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Publications 2016

  1. Alam A, Leoni G, Quiros M, Wu H, Desai C, Nishio H, Jones RM, Nusrat A, Neish AS. The microenvironment of injured murine gut elicits a local pro-restitutive microbiota. Nat Microbiol 2016; 1: 15021. https://www.ncbi.nlm.nih.gov/pubmed/27571978
  2. Braster Q, Silvestre Roig C, Hartwig H, Beckers L, den Toom M, Doring Y, Daemen MJ, Lutgens E, Soehnlein O. Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice. PLoS One 2016; 11(10): e0163922. https://www.ncbi.nlm.nih.gov/pubmed/27701440
  3. Braster Q, Silvestre-Roig C, Hartwig H, Kusters P, Aarts S, den Toom M, Gallo RL, Weber C, Lutgens E, Soehnlein O. Cathelicidin regulates myeloid cell accumulation in adipose tissue and promotes insulin resistance during obesity. Thromb Haemost 2016; 115(6): 1237-9. https://www.ncbi.nlm.nih.gov/pubmed/26939624
  4. Campa CC, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, Ghigo A, Camporeale A, Di Savino A, Martini M, Perino A, Megens RT, Kurz AR, Scheiermann C, Sperandio M, Gamba A, Hirsch E. Rac signal adaptation controls neutrophil mobilization from the bone marrow. Sci Signal 2016; 9(459): ra124. https://www.ncbi.nlm.nih.gov/pubmed/27999173
  5. Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Renia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med 2016; 213(11): 2293-314. https://www.ncbi.nlm.nih.gov/pubmed/27811056
  6. Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EPC, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T. Author response: Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. eLife Sciences Publications, Ltd 2016.
  7. Daugherty A, Hegele RA, Mackman N, Rader DJ, Schmidt AM, Weber C. Complying With the National Institutes of Health Guidelines and Principles for Rigor and Reproducibility: Refutations. Arterioscler Thromb Vasc Biol 2016; 36(7): 1303-4. https://www.ncbi.nlm.nih.gov/pubmed/27335467
  8. de Jong R, Leoni G, Drechsler M, Soehnlein O. The advantageous role of annexin A1 in cardiovascular disease. Cell Adh Migr 2017; 11(3): 261-74. https://www.ncbi.nlm.nih.gov/pubmed/27860536
  9. Deppe J, Popp T, Egea V, Steinritz D, Schmidt A, Thiermann H, Weber C, Ries C. Impairment of hypoxia-induced HIF-1alpha signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol 2016; 90(5): 1141-50. https://www.ncbi.nlm.nih.gov/pubmed/26082309
  10. Deppe J, Steinritz D, Santovito D, Egea V, Schmidt A, Weber C, Ries C. Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia. Toxicol Lett 2016; 244: 81-7. https://www.ncbi.nlm.nih.gov/pubmed/26383628
  11. Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Muller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sanchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Doring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Kohrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Hofmann SM, Yang B, Tschop MH, DiMarchi R, Muller TD. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell 2016; 167(3): 843-57 e14. https://www.ncbi.nlm.nih.gov/pubmed/27720451
  12. Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseno CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP. Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nat Commun 2016; 7: 12597. https://www.ncbi.nlm.nih.gov/pubmed/27576369
  13. Gerdes N, Seijkens T, Lievens D, Kuijpers MJ, Winkels H, Projahn D, Hartwig H, Beckers L, Megens RT, Boon L, Noelle RJ, Soehnlein O, Heemskerk JW, Weber C, Lutgens E. Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes. Arterioscler Thromb Vasc Biol 2016; 36(3): 482-90. https://www.ncbi.nlm.nih.gov/pubmed/26821950
  14. Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T. MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease. Circulation 2016; 134(24): 1973-90. https://www.ncbi.nlm.nih.gov/pubmed/27780851
  15. Hartmann P, Zhou Z, Natarelli L, Wei Y, Nazari-Jahantigh M, Zhu M, Grommes J, Steffens S, Weber C, Schober A. Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nat Commun 2016; 7: 10521. https://www.ncbi.nlm.nih.gov/pubmed/26837267
  16. Hibender S, Franken R, van Roomen C, Ter Braake A, van der Made I, Schermer EE, Gunst Q, van den Hoff MJ, Lutgens E, Pinto YM, Groenink M, Zwinderman AH, Mulder BJ, de Vries CJ, de Waard V. Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model. Arterioscler Thromb Vasc Biol 2016; 36(8): 1618-26. https://www.ncbi.nlm.nih.gov/pubmed/27283746
  17. Hu D, Yin C, Mohanta SK, Weber C, Habenicht AJ. Preparation of Single Cell Suspensions from Mouse Aorta. Bio Protoc 2016; 6(11): e1832. https://www.ncbi.nlm.nih.gov/pubmed/27335895
  18. Jamasbi J, Megens RT, Bianchini M, Uhland K, Munch G, Ungerer M, Sherman S, Faussner A, Brandl R, John C, Buchner J, Weber C, Lorenz R, Elia N, Siess W. Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation. JACC Basic Transl Sci 2016; 1(3): 131-42. https://www.ncbi.nlm.nih.gov/pubmed/27766315
  19. Jansen MF, Hollander MR, van Royen N, Horrevoets AJ, Lutgens E. CD40 in coronary artery disease: a matter of macrophages? Basic Res Cardiol 2016; 111(4): 38. https://www.ncbi.nlm.nih.gov/pubmed/27146510
  20. Leiva M, Hidalgo A. Bidirectional dialog in the haematopoietic niche. Cell Cycle 2016; 15(8): 1027-8. https://www.ncbi.nlm.nih.gov/pubmed/27097370
  21. Leiva M, Quintana JA, Ligos JM, Hidalgo A. Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFbeta availability. Nat Commun 2016; 7: 10222. https://www.ncbi.nlm.nih.gov/pubmed/26742601
  22. Li J, McArdle S, Gholami A, Kimura T, Wolf D, Gerhardt T, Miller J, Weber C, Ley K. CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis. Circ Res 2016; 118(10): 1540-52. https://www.ncbi.nlm.nih.gov/pubmed/27021296
  23. Lip GYH, Weber C. May your New Year be happy and prosperous with “Thrombosis and Haemostasis”. Thrombosis and Haemostasis 2016; 115(01): 1-2. http://dx.doi.org/10.1160/th15-11-0912
  24. Mahl C, Egea V, Megens RT, Pitsch T, Santovito D, Weber C, Ries C. RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/beta-catenin signaling in human mesenchymal stem cells. Cell Mol Life Sci 2016; 73(7): 1489-501. https://www.ncbi.nlm.nih.gov/pubmed/26459448
  25. Martinez-Moreno M, Leiva M, Aguilera-Montilla N, Sevilla-Movilla S, Isern de Val S, Arellano-Sanchez N, Gutierrez NC, Maldonado R, Martinez-Lopez J, Buno I, Garcia-Marco JA, Sanchez-Mateos P, Hidalgo A, Garcia-Pardo A, Teixido J. In vivo adhesion of malignant B cells to bone marrow microvasculature is regulated by alpha4beta1 cytoplasmic-binding proteins. Leukemia 2016; 30(4): 861-72. https://www.ncbi.nlm.nih.gov/pubmed/26658839
  26. Meiler S, Smeets E, Winkels H, Shami A, Pascutti MF, Nolte MA, Beckers L, Weber C, Gerdes N, Lutgens E. Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report. Arterioscler Thromb Vasc Biol 2016; 36(9): 1748-52. https://www.ncbi.nlm.nih.gov/pubmed/27444204
  27. Mohanta S, Yin C, Weber C, Hu D, Habenicht AJ. Aorta Atherosclerosis Lesion Analysis in Hyperlipidemic Mice. Bio Protoc 2016; 6(11): e1833. https://www.ncbi.nlm.nih.gov/pubmed/27366759
  28. Muhlstedt S, Ghadge SK, Duchene J, Qadri F, Jarve A, Vilianovich L, Popova E, Pohlmann A, Niendorf T, Boye P, Ozcelik C, Bader M. Cardiomyocyte-derived CXCL12 is not involved in cardiogenesis but plays a crucial role in myocardial infarction. J Mol Med (Berl) 2016; 94(9): 1005-14. https://www.ncbi.nlm.nih.gov/pubmed/27251706
  29. Nus M, Martinez-Poveda B, MacGrogan D, Chevre R, D'Amato G, Sbroggio M, Rodriguez C, Martinez-Gonzalez J, Andres V, Hidalgo A, de la Pompa JL. Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis. Cardiovasc Res 2016; 112(2): 568-80. https://www.ncbi.nlm.nih.gov/pubmed/27496872
  30. Ortega-Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong RJ, Megens RT, Jamasbi J, Doring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O. Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment. Circulation 2016; 134(16): 1176-88. https://www.ncbi.nlm.nih.gov/pubmed/27660294
  31. Petzold T, Thienel M, Konrad I, Schubert I, Regenauer R, Hoppe B, Lorenz M, Eckart A, Chandraratne S, Lennerz C, Kolb C, Braun D, Jamasbi J, Brandl R, Braun S, Siess W, Schulz C, Massberg S. Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis. Sci Transl Med 2016; 8(367): 367ra168. https://www.ncbi.nlm.nih.gov/pubmed/27903864
  32. Rajasekaran D, Groning S, Schmitz C, Zierow S, Drucker N, Bakou M, Kohl K, Mertens A, Lue H, Weber C, Xiao A, Luker G, Kapurniotu A, Lolis E, Bernhagen J. Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE. J Biol Chem 2016; 291(30): 15881-95. https://www.ncbi.nlm.nih.gov/pubmed/27226569
  33. Santovito D, Egea V, Weber C. Small but smart: MicroRNAs orchestrate atherosclerosis development and progression. Biochim Biophys Acta 2016; 1861(12 Pt B): 2075-86. https://www.ncbi.nlm.nih.gov/pubmed/26738655
  34. Schaftenaar F, Frodermann V, Kuiper J, Lutgens E. Atherosclerosis: the interplay between lipids and immune cells. Curr Opin Lipidol 2016; 27(3): 209-15. https://www.ncbi.nlm.nih.gov/pubmed/27031276
  35. Schloss MJ, Horckmans M, Nitz K, Duchene J, Drechsler M, Bidzhekov K, Scheiermann C, Weber C, Soehnlein O, Steffens S. The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment. EMBO Mol Med 2016; 8(8): 937-48. https://www.ncbi.nlm.nih.gov/pubmed/27226028
  36. Schmohl J, Santovito D, Guenther T, Sutanto W, Kroell T, Salih H, Pitsch T, Egea V, Weber C, Schmetzer H, Ries C. Expression of surface-associated 82kDa-proMMP-9 in primary acute leukemia blast cells inversely correlates with patients' risk. Exp Hematol 2016; 44(5): 358-62 e5. https://www.ncbi.nlm.nih.gov/pubmed/26845021
  37. Schober A, Weber C. Mechanisms of MicroRNAs in Atherosclerosis. Annu Rev Pathol 2016; 11(1): 583-616. https://www.ncbi.nlm.nih.gov/pubmed/27193456
  38. Silvestre-Roig C, Hidalgo A, Soehnlein O. Neutrophil heterogeneity: implications for homeostasis and pathogenesis. Blood 2016; 127(18): 2173-81. https://www.ncbi.nlm.nih.gov/pubmed/27002116
  39. Simsekyilmaz S, Liehn EA, Weinandy S, Schreiber F, Megens RT, Theelen W, Smeets R, Jockenhovel S, Gries T, Moller M, Klee D, Weber C, Zernecke A. Targeting In-Stent-Stenosis with RGD- and CXCL1-Coated Mini-Stents in Mice. PLoS One 2016; 11(5): e0155829. https://www.ncbi.nlm.nih.gov/pubmed/27192172
  40. Soehnlein O. Monocytes Chat With Atherosclerotic Lesions. Arterioscler Thromb Vasc Biol 2016; 36(9): 1720-1. https://www.ncbi.nlm.nih.gov/pubmed/27559145
  41. Spitz C, Winkels H, Burger C, Weber C, Lutgens E, Hansson GK, Gerdes N. Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential. Cell Mol Life Sci 2016; 73(5): 901-22. https://www.ncbi.nlm.nih.gov/pubmed/26518635
  42. Spronck B, Megens RT, Reesink KD, Delhaas T. A method for three-dimensional quantification of vascular smooth muscle orientation: application in viable murine carotid arteries. Biomech Model Mechanobiol 2016; 15(2): 419-32. https://www.ncbi.nlm.nih.gov/pubmed/26174758
  43. Srikakulapu P, Hu D, Yin C, Mohanta SK, Bontha SV, Peng L, Beer M, Weber C, McNamara CA, Grassia G, Maffia P, Manz RA, Habenicht AJ. Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice. Arterioscler Thromb Vasc Biol 2016; 36(6): 1174-85. https://www.ncbi.nlm.nih.gov/pubmed/27102965
  44. Steffens S. M1 signature mediators in atheroma-derived single cell secretome of symptomatic plaques. Thromb Haemost 2016; 115(5): 871. https://www.ncbi.nlm.nih.gov/pubmed/27052888
  45. Tilgner J, von Trotha KT, Gombert A, Jacobs MJ, Drechsler M, Doring Y, Soehnlein O, Grommes J. Aspirin, but Not Tirofiban Displays Protective Effects in Endotoxin Induced Lung Injury. PLoS One 2016; 11(9): e0161218. https://www.ncbi.nlm.nih.gov/pubmed/27583400
  46. van Dam AD, Bekkering S, Crasborn M, van Beek L, van den Berg SM, Vrieling F, Joosten SA, van Harmelen V, de Winther MPJ, Lutjohann D, Lutgens E, Boon MR, Riksen NP, Rensen PCN, Berbee JFP. BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice. Atherosclerosis 2016; 251: 6-14. https://www.ncbi.nlm.nih.gov/pubmed/27232458
  47. Viola J, Soehnlein O. Atherosclerosis - A matter of unresolved inflammation. Semin Immunol 2015; 27(3): 184-93. https://www.ncbi.nlm.nih.gov/pubmed/25865626
  48. Viola JR, Lemnitzer P, Jansen Y, Csaba G, Winter C, Neideck C, Silvestre-Roig C, Dittmar G, Doring Y, Drechsler M, Weber C, Zimmer R, Cenac N, Soehnlein O. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. Circ Res 2016; 119(9): 1030-8. https://www.ncbi.nlm.nih.gov/pubmed/27531933
  49. Weber C, Doring Y, Noels H. Potential cell-specific functions of CXCR4 in atherosclerosis. Hamostaseologie 2016; 36(2): 97-102. https://www.ncbi.nlm.nih.gov/pubmed/25586789
  50. Weber C, Shantsila E, Hristov M, Caligiuri G, Guzik T, Heine GH, Hoefer IE, Monaco C, Peter K, Rainger E, Siegbahn A, Steffens S, Wojta J, Lip GY. Role and analysis of monocyte subsets in cardiovascular disease. Joint consensus document of the European Society of Cardiology (ESC) Working Groups "Atherosclerosis & Vascular Biology" and "Thrombosis". Thromb Haemost 2016; 116(4): 626-37. https://www.ncbi.nlm.nih.gov/pubmed/27412877
  51. Wei Y, Schober A. MicroRNA regulation of macrophages in human pathologies. Cell Mol Life Sci 2016; 73(18): 3473-95. https://www.ncbi.nlm.nih.gov/pubmed/27137182
  52. Wichapong K, Alard JE, Ortega-Gomez A, Weber C, Hackeng TM, Soehnlein O, Nicolaes GA. Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1). J Med Chem 2016; 59(9): 4289-301. https://www.ncbi.nlm.nih.gov/pubmed/26871718
  53. Yin C, Mohanta SK, Srikakulapu P, Weber C, Habenicht AJ. Artery Tertiary Lymphoid Organs: Powerhouses of Atherosclerosis Immunity. Front Immunol 2016; 7: 387. https://www.ncbi.nlm.nih.gov/pubmed/27777573
  54. Ziegler T, Horstkotte M, Lange P, Ng J, Bongiovanni D, Hinkel R, Laugwitz KL, Sperandio M, Horstkotte J, Kupatt C. Endothelial RAGE exacerbates acute postischaemic cardiac inflammation. Thromb Haemost 2016; 116(2): 300-8. https://www.ncbi.nlm.nih.gov/pubmed/27412300