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Publications 2010

  1. Bai L, Beckers L, Wijnands E, Lutgens SP, Herias MV, Saftig P, Daemen MJ, Cleutjens K, Lutgens E, Biessen EA, Heeneman S. Cathepsin K gene disruption does not affect murine aneurysm formation. Atherosclerosis 2010; 209(1): 96-103. https://www.ncbi.nlm.nih.gov/pubmed/19775691
  2. Bampalis VG, Khandoga AL, Siess W. Fluoxetine inhibition of 5-HT-potentiated platelet aggregation in whole blood. Thromb Haemost 2010; 104(6): 1272-4. https://www.ncbi.nlm.nih.gov/pubmed/20806122
  3. Berres ML, Koenen RR, Rueland A, Zaldivar MM, Heinrichs D, Sahin H, Schmitz P, Streetz KL, Berg T, Gassler N, Weiskirchen R, Proudfoot A, Weber C, Trautwein C, Wasmuth HE. Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. J Clin Invest 2010; 120(11): 4129-40. https://www.ncbi.nlm.nih.gov/pubmed/20978355
  4. Braunersreuther V, Pellieux C, Pelli G, Burger F, Steffens S, Montessuit C, Weber C, Proudfoot A, Mach F, Arnaud C. Chemokine CCL5/RANTES inhibition reduces myocardial reperfusion injury in atherosclerotic mice. J Mol Cell Cardiol 2010; 48(4): 789-98. https://www.ncbi.nlm.nih.gov/pubmed/19665464
  5. Drechsler M, Megens RT, van Zandvoort M, Weber C, Soehnlein O. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation 2010; 122(18): 1837-45. https://www.ncbi.nlm.nih.gov/pubmed/20956207
  6. Dwivedi S, Pandey D, Khandoga AL, Brandl R, Siess W. Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque. J Transl Med 2010; 8: 128. https://www.ncbi.nlm.nih.gov/pubmed/21134286
  7. Felker P, Sere K, Lin Q, Becker C, Hristov M, Hieronymus T, Zenke M. TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells. J Immunol 2010; 185(9): 5326-35. https://www.ncbi.nlm.nih.gov/pubmed/20881193
  8. Gerdes N. From bystander to commander: how smooth muscle cells promote lymphoid tissue neogenesis. Arterioscler Thromb Vasc Biol 2010; 30(3): 393-4. https://www.ncbi.nlm.nih.gov/pubmed/20139359
  9. Goossens P, Gijbels MJ, Zernecke A, Eijgelaar W, Vergouwe MN, van der Made I, Vanderlocht J, Beckers L, Buurman WA, Daemen MJ, Kalinke U, Weber C, Lutgens E, de Winther MP. Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. Cell Metab 2010; 12(2): 142-53. https://www.ncbi.nlm.nih.gov/pubmed/20674859
  10. Hristov M, Gumbel D, Lutgens E, Zernecke A, Weber C. Soluble CD40 ligand impairs the function of peripheral blood angiogenic outgrowth cells and increases neointimal formation after arterial injury. Circulation 2010; 121(2): 315-24. https://www.ncbi.nlm.nih.gov/pubmed/20048211
  11. Hristov M, Leyendecker T, Schuhmann C, von Hundelshausen P, Heussen N, Kehmeier E, Krotz F, Sohn HY, Klauss V, Weber C. Circulating monocyte subsets and cardiovascular risk factors in coronary artery disease. Thromb Haemost 2010; 104(2): 412-4. https://www.ncbi.nlm.nih.gov/pubmed/20431842
  12. Jung C, Gerdes N, Fritzenwanger M, Figulla HR. Circulating levels of interleukin-1 family cytokines in overweight adolescents. Mediators Inflamm 2010; 2010: 958403. https://www.ncbi.nlm.nih.gov/pubmed/20169140
  13. Kenne E, Soehnlein O, Genove G, Rotzius P, Eriksson EE, Lindbom L. Immune cell recruitment to inflammatory loci is impaired in mice deficient in basement membrane protein laminin alpha4. J Leukoc Biol 2010; 88(3): 523-8. https://www.ncbi.nlm.nih.gov/pubmed/20483922
  14. Koenen RR, Weber C. Therapeutic targeting of chemokine interactions in atherosclerosis. Nat Rev Drug Discov 2010; 9(2): 141-53. https://www.ncbi.nlm.nih.gov/pubmed/20118962
  15. Koenen RR, Weber C. Platelet-derived chemokines in vascular remodeling and atherosclerosis. Semin Thromb Hemost 2010; 36(2): 163-9. https://www.ncbi.nlm.nih.gov/pubmed/20414831
  16. Liehn EA, Piccinini AM, Koenen RR, Soehnlein O, Adage T, Fatu R, Curaj A, Popescu A, Zernecke A, Kungl AJ, Weber C. A new monocyte chemotactic protein-1/chemokine CC motif ligand-2 competitor limiting neointima formation and myocardial ischemia/reperfusion injury in mice. J Am Coll Cardiol 2010; 56(22): 1847-57. https://www.ncbi.nlm.nih.gov/pubmed/21087715
  17. Lievens D, Gerdes N, Schober A, Weber C. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol 2010; 21(3): 284-5. https://www.ncbi.nlm.nih.gov/pubmed/20463476
  18. Lievens D, Zernecke A, Seijkens T, Soehnlein O, Beckers L, Munnix IC, Wijnands E, Goossens P, van Kruchten R, Thevissen L, Boon L, Flavell RA, Noelle RJ, Gerdes N, Biessen EA, Daemen MJ, Heemskerk JW, Weber C, Lutgens E. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood 2010; 116(20): 4317-27. https://www.ncbi.nlm.nih.gov/pubmed/20705757
  19. Linder A, Soehnlein O, Akesson P. Roles of heparin-binding protein in bacterial infections. J Innate Immun 2010; 2(5): 431-8. https://www.ncbi.nlm.nih.gov/pubmed/20505311
  20. Loges S, Schmidt T, Tjwa M, van Geyte K, Lievens D, Lutgens E, Vanhoutte D, Borgel D, Plaisance S, Hoylaerts M, Luttun A, Dewerchin M, Jonckx B, Carmeliet P. Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6. Blood 2010; 115(11): 2264-73. https://www.ncbi.nlm.nih.gov/pubmed/19965679
  21. Lutgens E, Lievens D, Beckers L, Wijnands E, Soehnlein O, Zernecke A, Seijkens T, Engel D, Cleutjens J, Keller AM, Naik SH, Boon L, Oufella HA, Mallat Z, Ahonen CL, Noelle RJ, de Winther MP, Daemen MJ, Biessen EA, Weber C. Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med 2010; 207(2): 391-404. https://www.ncbi.nlm.nih.gov/pubmed/20100871
  22. Mause SF, Ritzel E, Liehn EA, Hristov M, Bidzhekov K, Muller-Newen G, Soehnlein O, Weber C. Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury. Circulation 2010; 122(5): 495-506. https://www.ncbi.nlm.nih.gov/pubmed/20644015
  23. Mause SF, Weber C. Microparticles: protagonists of a novel communication network for intercellular information exchange. Circ Res 2010; 107(9): 1047-57. https://www.ncbi.nlm.nih.gov/pubmed/21030722
  24. Mause SF, Weber C, Sampol J, Dignat-George F. New horizons in vascular biology and thrombosis: Highlights from EMVBM 2009. Thromb Haemost 2010; 104(3): 421-3. https://www.ncbi.nlm.nih.gov/pubmed/20694282
  25. Meuwese MC, Broekhuizen LN, Kuikhoven M, Heeneman S, Lutgens E, Gijbels MJ, Nieuwdorp M, Peutz CJ, Stroes ES, Vink H, van den Berg BM. Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice. PLoS One 2010; 5(12): e14262. https://www.ncbi.nlm.nih.gov/pubmed/21170388
  26. Noels H, Weber C. Fractalkine as an important target of aspirin in the prevention of atherogenesis : Editorial to: "Aspirin inhibits fractalkine expression in atherosclerotic plaques and reduces atherosclerosis in ApoE gene knockout mice" by H. Liu et al. Cardiovasc Drugs Ther 2010; 24(1): 1-3. https://www.ncbi.nlm.nih.gov/pubmed/20033269
  27. Penz SM, Bernlochner I, Toth O, Lorenz R, Calatzis A, Siess W. Selective and rapid monitoring of dual platelet inhibition by aspirin and P2Y12 antagonists by using multiple electrode aggregometry. Thromb J 2010; 8: 9. https://www.ncbi.nlm.nih.gov/pubmed/20465804
  28. Preissner K, Lip G, Weber C. Editor´s choice articles 2008–2009. Thrombosis and Haemostasis 2017; 103(01): 3-6. http://dx.doi.org/10.1055/s-0037-1608916
  29. Rana OR, Schauerte P, Kluttig R, Schroder JW, Koenen RR, Weber C, Nolte KW, Weis J, Hoffmann R, Marx N, Saygili E. Acetylcholine as an age-dependent non-neuronal source in the heart. Auton Neurosci 2010; 156(1-2): 82-9. https://www.ncbi.nlm.nih.gov/pubmed/20510655
  30. Reininger AJ, Bernlochner I, Penz SM, Ravanat C, Smethurst P, Farndale RW, Gachet C, Brandl R, Siess W. A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol 2010; 55(11): 1147-58. https://www.ncbi.nlm.nih.gov/pubmed/20223370
  31. Ren M, Guo Q, Guo L, Lenz M, Qian F, Koenen RR, Xu H, Schilling AB, Weber C, Ye RD, Dinner AR, Tang WJ. Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme. EMBO J 2010; 29(23): 3952-66. https://www.ncbi.nlm.nih.gov/pubmed/20959807
  32. Rotzius P, Thams S, Soehnlein O, Kenne E, Tseng CN, Bjorkstrom NK, Malmberg KJ, Lindbom L, Eriksson EE. Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice. Am J Pathol 2010; 177(1): 493-500. https://www.ncbi.nlm.nih.gov/pubmed/20472897
  33. Saygili E, Schauerte P, Kuppers F, Heck L, Weis J, Weber C, Schwinger RH, Hoffmann R, Schroder JW, Marx N, Rana OR. Electrical stimulation of sympathetic neurons induces autocrine/paracrine effects of NGF mediated by TrkA. J Mol Cell Cardiol 2010; 49(1): 79-87. https://www.ncbi.nlm.nih.gov/pubmed/20138055
  34. Schober LJ, Khandoga AL, Penz SM, Siess W. The EP3-agonist sulprostone, but not prostaglandin E2 potentiates platelet aggregation in human blood. Thromb Haemost 2010; 103(6): 1268-9. https://www.ncbi.nlm.nih.gov/pubmed/20431854
  35. Schreinemachers MC, Doorschodt BM, Florquin S, van den Bergh Weerman MA, Zernecke A, Idu MM, Tolba RH, van Gulik TM. Pulsatile perfusion preservation of warm ischaemia-damaged experimental kidney grafts. Br J Surg 2010; 97(3): 349-58. https://www.ncbi.nlm.nih.gov/pubmed/20095019
  36. Schwarz N, Pruessmeyer J, Hess FM, Dreymueller D, Pantaler E, Koelsch A, Windoffer R, Voss M, Sarabi A, Weber C, Sechi AS, Uhlig S, Ludwig A. Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1. Cell Mol Life Sci 2010; 67(24): 4233-48. https://www.ncbi.nlm.nih.gov/pubmed/20559678
  37. Seijkens T, Engel D, Tjwa M, Lutgens E. The role of CD154 in haematopoietic development. Thromb Haemost 2010; 104(4): 693-701. https://www.ncbi.nlm.nih.gov/pubmed/20694278
  38. Shagdarsuren E, Bidzhekov K, Mause SF, Simsekyilmaz S, Polakowski T, Hawlisch H, Gessner JE, Zernecke A, Weber C. C5a receptor targeting in neointima formation after arterial injury in atherosclerosis-prone mice. Circulation 2010; 122(10): 1026-36. https://www.ncbi.nlm.nih.gov/pubmed/20733098
  39. Soehnlein O, Eriksson S, Hjelmqvist H, Andersson A, Morgelin M, Lindbom L, Rundgren M, Frithiof R. Anesthesia aggravates lung damage and precipitates hypotension in endotoxemic sheep. Shock 2010; 34(4): 412-9. https://www.ncbi.nlm.nih.gov/pubmed/20844413
  40. Soehnlein O, Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol 2010; 10(6): 427-39. https://www.ncbi.nlm.nih.gov/pubmed/20498669
  41. Subramanian P, Karshovska E, Reinhard P, Megens RT, Zhou Z, Akhtar S, Schumann U, Li X, van Zandvoort M, Ludin C, Weber C, Schober A. Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation. Circ Res 2010; 107(1): 96-105. https://www.ncbi.nlm.nih.gov/pubmed/20360252
  42. Subramanian P, Schober A. Neointima formation after vascular injury: is it all about CD39? Thromb Haemost 2010; 103(2): 257-8. https://www.ncbi.nlm.nih.gov/pubmed/20076840
  43. van Triest HJ, Megens RT, van Assen HC, ter Haar Romeny BM, van Zandvoort MA. Arterial radius estimation from microscopic data using a new algorithm for circle parameter estimation. J Biomed Opt 2010; 15(2): 026012. https://www.ncbi.nlm.nih.gov/pubmed/20459257
  44. Vasina E, Heemskerk JW, Weber C, Koenen RR. Platelets and platelet-derived microparticles in vascular inflammatory disease. Inflamm Allergy Drug Targets 2010; 9(5): 346-54. https://www.ncbi.nlm.nih.gov/pubmed/21054257
  45. Weber C. Far from the heart: Receptor cross-talk in remote conditioning. Nat Med 2010; 16(7): 760-2. https://www.ncbi.nlm.nih.gov/pubmed/20613755
  46. Weber C. Obstacles and options in the quest for drug candidates against vascular disease. Thromb Haemost 2010; 104(1): 1-3. https://www.ncbi.nlm.nih.gov/pubmed/20508900
  47. Weber C, Lip GY. Moving forward with a new editorial team for Thrombosis and Haemostasis. Thromb Haemost 2010; 103(1): 1-2. https://www.ncbi.nlm.nih.gov/pubmed/20062942
  48. Weber C, Schober A, Zernecke A. MicroRNAs in arterial remodelling, inflammation and atherosclerosis. Curr Drug Targets 2010; 11(8): 950-6. https://www.ncbi.nlm.nih.gov/pubmed/20415650
  49. Wiesner C, Faix J, Himmel M, Bentzien F, Linder S. KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophages. Blood 2010; 116(9): 1559-69. https://www.ncbi.nlm.nih.gov/pubmed/20505159
  50. Zaldivar MM, Pauels K, von Hundelshausen P, Berres ML, Schmitz P, Bornemann J, Kowalska MA, Gassler N, Streetz KL, Weiskirchen R, Trautwein C, Weber C, Wasmuth HE. CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis. Hepatology 2010; 51(4): 1345-53. https://www.ncbi.nlm.nih.gov/pubmed/20162727
  51. Zernecke A, Weber C. Chemokines in the vascular inflammatory response of atherosclerosis. Cardiovasc Res 2010; 86(2): 192-201. https://www.ncbi.nlm.nih.gov/pubmed/20007309
  52. Zimmermann HW, Seidler S, Nattermann J, Gassler N, Hellerbrand C, Zernecke A, Tischendorf JJ, Luedde T, Weiskirchen R, Trautwein C, Tacke F. Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One 2010; 5(6): e11049. https://www.ncbi.nlm.nih.gov/pubmed/20548789