The field of ncRNA is rapidly developing and probably most – if not all- key processes in cells are directly or indirectly controlled by these molecules. TRR 267 contributes to decipher the function of ncRNAs in the cardiovascular system thereby gaining important insights into the regulatory mechanisms of CV disease. This may – in long-term – also open novel therapeutic avenues. Our research includes two main research focus areas aiming at new targets for therapy development. They are complemented by infrastructural projects.The research program aims on targeting specific, unmet medical needs, particularly the aspect of cardiac remodelling and heart failure, vascular remodelling and reparative/regenerative processes. An important bassis for these studies are disease models in vitro and in vivo. Trr 267 includes 18 research projects under the leadership of 30 principal investigators.