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Publications 2011

  1. Bampalis VG, Dwivedi S, Shai E, Brandl R, Varon D, Siess W. Effect of 5-HT2A receptor antagonists on human platelet activation in blood exposed to physiologic stimuli and atherosclerotic plaque. J Thromb Haemost 2011; 9(10): 2112-2115. https://www.ncbi.nlm.nih.gov/pubmed/21848639
  2. Butoi ED, Gan AM, Manduteanu I, Stan D, Calin M, Pirvulescu M, Koenen RR, Weber C, Simionescu M. Cross talk between smooth muscle cells and monocytes/activated monocytes via CX3CL1/CX3CR1 axis augments expression of pro-atherogenic molecules. Biochim Biophys Acta 2011; 1813(12): 2026-2035. https://www.ncbi.nlm.nih.gov/pubmed/21888931
  3. Daissormont IT, Christ A, Temmerman L, Sampedro Millares S, Seijkens T, Manca M, Rousch M, Poggi M, Boon L, van der Loos C, Daemen M, Lutgens E, Halvorsen B, Aukrust P, Janssen E, Biessen EA. Plasmacytoid dendritic cells protect against atherosclerosis by tuning T-cell proliferation and activity. Circ Res 2011; 109(12): 1387-1395. https://www.ncbi.nlm.nih.gov/pubmed/22021930
  4. de Jager SC, Bermudez B, Bot I, Koenen RR, Bot M, Kavelaars A, de Waard V, Heijnen CJ, Muriana FJ, Weber C, van Berkel TJ, Kuiper J, Lee SJ, Abia R, Biessen EA. Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis. J Exp Med 2011; 208(2): 217-225. https://www.ncbi.nlm.nih.gov/pubmed/21242297
  5. Douma K, Megens RT, van Zandvoort MA. Optical molecular imaging of atherosclerosis using nanoparticles: shedding new light on the darkness. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2011; 3(4): 376-388. https://www.ncbi.nlm.nih.gov/pubmed/21448988
  6. Drechsler M, Doring Y, Megens RT, Soehnlein O. Neutrophilic granulocytes - promiscuous accelerators of atherosclerosis. Thromb Haemost 2011; 106(5): 839-848. https://www.ncbi.nlm.nih.gov/pubmed/22012406
  7. Engel D, Beckers L, Wijnands E, Seijkens T, Lievens D, Drechsler M, Gerdes N, Soehnlein O, Daemen MJ, Stan RV, Biessen EA, Lutgens E. Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response. FASEB J 2011; 25(11): 3838-3848. https://www.ncbi.nlm.nih.gov/pubmed/21795505
  8. Frithiof R, Soehnlein O, Eriksson S, Fenhammar J, Hjelmqvist H, Lindbom L, Rundgren M. The effects of isoflurane anesthesia and mechanical ventilation on renal function during endotoxemia. Acta Anaesthesiol Scand 2011; 55(4): 401-410. https://www.ncbi.nlm.nih.gov/pubmed/21391922
  9. Gerdes N, Zhu L, Ersoy M, Hermansson A, Hjemdahl P, Hu H, Hansson GK, Li N. Platelets regulate CD4(+) T-cell differentiation via multiple chemokines in humans. Thromb Haemost 2011; 106(2): 353-362. https://www.ncbi.nlm.nih.gov/pubmed/21655676
  10. Gerdes N, Zirlik A. Co-stimulatory molecules in and beyond co-stimulation - tipping the balance in atherosclerosis? Thromb Haemost 2011; 106(5): 804-813. https://www.ncbi.nlm.nih.gov/pubmed/21979444
  11. Goyal P, Behring A, Kumar A, Siess W. STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells. PLoS One 2011; 6(1): e16249. https://www.ncbi.nlm.nih.gov/pubmed/21283756
  12. Grommes J, Soehnlein O. Contribution of neutrophils to acute lung injury. Mol Med 2011; 17(3-4): 293-307. https://www.ncbi.nlm.nih.gov/pubmed/21046059
  13. Heinrichs D, Knauel M, Offermanns C, Berres ML, Nellen A, Leng L, Schmitz P, Bucala R, Trautwein C, Weber C, Bernhagen J, Wasmuth HE. Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74. Proc Natl Acad Sci U S A 2011; 108(42): 17444-17449. https://www.ncbi.nlm.nih.gov/pubmed/21969590
  14. Hristov M, Weber C. Differential role of monocyte subsets in atherosclerosis. Thromb Haemost 2011; 106(5): 757-762. https://www.ncbi.nlm.nih.gov/pubmed/21901241
  15. Khandoga AL, Pandey D, Welsch U, Brandl R, Siess W. GPR92/LPA(5) lysophosphatidate receptor mediates megakaryocytic cell shape change induced by human atherosclerotic plaques. Cardiovasc Res 2011; 90(1): 157-164. https://www.ncbi.nlm.nih.gov/pubmed/21106562
  16. Koenen RR, Weber C. Chemokines: established and novel targets in atherosclerosis. EMBO Mol Med 2011; 3(12): 713-725. https://www.ncbi.nlm.nih.gov/pubmed/22038924
  17. Kraemer S, Lue H, Zernecke A, Kapurniotu A, Andreetto E, Frank R, Lennartz B, Weber C, Bernhagen J. MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism. FASEB J 2011; 25(3): 894-906. https://www.ncbi.nlm.nih.gov/pubmed/21106938
  18. Kramp BK, Sarabi A, Koenen RR, Weber C. Heterophilic chemokine receptor interactions in chemokine signaling and biology. Exp Cell Res 2011; 317(5): 655-663. https://www.ncbi.nlm.nih.gov/pubmed/21146524
  19. Kuijpers MJ, Megens RT, Nikookhesal E, Feijge MA, De Mey JG, oude Egbrink MG, van Giezen JJ, Heemskerk JW. Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y(1)(2) antagonist ticagrelor. Thromb Haemost 2011; 106(6): 1179-1188. https://www.ncbi.nlm.nih.gov/pubmed/22071958
  20. Liehn EA, Tuchscheerer N, Kanzler I, Drechsler M, Fraemohs L, Schuh A, Koenen RR, Zander S, Soehnlein O, Hristov M, Grigorescu G, Urs AO, Leabu M, Bucur I, Merx MW, Zernecke A, Ehling J, Gremse F, Lammers T, Kiessling F, Bernhagen J, Schober A, Weber C. Double-edged role of the CXCL12/CXCR4 axis in experimental myocardial infarction. J Am Coll Cardiol 2011; 58(23): 2415-2423. https://www.ncbi.nlm.nih.gov/pubmed/22115649
  21. Lievens D, von Hundelshausen P. Platelets in atherosclerosis. Thromb Haemost 2011; 106(5): 827-838. https://www.ncbi.nlm.nih.gov/pubmed/22012554
  22. Lip GY, Weber C. Clinical and basic science articles from Thrombosis and Haemostasis. Thromb Haemost 2011; 105(1): 202-205. https://www.ncbi.nlm.nih.gov/pubmed/21249716
  23. Lutgens E, Binder CJ. Immunology of atherosclerosis. Thromb Haemost 2011; 106(5): 755-756. https://www.ncbi.nlm.nih.gov/pubmed/22011700
  24. Megens RT, Kemmerich K, Pyta J, Weber C, Soehnlein O. Intravital imaging of phagocyte recruitment. Thromb Haemost 2011; 105(5): 802-810. https://www.ncbi.nlm.nih.gov/pubmed/21437362
  25. Megens RT, Soehnlein O. Seeing is believing: an update on modalities to image inflammation in vivo. Thromb Haemost 2011; 105(5): 774-775. https://www.ncbi.nlm.nih.gov/pubmed/21437354
  26. Noels H, Weber C. Catching up with important players in atherosclerosis: type I interferons and neutrophils. Curr Opin Lipidol 2011; 22(2): 144-145. https://www.ncbi.nlm.nih.gov/pubmed/21415605
  27. Poggi M, Engel D, Christ A, Beckers L, Wijnands E, Boon L, Driessen A, Cleutjens J, Weber C, Gerdes N, Lutgens E. CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice. Arterioscler Thromb Vasc Biol 2011; 31(10): 2251-2260. https://www.ncbi.nlm.nih.gov/pubmed/21817098
  28. Rana OR, Saygili E, Gemein C, Zink MD, Buhr A, Saygili E, Mischke K, Nolte KW, Weis J, Weber C, Marx N, Schauerte P. Chronic electrical neuronal stimulation increases cardiac parasympathetic tone by eliciting neurotrophic effects. Circ Res 2011; 108(10): 1209-1219. https://www.ncbi.nlm.nih.gov/pubmed/21441135
  29. Reitsma S, Oude Egbrink MG, Heijnen VV, Megens RT, Engels W, Vink H, Slaaf DW, van Zandvoort MA. Endothelial glycocalyx thickness and platelet-vessel wall interactions during atherogenesis. Thromb Haemost 2011; 106(5): 939-946. https://www.ncbi.nlm.nih.gov/pubmed/21901228
  30. Sarabi A, Kramp BK, Drechsler M, Hackeng TM, Soehnlein O, Weber C, Koenen RR, Von Hundelshausen P. CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment. J Thromb Haemost 2011; 9(1): 209-219. https://www.ncbi.nlm.nih.gov/pubmed/20961394
  31. Saygili E, Schauerte P, Pekassa M, Saygili E, Rackauskas G, Schwinger RH, Weis J, Weber C, Marx N, Rana OR. Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion. Cell Mol Neurobiol 2011; 31(1): 17-25. https://www.ncbi.nlm.nih.gov/pubmed/20683769
  32. Schober A, Hristov M, Kofler S, Forbrig R, Lohr B, Heussen N, Zhe Z, Akhtar S, Schumann U, Krotz F, Leibig M, Konig A, Kaczmarek I, Reichart B, Klauss V, Weber C, Sohn HY. CD34+CD140b+ cells and circulating CXCL12 correlate with the angiographically assessed severity of cardiac allograft vasculopathy. Eur Heart J 2011; 32(4): 476-484. https://www.ncbi.nlm.nih.gov/pubmed/21036775
  33. Schober A, Weber C. Bone marrow-derived smooth muscle cells are breaking bad in atherogenesis. Arterioscler Thromb Vasc Biol 2011; 31(6): 1258-1259. https://www.ncbi.nlm.nih.gov/pubmed/21593459
  34. Schober LJ, Khandoga AL, Dwivedi S, Penz SM, Maruyama T, Brandl R, Siess W. The role of PGE(2) in human atherosclerotic plaque on platelet EP(3) and EP(4) receptor activation and platelet function in whole blood. J Thromb Thrombolysis 2011; 32(2): 158-166. https://www.ncbi.nlm.nih.gov/pubmed/21424266
  35. Simons D, Grieb G, Hristov M, Pallua N, Weber C, Bernhagen J, Steffens G. Hypoxia-induced endothelial secretion of macrophage migration inhibitory factor and role in endothelial progenitor cell recruitment. J Cell Mol Med 2011; 15(3): 668-678. https://www.ncbi.nlm.nih.gov/pubmed/20178462
  36. Soehnlein O, Wantha S, Simsekyilmaz S, Doring Y, Megens RT, Mause SF, Drechsler M, Smeets R, Weinandy S, Schreiber F, Gries T, Jockenhoevel S, Moller M, Vijayan S, van Zandvoort MA, Agerberth B, Pham CT, Gallo RL, Hackeng TM, Liehn EA, Zernecke A, Klee D, Weber C. Neutrophil-derived cathelicidin protects from neointimal hyperplasia. Sci Transl Med 2011; 3(103): 103ra198. https://www.ncbi.nlm.nih.gov/pubmed/21974936
  37. Vasina EM, Cauwenberghs S, Feijge MA, Heemskerk JW, Weber C, Koenen RR. Microparticles from apoptotic platelets promote resident macrophage differentiation. Cell Death Dis 2011; 2(9): e211. https://www.ncbi.nlm.nih.gov/pubmed/21956548
  38. Vonend O, Ockenfels N, Gao X, Allolio B, Lang K, Mai K, Quack I, Saleh A, Degenhart C, Seufert J, Seiler L, Beuschlein F, Quinkler M, Podrabsky P, Bidlingmaier M, Lorenz R, Reincke M, Rump LC, German Conn's R. Adrenal venous sampling: evaluation of the German Conn's registry. Hypertension 2011; 57(5): 990-995. https://www.ncbi.nlm.nih.gov/pubmed/21383311
  39. Weber C, Lip G. Commencing 2011 with Thrombosis and Haemostasis – and looking to the future. Thrombosis and Haemostasis 2011; 105(01): 1-2. http://dx.doi.org/10.1055/s-0037-1609003
  40. Weber C, Meiler S, Doring Y, Koch M, Drechsler M, Megens RT, Rowinska Z, Bidzhekov K, Fecher C, Ribechini E, van Zandvoort MA, Binder CJ, Jelinek I, Hristov M, Boon L, Jung S, Korn T, Lutz MB, Forster I, Zenke M, Hieronymus T, Junt T, Zernecke A. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest 2011; 121(7): 2898-2910. https://www.ncbi.nlm.nih.gov/pubmed/21633167
  41. Weber C, Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 2011; 17(11): 1410-1422. https://www.ncbi.nlm.nih.gov/pubmed/22064431
  42. Weber C, Soehnlein O. ApoE controls the interface linking lipids and inflammation in atherosclerosis. J Clin Invest 2011; 121(10): 3825-3827. https://www.ncbi.nlm.nih.gov/pubmed/21968109
  43. Wildhagen KC, Lutgens E, Loubele ST, ten Cate H, Nicolaes GA. The structure-function relationship of activated protein C. Lessons from natural and engineered mutations. Thromb Haemost 2011; 106(6): 1034-1045. https://www.ncbi.nlm.nih.gov/pubmed/22072231
  44. Yla-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PW, Waltenberger J, Weber C, Tokgozoglu L. Stabilisation of atherosclerotic plaques. Position paper of the European Society of Cardiology (ESC) Working Group on atherosclerosis and vascular biology. Thromb Haemost 2011; 106(1): 1-19. https://www.ncbi.nlm.nih.gov/pubmed/21670845
  45. Zhou Z, Subramanian P, Sevilmis G, Globke B, Soehnlein O, Karshovska E, Megens R, Heyll K, Chun J, Saulnier-Blache JS, Reinholz M, van Zandvoort M, Weber C, Schober A. Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium. Cell Metab 2011; 13(5): 592-600. https://www.ncbi.nlm.nih.gov/pubmed/21531341