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Publications 2014

  1. Aoqui C, Chmielewski S, Scherer E, Eissler R, Sollinger D, Heid I, Braren R, Schmaderer C, Megens RT, Weber C, Heemann U, Tschop M, Baumann M. Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet. Cardiovasc Diabetol 2014; 13: 31. https://www.ncbi.nlm.nih.gov/pubmed/24490784
  2. Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest 2014; 124(5): 2136-46. https://www.ncbi.nlm.nih.gov/pubmed/24743145
  3. Blanchet X, Cesarek K, Brandt J, Herwald H, Teupser D, Kuchenhoff H, Karshovska E, Mause SF, Siess W, Wasmuth H, Soehnlein O, Koenen RR, Weber C, von Hundelshausen P. Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome. Thromb Haemost 2014; 112(6): 1277-87. https://www.ncbi.nlm.nih.gov/pubmed/25183015
  4. Brantl SA, Khandoga AL, Siess W. Mechanism of platelet activation induced by endocannabinoids in blood and plasma. Platelets 2014; 25(3): 151-61. https://www.ncbi.nlm.nih.gov/pubmed/23789792
  5. Brantl SA, Khandoga AL, Siess W. Activation of platelets by the endocannabinoids 2-arachidonoylglycerol and virodhamine is mediated by their conversion to arachidonic acid and thromboxane A2, not by activation of cannabinoid receptors. Platelets 2014; 25(6): 465-6. https://www.ncbi.nlm.nih.gov/pubmed/24102401
  6. Chatzigeorgiou A, Chung KJ, Garcia-Martin R, Alexaki VI, Klotzsche-von Ameln A, Phieler J, Sprott D, Kanczkowski W, Tzanavari T, Bdeir M, Bergmann S, Cartellieri M, Bachmann M, Nikolakopoulou P, Androutsellis-Theotokis A, Siegert G, Bornstein SR, Muders MH, Boon L, Karalis KP, Lutgens E, Chavakis T. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology 2014; 60(4): 1196-210. https://www.ncbi.nlm.nih.gov/pubmed/24845056
  7. Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte KM, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T, Lutgens E. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A 2014; 111(7): 2686-91. https://www.ncbi.nlm.nih.gov/pubmed/24492375
  8. Chevre R, Gonzalez-Granado JM, Megens RT, Sreeramkumar V, Silvestre-Roig C, Molina-Sanchez P, Weber C, Soehnlein O, Hidalgo A, Andres V. High-resolution imaging of intravascular atherogenic inflammation in live mice. Circ Res 2014; 114(5): 770-9. https://www.ncbi.nlm.nih.gov/pubmed/24366169
  9. de Winther MP, Lutgens E. MiR-92a: at the heart of lipid-driven endothelial dysfunction. Circ Res 2014; 114(3): 399-401. https://www.ncbi.nlm.nih.gov/pubmed/24481837
  10. Doring Y, Noels H, Mandl M, Kramp B, Neideck C, Lievens D, Drechsler M, Megens RT, Tilstam PV, Langer M, Hartwig H, Theelen W, Marth JD, Sperandio M, Soehnlein O, Weber C. Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication. Circ Res 2014; 114(6): 976-81. https://www.ncbi.nlm.nih.gov/pubmed/24425712
  11. Doring Y, Pawig L, Weber C, Noels H. The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease. Front Physiol 2014; 5: 212. https://www.ncbi.nlm.nih.gov/pubmed/24966838
  12. Doring Y, Soehnlein O, Weber C. Neutrophils cast NETs in atherosclerosis: employing peptidylarginine deiminase as a therapeutic target. Circ Res 2014; 114(6): 931-4. https://www.ncbi.nlm.nih.gov/pubmed/24625721
  13. Duarte Campos DF, Vogt M, Lindner M, Kirsten A, Weber M, Megens RT, Pyta J, Zenke M, Van Zandvoort M, Fischer H. Two-photon laser scanning microscopy as a useful tool for imaging and evaluating macrophage-, IL-4 activated macrophage- and osteoclast-based in vitro degradation of beta-tricalcium phosphate bone substitute material. Microsc Res Tech 2014; 77(2): 143-52. https://www.ncbi.nlm.nih.gov/pubmed/24282165
  14. Giebeler A, Streetz KL, Soehnlein O, Neumann U, Wang JM, Brandenburg LO. Deficiency of formyl peptide receptor 1 and 2 is associated with increased inflammation and enhanced liver injury after LPS-stimulation. PLoS One 2014; 9(6): e100522. https://www.ncbi.nlm.nih.gov/pubmed/24956481
  15. Hartmann P, Schober A, Weber C. MicroRNA-155 and macrophages: a fatty liaison. Cardiovasc Res 2014; 103(1): 5-6. https://www.ncbi.nlm.nih.gov/pubmed/24907979
  16. Hartwig H, Drechsler M, Lievens D, Kramp B, von Hundelshausen P, Lutgens E, Weber C, Doring Y, Soehnlein O. Platelet-derived PF4 reduces neutrophil apoptosis following arterial occlusion. Thromb Haemost 2014; 111(3): 562-4. https://www.ncbi.nlm.nih.gov/pubmed/24258616
  17. Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Muller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C. MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2. Nat Commun 2014; 5(1): 3970. https://www.ncbi.nlm.nih.gov/pubmed/24910328
  18. Hoeksema MA, Gijbels MJ, Van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stoger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJ, Biessen EA, Daemen MJ, Lutgens E, de Winther MP. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol Med 2014; 6(9): 1124-32. https://www.ncbi.nlm.nih.gov/pubmed/25007801
  19. Jaczewska J, Abdulreda MH, Yau CY, Schmitt MM, Schubert I, Berggren PO, Weber C, Koenen RR, Moy VT, Wojcikiewicz EP. TNF-alpha and IFN-gamma promote lymphocyte adhesion to endothelial junctional regions facilitating transendothelial migration. J Leukoc Biol 2014; 95(2): 265-74. https://www.ncbi.nlm.nih.gov/pubmed/24072879
  20. Kapopara PR, von Felden J, Soehnlein O, Wang Y, Napp LC, Sonnenschein K, Wollert KC, Schieffer B, Gaestel M, Bauersachs J, Bavendiek U. Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodelling and promotes endothelial healing after arterial injury. Thromb Haemost 2014; 112(6): 1264-76. https://www.ncbi.nlm.nih.gov/pubmed/25120198
  21. Kwak BR, Back M, Bochaton-Piallat ML, Caligiuri G, Daemen MJ, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ, Evans PC. Biomechanical factors in atherosclerosis: mechanisms and clinical implications. Eur Heart J 2014; 35(43): 3013-20, 20a-20d. https://www.ncbi.nlm.nih.gov/pubmed/25230814
  22. Li X, Zhu M, Penfold ME, Koenen RR, Thiemann A, Heyll K, Akhtar S, Koyadan S, Wu Z, Gremse F, Kiessling F, van Zandvoort M, Schall TJ, Weber C, Schober A. Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue. Circulation 2014; 129(11): 1244-53. https://www.ncbi.nlm.nih.gov/pubmed/24374972
  23. Lip GYH, Weber C. A very happy new year 2014 from Thrombosis and Haemostasis! Reflections on the past, the present and the future 2014; 111(01): 1-2. http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1608911
  24. Lutgens E. CD40-CD40L: a Janus-faced interaction. Thromb Haemost 2014; 112(2): 223. https://www.ncbi.nlm.nih.gov/pubmed/25007918
  25. Mandl M, Schmitz S, Weber C, Hristov M. Characterization of the CD14++CD16+ monocyte population in human bone marrow. PLoS One 2014; 9(11): e112140. https://www.ncbi.nlm.nih.gov/pubmed/25369328
  26. Mastropasqua R, Toto L, Cipollone F, Santovito D, Carpineto P, Mastropasqua L. Role of microRNAs in the modulation of diabetic retinopathy. Prog Retin Eye Res 2014; 43: 92-107. https://www.ncbi.nlm.nih.gov/pubmed/25128741
  27. Merres J, Hoss J, Albrecht LJ, Kress E, Soehnlein O, Jansen S, Pufe T, Tauber SC, Brandenburg LO. Role of the cathelicidin-related antimicrobial peptide in inflammation and mortality in a mouse model of bacterial meningitis. J Innate Immun 2014; 6(2): 205-18. https://www.ncbi.nlm.nih.gov/pubmed/23969854
  28. Mion F, D'Inca F, Danelli L, Toffoletto B, Guarnotta C, Frossi B, Burocchi A, Rigoni A, Gerdes N, Lutgens E, Tripodo C, Colombo MP, Rivera J, Vitale G, Pucillo CE. Mast cells control the expansion and differentiation of IL-10-competent B cells. J Immunol 2014; 193(9): 4568-79. https://www.ncbi.nlm.nih.gov/pubmed/25267976
  29. Mohanta SK, Yin C, Peng L, Srikakulapu P, Bontha V, Hu D, Weih F, Weber C, Gerdes N, Habenicht AJ. Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis. Circ Res 2014; 114(11): 1772-87. https://www.ncbi.nlm.nih.gov/pubmed/24855201
  30. Natarelli L, Schober A. Janus-faced role of Kruppel-like factor 2-dependent regulation of microRNAs in endothelial proliferation. Arterioscler Thromb Vasc Biol 2014; 34(8): 1605-6. https://www.ncbi.nlm.nih.gov/pubmed/25031325
  31. Nencioni A, da Silva RF, Fraga-Silva RA, Steffens S, Fabre M, Bauer I, Caffa I, Magnone M, Sociali G, Quercioli A, Pelli G, Lenglet S, Galan K, Burger F, Vazquez Calvo S, Bertolotto M, Bruzzone S, Ballestrero A, Patrone F, Dallegri F, Santos RA, Stergiopulos N, Mach F, Vuilleumier N, Montecucco F. Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice. Thromb Haemost 2014; 111(2): 308-22. https://www.ncbi.nlm.nih.gov/pubmed/24196571
  32. Noels H, Zhou B, Tilstam PV, Theelen W, Li X, Pawig L, Schmitz C, Akhtar S, Simsekyilmaz S, Shagdarsuren E, Schober A, Adams RH, Bernhagen J, Liehn EA, Doring Y, Weber C. Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol 2014; 34(6): 1209-20. https://www.ncbi.nlm.nih.gov/pubmed/24723559
  33. Oldekamp S, Pscheidl S, Kress E, Soehnlein O, Jansen S, Pufe T, Wang JM, Tauber SC, Brandenburg LO. Lack of formyl peptide receptor 1 and 2 leads to more severe inflammation and higher mortality in mice with of pneumococcal meningitis. Immunology 2014; 143(3): 447-61. https://www.ncbi.nlm.nih.gov/pubmed/24863484
  34. Popp T, Steinritz D, Breit A, Deppe J, Egea V, Schmidt A, Gudermann T, Weber C, Ries C. Wnt5a/beta-catenin signaling drives calcium-induced differentiation of human primary keratinocytes. J Invest Dermatol 2014; 134(8): 2183-91. https://www.ncbi.nlm.nih.gov/pubmed/24658506
  35. Projahn D, Simsekyilmaz S, Singh S, Kanzler I, Kramp BK, Langer M, Burlacu A, Bernhagen J, Klee D, Zernecke A, Hackeng TM, Groll J, Weber C, Liehn EA, Koenen RR. Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction. J Cell Mol Med 2014; 18(5): 790-800. https://www.ncbi.nlm.nih.gov/pubmed/24512349
  36. Rassaf T, Weber C, Bernhagen J. Macrophage migration inhibitory factor in myocardial ischaemia/reperfusion injury. Cardiovasc Res 2014; 102(2): 321-8. https://www.ncbi.nlm.nih.gov/pubmed/24675723
  37. Richter R, Jochheim-Richter A, Ciuculescu F, Kollar K, Seifried E, Forssmann U, Verzijl D, Smit MJ, Blanchet X, von Hundelshausen P, Weber C, Forssmann WG, Henschler R. Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells. Stem Cells Dev 2014; 23(16): 1959-74. https://www.ncbi.nlm.nih.gov/pubmed/24708339
  38. Ries C. Cytokine functions of TIMP-1. Cell Mol Life Sci 2014; 71(4): 659-72. https://www.ncbi.nlm.nih.gov/pubmed/23982756
  39. Ring L, Neth P, Weber C, Steffens S, Faussner A. beta-Catenin-dependent pathway activation by both promiscuous "canonical" WNT3a-, and specific "noncanonical" WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency. Cell Signal 2014; 26(2): 260-7. https://www.ncbi.nlm.nih.gov/pubmed/24269653
  40. Rossaint J, Herter JM, Van Aken H, Napirei M, Doring Y, Weber C, Soehnlein O, Zarbock A. Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation. Blood 2014; 123(16): 2573-84. https://www.ncbi.nlm.nih.gov/pubmed/24335230
  41. Santovito D, De Nardis V, Marcantonio P, Mandolini C, Paganelli C, Vitale E, Buttitta F, Bucci M, Mezzetti A, Consoli A, Cipollone F. Plasma exosome microRNA profiling unravels a new potential modulator of adiponectin pathway in diabetes: effect of glycemic control. J Clin Endocrinol Metab 2014; 99(9): E1681-5. https://www.ncbi.nlm.nih.gov/pubmed/24937531
  42. Schiener M, Hossann M, Viola JR, Ortega-Gomez A, Weber C, Lauber K, Lindner LH, Soehnlein O. Nanomedicine-based strategies for treatment of atherosclerosis. Trends Mol Med 2014; 20(5): 271-81. https://www.ncbi.nlm.nih.gov/pubmed/24594264
  43. Schmitt MM, Fraemohs L, Hackeng TM, Weber C, Koenen RR. Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution. Atherosclerosis 2014; 234(2): 254-64. https://www.ncbi.nlm.nih.gov/pubmed/24704627
  44. Schmitt MM, Megens RT, Zernecke A, Bidzhekov K, van den Akker NM, Rademakers T, van Zandvoort MA, Hackeng TM, Koenen RR, Weber C. Endothelial junctional adhesion molecule-a guides monocytes into flow-dependent predilection sites of atherosclerosis. Circulation 2014; 129(1): 66-76. https://www.ncbi.nlm.nih.gov/pubmed/24065611
  45. Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RT, Heyll K, Noels H, Hristov M, Wang S, Kiessling F, Olson EN, Weber C. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med 2014; 20(4): 368-76. https://www.ncbi.nlm.nih.gov/pubmed/24584117
  46. Seijkens T, Hoeksema MA, Beckers L, Smeets E, Meiler S, Levels J, Tjwa M, de Winther MP, Lutgens E. Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis. FASEB J 2014; 28(5): 2202-13. https://www.ncbi.nlm.nih.gov/pubmed/24481967
  47. Seijkens T, Kusters P, Chatzigeorgiou A, Chavakis T, Lutgens E. Immune cell crosstalk in obesity: a key role for costimulation? Diabetes 2014; 63(12): 3982-91. https://www.ncbi.nlm.nih.gov/pubmed/25414012
  48. Silvestre-Roig C, de Winther MP, Weber C, Daemen MJ, Lutgens E, Soehnlein O. Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies. Circ Res 2014; 114(1): 214-26. https://www.ncbi.nlm.nih.gov/pubmed/24385514
  49. Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A. Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation 2014; 129(5): 598-606. https://www.ncbi.nlm.nih.gov/pubmed/24201302
  50. Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A. Response to letter regarding article "Role of extracellular RNA in atherosclerotic plaque formation in mice". Circulation 2014; 130(16): e144-5. https://www.ncbi.nlm.nih.gov/pubmed/25311624
  51. Soehnlein O. Macrophages shine bright. Blood 2014; 124(15): 2320-2. https://www.ncbi.nlm.nih.gov/pubmed/25301333
  52. Soehnlein O. The ABC of Thrombopoiesis. Arterioscler Thromb Vasc Biol 2014; 34(4): 700-1. https://www.ncbi.nlm.nih.gov/pubmed/24665122
  53. Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nacher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi MD, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A. Neutrophils scan for activated platelets to initiate inflammation. Science 2014; 346(6214): 1234-8. https://www.ncbi.nlm.nih.gov/pubmed/25477463
  54. Steffens S. Fine tuning effector and regulatory T-cell dynamics: a novel tool for plaque regression? Cardiovasc Res 2014; 102(1): 3-5. https://www.ncbi.nlm.nih.gov/pubmed/24556952
  55. Tilstam PV, Gijbels MJ, Habbeddine M, Cudejko C, Asare Y, Theelen W, Zhou B, Doring Y, Drechsler M, Pawig L, Simsekyilmaz S, Koenen RR, de Winther MP, Lawrence T, Bernhagen J, Zernecke A, Weber C, Noels H. Bone marrow-specific knock-in of a non-activatable Ikkalpha kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice. PLoS One 2014; 9(2): e87452. https://www.ncbi.nlm.nih.gov/pubmed/24498325
  56. von Hundelshausen P, Schmitt MM. Platelets and their chemokines in atherosclerosis-clinical applications. Front Physiol 2014; 5: 294. https://www.ncbi.nlm.nih.gov/pubmed/25152735
  57. Wan M, Soehnlein O, Tang X, van der Does AM, Smedler E, Uhlen P, Lindbom L, Agerberth B, Haeggstrom JZ. Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo. FASEB J 2014; 28(8): 3456-67. https://www.ncbi.nlm.nih.gov/pubmed/24736410
  58. Weber C, Lip GYH. Editors’ Choice papers in Thrombosis and Haemostasis. Thromb Haemost 2014; 111(01): 183-188. http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1608912
  59. Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I. Rubbing salt into wounded endothelium: sodium potentiates proatherogenic effects of TNF-alpha under non-uniform shear stress. Thromb Haemost 2014; 112(1): 183-95. https://www.ncbi.nlm.nih.gov/pubmed/24573382
  60. Wildhagen KC, Garcia de Frutos P, Reutelingsperger CP, Schrijver R, Areste C, Ortega-Gomez A, Deckers NM, Hemker HC, Soehnlein O, Nicolaes GA. Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood 2014; 123(7): 1098-101. https://www.ncbi.nlm.nih.gov/pubmed/24264231
  61. Wildhagen KC, Schrijver R, Beckers L, ten Cate H, Reutelingsperger CP, Lutgens E, Nicolaes GA. Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis. PLoS One 2014; 9(7): e101446. https://www.ncbi.nlm.nih.gov/pubmed/25032959
  62. Winkels H, Weber C, Lutgens E, Gerdes N. Atherosclerosis: cell biology and lipoproteins focus on iNKT cells and CD40/CD40L in atherosclerosis and metabolic disorders. Curr Opin Lipidol 2014; 25(5): 408-9. https://www.ncbi.nlm.nih.gov/pubmed/25186203
  63. Zernecke A, Weber C. Chemokines in atherosclerosis: proceedings resumed. Arterioscler Thromb Vasc Biol 2014; 34(4): 742-50. https://www.ncbi.nlm.nih.gov/pubmed/24436368