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Publications 2017

  1. A-Gonzalez N, Quintana JA, Garcia-Silva S, Mazariegos M, Gonzalez de la Aleja A, Nicolas-Avila JA, Walter W, Adrover JM, Crainiciuc G, Kuchroo VK, Rothlin CV, Peinado H, Castrillo A, Ricote M, Hidalgo A. Phagocytosis imprints heterogeneity in tissue-resident macrophages. J Exp Med 2017; 214(5): 1281-96. https://www.ncbi.nlm.nih.gov/pubmed/28432199
  2. Aarts S, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen P, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E. Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. J Neuroinflammation 2017; 14(1): 105. https://www.ncbi.nlm.nih.gov/pubmed/28494768
  3. Aarts S, Seijkens TTP, van Dorst KJF, Dijkstra CD, Kooij G, Lutgens E. The CD40-CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Front Immunol 2017; 8: 1791. https://www.ncbi.nlm.nih.gov/pubmed/29312317
  4. Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, de Winther MP, Noels H, Bernhagen J. Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A 2017; 114(13): E2766-E75. https://www.ncbi.nlm.nih.gov/pubmed/28292897
  5. Atzler D, McAndrew DJ, Cordts K, Schneider JE, Zervou S, Schwedhelm E, Neubauer S, Lygate CA. Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure. Circulation 2017; 135(4): 400-2. https://www.ncbi.nlm.nih.gov/pubmed/28115416
  6. Bamberg F, Hetterich H, Rospleszcz S, Lorbeer R, Auweter SD, Schlett CL, Schafnitzel A, Bayerl C, Schindler A, Saam T, Muller-Peltzer K, Sommer W, Zitzelsberger T, Machann J, Ingrisch M, Selder S, Rathmann W, Heier M, Linkohr B, Meisinger C, Weber C, Ertl-Wagner B, Massberg S, Reiser MF, Peters A. Subclinical Disease Burden as Assessed by Whole-Body MRI in Subjects With Prediabetes, Subjects With Diabetes, and Normal Control Subjects From the General Population: The KORA-MRI Study. Diabetes 2017; 66(1): 158-69. https://www.ncbi.nlm.nih.gov/pubmed/27999110
  7. Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T. CD40-signalling abrogates induction of RORgammat(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis. Nat Commun 2017; 8: 14715. https://www.ncbi.nlm.nih.gov/pubmed/28276457
  8. Beldman TJ, Senders ML, Alaarg A, Perez-Medina C, Tang J, Zhao Y, Fay F, Deichmoller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E. Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis. ACS Nano 2017; 11(6): 5785-99. https://www.ncbi.nlm.nih.gov/pubmed/28463501
  9. Bermudez B, Dahl TB, Medina I, Groeneweg M, Holm S, Montserrat-de la Paz S, Rousch M, Otten J, Herias V, Varela LM, Ranheim T, Yndestad A, Ortega-Gomez A, Abia R, Nagy L, Aukrust P, Muriana FJG, Halvorsen B, Biessen EAL. Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARgamma-Dependent Monocyte Differentiation and Function. Arterioscler Thromb Vasc Biol 2017; 37(6): 1157-67. https://www.ncbi.nlm.nih.gov/pubmed/28408371
  10. Bernelot Moens SJ, Neele AE, Kroon J, van der Valk FM, Van den Bossche J, Hoeksema MA, Hoogeveen RM, Schnitzler JG, Baccara-Dinet MT, Manvelian G, de Winther MPJ, Stroes ESG. PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia. Eur Heart J 2017; 38(20): 1584-93. https://www.ncbi.nlm.nih.gov/pubmed/28329114
  11. Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D. Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes. Eur Heart J 2017; 38(4): 292-301. https://www.ncbi.nlm.nih.gov/pubmed/28182242
  12. Cheng HS, Besla R, Li A, Chen Z, Shikatani EA, Nazari-Jahantigh M, Hammoutene A, Nguyen MA, Geoffrion M, Cai L, Khyzha N, Li T, MacParland SA, Husain M, Cybulsky MI, Boulanger CM, Temel RE, Schober A, Rayner KJ, Robbins CS, Fish JE. Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a. Circ Res 2017; 121(4): 354-67. https://www.ncbi.nlm.nih.gov/pubmed/28637783
  13. de Jong R, Leoni G, Drechsler M, Soehnlein O. The advantageous role of annexin A1 in cardiovascular disease. Cell Adh Migr 2017; 11(3): 261-74. https://www.ncbi.nlm.nih.gov/pubmed/27860536
  14. de Jong RJ, Paulin N, Lemnitzer P, Viola JR, Winter C, Ferraro B, Grommes J, Weber C, Reutelingsperger C, Drechsler M, Soehnlein O. Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report. Arterioscler Thromb Vasc Biol 2017; 37(2): 312-5. https://www.ncbi.nlm.nih.gov/pubmed/28062503
  15. Degen H, Borst O, Ziegler M, Mojica Munoz AK, Jamasbi J, Walker B, Gobel S, Fassbender J, Adler K, Brandl R, Munch G, Lorenz R, Siess W, Gawaz M, Ungerer M. ADPase CD39 Fused to Glycoprotein VI-Fc Boosts Local Antithrombotic Effects at Vascular Lesions. J Am Heart Assoc 2017; 6(8): e005991. https://www.ncbi.nlm.nih.gov/pubmed/28751543
  16. Doring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schroder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gabel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C. Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies. Circulation 2017; 136(4): 388-403. https://www.ncbi.nlm.nih.gov/pubmed/28450349
  17. Doring Y, Soehnlein O, Weber C. Neutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis. Circ Res 2017; 120(4): 736-43. https://www.ncbi.nlm.nih.gov/pubmed/28209798
  18. Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K, Caamano J, Rulicke T, Moss P, Megens RTA, von Andrian UH, Hidalgo A, Weber C, Rot A. Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. Nat Immunol 2017; 18(7): 753-61. https://www.ncbi.nlm.nih.gov/pubmed/28553950
  19. Enamorado M, Iborra S, Priego E, Cueto FJ, Quintana JA, Martinez-Cano S, Mejias-Perez E, Esteban M, Melero I, Hidalgo A, Sancho D. Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells. Nat Commun 2017; 8: 16073. https://www.ncbi.nlm.nih.gov/pubmed/28714465
  20. Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S, Thompson AAR, Jo H, Weber C, Ridger V, Schober A, Evans PC. Mechanical Activation of Hypoxia-Inducible Factor 1alpha Drives Endothelial Dysfunction at Atheroprone Sites. Arterioscler Thromb Vasc Biol 2017; 37(11): 2087-101. https://www.ncbi.nlm.nih.gov/pubmed/28882872
  21. Ferrari E, Lutgens E, Weber C, Gerdes N. Atherosclerosis: cell biology and lipoproteins focus on epigenetic modification and macrophage biology. Curr Opin Lipidol 2017; 28(2): 220-1. https://www.ncbi.nlm.nih.gov/pubmed/28272157
  22. Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J. Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Oncotarget 2017; 8(22): 35542-57. https://www.ncbi.nlm.nih.gov/pubmed/28415767
  23. Hakimzadeh N, Pinas VA, Molenaar G, de Waard V, Lutgens E, van Eck-Smit BLF, de Bruin K, Piek JJ, Eersels JLH, Booij J, Verberne HJ, Windhorst AD. Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques. PLoS One 2017; 12(11): e0187767. https://www.ncbi.nlm.nih.gov/pubmed/29190653
  24. Horckmans M, Ring L, Duchene J, Santovito D, Schloss MJ, Drechsler M, Weber C, Soehnlein O, Steffens S. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype. Eur Heart J 2017; 38(3): 187-97. https://www.ncbi.nlm.nih.gov/pubmed/28158426
  25. Hyafil F, Pelisek J, Laitinen I, Schottelius M, Mohring M, Doring Y, van der Vorst EP, Kallmayer M, Steiger K, Poschenrieder A, Notni J, Fischer J, Baumgartner C, Rischpler C, Nekolla SG, Weber C, Eckstein HH, Wester HJ, Schwaiger M. Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer (68)Ga-Pentixafor for PET. J Nucl Med 2017; 58(3): 499-506. https://www.ncbi.nlm.nih.gov/pubmed/27789718
  26. Jamasbi J, Ayabe K, Goto S, Nieswandt B, Peter K, Siess W. Platelet receptors as therapeutic targets: Past, present and future. Thromb Haemost 2017; 117(7): 1249-57. https://www.ncbi.nlm.nih.gov/pubmed/28597906
  27. Jung C, Lichtenauer M, Strodthoff D, Winkels H, Wernly B, Burger C, Kamchybekov U, Lutgens E, Figulla HR, Gerdes N. Alterations in systemic levels of Th1, Th2, and Th17 cytokines in overweight adolescents and obese mice. Pediatr Diabetes 2017; 18(8): 714-21. https://www.ncbi.nlm.nih.gov/pubmed/27597513
  28. Krishnasamy K, Limbourg A, Kapanadze T, Gamrekelashvili J, Beger C, Hager C, Lozanovski VJ, Falk CS, Napp LC, Bauersachs J, Mack M, Haller H, Weber C, Adams RH, Limbourg FP. Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia. Nat Commun 2017; 8(1): 952. https://www.ncbi.nlm.nih.gov/pubmed/29038527
  29. Kusters P, Seijkens T, Burger C, Legein B, Winkels H, Gijbels M, Barthels C, Bennett R, Beckers L, Atzler D, Biessen E, Brocker T, Weber C, Gerdes N, Lutgens E. Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption. Am J Pathol 2017; 187(12): 2912-9. https://www.ncbi.nlm.nih.gov/pubmed/28935569
  30. Ley K, Gerdes N, Winkels H. ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis. Arterioscler Thromb Vasc Biol 2017; 37(5): 764-77. https://www.ncbi.nlm.nih.gov/pubmed/28360089
  31. Li JL, Zarbock A, Hidalgo A. Platelets as autonomous drones for hemostatic and immune surveillance. J Exp Med 2017; 214(8): 2193-204. https://www.ncbi.nlm.nih.gov/pubmed/28720569
  32. Lip GY, Weber C. A happy and prosperous New Year 2017 with "Thrombosis and Haemostasis" .... and our 60(th) Anniversary! Thromb Haemost 2017; 117(1): 1-2. https://www.ncbi.nlm.nih.gov/pubmed/28066853
  33. Lip GYH, Weber C. Thrombosis and Haemostasis: Past, present and future. Thromb Haemost 2017; 117(7): 1217-8. https://www.ncbi.nlm.nih.gov/pubmed/30457155
  34. Maffia P, Doring Y, Biessen EA, Mallat Z. Commentary: Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. Front Immunol 2017; 8: 140. https://www.ncbi.nlm.nih.gov/pubmed/28243244
  35. Mitroulis I, Chen LS, Singh RP, Kourtzelis I, Economopoulou M, Kajikawa T, Troullinaki M, Ziogas A, Ruppova K, Hosur K, Maekawa T, Wang B, Subramanian P, Tonn T, Verginis P, von Bonin M, Wobus M, Bornhauser M, Grinenko T, Di Scala M, Hidalgo A, Wielockx B, Hajishengallis G, Chavakis T. Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J Clin Invest 2017; 127(10): 3624-39. https://www.ncbi.nlm.nih.gov/pubmed/28846069
  36. Mojica Munoz AK, Jamasbi J, Uhland K, Degen H, Munch G, Ungerer M, Brandl R, Megens R, Weber C, Lorenz R, Siess W. Recombinant GPVI-Fc added to single or dual antiplatelet therapy in vitro prevents plaque-induced platelet thrombus formation. Thromb Haemost 2017; 117(8): 1651-9. https://www.ncbi.nlm.nih.gov/pubmed/28569920
  37. Neele AE, Prange KH, Hoeksema MA, van der Velden S, Lucas T, Dimmeler S, Lutgens E, Van den Bossche J, de Winther MP. Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells. Epigenomics 2017; 9(4): 383-91. https://www.ncbi.nlm.nih.gov/pubmed/28322580
  38. Newland SA, Mohanta S, Clement M, Taleb S, Walker JA, Nus M, Sage AP, Yin C, Hu D, Kitt LL, Finigan AJ, Rodewald HR, Binder CJ, McKenzie ANJ, Habenicht AJ, Mallat Z. Type-2 innate lymphoid cells control the development of atherosclerosis in mice. Nat Commun 2017; 8: 15781. https://www.ncbi.nlm.nih.gov/pubmed/28589929
  39. Nicolaou A, Zhao Z, Northoff BH, Sass K, Herbst A, Kohlmaier A, Chalaris A, Wolfrum C, Weber C, Steffens S, Rose-John S, Teupser D, Holdt LM. Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice. Arterioscler Thromb Vasc Biol 2017; 37(2): 247-57. https://www.ncbi.nlm.nih.gov/pubmed/28062509
  40. Nicolas-Avila JA, Adrover JM, Hidalgo A. Neutrophils in Homeostasis, Immunity, and Cancer. Immunity 2017; 46(1): 15-28. https://www.ncbi.nlm.nih.gov/pubmed/28099862
  41. Paulin N, Doring Y, Kooijman S, Blanchet X, Viola JR, de Jong R, Mandl M, Hendrikse J, Schiener M, von Hundelshausen P, Vogt A, Weber C, Bdeir K, Hofmann SM, Rensen PCN, Drechsler M, Soehnlein O. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance. EBioMedicine 2017; 16: 204-11. https://www.ncbi.nlm.nih.gov/pubmed/28111237
  42. Pellico J, Lechuga-Vieco AV, Almarza E, Hidalgo A, Mesa-Nunez C, Fernandez-Barahona I, Quintana JA, Bueren J, Enriquez JA, Ruiz-Cabello J, Herranz F. In vivo imaging of lung inflammation with neutrophil-specific (68)Ga nano-radiotracer. Sci Rep 2017; 7(1): 13242. https://www.ncbi.nlm.nih.gov/pubmed/29038592
  43. Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, Hilgarth R, O'Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A. Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling. J Clin Invest 2017; 127(9): 3510-20. https://www.ncbi.nlm.nih.gov/pubmed/28783045
  44. Rademakers T, van der Vorst EP, Daissormont IT, Otten JJ, Theodorou K, Theelen TL, Gijbels M, Anisimov A, Nurmi H, Lindeman JH, Schober A, Heeneman S, Alitalo K, Biessen EA. Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis. Sci Rep 2017; 7: 45263. https://www.ncbi.nlm.nih.gov/pubmed/28349940
  45. Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat ML, Boilard E, Buzas EI, Caporali A, Dignat-George F, Evans PC, Lacroix R, Lutgens E, Ketelhuth DFJ, Nieuwland R, Toti F, Tunon J, Weber C, Hoefer IE. Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. Thromb Haemost 2017; 117(7): 1296-316. https://www.ncbi.nlm.nih.gov/pubmed/28569921
  46. Rinne P, Rami M, Nuutinen S, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikainen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimaki T, Weber C, Steffens S. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. Circulation 2017; 136(1): 83-97. https://www.ncbi.nlm.nih.gov/pubmed/28450348
  47. Rowinska Z, Koeppel TA, Sanati M, Schelzig H, Jankowski J, Weber C, Zernecke A, Liehn EA. Role of the CX3C chemokine receptor CX3CR1 in the pathogenesis of atherosclerosis after aortic transplantation. PLoS One 2017; 12(2): e0170644. https://www.ncbi.nlm.nih.gov/pubmed/28234900
  48. Santovito D. Fat or fit: The big oxymoron of (metabolically) healthy obesity. Atherosclerosis 2017; 262: 143-5. https://www.ncbi.nlm.nih.gov/pubmed/28499608
  49. Santovito D, Weber C. Atherosclerosis revisited from a clinical perspective: still an inflammatory disease? Thromb Haemost 2017; 117(2): 231-7. https://www.ncbi.nlm.nih.gov/pubmed/27975102
  50. Santovito D, Weber C. Zooming in on microRNAs for refining cardiovascular risk prediction in secondary prevention. Eur Heart J 2017; 38(7): 524-8. https://www.ncbi.nlm.nih.gov/pubmed/27371715
  51. Schloss MJ, Hilby M, Nitz K, Guillamat Prats R, Ferraro B, Leoni G, Soehnlein O, Kessler T, He W, Luckow B, Horckmans M, Weber C, Duchene J, Steffens S. Ly6C(high) Monocytes Oscillate in the Heart During Homeostasis and After Myocardial Infarction-Brief Report. Arterioscler Thromb Vasc Biol 2017; 37(9): 1640-5. https://www.ncbi.nlm.nih.gov/pubmed/28663258
  52. Soehnlein O, Silvestre-Roig C. Basic research: Standardizing animal atherosclerosis studies to improve reproducibility. Nat Rev Cardiol 2017; 14(10): 574-5. https://www.ncbi.nlm.nih.gov/pubmed/28880022
  53. Soehnlein O, Steffens S, Hidalgo A, Weber C. Neutrophils as protagonists and targets in chronic inflammation. Nat Rev Immunol 2017; 17(4): 248-61. https://www.ncbi.nlm.nih.gov/pubmed/28287106
  54. Steffens S, Winter C, Schloss MJ, Hidalgo A, Weber C, Soehnlein O. Circadian Control of Inflammatory Processes in Atherosclerosis and Its Complications. Arterioscler Thromb Vasc Biol 2017; 37(6): 1022-8. https://www.ncbi.nlm.nih.gov/pubmed/28450299
  55. Theodorou K, van der Vorst EPC, Gijbels MJ, Wolfs IMJ, Jeurissen M, Theelen TL, Sluimer JC, Wijnands E, Cleutjens JP, Li Y, Jansen Y, Weber C, Ludwig A, Bentzon JF, Bartsch JW, Biessen EAL, Donners M. Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression. Sci Rep 2017; 7(1): 11670. https://www.ncbi.nlm.nih.gov/pubmed/28916789
  56. Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Cimen I, Walter P, Weber C, Erbay E. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A 2017; 114(8): E1395-E404. https://www.ncbi.nlm.nih.gov/pubmed/28137856
  57. van den Berg SM, van Dam AD, Kusters PJH, Beckers L, den Toom M, van der Velden S, Van den Bossche J, van Die I, Boon MR, Rensen PCN, Lutgens E, de Winther MPJ. Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils. J Mol Endocrinol 2017; 59(3): 245-55. https://www.ncbi.nlm.nih.gov/pubmed/28694301
  58. van den Berg SM, van Dam AD, Rensen PC, de Winther MP, Lutgens E. Immune Modulation of Brown(ing) Adipose Tissue in Obesity. Endocr Rev 2017; 38(1): 46-68. https://www.ncbi.nlm.nih.gov/pubmed/27849358
  59. van der Vorst EP, Zhao Z, Rami M, Holdt LM, Teupser D, Steffens S, Weber C. Contrasting effects of myeloid and endothelial ADAM17 on atherosclerosis development. Thromb Haemost 2017; 117(3): 644-6. https://www.ncbi.nlm.nih.gov/pubmed/28004058
  60. van der Vorst EPC, Maas SL, Ortega-Gomez A, Hameleers JMM, Bianchini M, Asare Y, Soehnlein O, Doring Y, Weber C, Megens RTA. Functional ex-vivo Imaging of Arterial Cellular Recruitment and Lipid Extravasation. Bio Protoc 2017; 7(12): e2344. https://www.ncbi.nlm.nih.gov/pubmed/28890907
  61. van der Vorst EPC, Theodorou K, Biessen EAL, Donners M. HDL and macrophages: explaining the clinical failures and advancing HDL-based therapeutics in cardiovascular diseases? Expert Rev Cardiovasc Ther 2017; 15(5): 343-4. https://www.ncbi.nlm.nih.gov/pubmed/28349717
  62. van der Vorst EPC, Theodorou K, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LFA, Tas SW, Wolfs IMJ, Kuijpers MJE, Gijbels MJ, Schalkwijk CG, Koonen DPY, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, de Winther MPJ, Biessen EAL, Donners M. High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-kappaB/STAT1-IRF1 Signaling. Cell Metab 2017; 25(1): 197-207. https://www.ncbi.nlm.nih.gov/pubmed/27866837
  63. Varasteh Z, Hyafil F, Anizan N, Diallo D, Aid-Launais R, Mohanta S, Li Y, Braeuer M, Steiger K, Vigne J, Qin Z, Nekolla SG, Fabre JE, Doring Y, Le Guludec D, Habenicht A, Vera DR, Schwaiger M. Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using (111)In-tilmanocept. EJNMMI Res 2017; 7(1): 40. https://www.ncbi.nlm.nih.gov/pubmed/28470406
  64. von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, Doring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C. Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Sci Transl Med 2017; 9(384). https://www.ncbi.nlm.nih.gov/pubmed/28381538
  65. Weber C, Badimon L, Mach F, van der Vorst EPC. Therapeutic strategies for atherosclerosis and atherothrombosis: Past, present and future. Thromb Haemost 2017; 117(7): 1258-64. https://www.ncbi.nlm.nih.gov/pubmed/28594053
  66. Weber C, Lip GY. Editors' Choice 2016 papers in Thrombosis and Haemostasis. Thromb Haemost 2017; 117(1): 204-6. https://www.ncbi.nlm.nih.gov/pubmed/28066852
  67. Weber C, von Hundelshausen P. CANTOS Trial Validates the Inflammatory Pathogenesis of Atherosclerosis: Setting the Stage for a New Chapter in Therapeutic Targeting. Circ Res 2017; 121(10): 1119-21. https://www.ncbi.nlm.nih.gov/pubmed/29074528
  68. Winkels H, Meiler S, Lievens D, Engel D, Spitz C, Burger C, Beckers L, Dandl A, Reim S, Ahmadsei M, Hartwig H, Holdt LM, Hristov M, Megens RTA, Schmitt MM, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N. CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice. Eur Heart J 2017; 38(48): 3590-9. https://www.ncbi.nlm.nih.gov/pubmed/29045618
  69. Wolf D, Bukosza N, Engel D, Poggi M, Jehle F, Anto Michel N, Chen YC, Colberg C, Hoppe N, Dufner B, Boon L, Blankenbach H, Hilgendorf I, von Zur Muhlen C, Reinohl J, Sommer B, Marchini T, Febbraio MA, Weber C, Bode C, Peter K, Lutgens E, Zirlik A. Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO). Thromb Haemost 2017; 117(2): 325-38. https://www.ncbi.nlm.nih.gov/pubmed/27853810
  70. Wu Z, Rademakers T, Kiessling F, Vogt M, Westein E, Weber C, Megens RTA, van Zandvoort M. Multi-photon microscopy in cardiovascular research. Methods 2017; 130: 79-89. https://www.ncbi.nlm.nih.gov/pubmed/28434997
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