Lysis. ACS Nano 2021; 15(10): 15930-15939. https://www.ncbi.nlm.nih.gov/pubmed/34586780
  39. Lemmer IL, Willemsen N, Hilal N, Bartelt A. A guide to understanding endoplasmic reticulum stress in metabolic disorders. Mol Metab 2021; 47: 101169. https://www.ncbi.nlm.nih.gov/pubmed/33484951
  40. Lesch S, Blumenberg V, Stoiber S, Gottschlich A, Ogonek J, Cadilha BL, Dantes Z, Rataj F, Dorman K, Lutz J, Karches CH, Heise C, Kurzay M, Larimer BM, Grassmann S, Rapp M, Nottebrock A, Kruger S, Tokarew N, Metzger P, Hoerth C, Benmebarek MR, Dhoqina D, Grunmeier R, Seifert M, Oener A, Umut O, Joaquina S, Vimeux L, Tran T, Hank T, Baba T, Huynh D, Megens RTA, Janssen KP, Jastroch M, Lamp D, Ruehland S, Di Pilato M, Pruessmann JN, Thomas M, Marr C, Ormanns S, Reischer A, Hristov M, Tartour E, Donnadieu E, Rothenfusser S, Duewell P, Konig LM, Schnurr M, Subklewe M, Liss AS, Halama N, Reichert M, Mempel TR, Endres S, Kobold S. T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours. Nat Biomed Eng 2021; 5(11): 1246-1260. https://www.ncbi.nlm.nih.gov/pubmed/34083764
  41. Lip GYH, Rigby A, Weber C. Looking Back on 2020, Looking Forward to 2021. Thromb Haemost 2021; 121(1): 1-3. https://www.ncbi.nlm.nih.gov/pubmed/33477196
  42. Lutgens E, Joffre J, van Os B, Ait-Oufella H. Targeting cytokines and immune checkpoints in atherosclerosis with monoclonal antibodies. Atherosclerosis 2021; 335: 98-109. https://www.ncbi.nlm.nih.gov/pubmed/34593238
  43. Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF, Soehnlein O, Chapman TM. Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists. Eur J Med Chem 2021; 226: 113805. https://www.ncbi.nlm.nih.gov/pubmed/34536667
  44. Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O, Chapman TM. Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation. Eur J Med Chem 2021; 214: 113194. https://www.ncbi.nlm.nih.gov/pubmed/33548634
  45. Marquez AB, van der Vorst EPC, Maas SL. Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential. J Clin Med 2021; 10(17). https://www.ncbi.nlm.nih.gov/pubmed/34501271
  46. Muley C, Bartelt A. Fuse your mitochondria, lose appetite: an anorexic, anti-obesity sphingolipid. EMBO Mol Med 2021; 13(8): e14618. https://www.ncbi.nlm.nih.gov/pubmed/34288516
  47. Muley C, Kotschi S, Bartelt A. Role of Ubiquilins for Brown Adipocyte Proteostasis and Thermogenesis. Front Endocrinol (Lausanne) 2021; 12: 739021. https://www.ncbi.nlm.nih.gov/pubmed/34650520
  48. Natarelli L, Parca L, Mazza T, Weber C, Virgili F, Fratantonio D. MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2. Noncoding RNA 2021; 7(1). https://www.ncbi.nlm.nih.gov/pubmed/33670580
  49. Natarelli L, Virgili F, Weber C. SARS-CoV-2, Cardiovascular Diseases, and Noncoding RNAs: A Connected Triad. Int J Mol Sci 2021; 22(22). https://www.ncbi.nlm.nih.gov/pubmed/34830125
  50. Nording H, Baron L, Haberthur D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, Meusel M, Meyer-Saraei R, Hlushchuk R, Sedding D, Borst O, Eitel I, Karsten CM, Feil R, Pichler B, Erdmann J, Verschoor A, Chavakis E, Chavakis T, von Hundelshausen P, Kohl J, Gawaz M, Langer HF. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun 2021; 12(1): 3352. https://www.ncbi.nlm.nih.gov/pubmed/34099640
  51. Perrino C, Ferdinandy P, Botker HE, Brundel B, Collins P, Davidson SM, den Ruijter HM, Engel FB, Gerdts E, Girao H, Gyongyosi M, Hausenloy DJ, Lecour S, Madonna R, Marber M, Murphy E, Pesce M, Regitz-Zagrosek V, Sluijter JPG, Steffens S, Gollmann-Tepekoylu C, Van Laake LW, Van Linthout S, Schulz R, Ytrehus K. Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res 2021; 117(2): 367-385. https://www.ncbi.nlm.nih.gov/pubmed/32484892
  52. Pesce M, Agostoni P, Botker HE, Brundel B, Davidson SM, Caterina R, Ferdinandy P, Girao H, Gyongyosi M, Hulot JS, Lecour S, Perrino C, Schulz R, Sluijter JP, Steffens S, Tancevski I, Gollmann-Tepekoylu C, Tschope C, Linthout SV, Madonna R. COVID-19-related cardiac complications from clinical evidences to basic mechanisms: opinion paper of the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res 2021; 117(10): 2148-2160. https://www.ncbi.nlm.nih.gov/pubmed/34117887
  53. Peters LJF, Jans A, Bartneck M, van der Vorst EPC. Immunomodulatory Nanomedicine for the Treatment of Atherosclerosis. J Clin Med 2021; 10(14). https://www.ncbi.nlm.nih.gov/pubmed/34300351
  54. Poels K, Neppelenbroek SIM, Kersten MJ, Antoni ML, Lutgens E, Seijkens TTP. Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem. J Immunother Cancer 2021; 9(6). https://www.ncbi.nlm.nih.gov/pubmed/34168005
  55. Puhl SL, Hilby M, Kohlhaas M, Keidel LM, Jansen Y, Hristov M, Schindler J, Maack C, Steffens S. Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodelling. Sci Rep 2021; 11(1): 14385. https://www.ncbi.nlm.nih.gov/pubmed/34257332
  56. Reiche ME, Lutgens E. Lose the helpers... get 'remote' regulators! Cardiovasc Res 2021; 117(3): 635-636. https://www.ncbi.nlm.nih.gov/pubmed/32637996
  57. Reilly NA, Lutgens E, Kuiper J, Heijmans BT, Jukema JW. Effects of fatty acids on T cell function: role in atherosclerosis. Nat Rev Cardiol 2021; 18(12): 824-837. https://www.ncbi.nlm.nih.gov/pubmed/34253911
  58. Rossaint J, Thomas K, Mersmann S, Skupski J, Margraf A, Tekath T, Jouvene CC, Dalli J, Hidalgo A, Meuth SG, Soehnlein O, Zarbock A. Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education. J Exp Med 2021; 218(7). https://www.ncbi.nlm.nih.gov/pubmed/34014253
  59. Santovito D, Steffens S. DNA damage and extranuclear DNA sensors: a dangerous duo in atherosclerosis. Eur Heart J 2021; 42(42): 4349-4351. https://www.ncbi.nlm.nih.gov/pubmed/34226940
  60. Santovito D, Toto L, De Nardis V, Marcantonio P, D'Aloisio R, Mastropasqua A, De Cesare D, Bucci M, Paganelli C, Natarelli L, Weber C, Consoli A, Mastropasqua R, Cipollone F. Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes. Sci Rep 2021; 11(1): 4136. https://www.ncbi.nlm.nih.gov/pubmed/33602976
  61. Santovito D, Weber C. Not all myocardial infarctions are created equal: The potential of circulating microRNAs to discern coronary artery dissection. EBioMedicine 2021; 67: 103366. https://www.ncbi.nlm.nih.gov/pubmed/33965874
  62. Schindler L, Zwissler L, Krammer C, Hendgen-Cotta U, Rassaf T, Hampton MB, Dickerhof N, Bernhagen J. Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells. J Leukoc Biol 2021; 110(5): 893-905. https://www.ncbi.nlm.nih.gov/pubmed/33565160
  63. Schlein C, Fischer AW, Sass F, Worthmann A, Todter K, Jaeckstein MY, Behrens J, Lynes MD, Kiebish MA, Narain NR, Bussberg V, Darkwah A, Jespersen NZ, Nielsen S, Scheele C, Schweizer M, Braren I, Bartelt A, Tseng YH, Heeren J, Scheja L. Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. Cell Rep 2021; 34(2): 108624. https://www.ncbi.nlm.nih.gov/pubmed/33440156
  64. Schmohl J, Moebius S, Guenther T, Pepeldjyika E, Seidel CL, Sutanto W, Schuster F, Kraemer D, Salih H, Hartmann A, Tischer J, Ries C, Schmetzer H. Expression of Surface-associated 82 kDa proMMP-9 in Lymphatic Leukemia Blast Cells Differentially Correlates With Prognosis. Anticancer Res 2021; 41(8): 3891-3898. https://www.ncbi.nlm.nih.gov/pubmed/34281851
  65. Schober A, Blay RM, Saboor Maleki S, Zahedi F, Winklmaier AE, Kakar MY, Baatsch IM, Zhu M, Geissler C, Fusco AE, Eberlein A, Li N, Megens RTA, Banafsche R, Kumbrink J, Weber C, Nazari-Jahantigh M. MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions. Circulation 2021; 144(13): 1059-1073. https://www.ncbi.nlm.nih.gov/pubmed/34233454
  66. Schoeps B, Eckfeld C, Prokopchuk O, Bottcher J, Haussler D, Steiger K, Demir IE, Knolle P, Soehnlein O, Jenne DE, Hermann CD, Kruger A. TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer. Cancer Res 2021; 81(13): 3568-3579. https://www.ncbi.nlm.nih.gov/pubmed/33941611
  67. Schumacher D, Curaj A, Simsekyilmaz S, Schober A, Liehn EA, Mause SF. miR155 Deficiency Reduces Myofibroblast Density but Fails to Improve Cardiac Function after Myocardial Infarction in Dyslipidemic Mouse Model. Int J Mol Sci 2021; 22(11). https://www.ncbi.nlm.nih.gov/pubmed/34067440
  68. Schumacher D, Liehn EA, Singh A, Curaj A, Wijnands E, Lira SA, Tacke F, Jankowski J, Biessen EAL, van der Vorst EPC. CCR6 Deficiency Increases Infarct Size after Murine Acute Myocardial Infarction. Biomedicines 2021; 9(11). https://www.ncbi.nlm.nih.gov/pubmed/34829761
  69. Schumski A, Ortega-Gomez A, Wichapong K, Winter C, Lemnitzer P, Viola JR, Pinilla-Vera M, Folco E, Solis-Mezarino V, Volker-Albert M, Maas SL, Pan C, Perez Olivares L, Winter J, Hackeng T, Karlsson MCI, Zeller T, Imhof A, Baron RM, Nicolaes GAF, Libby P, Maegdefessel L, Kamp F, Benoit M, Doring Y, Soehnlein O. Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion. Circulation 2021; 143(3): 254-266. https://www.ncbi.nlm.nih.gov/pubmed/33167684
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  72. Silvestre-Roig C, Lemnitzer P, Gall J, Schwager S, Toska A, Yvan-Charvet L, Detmar M, Soehnlein O. Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions. Circ Res 2021; 128(2): 284-286. https://www.ncbi.nlm.nih.gov/pubmed/33210556
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  76. Sundararaman SS, Peters LJF, Jansen Y, Gencer S, Yan Y, Nazir S, Bonnin Marquez A, Kahles F, Lehrke M, Biessen EAL, Jankowski J, Weber C, Doring Y, van der Vorst EPC. Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe(-/-) mice. Sci Rep 2021; 11(1): 10409. https://www.ncbi.nlm.nih.gov/pubmed/34001955
  77. Sundararaman SS, Peters LJF, Nazir S, Marquez AB, Bouma JE, Bayasgalan S, Doring Y, van der Vorst EPC. PCSK9 Imperceptibly Affects Chemokine Receptor Expression In Vitro and In Vivo. Int J Mol Sci 2021; 22(23). https://www.ncbi.nlm.nih.gov/pubmed/34884827
  78. Sundararaman SS, van der Vorst EPC. Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health. Int J Mol Sci 2021; 22(5). https://www.ncbi.nlm.nih.gov/pubmed/33804544
  79. Tahir S, Steffens S. Nonclassical monocytes in cardiovascular physiology and disease. Am J Physiol Cell Physiol 2021; 320(5): C761-C770. https://www.ncbi.nlm.nih.gov/pubmed/33596150
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Highlights

LMU Klinikum

BTK inhibitors against vaccine-related thrombotic complications

NEJM 2021 ➤ IPEK scientists propose treatment for rare, life-threatening complication from Astra-Zeneca vaccine.

Chuttersnap | Unsplash

Why is the risk of heart attack higher early in the day

CIRCULATION 2021 ➤ In the journal Circulation, a team led by IPEK scientists Maliheh Nazari-Jahantigh and Andreas Schober provides an answer.

Atherosclerosis and the immune system

NATURE  COMMUNICATIONS 2021 ➤ IPEK scientist have uncovered how signal proteins of the immune system regulate the development of atherosclerosis.