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Publications 2013

  1. Akhtar S, Gremse F, Kiessling F, Weber C, Schober A. CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice. Arterioscler Thromb Vasc Biol 2013; 33(4): 679-686. https://www.ncbi.nlm.nih.gov/pubmed/23393393
  2. Asare Y, Shagdarsuren E, Schmid JA, Tilstam PV, Grommes J, El Bounkari O, Schutz AK, Weber C, de Winther MP, Noels H, Bernhagen J. Endothelial CSN5 impairs NF-kappaB activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions. Thromb Haemost 2013; 110(1): 141-152. https://www.ncbi.nlm.nih.gov/pubmed/23636414
  3. Badr Eslam R, Lang IM, Koppensteiner R, Calatzis A, Panzer S, Gremmel T. Residual platelet activation through protease-activated receptors (PAR)-1 and -4 in patients on P2Y12 inhibitors. Int J Cardiol 2013; 168(1): 403-406. https://www.ncbi.nlm.nih.gov/pubmed/23041015
  4. Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele ST, Hamulyak K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EA, Spronk HM, ten Cate H. Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner. PLoS One 2013; 8(2): e55784. https://www.ncbi.nlm.nih.gov/pubmed/23409043
  5. Bras G, Bochenska O, Rapala-Kozik M, Guevara-Lora I, Faussner A, Kamysz W, Kozik A. Release of biologically active kinin peptides, Met-Lys-bradykinin and Leu-Met-Lys-bradykinin from human kininogens by two major secreted aspartic proteases of Candida parapsilosis. Peptides 2013; 48: 114-123. https://www.ncbi.nlm.nih.gov/pubmed/23954712
  6. Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chevre R, N AG, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell 2013; 153(5): 1025-1035. https://www.ncbi.nlm.nih.gov/pubmed/23706740
  7. Doring Y, Weber C, Soehnlein O. Footprints of neutrophil extracellular traps as predictors of cardiovascular risk. Arterioscler Thromb Vasc Biol 2013; 33(8): 1735-1736. https://www.ncbi.nlm.nih.gov/pubmed/23818484
  8. Drechsler M, Soehnlein O. The complexity of arterial classical monocyte recruitment. J Innate Immun 2013; 5(4): 358-366. https://www.ncbi.nlm.nih.gov/pubmed/23571485
  9. Drechsler M, Soehnlein O, Weber C. Nitric oxide-donating statins upgrade the benefits of lipid-lowering in vascular inflammation by desensitizing neutrophil activation: editorial to: "Nitric oxide-donating atorvastatin attenuates neutrophil recruitment during vascular inflammation independent of changes in plasma cholesterol" by R. Baetta et al. Cardiovasc Drugs Ther 2013; 27(3): 183-185. https://www.ncbi.nlm.nih.gov/pubmed/23440356
  10. Fujita B, Strodthoff D, Fritzenwanger M, Pfeil A, Ferrari M, Goebel B, Figulla HR, Gerdes N, Jung C. Altered red blood cell distribution width in overweight adolescents and its association with markers of inflammation. Pediatr Obes 2013; 8(5): 385-391. https://www.ncbi.nlm.nih.gov/pubmed/23239558
  11. Gerdes N, Winkels H, Weber C. Atherosclerosis: cell biology and lipoproteins-focus on anti-inflammatory mechanisms as therapeutic options. Curr Opin Lipidol 2013; 24(2): 187-188. https://www.ncbi.nlm.nih.gov/pubmed/23481233
  12. Ghosh M, van den Akker NM, Wijnands KA, Poeze M, Weber C, McQuade LE, Pluth MD, Lippard SJ, Post MJ, Molin DG, van Zandvoort MA. Specific visualization of nitric oxide in the vasculature with two-photon microscopy using a copper based fluorescent probe. PLoS One 2013; 8(9): e75331. https://www.ncbi.nlm.nih.gov/pubmed/24086509
  13. Goyal P, Pandey D, Brunnert D, Hammer E, Zygmunt M, Siess W. Cofilin oligomer formation occurs in vivo and is regulated by cofilin phosphorylation. PLoS One 2013; 8(8): e71769. https://www.ncbi.nlm.nih.gov/pubmed/23951242
  14. Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stoger L, Wijnands E, Janssen BJ, Creemers EE, Pinto YM, Grimm D, Schurmann N, Vigorito E, Thum T, Stassen F, Yin X, Mayr M, de Windt LJ, Lutgens E, Wouters K, de Winther MP, Zacchigna S, Giacca M, van Bilsen M, Papageorgiou AP, Schroen B. Macrophage microRNA-155 promotes cardiac hypertrophy and failure. Circulation 2013; 128(13): 1420-1432. https://www.ncbi.nlm.nih.gov/pubmed/23956210
  15. Kanzler I, Tuchscheerer N, Steffens G, Simsekyilmaz S, Konschalla S, Kroh A, Simons D, Asare Y, Schober A, Bucala R, Weber C, Bernhagen J, Liehn EA. Differential roles of angiogenic chemokines in endothelial progenitor cell-induced angiogenesis. Basic Res Cardiol 2013; 108(1): 310. https://www.ncbi.nlm.nih.gov/pubmed/23184390
  16. Karshovska E, Weber C, von Hundelshausen P. Platelet chemokines in health and disease. Thromb Haemost 2013; 110(5): 894-902. https://www.ncbi.nlm.nih.gov/pubmed/23783401
  17. Klingenberg R, Gerdes N, Badeau RM, Gistera A, Strodthoff D, Ketelhuth DF, Lundberg AM, Rudling M, Nilsson SK, Olivecrona G, Zoller S, Lohmann C, Luscher TF, Jauhiainen M, Sparwasser T, Hansson GK. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 2013; 123(3): 1323-1334. https://www.ncbi.nlm.nih.gov/pubmed/23426179
  18. Kozik A, Faussner A, Blonska B, Guevara-Lora I. Kinin-generating cellular model obtained from human glioblastoma cell line U-373. Acta Biochimica Polonica 2013; 60(3). http://dx.doi.org/10.18388/abp.2013_1985
  19. Kramp BK, Megens RT, Sarabi A, Winkler S, Projahn D, Weber C, Koenen RR, von Hundelshausen P. Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment. Thromb Haemost 2013; 110(4): 795-806. https://www.ncbi.nlm.nih.gov/pubmed/23925484
  20. Kumar N, Ippel H, Weber C, Hackeng T, Mayo KH. Protein lysine-Nzeta alkylation and O-phosphorylation mediated by DTT-generated reactive oxygen species. Protein Sci 2013; 22(3): 327-346. https://www.ncbi.nlm.nih.gov/pubmed/23315912
  21. Langer HF, Weber C, Gawaz M. The platelet--thrombosis and beyond. Thromb Haemost 2013; 110(5): 857-858. https://www.ncbi.nlm.nih.gov/pubmed/24108387
  22. Legein B, Temmerman L, Biessen EA, Lutgens E. Inflammation and immune system interactions in atherosclerosis. Cell Mol Life Sci 2013; 70(20): 3847-3869. https://www.ncbi.nlm.nih.gov/pubmed/23430000
  23. Lenglet S, Thomas A, Soehnlein O, Montecucco F, Burger F, Pelli G, Galan K, Cravatt B, Staub C, Steffens S. Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. Arterioscler Thromb Vasc Biol 2013; 33(2): 215-223. https://www.ncbi.nlm.nih.gov/pubmed/23241405
  24. Leschner J, Wennerberg G, Feierler J, Bermudez M, Welte B, Kalatskaya I, Wolber G, Faussner A. Interruption of the ionic lock in the bradykinin B2 receptor results in constitutive internalization and turns several antagonists into strong agonists. J Pharmacol Exp Ther 2013; 344(1): 85-95. https://www.ncbi.nlm.nih.gov/pubmed/23086229
  25. Liehn EA, Kanzler I, Konschalla S, Kroh A, Simsekyilmaz S, Sonmez TT, Bucala R, Bernhagen J, Weber C. Compartmentalized protective and detrimental effects of endogenous macrophage migration-inhibitory factor mediated by CXCR2 in a mouse model of myocardial ischemia/reperfusion. Arterioscler Thromb Vasc Biol 2013; 33(9): 2180-2186. https://www.ncbi.nlm.nih.gov/pubmed/23868943
  26. Lievens D, Habets KL, Robertson AK, Laouar Y, Winkels H, Rademakers T, Beckers L, Wijnands E, Boon L, Mosaheb M, Ait-Oufella H, Mallat Z, Flavell RA, Rudling M, Binder CJ, Gerdes N, Biessen EA, Weber C, Daemen MJ, Kuiper J, Lutgens E. Abrogated transforming growth factor beta receptor II (TGFbetaRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis. Eur Heart J 2013; 34(48): 3717-3727. https://www.ncbi.nlm.nih.gov/pubmed/22613345
  27. Lundberg AM, Ketelhuth DF, Johansson ME, Gerdes N, Liu S, Yamamoto M, Akira S, Hansson GK. Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis. Cardiovasc Res 2013; 99(2): 364-373. https://www.ncbi.nlm.nih.gov/pubmed/23417039
  28. Manthey HD, Cochain C, Barnsteiner S, Karshovska E, Pelisek J, Koch M, Chaudhari SM, Busch M, Eckstein HH, Weber C, Koenen RR, Zernecke A. CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice. Thromb Haemost 2013; 110(6): 1267-1277. https://www.ncbi.nlm.nih.gov/pubmed/24114205
  29. Molica F, Burger F, Thomas A, Staub C, Tailleux A, Staels B, Pelli G, Zimmer A, Cravatt B, Matter CM, Pacher P, Steffens S. Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation. J Lipid Res 2013; 54(5): 1360-1368. https://www.ncbi.nlm.nih.gov/pubmed/23479425
  30. Nakahata AM, Mayer B, Neth P, Hansen D, Sampaio MU, Oliva ML. Blocking the proliferation of human tumor cell lines by peptidase inhibitors from Bauhinia seeds. Planta Med 2013; 79(3-4): 227-235. https://www.ncbi.nlm.nih.gov/pubmed/23345168
  31. Neth P, Nazari-Jahantigh M, Schober A, Weber C. MicroRNAs in flow-dependent vascular remodelling. Cardiovasc Res 2013; 99(2): 294-303. https://www.ncbi.nlm.nih.gov/pubmed/23612583
  32. Oral H, Kanzler I, Tuchscheerer N, Curaj A, Simsekyilmaz S, Sonmez TT, Radu E, Postea O, Weber C, Schuh A, Liehn EA. CXC chemokine KC fails to induce neutrophil infiltration and neoangiogenesis in a mouse model of myocardial infarction. J Mol Cell Cardiol 2013; 60: 1-7. https://www.ncbi.nlm.nih.gov/pubmed/23598282
  33. Ortega-Gomez A, Perretti M, Soehnlein O. Resolution of inflammation: an integrated view. EMBO Mol Med 2013; 5(5): 661-674. https://www.ncbi.nlm.nih.gov/pubmed/23592557
  34. Petzold T, Ruppert R, Pandey D, Barocke V, Meyer H, Lorenz M, Zhang L, Siess W, Massberg S, Moser M. beta1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse. Blood 2013; 122(15): 2723-2731. https://www.ncbi.nlm.nih.gov/pubmed/24004668
  35. Poti F, Gualtieri F, Sacchi S, Weissen-Plenz G, Varga G, Brodde M, Weber C, Simoni M, Nofer JR. KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol 2013; 33(7): 1505-1512. https://www.ncbi.nlm.nih.gov/pubmed/23640484
  36. Preissner KT, Weber C. Go with the flow: the passion for vascular biology research. Highlights from IVBM 2012. Thromb Haemost 2013; 109(3): 366-367. https://www.ncbi.nlm.nih.gov/pubmed/23407867
  37. Schaffer S, Tandon R, Zipse H, Siess W, Schmidt A, Jamasbi J, Karshovska E, Steglich W, Lorenz R. Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages. Biochem Pharmacol 2013; 86(2): 279-285. https://www.ncbi.nlm.nih.gov/pubmed/23665353
  38. Seijkens T, Kusters P, Engel D, Lutgens E. CD40-CD40L: linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications. Diab Vasc Dis Res 2013; 10(2): 115-122. https://www.ncbi.nlm.nih.gov/pubmed/22965071
  39. Smeets E, Meiler S, Lutgens E. Lymphocytic tumor necrosis factor receptor superfamily co-stimulatory molecules in the pathogenesis of atherosclerosis. Curr Opin Lipidol 2013; 24(6): 518-524. https://www.ncbi.nlm.nih.gov/pubmed/24184937
  40. Soehnlein O. Myeloid cells in traffic. J Innate Immun 2013; 5(4): 301-303. https://www.ncbi.nlm.nih.gov/pubmed/23594523
  41. Soehnlein O, Drechsler M, Doring Y, Lievens D, Hartwig H, Kemmerich K, Ortega-Gomez A, Mandl M, Vijayan S, Projahn D, Garlichs CD, Koenen RR, Hristov M, Lutgens E, Zernecke A, Weber C. Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes. EMBO Mol Med 2013; 5(3): 471-481. https://www.ncbi.nlm.nih.gov/pubmed/23417922
  42. Soehnlein O, Swirski FK. Hypercholesterolemia links hematopoiesis with atherosclerosis. Trends Endocrinol Metab 2013; 24(3): 129-136. https://www.ncbi.nlm.nih.gov/pubmed/23228326
  43. Strodthoff D, Lundberg AM, Agardh HE, Ketelhuth DF, Paulsson-Berne G, Arner P, Hansson GK, Gerdes N. Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice. Arterioscler Thromb Vasc Biol 2013; 33(6): 1189-1196. https://www.ncbi.nlm.nih.gov/pubmed/23520162
  44. Strussmann T, Tillmann S, Wirtz T, Bucala R, von Hundelshausen P, Bernhagen J. Platelets are a previously unrecognised source of MIF. Thromb Haemost 2013; 110(5): 1004-1013. https://www.ncbi.nlm.nih.gov/pubmed/23846621
  45. von Hundelshausen P, Weber C. [Chronic inflammation and atherosclerosis]. Dtsch Med Wochenschr 2013; 138(37): 1839-1844. https://www.ncbi.nlm.nih.gov/pubmed/24006166
  46. Wantha S, Alard JE, Megens RT, van der Does AM, Doring Y, Drechsler M, Pham CT, Wang MW, Wang JM, Gallo RL, von Hundelshausen P, Lindbom L, Hackeng T, Weber C, Soehnlein O. Neutrophil-derived cathelicidin promotes adhesion of classical monocytes. Circ Res 2013; 112(5): 792-801. https://www.ncbi.nlm.nih.gov/pubmed/23283724
  47. Weber C. MicroRNAs: from basic mechanisms to clinical application in cardiovascular medicine. Arterioscler Thromb Vasc Biol 2013; 33(2): 168-169. https://www.ncbi.nlm.nih.gov/pubmed/23325472
  48. Weber C, Lip GYH. Editors’ Choice papers in Thrombosis and Haemostasis. Thrombosis and Haemostasis 2013; 109(01): 170-173. http://dx.doi.org/10.1055/s-0037-1609008
  49. Weber C, Lip GYH. A Happy New Year 2013 for Thrombosis and Haemostasis …. Thrombosis and Haemostasis 2013; 109(01): 1-2. http://dx.doi.org/10.1055/s-0037-1609007
  50. Wei Y, Nazari-Jahantigh M, Chan L, Zhu M, Heyll K, Corbalan-Campos J, Hartmann P, Thiemann A, Weber C, Schober A. The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis. Circulation 2013; 127(15): 1609-1619. https://www.ncbi.nlm.nih.gov/pubmed/23513069
  51. Wei Y, Nazari-Jahantigh M, Neth P, Weber C, Schober A. MicroRNA-126, -145, and -155: a therapeutic triad in atherosclerosis? Arterioscler Thromb Vasc Biol 2013; 33(3): 449-454. https://www.ncbi.nlm.nih.gov/pubmed/23324496
  52. Wei Y, Schober A, Weber C. Pathogenic arterial remodeling: the good and bad of microRNAs. Am J Physiol Heart Circ Physiol 2013; 304(8): H1050-1059. https://www.ncbi.nlm.nih.gov/pubmed/23396454
  53. Wu Z, Curaj A, Fokong S, Liehn EA, Weber C, Lammers T, Kiessling F, Zandvoort van M. Rhodamine-loaded intercellular adhesion molecule-1-targeted microbubbles for dual-modality imaging under controlled shear stresses. Circ Cardiovasc Imaging 2013; 6(6): 974-981. https://www.ncbi.nlm.nih.gov/pubmed/24036383
  54. Yla-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PW, Waltenberger J, Weber C, Tokgozoglu L, Atherosclerosis ESCWGo, Vascular B. Stabilization of atherosclerotic plaques: an update. Eur Heart J 2013; 34(42): 3251-3258. https://www.ncbi.nlm.nih.gov/pubmed/23966311
  55. Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, Rohwedder I, Hinkel R, Gross L, Lee S, Hu J, Soehnlein O, Franz WM, Sperandio M, Pohl U, Thomas M, Weber C, Augustin HG, Fassler R, Deutsch U, Kupatt C. Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest 2013; 123(8): 3436-3445. https://www.ncbi.nlm.nih.gov/pubmed/23863629
  56. Zimmermann R, Krueger J, Filipovic MR, Ivanovic-Burmazovic I, Calatzis A, Weiss DR, Eckstein R. A detailed examination of platelet function inhibition by nitric oxide in platelet-rich plasma and whole blood. Clin Lab 2013; 59(5-6): 629-638. https://www.ncbi.nlm.nih.gov/pubmed/23865363